ATE350397T1 - Par-2-aktivierendes peptidderivat und pharmazeutische zusammensetzung, in der dieses verwendet wird - Google Patents

Par-2-aktivierendes peptidderivat und pharmazeutische zusammensetzung, in der dieses verwendet wird

Info

Publication number: ATE350397T1
Authority: AT; Austria
Prior art keywords: peptide derivative; intra; oral cavity; pharmaceutical composition; par
Prior art date: 2002-06-10

Application number

AT03733343T

Other languages

English (en)

Inventor

Robert Ramage

Robin Plevin

Kevin Thomas Shaw

Lu Jiang

Louise Claire Young

Alan Lang Harvey

Pu Wang

Toru Kanke

Junichi Kawagoe

Mototsugu Kabeya

Original Assignee

Univ Edinburgh

Univ Strathclyde

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-10

Filing date

2003-06-10

Publication date

2007-01-15

2003-06-10 Application filed by Univ Edinburgh, Univ Strathclyde, Kowa Co filed Critical Univ Edinburgh

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE350397T1 publication Critical patent/ATE350397T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
NTQVODZUQIATFS-WAUHAFJUSA-N (2s)-2-[[(2s)-6-amino-2-[[2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-methylbutanoic acid Chemical compound OC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O NTQVODZUQIATFS-WAUHAFJUSA-N 0.000 title 1
102100037132 Proteinase-activated receptor 2 Human genes 0.000 title 1
101710121435 Proteinase-activated receptor 2 Proteins 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
WYBVBIHNJWOLCJ-IUCAKERBSA-N Arg-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCNC(N)=N WYBVBIHNJWOLCJ-IUCAKERBSA-N 0.000 abstract 1
206010010741 Conjunctivitis Diseases 0.000 abstract 1
208000019505 Deglutition disease Diseases 0.000 abstract 1
206010012735 Diarrhoea Diseases 0.000 abstract 1
208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
206010013774 Dry eye Diseases 0.000 abstract 1
206010013911 Dysgeusia Diseases 0.000 abstract 1
206010013954 Dysphoria Diseases 0.000 abstract 1
208000004232 Enteritis Diseases 0.000 abstract 1
208000007882 Gastritis Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
YQAIUOWPSUOINN-IUCAKERBSA-N Lys-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN YQAIUOWPSUOINN-IUCAKERBSA-N 0.000 abstract 1
WYBVBIHNJWOLCJ-UHFFFAOYSA-N N-L-arginyl-L-leucine Natural products CC(C)CC(C(O)=O)NC(=O)C(N)CCCN=C(N)N WYBVBIHNJWOLCJ-UHFFFAOYSA-N 0.000 abstract 1
208000021386 Sjogren Syndrome Diseases 0.000 abstract 1
208000007107 Stomach Ulcer Diseases 0.000 abstract 1
206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
201000007717 corneal ulcer Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
208000000718 duodenal ulcer Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
235000019564 dysgeusia Nutrition 0.000 abstract 1
201000005917 gastric ulcer Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
206010023332 keratitis Diseases 0.000 abstract 1
108010017391 lysylvaline Proteins 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Toxicology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Nutrition Science (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03733343T 2002-06-10 2003-06-10 Par-2-aktivierendes peptidderivat und pharmazeutische zusammensetzung, in der dieses verwendet wird ATE350397T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0213286.8A GB0213286D0 (en)	2002-06-10	2002-06-10	Par-2-Activating peptide derivative and pharmaceutical composition using the same

Publications (1)

Publication Number	Publication Date
ATE350397T1 true ATE350397T1 (de)	2007-01-15

Family

ID=9938287

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03733343T ATE350397T1 (de)	2002-06-10	2003-06-10	Par-2-aktivierendes peptidderivat und pharmazeutische zusammensetzung, in der dieses verwendet wird

Country Status (12)

