ATE198753T1 - Androstan- und pregnanserien für die allosterische modulation des gaba-rezeptors - Google Patents
Androstan- und pregnanserien für die allosterische modulation des gaba-rezeptorsInfo
- Publication number
- ATE198753T1 ATE198753T1 AT95942879T AT95942879T ATE198753T1 AT E198753 T1 ATE198753 T1 AT E198753T1 AT 95942879 T AT95942879 T AT 95942879T AT 95942879 T AT95942879 T AT 95942879T AT E198753 T1 ATE198753 T1 AT E198753T1
- Authority
- AT
- Austria
- Prior art keywords
- androstane
- gaba receptor
- allosteric modulation
- pregnan series
- pregnan
- Prior art date
Links
- QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical compound C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 title 1
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
- JWMFYGXQPXQEEM-WZBAXQLOSA-N pregnane Chemical class C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 JWMFYGXQPXQEEM-WZBAXQLOSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34692694A | 1994-11-23 | 1994-11-23 | |
| PCT/US1995/015210 WO1996016076A1 (en) | 1994-11-23 | 1995-11-22 | Androstane and pregnane series for allosteric modulation of gaba receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE198753T1 true ATE198753T1 (de) | 2001-02-15 |
Family
ID=23361616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95942879T ATE198753T1 (de) | 1994-11-23 | 1995-11-22 | Androstan- und pregnanserien für die allosterische modulation des gaba-rezeptors |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0808325B1 (de) |
| JP (1) | JPH10509458A (de) |
| KR (1) | KR100394548B1 (de) |
| CN (1) | CN1171114A (de) |
| AP (1) | AP653A (de) |
| AT (1) | ATE198753T1 (de) |
| AU (1) | AU707486B2 (de) |
| BR (1) | BR9509764A (de) |
| CA (1) | CA2205919A1 (de) |
| CZ (1) | CZ292881B6 (de) |
| DE (1) | DE69519945T2 (de) |
| DK (1) | DK0808325T3 (de) |
| ES (1) | ES2155543T3 (de) |
| FI (1) | FI972202L (de) |
| GE (1) | GEP20002033B (de) |
| GR (1) | GR3035562T3 (de) |
| HU (1) | HUT77087A (de) |
| IL (1) | IL116108A (de) |
| IS (1) | IS4488A (de) |
| MX (1) | MX9703826A (de) |
| NO (1) | NO308950B1 (de) |
| NZ (1) | NZ298567A (de) |
| PL (1) | PL182898B1 (de) |
| PT (1) | PT808325E (de) |
| RU (1) | RU2176248C2 (de) |
| UA (1) | UA48154C2 (de) |
| WO (1) | WO1996016076A1 (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5767117A (en) * | 1994-11-18 | 1998-06-16 | The General Hospital Corporation | Method for treating vascular headaches |
| PL185523B1 (pl) * | 1995-06-06 | 2003-05-30 | Cocensys Inc | Neuroaktywne steroidy z grupy pochodnych androstanu i pregnanu oraz kompozycja farmaceutyczna |
| US6780853B1 (en) | 1995-06-06 | 2004-08-24 | Euro-Celtique S.A. | Neuroactive steroids of the androstane and pregnane series |
| US20010051599A1 (en) | 1997-05-02 | 2001-12-13 | Michael Z. Kagan | Pregnan-3-ol-20-ones |
| WO1999045931A1 (en) * | 1998-03-11 | 1999-09-16 | Baeckstroem Torbjoern | Epiallopregnanolone in the treatment of cns disorders |
| US7078057B2 (en) | 1999-12-20 | 2006-07-18 | Kerkhof Nicholas J | Process for producing nanometer particles by fluid bed spray-drying |
| US8771740B2 (en) | 1999-12-20 | 2014-07-08 | Nicholas J. Kerkhof | Process for producing nanoparticles by spray drying |
| AR031473A1 (es) * | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
| WO2006012563A2 (en) * | 2004-07-23 | 2006-02-02 | The Regents Of The University Of California | Method for the treatment and diagnosis of certain psychiatric disorders related to the menstrual cycle |
| RU2413516C2 (ru) * | 2004-11-18 | 2011-03-10 | Умекрин Аб | Гамк-стероидные антагонисты и их применение в лечении нарушений цнс |
| EP2258357A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| AU2006282896A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2377531A2 (de) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
| HUE036410T2 (hu) | 2006-11-21 | 2018-07-30 | Asarina Pharma Ab | Pregnán és androsztán szteroidok alkalmazása CNS rendellenességek kezelésére szolgáló gyógyszerkészítmény elõállítására |
| CN101585862B (zh) * | 2008-05-20 | 2014-12-17 | 梅克芳股份公司 | 甾族化合物 |
| CN103819525A (zh) * | 2008-05-20 | 2014-05-28 | 梅克芳股份公司 | 甾族化合物 |
| CN103880909A (zh) * | 2008-05-20 | 2014-06-25 | 梅克芳股份公司 | 甾族化合物 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| ES2524724T3 (es) * | 2009-08-13 | 2014-12-11 | Marinus Pharmaceuticals, Inc. | Método para preparar 3alfa-hidroxi,3beta-metil-5alfa-pregnán-20-ona (ganaxolona) |
| MX2012008257A (es) | 2010-01-14 | 2012-11-21 | Umecrine Mood Ab | Una composicion farmaceutica que comprende 3-beta-hidroxi-5-alfa-p regnan-20-ona con propiedades mejoradas de almacenamiento y solubilidad. |
| US20130245253A1 (en) * | 2010-03-26 | 2013-09-19 | Department Of Veterans Affairs | Conjugated Neuroactive Steroid Compositions And Methods Of Use |
| CA2843436A1 (en) * | 2011-07-29 | 2013-02-07 | The Regents Of The University Of California | Novel 17.beta.-heteroaryl-substituted steroids as modulators of gaba a receptors |
| AU2012304412A1 (en) * | 2011-09-08 | 2014-03-27 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| WO2013043985A1 (en) | 2011-09-23 | 2013-03-28 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| PT2766380T (pt) * | 2011-10-14 | 2019-07-29 | Sage Therapeutics Inc | Compostos de 19-nor pregnano 3,3-dissubstituídos, composições e seus usos |
| RS59734B1 (sr) | 2012-01-23 | 2020-02-28 | Sage Therapeutics Inc | Formulacije neuroaktivnog steroida koje uključuju kompleks alopregnanolona i sulfobutil etar beta-ciklodekstrina |
| EP2887944B1 (de) | 2012-08-21 | 2021-10-06 | Sage Therapeutics, Inc. | Allopregnanolon zur behandlung von refraktärem status epilepticus |
| EP2925327B1 (de) | 2012-11-30 | 2024-01-10 | The Regents of The University of California | Allopregnanolon zur behandlung, verminderung oder milderung von symptomen der wochenbettdepression |
| PT2968369T (pt) | 2013-03-13 | 2018-12-05 | Sage Therapeutics Inc | Esteroides neuroativos e métodos para o seu uso |
| WO2014169836A1 (en) * | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| PL2986624T3 (pl) | 2013-04-17 | 2020-11-16 | Sage Therapeutics, Inc. | Neuroaktywne steroidy 19-NOR do stosowania w sposobach leczenia |
| KR102614507B1 (ko) | 2013-04-17 | 2023-12-19 | 세이지 테라퓨틱스, 인크. | 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법 |
| WO2014169831A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
| CA3199003A1 (en) | 2013-07-19 | 2015-01-22 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| HUE052308T2 (hu) | 2013-08-23 | 2021-04-28 | Sage Therapeutics Inc | Neuroaktív szteroidok, készítmények és alkalmazásuk |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| WO2015195967A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2016036724A1 (en) | 2014-09-02 | 2016-03-10 | The Texas A&M University System | Method of treating organophosphate intoxication |
| JOP20200195A1 (ar) * | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| CN117024502A (zh) | 2014-10-16 | 2023-11-10 | 萨奇治疗股份有限公司 | 靶向cns障碍的组合物和方法 |
| EP3206493B1 (de) | 2014-10-16 | 2020-05-06 | Sage Therapeutics, Inc. | Zusammensetzungen und verfahren zur behandlung von störungen des zentralen nervensystems |
| EP3719029A1 (de) | 2014-11-27 | 2020-10-07 | Sage Therapeutics, Inc. | Zusammensetzungen zur induzierung von sedation |
| ES2857082T3 (es) | 2015-01-26 | 2021-09-28 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
| JP6875996B2 (ja) | 2015-02-20 | 2021-05-26 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド、組成物、およびその使用 |
| PT3319612T (pt) | 2015-07-06 | 2021-08-24 | Sage Therapeutics Inc | Oxisteróis e métodos de utilização dos mesmos |
| CN113292623A (zh) | 2015-07-06 | 2021-08-24 | 萨奇治疗股份有限公司 | 孕甾醇及其使用方法 |
| AU2017229656B2 (en) | 2016-03-08 | 2022-09-29 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| ES2921010T3 (es) | 2016-04-01 | 2022-08-16 | Sage Therapeutics Inc | Oxisteroles y procedimientos de uso de los mismos |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| AU2017296295B2 (en) | 2016-07-11 | 2022-02-24 | Sage Therapeutics, Inc. | C7, C12, and C16 substituted neuroactive steroids and their methods of use |
| MA45599A (fr) | 2016-07-11 | 2019-05-15 | Sage Therapeutics Inc | Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation |
| ES2935057T3 (es) | 2016-09-30 | 2023-03-01 | Sage Therapeutics Inc | C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA |
| EP4105223B1 (de) | 2016-10-18 | 2025-04-30 | Sage Therapeutics, Inc. | Oxysterole und verfahren zur verwendung davon |
| BR112019008032A2 (pt) | 2016-10-18 | 2019-09-03 | Sage Therapeutics, Inc. | oxiesteróis e métodos de uso dos mesmos |
| IL270962B2 (en) * | 2017-06-01 | 2023-09-01 | Sumitomo Chemical Co | A heterocyclic compound and a mixture containing it |
| JP7538040B2 (ja) * | 2018-01-12 | 2024-08-21 | セージ セラピューティクス， インコーポレイテッド | ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物 |
| US11542296B2 (en) | 2018-04-23 | 2023-01-03 | The Texas A&M University System | Neurosteroid compounds and methods for their preparation and use in treating central nervous system disorders |
| JP7671244B2 (ja) | 2018-10-12 | 2025-05-01 | セージ セラピューティクス， インコーポレイテッド | Ｃｎｓ障害の処置において使用するための、１０位において環式基で置換された神経刺激性ステロイド |
| MX2021006618A (es) | 2018-12-05 | 2021-09-23 | Sage Therapeutics Inc | Esteroides neuroactivos y sus metodos de uso. |
| GB201820887D0 (en) * | 2018-12-20 | 2019-02-06 | Nzp Uk Ltd | Compounds |
| CN111410673A (zh) * | 2019-01-08 | 2020-07-14 | 成都康弘药业集团股份有限公司 | 甾体类化合物、用途及其制备方法 |
| WO2020243488A1 (en) | 2019-05-31 | 2020-12-03 | Sage Therapeutics, Inc. | Neuroactive steroids and compositions thereof |
| JP7670632B2 (ja) * | 2019-06-27 | 2025-04-30 | セージ セラピューティクス， インコーポレイテッド | Ｃｎｓ障害を治療するための組成物及び方法 |
| KR20230037006A (ko) * | 2020-02-27 | 2023-03-15 | 브리 바이오사이언시스, 인크. | 신경활성 스테로이드의 프로드러그 |
| WO2021188778A2 (en) * | 2020-03-18 | 2021-09-23 | Sage Therapeutics, Inc. | Neuroactive steroids and their methods of use |
| WO2023023650A1 (en) * | 2021-08-20 | 2023-02-23 | University Of Mississippi | Allopregnanolone analogues for hiv viremia and neurotoxicity protection |
| WO2023060067A1 (en) | 2021-10-04 | 2023-04-13 | Marinus Pharmaceuticals, Inc. | Amorphous solid dispersion ganaxolone formulation |
| CN115974950A (zh) * | 2022-12-23 | 2023-04-18 | 上海彩迩文生化科技有限公司 | 一种3-烷基化的甾体中间体及其制备和应用 |
| CN117801047B (zh) * | 2023-01-19 | 2024-12-20 | 北京华睿鼎信科技有限公司 | 神经甾体衍生物及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953429A (en) * | 1970-12-17 | 1976-04-27 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstance and pregnane series |
| US5120723A (en) * | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| WO1993005786A1 (en) * | 1991-09-13 | 1993-04-01 | Cocensys, Inc. | Novel gabaa receptor with steroid binding sites |
| US5371077A (en) * | 1992-08-03 | 1994-12-06 | William Marsh Rice University | Side chain derivatized 15-oxygenated sterols, methods of using them and a process for preparing them |
| EP0701444B1 (de) * | 1993-05-24 | 2010-04-07 | Purdue Pharma Ltd. | Verfahren und zusammensetzungen zum hervorrufen von schlaf |
-
1995
- 1995-11-22 BR BR9509764A patent/BR9509764A/pt not_active Application Discontinuation
- 1995-11-22 DE DE69519945T patent/DE69519945T2/de not_active Expired - Fee Related
- 1995-11-22 JP JP8517059A patent/JPH10509458A/ja not_active Ceased
- 1995-11-22 AT AT95942879T patent/ATE198753T1/de not_active IP Right Cessation
- 1995-11-22 CZ CZ19971553A patent/CZ292881B6/cs not_active IP Right Cessation
- 1995-11-22 RU RU97110790/04A patent/RU2176248C2/ru active
- 1995-11-22 UA UA97063025A patent/UA48154C2/uk unknown
- 1995-11-22 ES ES95942879T patent/ES2155543T3/es not_active Expired - Lifetime
- 1995-11-22 FI FI972202A patent/FI972202L/fi not_active IP Right Cessation
- 1995-11-22 HU HU9701972A patent/HUT77087A/hu not_active Application Discontinuation
- 1995-11-22 AP APAP/P/1997/000998A patent/AP653A/en active
- 1995-11-22 PT PT95942879T patent/PT808325E/pt unknown
- 1995-11-22 GE GEAP19953794A patent/GEP20002033B/en unknown
- 1995-11-22 CN CN95197071A patent/CN1171114A/zh active Pending
- 1995-11-22 AU AU44085/96A patent/AU707486B2/en not_active Ceased
- 1995-11-22 KR KR1019970703470A patent/KR100394548B1/ko not_active Expired - Fee Related
- 1995-11-22 NZ NZ298567A patent/NZ298567A/xx unknown
- 1995-11-22 WO PCT/US1995/015210 patent/WO1996016076A1/en not_active Ceased
- 1995-11-22 MX MX9703826A patent/MX9703826A/es not_active IP Right Cessation
- 1995-11-22 DK DK95942879T patent/DK0808325T3/da active
- 1995-11-22 CA CA002205919A patent/CA2205919A1/en not_active Abandoned
- 1995-11-22 PL PL95320416A patent/PL182898B1/pl not_active IP Right Cessation
- 1995-11-22 EP EP95942879A patent/EP0808325B1/de not_active Expired - Lifetime
- 1995-11-23 IL IL11610895A patent/IL116108A/en not_active IP Right Cessation
-
1997
- 1997-05-21 NO NO972320A patent/NO308950B1/no unknown
- 1997-05-23 IS IS4488A patent/IS4488A/is unknown
-
2001
- 2001-03-13 GR GR20010400408T patent/GR3035562T3/el not_active IP Right Cessation
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |