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WO1998029436A3 - Lebetin peptides as platelet aggregation inhibitors - Google Patents

Lebetin peptides as platelet aggregation inhibitors Download PDF

Info

Publication number
WO1998029436A3
WO1998029436A3 PCT/EP1997/007335 EP9707335W WO9829436A3 WO 1998029436 A3 WO1998029436 A3 WO 1998029436A3 EP 9707335 W EP9707335 W EP 9707335W WO 9829436 A3 WO9829436 A3 WO 9829436A3
Authority
WO
WIPO (PCT)
Prior art keywords
lebetin
peptides
platelet aggregation
aggregation inhibitors
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1997/007335
Other languages
French (fr)
Other versions
WO1998029436A2 (en
Inventor
Herve Rochat
Kamel Mabrouk
Mohammed El-Ayeb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armel SA
Original Assignee
Armel SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armel SA filed Critical Armel SA
Priority to CA002275544A priority Critical patent/CA2275544A1/en
Priority to AU58612/98A priority patent/AU5861298A/en
Publication of WO1998029436A2 publication Critical patent/WO1998029436A2/en
Publication of WO1998029436A3 publication Critical patent/WO1998029436A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Lebetin peptides having the amino acid sequence: (X)mNKPPKKGPPNG(CFGHKIDRIGSHSGLGCNKVDDNKG)n(X)p where m=0 to 6, n=0 or 1, p=0 to 4 and each X is an amino acid residue are effective agents for the inhibition of platelet aggregation, and may be useful for the treatment of thrombosis or thromboembolism.
PCT/EP1997/007335 1996-12-31 1997-12-30 Lebetin peptides as platelet aggregation inhibitors Ceased WO1998029436A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002275544A CA2275544A1 (en) 1996-12-31 1997-12-30 Lebetin peptides as platelet aggregation inhibitors
AU58612/98A AU5861298A (en) 1996-12-31 1997-12-30 Lebetin peptides as platelet aggregation inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9627116.8A GB9627116D0 (en) 1996-12-31 1996-12-31 Lebetin peptides as platelet aggregation inhibitors
GB9627116.8 1996-12-31

Publications (2)

Publication Number Publication Date
WO1998029436A2 WO1998029436A2 (en) 1998-07-09
WO1998029436A3 true WO1998029436A3 (en) 1998-09-03

Family

ID=10805141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/007335 Ceased WO1998029436A2 (en) 1996-12-31 1997-12-30 Lebetin peptides as platelet aggregation inhibitors

Country Status (4)

Country Link
AU (1) AU5861298A (en)
CA (1) CA2275544A1 (en)
GB (1) GB9627116D0 (en)
WO (1) WO1998029436A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3099056B1 (en) * 2019-07-26 2022-08-12 Univ Rouen Normandie Use of ANP to destroy bacterial biofilms

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
R BARBOUCHE ET AL.: "Novel anti-platelet aggregation polypeptides from Vipera lebetina venom; isolation and characterization", FEBS LETTERS., vol. 392, no. 1, 19 August 1996 (1996-08-19), AMSTERDAM NL, pages 6 - 10, XP002066590 *

Also Published As

Publication number Publication date
CA2275544A1 (en) 1998-07-09
WO1998029436A2 (en) 1998-07-09
GB9627116D0 (en) 1997-02-19
AU5861298A (en) 1998-07-31

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