Country	Link
US (1)	US7541339B2 (de)
EP (1)	EP1511765B1 (de)
JP (1)	JP4263169B2 (de)
KR (1)	KR20050011742A (de)
CN (1)	CN1659183A (de)
AT (1)	ATE350397T1 (de)
AU (1)	AU2003238697A1 (de)
CA (1)	CA2488937A1 (de)
DE (1)	DE60310928T2 (de)
GB (1)	GB0213286D0 (de)
TW (1)	TW200400971A (de)
WO (1)	WO2003104268A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4653516B2 (ja) *	2004-02-27	2011-03-16	扶桑薬品工業株式会社	涙液分泌促進ペプチドおよびその組成物
EP1806355A4 (de)	2004-09-30	2008-10-08	Kowa Co	Verfahren zur herstellung von (1,3-disubstituiertes indolyl)-harnstoffderivaten, zwischenprodukte dafür und verfahren zur herstellung der zwischenprodukte
JP4927566B2 (ja) *	2004-12-28	2012-05-09	興和株式会社	Ｐａｒ−２アゴニスト
EP1864994B1 (de) *	2005-03-29	2011-10-26	Kowa Company, Ltd.	Par-2-agonist
EP2427205A2 (de) *	2009-05-04	2012-03-14	INSERM - Institut National de la Santé et de la Recherche Médicale	Par2-agonisten zur verwendung bei der behandlung oder prävention von infektionen mit dem grippevirus typ a
EP2335717A1 (de)	2009-11-16	2011-06-22	Institut National De La Recherche Agronomique	PAR-1-Antagonisten zur Verwendung bei der Behandlung oder Prävention von Influenzavirus-Typ-A-Infektionen
WO2013159181A1 (en)	2012-04-28	2013-10-31	Litens Automotive Partnership	Adjustable tensioner
WO2014173859A2 (en)	2013-04-22	2014-10-30	Institut National De La Recherche Agronomique	Par-4 antagonists for use in the treatment or prevention of influenza virus type a infections
WO2015048245A1 (en)	2013-09-25	2015-04-02	Vertex Pharmaceuticals Incorporated	Imidazopyridazines useful as inhibitors of the par-2 signaling pathway
WO2019208435A1 (ja)	2018-04-26	2019-10-31	ライオン株式会社	外分泌促進剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6037324A (en)	1996-01-04	2000-03-14	Leukosite, Inc.	Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
GB9908513D0 (en)	1999-04-15	1999-06-09	Rolls Royce Plc	Molecular cloning of a new DNA sequence for protease activated receptor 2
US6908900B2 (en)	2001-01-17	2005-06-21	Zimmer & Associates Ag	Compositions and methods for enhanced pharmacological activity through oral and parenteral administration of compositions comprising polypeptide drug substances and other poorly absorbed active ingredients
JP3677421B2 (ja) *	1999-12-27	2005-08-03	扶桑薬品工業株式会社	涙液分泌促進組成物
JP4065642B2 (ja)	2000-02-24	2008-03-26	扶桑薬品工業株式会社	消化器系疾患の予防、治療用組成物
US7214655B2 (en) *	2001-05-21	2007-05-08	Johnson & Johnson Consumer Companies, Inc.	Peptides and the use thereof in darkening the skin

2002
- 2002-06-10 GB GBGB0213286.8A patent/GB0213286D0/en not_active Ceased
2003
- 2003-06-10 CN CN038128306A patent/CN1659183A/zh active Pending
- 2003-06-10 DE DE60310928T patent/DE60310928T2/de not_active Expired - Lifetime
- 2003-06-10 US US10/517,803 patent/US7541339B2/en not_active Expired - Fee Related
- 2003-06-10 AT AT03733343T patent/ATE350397T1/de not_active IP Right Cessation
- 2003-06-10 AU AU2003238697A patent/AU2003238697A1/en not_active Abandoned
- 2003-06-10 KR KR10-2004-7016267A patent/KR20050011742A/ko not_active Withdrawn
- 2003-06-10 JP JP2004511336A patent/JP4263169B2/ja not_active Expired - Fee Related
- 2003-06-10 TW TW092115632A patent/TW200400971A/zh unknown
- 2003-06-10 WO PCT/JP2003/007333 patent/WO2003104268A1/en not_active Ceased
- 2003-06-10 CA CA002488937A patent/CA2488937A1/en not_active Abandoned
- 2003-06-10 EP EP03733343A patent/EP1511765B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60310928D1 (de)	2007-02-15
WO2003104268A1 (en)	2003-12-18
CA2488937A1 (en)	2003-12-18
KR20050011742A (ko)	2005-01-29
EP1511765B1 (de)	2007-01-03
JP4263169B2 (ja)	2009-05-13
EP1511765A4 (de)	2005-10-12
US7541339B2 (en)	2009-06-02
JP2005538961A (ja)	2005-12-22
DE60310928T2 (de)	2007-10-11
AU2003238697A1 (en)	2003-12-22
CN1659183A (zh)	2005-08-24
TW200400971A (en)	2004-01-16
US20050222384A1 (en)	2005-10-06
GB0213286D0 (en)	2002-07-24
AU2003238697A8 (en)	2003-12-22
EP1511765A1 (de)	2005-03-09

