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MXPA01011104A - Procedimiento de sintesis de derivados n-(mercaptoail)-aminoacidos a partir de acidos acrilicos alfa substituidos. - Google Patents

Procedimiento de sintesis de derivados n-(mercaptoail)-aminoacidos a partir de acidos acrilicos alfa substituidos.

Info

Publication number
MXPA01011104A
MXPA01011104A MXPA01011104A MXPA01011104A MXPA01011104A MX PA01011104 A MXPA01011104 A MX PA01011104A MX PA01011104 A MXPA01011104 A MX PA01011104A MX PA01011104 A MXPA01011104 A MX PA01011104A MX PA01011104 A MXPA01011104 A MX PA01011104A
Authority
MX
Mexico
Prior art keywords
alpha
mercaptoacyl
synthesizing
amino acid
acid derivatives
Prior art date
Application number
MXPA01011104A
Other languages
English (en)
Inventor
Piettre Serge
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Publication of MXPA01011104A publication Critical patent/MXPA01011104A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/06—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C07C327/16—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

La presente invencion tiene por objeto un procedimiento de preparacion de un compuesto de formula (I) (ver formula) dicho procedimiento que comprende una etapa (B) que consiste en realizar una adicion de Michael de un tioacido RS4H sobre un derivado de amida acrilica alfa-substituida. La invencion concierne igualmente a la sintesis enantioselectiva de compuestos de formula(I) en donde R2 es diferente de H, en la configuracion preferencial (S,S): (ver formula).
MXPA01011104A 2000-11-09 2001-10-31 Procedimiento de sintesis de derivados n-(mercaptoail)-aminoacidos a partir de acidos acrilicos alfa substituidos. MXPA01011104A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0014419A FR2816309B1 (fr) 2000-11-09 2000-11-09 Procede de synthese de derives n-(mercaptoacyl)-amino-acides a partir d'acides acryliques alpha-substitues

Publications (1)

Publication Number Publication Date
MXPA01011104A true MXPA01011104A (es) 2004-08-12

Family

ID=8856263

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01011104A MXPA01011104A (es) 2000-11-09 2001-10-31 Procedimiento de sintesis de derivados n-(mercaptoail)-aminoacidos a partir de acidos acrilicos alfa substituidos.

Country Status (13)

Country Link
US (1) US6835851B2 (es)
EP (1) EP1205476B1 (es)
JP (1) JP3965450B2 (es)
KR (1) KR100825531B1 (es)
AT (1) ATE238292T1 (es)
CA (1) CA2363284C (es)
DE (1) DE60100207T2 (es)
DK (1) DK1205476T3 (es)
ES (1) ES2198389T3 (es)
FR (1) FR2816309B1 (es)
MX (1) MXPA01011104A (es)
PT (1) PT1205476E (es)
TR (1) TR200300019T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008290958A (ja) * 2007-05-23 2008-12-04 Shiseido Co Ltd マイクロリアクターを用いた不飽和有機化合物の合成方法
CN102093272B (zh) * 2011-01-28 2013-03-20 海南美大制药有限公司 消旋卡多曲化合物及其制法
WO2012117410A1 (en) * 2011-03-02 2012-09-07 Symed Labs Limited A process for the preparation of n-[2-[(acetylthio) methyl]-1-oxo-3-phenylpropyl] glycine phenyl methyl ester and intermediates thereof
CN102391146B (zh) * 2011-08-01 2014-01-08 山东铂源药业有限公司 一种消旋卡多曲中间体2-（苄基丙烯酰胺）乙酸苄酯的制备方法
CN103755611A (zh) * 2014-01-16 2014-04-30 陕西汉江药业集团股份有限公司 一种消旋卡多曲的制备方法
CN107129450B (zh) * 2017-06-05 2019-05-03 山东裕欣药业有限公司 一种消旋卡多曲晶体化合物及其制备方法
CN110272363A (zh) * 2019-06-11 2019-09-24 扬子江药业集团江苏海慈生物药业有限公司 一种消旋卡多曲的合成方法
CN110283109B (zh) * 2019-07-10 2021-01-08 陕西汉江药业集团股份有限公司 一种工业化制备消旋卡多曲的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3047082A1 (de) * 1980-12-13 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4474799A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4401677A (en) * 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5599951A (en) * 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
FR2731219B1 (fr) * 1995-03-03 1997-04-25 Bioprojet Soc Civ Procede de synthese d'acides acryliques alpha-substitues et leur application

Also Published As

Publication number Publication date
EP1205476A1 (fr) 2002-05-15
FR2816309B1 (fr) 2002-12-27
PT1205476E (pt) 2003-08-29
DE60100207T2 (de) 2004-03-04
KR20030037602A (ko) 2003-05-14
DE60100207D1 (de) 2003-05-28
CA2363284C (fr) 2012-04-03
EP1205476B1 (fr) 2003-04-23
ATE238292T1 (de) 2003-05-15
US20020055645A1 (en) 2002-05-09
JP2002234869A (ja) 2002-08-23
ES2198389T3 (es) 2004-02-01
CA2363284A1 (fr) 2002-05-09
FR2816309A1 (fr) 2002-05-10
US6835851B2 (en) 2004-12-28
DK1205476T3 (da) 2003-08-11
JP3965450B2 (ja) 2007-08-29
KR100825531B1 (ko) 2008-04-25
TR200300019T3 (tr) 2003-02-21

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