ATE115123T1 - Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte. - Google Patents

Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.

Info

Publication number: ATE115123T1
Authority: AT; Austria
Prior art keywords: formula; compound; oxazoline; oxazoline compound; pct
Prior art date: 1990-10-25

Application number

AT91920162T

Other languages

English (en)

Inventor

Jon E Clark

Doris P Schumacher

Guang-Zhong Wu

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-25

Filing date

1991-10-23

Publication date

1994-12-15

1991-10-23 Application filed by Schering Corp filed Critical Schering Corp

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE115123T1 publication Critical patent/ATE115123T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Compounds Of Unknown Constitution (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)

AT91920162T 1990-10-25 1991-10-23 Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte. ATE115123T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US60357590A	1990-10-25	1990-10-25

Publications (1)

Publication Number	Publication Date
ATE115123T1 true ATE115123T1 (de)	1994-12-15

Family

ID=24416027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91920162T ATE115123T1 (de)	1990-10-25	1991-10-23	Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.

Country Status (19)

Country	Link
US (1)	US5382673A (de)
EP (1)	EP0555340B1 (de)
JP (1)	JPH0645580B2 (de)
KR (1)	KR960008665B1 (de)
AT (1)	ATE115123T1 (de)
AU (1)	AU646910B2 (de)
CA (1)	CA2094810C (de)
CZ (1)	CZ286239B6 (de)
DE (1)	DE69105752T2 (de)
DK (1)	DK0555340T3 (de)
ES (1)	ES2067958T3 (de)
GR (1)	GR3015221T3 (de)
HK (1)	HK185496A (de)
HU (2)	HU212617B (de)
NZ (2)	NZ240319A (de)
PL (1)	PL166385B1 (de)
RU (1)	RU2071468C1 (de)
SK (1)	SK281740B6 (de)
WO (1)	WO1992007824A1 (de)

Families Citing this family (45)

