ATE350388T1 - Verfahren zur herstellung von n-neohexyl-(a)- aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthalten - Google Patents
Verfahren zur herstellung von n-neohexyl-(a)- aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthaltenInfo
- Publication number
- ATE350388T1 ATE350388T1 AT99960417T AT99960417T ATE350388T1 AT E350388 T1 ATE350388 T1 AT E350388T1 AT 99960417 T AT99960417 T AT 99960417T AT 99960417 T AT99960417 T AT 99960417T AT E350388 T1 ATE350388 T1 AT E350388T1
- Authority
- AT
- Austria
- Prior art keywords
- aspartyl
- methyl ester
- neohexyl
- imidazolidin
- contain
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- GVONPBONFIJAHJ-UHFFFAOYSA-N imidazolidin-4-one Chemical compound O=C1CNCN1 GVONPBONFIJAHJ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 abstract 1
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10913298P | 1998-11-19 | 1998-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE350388T1 true ATE350388T1 (de) | 2007-01-15 |
Family
ID=22325963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99960417T ATE350388T1 (de) | 1998-11-19 | 1999-11-18 | Verfahren zur herstellung von n-neohexyl-(a)- aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthalten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6465677B1 (de) |
| EP (1) | EP1133518B1 (de) |
| AT (1) | ATE350388T1 (de) |
| AU (1) | AU1730800A (de) |
| DE (1) | DE69934712T2 (de) |
| ES (1) | ES2277456T3 (de) |
| WO (1) | WO2000031117A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6852875B2 (en) * | 2000-05-19 | 2005-02-08 | The Nutrasweet Co. | Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives |
| AU2001297682A1 (en) * | 2000-11-06 | 2002-09-04 | The Nutrasweet Company | Catalyst modification to enhance neotame production |
| CN101775066B (zh) * | 2010-01-29 | 2012-05-02 | 常茂生物化学工程股份有限公司 | 一种合成纽甜的方法 |
| CN102863511B (zh) * | 2012-09-27 | 2015-07-08 | 嘉兴百思食品科技有限公司 | 制备纽甜的一种方法 |
| CN103145796B (zh) * | 2013-03-25 | 2015-02-04 | 重庆民泰香料化工有限责任公司 | 一种纽甜合成工艺 |
| CN103333085B (zh) * | 2013-07-11 | 2015-01-07 | 济南诚汇双达化工有限公司 | 一种纽甜中间体亚胺的制备分离方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU628257B2 (en) | 1990-03-15 | 1992-09-10 | Nutrasweet Company, The | Process for manufacturing aspartame from a diketopiperazine and novel intermediates and derivatives therefor |
| FR2697844B1 (fr) | 1992-11-12 | 1995-01-27 | Claude Nofre | Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation. |
| FR2719590B1 (fr) | 1994-05-09 | 1996-07-26 | Claude Nofre | Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant. |
| US5728862A (en) | 1997-01-29 | 1998-03-17 | The Nutrasweet Company | Method for preparing and purifying an N-alkylated aspartame derivative |
-
1999
- 1999-11-17 US US09/441,512 patent/US6465677B1/en not_active Expired - Lifetime
- 1999-11-18 AT AT99960417T patent/ATE350388T1/de not_active IP Right Cessation
- 1999-11-18 DE DE69934712T patent/DE69934712T2/de not_active Expired - Lifetime
- 1999-11-18 AU AU17308/00A patent/AU1730800A/en not_active Abandoned
- 1999-11-18 WO PCT/US1999/027235 patent/WO2000031117A1/en not_active Ceased
- 1999-11-18 ES ES99960417T patent/ES2277456T3/es not_active Expired - Lifetime
- 1999-11-18 EP EP99960417A patent/EP1133518B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU1730800A (en) | 2000-06-13 |
| EP1133518B1 (de) | 2007-01-03 |
| WO2000031117A1 (en) | 2000-06-02 |
| EP1133518A1 (de) | 2001-09-19 |
| ES2277456T3 (es) | 2007-07-01 |
| DE69934712D1 (de) | 2007-02-15 |
| US6465677B1 (en) | 2002-10-15 |
| DE69934712T2 (de) | 2007-10-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE255604T1 (de) | Verfahren zur herstellung von polyalkenaminen | |
| DE59706114D1 (de) | Verfahren zur herstellung von 1,4-butandiol durch katalytische hydrierung von 1,4-butindiol | |
| BG101833A (bg) | Гуаниново производно | |
| SE9604341D0 (sv) | Hepta-peptide oxytocin analogue | |
| DE69609958D1 (de) | Verfahren zur herstellung von produkten, die bisalze der ameisensäure enthalten | |
| ATE328965T1 (de) | Azoverbindungen sowie verfahren zur herstellung derselben | |
| AU2001264679A1 (en) | Synthesis of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester using oxazolidinone derivatives | |
| DE69823662D1 (de) | 1,4,7,10-tetraazabicyclo(8.2.2)tetradecan-2-on, verfahren zu ihrer herstellung und ihrer verwendung für die herstellung von tetraazamacrocyclen | |
| ATE245435T1 (de) | Totalsynthese des amino hip analogen von didemnin a | |
| DE69703935D1 (de) | 2-chloro-3,5-bis(trifluoromethyl)phenyl-benzoylharnstoff-derivate und verfahren zur herstellung derselben | |
| ATE375090T1 (de) | Bioaktive peptide, ihre verwendung und verfahren zu ihre herstellung | |
| DE59803517D1 (de) | Einstufiges verfahren zur herstellung von glykolmonoethern aus olefinen | |
| ATE350388T1 (de) | Verfahren zur herstellung von n-neohexyl-(a)- aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthalten | |
| DE69415345D1 (de) | Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol | |
| DE69706382D1 (de) | Verfahren zur herstellung von 2,2'-bipyrrolyl-pyrromethen-derivaten (prodigiosine) | |
| EA199900790A1 (ru) | Способы получения пестицидных промежуточных соединений | |
| ATE239701T1 (de) | Polyethoxylierte retinamid-derivate und verfahren zu ihrer herstellung | |
| DE69917615D1 (de) | Ein verfahren zur herstellung von (2s,2'r,3'r)-2-(2,3-dicarboxycyclopropyl)-glycin | |
| DE59508742D1 (de) | Verfahren zur herstellung 1,3-disubstituierter imidazolidinone | |
| ATE353937T1 (de) | Verfahren zur synthese einer oxonolverbindung | |
| DE59712632D1 (de) | Verfahren zur herstellung von 3-pyrrolin-2-carbonsäure-derivaten | |
| MXPA01011104A (es) | Procedimiento de sintesis de derivados n-(mercaptoail)-aminoacidos a partir de acidos acrilicos alfa substituidos. | |
| DE69513408D1 (de) | Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden | |
| DE69814395D1 (de) | Verfahren zur herstellung von alkoxyfuranon-amin-derivaten, durch dieses verfahren erhaltene verbindungen und verwendung dieser verbindungen | |
| EP0858992A4 (de) | Verfahren zur herstellung halogenierter cyclopropan-derivate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |