ATE210993T1 - Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren - Google Patents
Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basierenInfo
- Publication number
- ATE210993T1 ATE210993T1 AT94920294T AT94920294T ATE210993T1 AT E210993 T1 ATE210993 T1 AT E210993T1 AT 94920294 T AT94920294 T AT 94920294T AT 94920294 T AT94920294 T AT 94920294T AT E210993 T1 ATE210993 T1 AT E210993T1
- Authority
- AT
- Austria
- Prior art keywords
- iminodiesacetic
- acid
- ester bonds
- compounds based
- selectively cleavable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fertilizers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8038893A | 1993-06-21 | 1993-06-21 | |
| US8199793A | 1993-06-23 | 1993-06-23 | |
| PCT/US1994/007012 WO1995000165A1 (en) | 1993-06-21 | 1994-06-21 | Selectively cleavable linkers based on iminodiacetic acid ester bonds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210993T1 true ATE210993T1 (de) | 2002-01-15 |
Family
ID=26763448
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94920294T ATE210993T1 (de) | 1993-06-21 | 1994-06-21 | Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren |
| AT01114395T ATE369376T1 (de) | 1993-06-21 | 1994-06-21 | Selektiv spaltbare linker, die auf einer methionin- und einer estergruppe basieren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01114395T ATE369376T1 (de) | 1993-06-21 | 1994-06-21 | Selektiv spaltbare linker, die auf einer methionin- und einer estergruppe basieren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5635598A (de) |
| EP (2) | EP1156059B1 (de) |
| JP (2) | JP3469579B2 (de) |
| AT (2) | ATE210993T1 (de) |
| AU (1) | AU689116B2 (de) |
| DE (2) | DE69435011T2 (de) |
| DK (2) | DK1156059T3 (de) |
| ES (2) | ES2291245T3 (de) |
| NZ (1) | NZ268292A (de) |
| PT (2) | PT1156059E (de) |
| WO (1) | WO1995000165A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5463564A (en) * | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
| ATE272058T1 (de) * | 1995-10-17 | 2004-08-15 | Combichem Inc | Matrize für die synthese kombinatorischer bibliotheken in lösung |
| US6475807B1 (en) * | 1996-04-08 | 2002-11-05 | Smithkline Beecham Corporation | Mass-based encoding and qualitative analysis of combinatorial libraries |
| DE19626762A1 (de) * | 1996-07-03 | 1998-01-08 | Basf Ag | Enzymatisch spaltbare Linker für Festphasensynthesen |
| JP2001507675A (ja) * | 1996-11-04 | 2001-06-12 | ３―ディメンショナル ファーマシューティカルズ インコーポレイテッド | 所望の特性を有する化合物を識別するシステム、方法、コンピュータ・プログラム製品 |
| US6453246B1 (en) | 1996-11-04 | 2002-09-17 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for representing proximity data in a multi-dimensional space |
| US6571227B1 (en) * | 1996-11-04 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Method, system and computer program product for non-linear mapping of multi-dimensional data |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| US20030129589A1 (en) | 1996-11-06 | 2003-07-10 | Hubert Koster | Dna diagnostics based on mass spectrometry |
| ATE259056T1 (de) | 1996-11-06 | 2004-02-15 | Sequenom Inc | Verfahren zur massenspektrometrie |
| US5958703A (en) * | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
| US6168913B1 (en) * | 1997-10-14 | 2001-01-02 | Abbott Laboratories | Coding combinatorial libraries with fluorine tags |
| WO1999025752A1 (en) * | 1997-11-18 | 1999-05-27 | Aventis Pharmaceuticals Products Inc. | Functionalized resin for the synthesis of amides and peptides |
| CA2260472A1 (en) * | 1998-02-11 | 1999-08-11 | Xiao-Yi Xiao | Safety-catch linkers |
| US7094943B2 (en) | 1998-04-27 | 2006-08-22 | Hubert Köster | Solution phase biopolymer synthesis |
| GB9912911D0 (en) * | 1999-06-04 | 1999-08-04 | Zeneca Ltd | Chemical process |
| US6309889B1 (en) | 1999-12-23 | 2001-10-30 | Glaxo Wellcome Inc. | Nano-grid micro reactor and methods |
| US7416524B1 (en) | 2000-02-18 | 2008-08-26 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | System, method and computer program product for fast and efficient searching of large chemical libraries |
| US20010031475A1 (en) * | 2000-02-23 | 2001-10-18 | Gallop Mark A. | Self-encoded combinatorial synthesis of compound multiplets |
| AU2001241800A1 (en) | 2000-02-29 | 2001-09-12 | 3-Dimensional Pharmaceuticals, Inc. | Method and computer program product for designing combinatorial arrays |
| AU2001247627A1 (en) | 2000-03-22 | 2001-10-03 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for representing object relationships in a multidimensional space |
| AU2001249805A1 (en) | 2000-04-03 | 2001-10-15 | 3-Dimensional Pharmaceuticals, Inc. | Method, system, and computer program product for representing object relationships in a multidimensional space |
| CA2419600A1 (en) * | 2000-08-22 | 2002-02-28 | 3-Dimensional Pharmaceuticals, Inc. | Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks |
| US6678619B2 (en) * | 2000-09-20 | 2004-01-13 | Victor S. Lobanov | Method, system, and computer program product for encoding and building products of a virtual combinatorial library |
| US7054757B2 (en) * | 2001-01-29 | 2006-05-30 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Method, system, and computer program product for analyzing combinatorial libraries |
| US6670142B2 (en) | 2001-10-26 | 2003-12-30 | The Regents Of The University Of California | Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells |
| US7262269B2 (en) * | 2001-10-26 | 2007-08-28 | The Regents Of University Of California | Method for screening combinational bead library; ligands for cancer cells |
| US7291456B2 (en) | 2002-01-24 | 2007-11-06 | The Regents Of The University Of California | Method for determining differences in molecular interactions and for screening a combinatorial library |
| US20040185499A1 (en) * | 2003-03-20 | 2004-09-23 | Jolley Michael E. | Method of epitope scanning using fluorescence polarization |
| CA2585664C (en) * | 2004-11-05 | 2014-05-20 | The Children's Hospital Of Philadelphia | Biodegradable linkers for molecular therapies |
| EP2592103A1 (de) | 2011-11-08 | 2013-05-15 | Adriacell S.p.A. | Polymeraldehydderivate |
| CN105254576A (zh) * | 2014-02-26 | 2016-01-20 | 中国科学院长春应用化学研究所 | 一种谷氨酸二酮哌嗪的制备方法 |
| HK1244318A1 (zh) * | 2015-02-02 | 2018-08-03 | 奥特拉公司 | 用於生物标志物检测的不稳定的接头 |
| EP3262059B1 (de) * | 2015-02-24 | 2022-01-05 | City of Hope | Plattform zum screening von chemisch codierten räumlich adressierten bibliotheken |
| DE102015117567B4 (de) | 2015-10-15 | 2017-05-11 | Stochastic Combinatorics GbR (vertretungsberechtigter Gesellschafter: Dr. Alexander Nesterov-Müller, 76661 Philippsburg) | Ultra-hochdichte Oligomerarrays und Verfahren zu deren Herstellung |
| ES2919779T3 (es) | 2017-06-20 | 2022-07-28 | Imbria Pharmaceuticals Inc | Derivado de 1-[(2,3,4-trimetoxifenil)metil]-piperazina, composiciones del mismo y métodos para aumentar la eficiencia del metabolismo cardíaco |
| US12318382B2 (en) | 2018-10-17 | 2025-06-03 | Imbria Pharmaceuticals, Inc. | Methods of treating rheumatic diseases using trimetazidine-based compounds |
| CA3158746A1 (en) * | 2019-11-14 | 2021-05-20 | Bcd Bioscience, Inc. | High-yield peroxide quench-controlled polysaccharide depolymerization and compositions thereof |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
| US20250147030A1 (en) * | 2021-12-03 | 2025-05-08 | Massachusetts Institute Of Technology | Peptide-encoded libraries of small molecules for de novo drug discovery |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3963701A (en) * | 1972-04-17 | 1976-06-15 | Richardson-Merrell Inc. | Substituted benzhydryl lactamimide derivatives |
| FR2595695B1 (fr) * | 1986-03-12 | 1988-12-02 | Synthelabo | Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique |
| ES2003862A4 (es) * | 1986-12-24 | 1988-12-01 | Monsanto Co | Resina soporte para la sintesis de peptidos en fase solida. |
| ES2061714T3 (es) * | 1987-12-22 | 1994-12-16 | Hoechst Ag | Grupos de anclaje inestables frente a acidos para la sintesis de amidas peptidicas mediante el metodo en fase solida. |
| JP2815362B2 (ja) * | 1988-02-29 | 1998-10-27 | 中外製薬株式会社 | ベンズヒドリルアミン誘導体及びその製法 |
| US5066716A (en) * | 1988-12-13 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
| DK0458841T3 (da) * | 1989-02-17 | 1995-11-20 | Chiron Mimotopes Pty Ltd | Fremgangsmåde til anvendelse og fremstilling af peptider |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| NL9002611A (nl) * | 1990-11-29 | 1992-06-16 | Crown Gear Bv | Gereedschap voor het vervaardigen van kroonwielen, alsmede werkwijze voor het vervaardigen van een dergelijk gereedschap. |
| CS103091A3 (en) * | 1991-04-12 | 1992-10-14 | Ustav Organicke Chemie A Bioch | Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use |
-
1994
- 1994-06-21 EP EP01114395A patent/EP1156059B1/de not_active Expired - Lifetime
- 1994-06-21 PT PT01114395T patent/PT1156059E/pt unknown
- 1994-06-21 JP JP50304795A patent/JP3469579B2/ja not_active Expired - Fee Related
- 1994-06-21 EP EP94920294A patent/EP0751779B1/de not_active Expired - Lifetime
- 1994-06-21 WO PCT/US1994/007012 patent/WO1995000165A1/en not_active Ceased
- 1994-06-21 AU AU71145/94A patent/AU689116B2/en not_active Ceased
- 1994-06-21 NZ NZ268292A patent/NZ268292A/en not_active IP Right Cessation
- 1994-06-21 PT PT94920294T patent/PT751779E/pt unknown
- 1994-06-21 AT AT94920294T patent/ATE210993T1/de active
- 1994-06-21 DK DK01114395T patent/DK1156059T3/da active
- 1994-06-21 US US08/263,289 patent/US5635598A/en not_active Expired - Lifetime
- 1994-06-21 AT AT01114395T patent/ATE369376T1/de active
- 1994-06-21 ES ES01114395T patent/ES2291245T3/es not_active Expired - Lifetime
- 1994-06-21 DE DE69435011T patent/DE69435011T2/de not_active Expired - Lifetime
- 1994-06-21 ES ES94920294T patent/ES2165880T3/es not_active Expired - Lifetime
- 1994-06-21 DE DE69429542T patent/DE69429542T2/de not_active Expired - Lifetime
- 1994-06-21 DK DK94920294T patent/DK0751779T3/da active
-
2003
- 2003-06-04 JP JP2003159838A patent/JP3672558B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ268292A (en) | 1997-09-22 |
| ES2291245T3 (es) | 2008-03-01 |
| AU7114594A (en) | 1995-01-17 |
| JPH09500111A (ja) | 1997-01-07 |
| JP3672558B2 (ja) | 2005-07-20 |
| PT751779E (pt) | 2002-05-31 |
| EP0751779B1 (de) | 2001-12-19 |
| WO1995000165A1 (en) | 1995-01-05 |
| DK1156059T3 (da) | 2007-11-12 |
| JP3469579B2 (ja) | 2003-11-25 |
| EP0751779A1 (de) | 1997-01-08 |
| DE69435011T2 (de) | 2008-10-23 |
| JP2003327597A (ja) | 2003-11-19 |
| ATE369376T1 (de) | 2007-08-15 |
| US5635598A (en) | 1997-06-03 |
| PT1156059E (pt) | 2007-10-19 |
| ES2165880T3 (es) | 2002-04-01 |
| EP0751779A4 (de) | 1998-12-09 |
| DE69429542D1 (de) | 2002-01-31 |
| DE69429542T2 (de) | 2002-08-08 |
| EP1156059A1 (de) | 2001-11-21 |
| DK0751779T3 (da) | 2002-04-15 |
| EP1156059B1 (de) | 2007-08-08 |
| DE69435011D1 (de) | 2007-09-20 |
| AU689116B2 (en) | 1998-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EEIH | Change in the person of patent owner |