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US5332835A (en) *	1984-02-03	1994-07-26	Zambon S.P.A.	Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US5352832A (en) *	1992-12-18	1994-10-04	Schering Corporation	Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US5663361A (en) †	1996-08-19	1997-09-02	Schering Corporation	Process for preparing intermediates to florfenicol
CO5031296A1 (es) *	1997-11-04	2001-04-27	Novartis Ag	Derivados de azolina, compuestos que la contienen y metodo para la preparacion y aplicacion de dicho compuesto
US6348625B1 (en) *	2000-11-10	2002-02-19	Gloria Long Anderson	Method for preparing some 1-adamantancecarboxamides
CA2468748C (en) *	2001-12-05	2010-01-26	Barr Laboratories, Inc.	Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
BR0308289A (pt) *	2002-03-08	2005-01-11	Schering Plough Ltd	Antibióticos do tipo florfenicol
US7439268B2 (en) *	2003-07-18	2008-10-21	Idexx Laboratories	Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) *	2003-08-27	2005-03-03	Idexx Laboratories, Inc.	Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en)	2003-10-06	2006-10-24	Aurobindo Pharma Limited	Process for preparing florfenicol
MX2007001811A (es) *	2004-08-13	2007-03-26	Schering Plough Ltd	Formulacion farmaceutica que comprende un antibiotico, un triazol y un corticoesteroide.
US7312248B2 (en)	2004-09-23	2007-12-25	Schering-Plough Animal Health Corporation	Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
MX2007006072A (es) *	2004-11-19	2007-07-11	Schering Plough Ltd	Control de parasitos en animales mediante el uso de derivados del parasiticida 2-fenil-3-(1h-pirrol-2-il)acrilonitrilo.
DK1830885T3 (da) *	2004-12-21	2009-01-05	Intervet Int Bv	Injicerbar veterinærmedicinsk sammensætning omfattende florfenicol
MX2007015729A (es) *	2005-06-09	2008-02-21	Schering Plough Ltd	Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida.
CN1331849C (zh) *	2005-08-12	2007-08-15	中国科学院上海有机化学研究所	甲砜霉素和氟苯尼考的新合成方法及其关键中间体
US8119667B2 (en) *	2005-12-29	2012-02-21	Schering-Plough Animal Health Corporation	Carbonates of fenicol antibiotics
US7518017B2 (en)	2006-02-17	2009-04-14	Idexx Laboratories	Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) *	2006-04-10	2007-10-11	Winzenberg Kevin N	N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
EP2102154A1 (de) *	2006-12-13	2009-09-23	Schering-Plough Ltd.	Wasserlösliche chloramphenicol- und thiamphenicol-prodrugs sowie analoga davon
WO2008076259A1 (en) *	2006-12-13	2008-06-26	Schering-Plough Ltd.	Water-soluble prodrugs of florfenicol and its analogs
RU2009143731A (ru) *	2007-04-27	2011-06-10	Шеринг-Плоу Лтд. (CH)	Соединения и способы улучшения растворимости флорфеникола и структурно родственных антибиотиков с помощью циклодекстринов
TWI430995B (zh)	2007-06-26	2014-03-21	Du Pont	萘異唑啉無脊椎有害動物控制劑
LT2957284T (lt)	2007-06-27	2018-04-10	E. I. Du Pont De Nemours And Company	Kovos su gyvūnų kenkėjais būdas
US7550625B2 (en) *	2007-10-19	2009-06-23	Idexx Laboratories	Esters of florfenicol
NZ585219A (en) *	2007-11-09	2012-11-30	Intervet Int Bv	Fast release solid formulation, preparation and use thereof
TWI468407B (zh)	2008-02-06	2015-01-11	Du Pont	中離子農藥
CN102131772B (zh) *	2008-07-30	2015-03-11	英特威国际有限公司	用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
UA107804C2 (en)	2009-08-05	2015-02-25	Du Pont	Mixtures of pesticides mezoionnyh
BR112012002519A2 (pt)	2009-08-05	2019-09-24	Du Pont	"pesticidas mesoiônicos"
WO2011017347A2 (en)	2009-08-05	2011-02-10	E. I. Du Pont De Nemours And Company	Mesoionic pesticides
UA110924C2 (uk)	2009-08-05	2016-03-10	Е. І. Дю Пон Де Немур Енд Компані	Мезоіонні пестициди
BRPI1002023A2 (pt)	2010-03-01	2011-10-25	Nanocore Biotecnologia S A	forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
EP2576523B1 (de)	2010-05-27	2016-01-13	E. I. du Pont de Nemours and Company	Kristalline form von 4- [5 - [3 -chlor-5 - (trifluormethyl) phenyl]-4, 5 - dihydro - 5 - (trifluormethyl) -3 - isoxazolyl]-n- [2-0x0-2- [ ( 2, 2, 2 - trifluorethyl) amino]ethyl]-1- naphthalencarboxamid
WO2012087630A1 (en)	2010-12-20	2012-06-28	E.I. Du Pont De Nemours And Company	Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en)	2012-04-17	2013-10-24	E. I. Du Pont De Nemours And Company	Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) *	2012-10-31	2014-07-02	绍兴民生医药有限公司	(4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103980167B (zh) *	2014-04-17	2016-06-08	天津大学	一种无定形氟苯尼考及其制备方法
CN105218474B (zh) *	2015-10-22	2017-12-05	山东国邦药业股份有限公司	(4r,5r)‑2‑二氯甲基‑4,5‑二氢‑5‑(4‑甲砜基苯基)‑4‑恶唑甲醇的合成方法
CN106278964B (zh) *	2016-07-31	2018-01-16	浙江润康药业有限公司	氟苯尼考的制备方法
CN109678811B (zh) *	2019-01-25	2020-12-29	湖北中牧安达药业有限公司	一种氟苯尼考中间体环合物的不对称制备方法
CN110330463B (zh) *	2019-08-02	2021-05-14	山东国邦药业有限公司	一种氟苯尼考中间体的制备方法
CN113264892B (zh) *	2021-04-05	2022-12-20	复旦大学	一种使用微反应系统连续制备氟苯尼考关键中间体的方法
CN113185473B (zh) *	2021-06-30	2021-10-08	山东国邦药业有限公司	一种氟苯尼考中间体氟甲砜噁唑的制备方法
CN113185474B (zh) *	2021-07-02	2021-11-05	山东国邦药业有限公司	一种氟苯尼考中间体的制备方法

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US2718520A (en) *		1955-09-20		Nitrophenyl-oxazolines and processes
US2820041A (en) *		1958-01-14		Preparation of nitrophenyloxazolines
US2686787A (en) *		1954-08-17		x xx xx - -
US2694071A (en) *		1954-11-09		Process for the preparation of tech
US2402198A (en) *	1944-09-06	1946-06-18	Du Pont	Preparation of oxazolines
US2759001A (en) *	1952-03-01	1956-08-14	Parke Davis & Co	Process for the production of delta2-oxazolines
US2692897A (en) *	1952-03-01	1954-10-26	Parke Davis & Co	Process for the production of acylamido diol compounds
FR1071077A (fr) *	1952-03-01	1954-08-24	Parke Davis & Co	Procédé de production de delta 2-oxazolines
US2786870A (en) *	1954-04-19	1957-03-26	Parke Davis & Co	Synthesis of chloramphenicol and related acylamidodiols
DE2127776A1 (de) *	1971-06-04	1972-12-14	Chemische Werke Hüls AG, 4370 Mari	Verfahren zur Herstellung cyclischer Imidsäureester
HU167760B (de) *	1972-10-20	1975-12-25
DE2732213A1 (de) *	1977-07-16	1979-01-25	Bayer Ag	Derivate der cyclopropancarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte zur herstellung von insektiziden
US4235892A (en) *	1979-02-05	1980-11-25	Schering Corporation, Patent Dept.	1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
US4361557A (en) *	1980-01-28	1982-11-30	Schering Corporation	1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
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ATE143953T1 (de) *	1983-06-02	1996-10-15	Zambon Spa	Verfahren zur herstellung von 1-(phenyl)-1- hydroxy-2-amino-3-fluor-propan-derivaten
US5105009A (en) *	1983-06-02	1992-04-14	Zambon S.P.A.	Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives
US5227494A (en) *	1988-09-14	1993-07-13	Schering Corporation	Process for preparing oxazoline compounds
WO1990002738A1 (en) *	1988-09-14	1990-03-22	Schering Corporation	Process for preparing oxazoline compounds
US4876352A (en) *	1988-09-14	1989-10-24	Schering Corporation	Pressurized fluorination of hydroxy alkyl groups
IT1237798B (it) *	1989-10-20	1993-06-17	Zambon Spa	Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
US5243050A (en) *	1990-12-20	1993-09-07	North Carolina State University	Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs

1991
- 1991-10-23 HU HU9301182A patent/HU212617B/hu unknown
- 1991-10-23 WO PCT/US1991/007608 patent/WO1992007824A1/en not_active Ceased
- 1991-10-23 JP JP4500718A patent/JPH0645580B2/ja not_active Expired - Lifetime
- 1991-10-23 NZ NZ240319A patent/NZ240319A/en not_active IP Right Cessation
- 1991-10-23 RU RU9193040370A patent/RU2071468C1/ru active
- 1991-10-23 AU AU89279/91A patent/AU646910B2/en not_active Expired
- 1991-10-23 PL PL91299059A patent/PL166385B1/pl unknown
- 1991-10-23 AT AT91920162T patent/ATE115123T1/de not_active IP Right Cessation
- 1991-10-23 DK DK91920162.4T patent/DK0555340T3/da active
- 1991-10-23 NZ NZ250394A patent/NZ250394A/en not_active IP Right Cessation
- 1991-10-23 CA CA002094810A patent/CA2094810C/en not_active Expired - Lifetime
- 1991-10-23 CZ CZ1993710A patent/CZ286239B6/cs not_active IP Right Cessation
- 1991-10-23 HU HU931182A patent/HU9301182D0/hu unknown
- 1991-10-23 US US08/039,450 patent/US5382673A/en not_active Expired - Lifetime
- 1991-10-23 ES ES91920162T patent/ES2067958T3/es not_active Expired - Lifetime
- 1991-10-23 EP EP91920162A patent/EP0555340B1/de not_active Expired - Lifetime
- 1991-10-23 SK SK377-93A patent/SK281740B6/sk not_active IP Right Cessation
- 1991-10-23 DE DE69105752T patent/DE69105752T2/de not_active Expired - Lifetime
1993
- 1993-04-24 KR KR93701226A patent/KR960008665B1/ko not_active Expired - Lifetime
1995
- 1995-02-28 GR GR950400425T patent/GR3015221T3/el unknown
1996
- 1996-10-03 HK HK185496A patent/HK185496A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
SK37793A3 (en)	1993-10-06
KR960008665B1 (en)	1996-06-28
WO1992007824A1 (en)	1992-05-14
AU8927991A (en)	1992-05-26
CA2094810C (en)	2002-06-04
EP0555340A1 (de)	1993-08-18
HK185496A (en)	1996-10-11
DE69105752D1 (de)	1995-01-19
EP0555340B1 (de)	1994-12-07
CA2094810A1 (en)	1992-04-26
NZ240319A (en)	1994-10-26
SK281740B6 (sk)	2001-07-10
JPH0645580B2 (ja)	1994-06-15
DE69105752T2 (de)	1995-05-11
RU2071468C1 (ru)	1997-01-10
ES2067958T3 (es)	1995-04-01
CZ286239B6 (cs)	2000-02-16
DK0555340T3 (da)	1995-03-06
NZ250394A (en)	1994-10-26
JPH05507289A (ja)	1993-10-21
CZ71093A3 (en)	1994-02-16
HUT65402A (en)	1994-06-28
HU9301182D0 (en)	1993-08-30
AU646910B2 (en)	1994-03-10
HU212617B (en)	1996-09-30
US5382673A (en)	1995-01-17
PL166385B1 (en)	1995-05-31
GR3015221T3 (en)	1995-05-31

Publication	Publication Date	Title
ATE115123T1 (de)	1994-12-15	Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.
ATE67497T1 (de)	1991-10-15	Verfahren zur herstellung von thiazolidinedionderivaten.
KR840005083A (ko)	1984-11-03	항고혈압제로서 유용한 아미노산유도체의 제조방법
KR910021366A (ko)	1991-12-20	4-(4-알콕시페닐)-2-부틸아민 유도체 및 그의 제조방법
ATE8047T1 (de)	1984-07-15	(2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthioessigs[ure, ihre salze und ester, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
KR840003610A (ko)	1984-09-15	요소 유도체의 제조방법
PT71773A (de)	1980-10-01	Verfahren zur herstellung von substituierten oxirancarbonsauren
DE69312566D1 (de)	1997-09-04	Verfahren zur Herstellung von Alkylpolyglukosiden
DE3877423D1 (de)	1993-02-25	Verfahren zur herstellung von gamma-halogen-tiglinsaeurealkylestern sowie deren weiterverarbeitung zu 0,0-dialkyl-gamma-phosphono-tiglin-saeurealkylestern.
ATE84074T1 (de)	1993-01-15	Verfahren zur fermentativen herstellung von 2-(4- hydroxiphenoxi-)propionsaeure.
ATE49402T1 (de)	1990-01-15	Verfahren zur herstellung von zirkoniumcarboxylat.
BR8900689A (pt)	1989-10-10	Processo para a preparacao de amidas do acido 3,3-dl-arilacrilico
DE68903570D1 (de)	1993-01-07	Verfahren zur herstellung von hydroxyalkylierungsmitteln, die erhaltenen mittel und deren verwendung.
ATE1707T1 (de)	1982-11-15	Verfahren zur herstellung von thiochlorformiaten.
IT1237529B (it)	1993-06-08	Composti spiro-indolino-ossazine con caratteristiche fotocromatiche e fotosensibilizzatrici e procedimento per la loro preparazione
DE69024999D1 (de)	1996-03-07	Verfahren zur Herstellung von 2-Oxindol-1-carboxamiden
DE68917160D1 (de)	1994-09-08	Herstellung von Aminosäure-Derivaten.
IT1077336B (it)	1985-05-04	Estere dell'acido fenossiacetico,processo di sua preparazione e metodo di suo impiego
ES8101889A1 (es)	1980-12-16	Procedimiento para la obtencion de pastas endoparasiticidas para caballos
KR920016441A (ko)	1992-09-24	글리세르알데하이드-3-펜타나이드 및 이의 제조방법
IT1099589B (it)	1985-09-18	Processo per la preparazione di derivati dell'acido benzoxazolil propionico
KR840007591A (ko)	1984-12-08	니자티딘의 합성법
ATE93845T1 (de)	1993-09-15	Verfahren zur herstellung von 4,4'-bis-(4aminophenoxy)-diphenylsulfon.
DE59107514D1 (de)	1996-04-11	Verfahren zur Herstellung von Cyclopropannitrilderivaten
DE69000437D1 (de)	1992-12-17	Verfahren zur herstellung von nichtionischen oberflaechenaktiven mitteln aus 1,2-isopropyliden-3-epoxypropylglycerol und einer carbonsaeure, nichtionische oberflaechenaktive mittel und ihre anwendung.

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2012-01-15	EELA	Cancelled due to lapse of time