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ATE227567T1 - Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption - Google Patents

Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption

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Publication number
ATE227567T1
ATE227567T1 AT95920409T AT95920409T ATE227567T1 AT E227567 T1 ATE227567 T1 AT E227567T1 AT 95920409 T AT95920409 T AT 95920409T AT 95920409 T AT95920409 T AT 95920409T AT E227567 T1 ATE227567 T1 AT E227567T1
Authority
AT
Austria
Prior art keywords
bone resorption
osteoclasts
preparations
inhibiting bone
resorption mediated
Prior art date
Application number
AT95920409T
Other languages
English (en)
Inventor
George D Hartman
Mark E Duggan
Nathan C Ihle
William F Hoffman
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE227567T1 publication Critical patent/ATE227567T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
AT95920409T 1994-05-27 1995-05-12 Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption ATE227567T1 (de)

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EP0760658A4 (de) 1997-09-17
DE69528829T2 (de) 2003-08-07
US5741796A (en) 1998-04-21
WO1995032710A1 (en) 1995-12-07
JPH10501222A (ja) 1998-02-03
EP0760658B1 (de) 2002-11-13
US5929120A (en) 1999-07-27
AU2586895A (en) 1995-12-21
ES2186720T3 (es) 2003-05-16
DE69528829D1 (de) 2002-12-19
CA2190870A1 (en) 1995-12-07
AU701776B2 (en) 1999-02-04

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