Publication	Publication Date	Title
RU2005123807A (ru)	2006-01-20	Тетрагидро-4н-пиридо[1,2-а]пиримидины и родственные соединения, полезные в качестве ингибиторов вич-интегразы
DK2314582T3 (da)	2014-06-10	Heterocykliske forbindelser som antivirusmidler
EA200301094A1 (ru)	2004-06-24	Аминопроизводные как ингибиторы протеазы
NO20062713L (no)	2006-08-01	2,6 bisheteroaryl-4-aminopyrimidiner som adenosin reseptor antagonister
NO20056010L (no)	2006-01-20	Biaryloksymetylaren-karboksylsyrer
DK1086124T3 (da)	2004-03-29	Nye cyclosporiner
AR036906A1 (es)	2004-10-13	Compuestos de imidazopiridin como moduladores del receptor 5-ht4
EA200600811A1 (ru)	2006-10-27	НОВЫЕ ПРОИЗВОДНЫЕ ТЕТРАГИДРОСПИРО {ПИПЕРИДИН-2,7'-ПИРРОЛО [3,2-b]ПИРИДИНА} И НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАССТРОЙСТВ, СВЯЗАННЫХ С 5-HT-РЕЦЕПТОРОМ
NO20072515L (no)	2007-06-28	2-amido-4-fenyltnazolderivater, fremstilling og terapeutsik anvendelse derav
ATE350397T1 (de)	2007-01-15	Par-2-aktivierendes peptidderivat und pharmazeutische zusammensetzung, in der dieses verwendet wird
ATE372995T1 (de)	2007-09-15	Benzo(b)(1,4)dioxepinderivate
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
EE9800144A (et)	1998-10-15	Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
NO971625L (no)	1997-05-30	Nye peptider med immunomodulatoriske effekter
NO20050664L (no)	2005-04-15	2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer
NO20050666L (no)	2005-03-11	2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer
WO2024100452A3 (en)	2024-06-20	Heterocyclic compounds as sting agonists
RU2010116779A (ru)	2011-11-10	Производное амида индазолакриловой кислоты
EP0810221A4 (de)	2001-04-11	Sauerstoffhaltige heterocyclische derivate
WO2005061475A3 (en)	2006-05-04	Ornithine derivatives as prostaglandin e2 agonists or antagonists
BR0314860A (pt)	2005-08-02	Derivados de pirazol
BR0315620A (pt)	2005-08-23	Derivados de n-benzodioxolil, n-benzodioxanil e n-benzodioxepinil arilcarboxamida, e composições farmacêuticas compreendendo os mesmos
PE20040658A1 (es)	2004-11-09	Derivados de 3-guanidinocarbonil-1-heteroaril-pirrol, procedimiento de preparacion e intermediarios de este procedimiento y composiciones farmaceuticas que los comprenden
AR047409A1 (es)	2006-01-18	Derivados ciclicos de fenilalanina, proceso de obtencion y composiciones farmaceuticas.
EA200201232A1 (ru)	2003-04-24	Производные сульфонамида

Legal Events

Date	Code	Title	Description
2007-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties