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ATE210679T1 - Ein inhibitor der collagenstimulierten plättchenaggregation - Google Patents

Ein inhibitor der collagenstimulierten plättchenaggregation

Info

Publication number
ATE210679T1
ATE210679T1 AT94923690T AT94923690T ATE210679T1 AT E210679 T1 ATE210679 T1 AT E210679T1 AT 94923690 T AT94923690 T AT 94923690T AT 94923690 T AT94923690 T AT 94923690T AT E210679 T1 ATE210679 T1 AT E210679T1
Authority
AT
Austria
Prior art keywords
collagen
protein
pct
stimulated
sec
Prior art date
Application number
AT94923690T
Other languages
English (en)
Inventor
Juergen Hemberger
Guido Melzer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE210679T1 publication Critical patent/ATE210679T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/858—Proteins from animals other than mammals or birds insects; venom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT94923690T 1993-07-01 1994-06-28 Ein inhibitor der collagenstimulierten plättchenaggregation ATE210679T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93110528 1993-07-01
PCT/EP1994/002087 WO1995001375A1 (en) 1993-07-01 1994-06-28 Inhibitor of collagen-stimulated platelet aggregation

Publications (1)

Publication Number Publication Date
ATE210679T1 true ATE210679T1 (de) 2001-12-15

Family

ID=8213032

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923690T ATE210679T1 (de) 1993-07-01 1994-06-28 Ein inhibitor der collagenstimulierten plättchenaggregation

Country Status (22)

Country Link
US (1) US5710131A (de)
EP (1) EP0662088B1 (de)
JP (1) JP3742429B2 (de)
KR (2) KR100455639B1 (de)
CN (1) CN1134451C (de)
AT (1) ATE210679T1 (de)
AU (1) AU680929B2 (de)
CA (1) CA2143416C (de)
CZ (1) CZ287472B6 (de)
DE (1) DE69429419T2 (de)
DK (1) DK0662088T3 (de)
ES (1) ES2169080T3 (de)
HU (1) HU214580B (de)
NO (1) NO320150B1 (de)
PL (1) PL180752B1 (de)
PT (1) PT662088E (de)
RU (1) RU2160280C2 (de)
SK (1) SK282961B6 (de)
TW (1) TW281678B (de)
UA (1) UA41332C2 (de)
WO (1) WO1995001375A1 (de)
ZA (1) ZA944738B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2153760B1 (es) * 1998-11-25 2001-07-01 Univ Barcelona Autonoma Inhibidor de metalocarboxipeptidasas como agente fibrinolitico.
US6774107B1 (en) 1999-03-18 2004-08-10 Merck Patent Gmbh Protein for blocking platelet adhesion
EP1942186B1 (de) 1999-05-07 2017-04-12 Sanofi-Aventis Deutschland GmbH Rekombinantes Plättchencollagen-Rezeptor-Glycoprotein VI und seine pharmazeutische Anwendung
MY128992A (en) 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen
GB0031448D0 (en) * 2000-12-22 2001-02-07 Leuven K U Res & Dev Inhibition of the vWF-collagen interaction by anti-human vWF monoclonal antibody (82D6A3) results in abolition of in vivo arterial platelet thrombus formation
RU2203074C2 (ru) * 2001-02-12 2003-04-27 Амиров Наиль Хабибулович Способ лечения ревматоидного артрита и остеоартроза
WO2006029258A2 (en) * 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
CA2579374A1 (en) 2004-09-07 2006-03-30 Archemix Corp. Aptamers to von willebrand factor and their use as thrombotic disease therapeutics
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
US20060286548A1 (en) * 2005-06-16 2006-12-21 Gregory Liposky Method of making recombinant human antibodies for use in biosensor technology
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US7691839B2 (en) * 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
TWI391143B (zh) * 2005-11-04 2013-04-01 Otsuka Pharma Co Ltd 血小板凝集抑制劑組成物
US20080015145A1 (en) * 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
WO2008150495A2 (en) * 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
EP2316465A1 (de) * 2009-10-15 2011-05-04 Centre National De La Recherche Scientifique Verwendung von Extrakt von Blutegelspeichel als antibakterielles Mittel zur Herstellung unterschiedlicher Zusammensetzungen
EP2670722B1 (de) 2011-01-31 2016-10-12 Council of Scientific & Industrial Research Chirale 1-(4-methylphenylmethyl) -5-oxo- {n-[(3-t-butoxycarbonyl-aminomethyl] piperidin-1-yl} -pyrrolidin-2-carboxamide als inhibitoren von kollageninduzierter thrombozytenaktivierung und -adhäsion

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238919A (en) * 1986-05-30 1993-08-24 Scipps Clinic And Research Foundation Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
ATE120206T1 (de) * 1986-05-30 1995-04-15 Scripps Clinic Res Peptide, die die bindung des von-willebrand- faktors inhibieren.
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
IL86856A0 (en) * 1988-06-24 1988-11-30 Yissum Res Dev Co Bovine xa factor and pharmaceutical compositions containing the same
JPH04503660A (ja) * 1988-12-05 1992-07-02 バイオジェン インコーポレイテッド 血小板凝集抑制の方法及び組成物
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) * 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents

Also Published As

Publication number Publication date
HU214580B (hu) 1998-04-28
SK27095A3 (en) 1995-08-09
JP3742429B2 (ja) 2006-02-01
NO320150B1 (no) 2005-10-31
RU2160280C2 (ru) 2000-12-10
PL307726A1 (en) 1995-06-12
TW281678B (de) 1996-07-21
EP0662088A1 (de) 1995-07-12
ES2169080T3 (es) 2002-07-01
HU9500613D0 (en) 1995-04-28
DE69429419T2 (de) 2002-08-01
PL180752B1 (pl) 2001-04-30
NO950732D0 (no) 1995-02-27
CA2143416A1 (en) 1995-01-12
DK0662088T3 (da) 2002-02-25
KR950703004A (ko) 1995-08-23
DE69429419D1 (de) 2002-01-24
CA2143416C (en) 2003-06-10
EP0662088B1 (de) 2001-12-12
KR100455639B1 (ko) 2004-11-09
ZA944738B (en) 1995-02-15
CZ52895A3 (en) 1995-09-13
JPH08500848A (ja) 1996-01-30
CN1111058A (zh) 1995-11-01
WO1995001375A1 (en) 1995-01-12
SK282961B6 (sk) 2003-01-09
UA41332C2 (uk) 2001-09-17
US5710131A (en) 1998-01-20
KR100445309B1 (ko) 2004-11-12
CN1134451C (zh) 2004-01-14
HUT71399A (en) 1995-11-28
AU680929B2 (en) 1997-08-14
NO950732L (no) 1995-02-27
AU7383694A (en) 1995-01-24
PT662088E (pt) 2002-06-28
CZ287472B6 (en) 2000-12-13
KR20040030124A (ko) 2004-04-08

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