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AR130079A1 - Restos escindibles por proteasas, y métodos de uso de los mismos - Google Patents

Restos escindibles por proteasas, y métodos de uso de los mismos

Info

Publication number
AR130079A1
AR130079A1 ARP230102013A ARP230102013A AR130079A1 AR 130079 A1 AR130079 A1 AR 130079A1 AR P230102013 A ARP230102013 A AR P230102013A AR P230102013 A ARP230102013 A AR P230102013A AR 130079 A1 AR130079 A1 AR 130079A1
Authority
AR
Argentina
Prior art keywords
protease
seq
substrate
acid sequence
amino acid
Prior art date
Application number
ARP230102013A
Other languages
English (en)
Inventor
Olga Vasiljeva
Michael B Winter
Original Assignee
Cytomx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytomx Therapeutics Inc filed Critical Cytomx Therapeutics Inc
Publication of AR130079A1 publication Critical patent/AR130079A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24024—Gelatinase A (3.4.24.24), i.e. matrix metalloproteinase 2 or MMP2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24035—Gelatinase B (3.4.24.35), i.e. matrix metalloprotease 9 or MMP9
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/2408—Membrane-type matrix metalloproteinase-1 (3.4.24.80)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se divulgan polipéptidos aislados que incluyen un resto escindible que es un substrato para al menos una proteasa (por ej., MMP). Se divulgan moléculas activables que incluyen los polipéptidos aislados. Se divulgan métodos para preparar y usar los polipéptidos aislados y las moléculas activables que incluyen los polipéptidos aislados en una variedad de aplicaciones terapéuticas, de diagnóstico y profilácticas, por ej. cáncer, una infección, un trastorno inflamatorio, cardiovascular, neurodegenerativo o autoinmunitario. Reivindicación 1: Un polipéptido aislado que comprende un resto escindible (CM) caracterizado porque comprende la secuencia de aminoácidos AIALY (SEQ ID Nº 5), en donde el CM es un substrato para una proteasa. Reivindicación 2: El polipéptido aislado de la reivindicación 1, caracterizado porque el CM comprende la secuencia de aminoácidos AIALYA (SEQ ID Nº 2) o AIALYAD (SEQ ID Nº 1). Reivindicación 3: Un polipéptido aislado que comprende un resto escindible (CM) caracterizado porque comprende una secuencia de aminoácidos seleccionada entre las SEQ ID Nº 1 - 14, en donde el CM es un substrato para una proteasa. Reivindicación 4: Un polipéptido aislado que comprende un resto escindible (CM) caracterizado porque comprende una secuencia de aminoácidos con una o más mutaciones de uno o dos aminoácidos en una cualquiera de las SEQ ID Nº 1 - 14, en donde el CM es un substrato para una proteasa.
ARP230102013A 2022-08-01 2023-07-31 Restos escindibles por proteasas, y métodos de uso de los mismos AR130079A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202263370021P 2022-08-01 2022-08-01

Publications (1)

Publication Number Publication Date
AR130079A1 true AR130079A1 (es) 2024-10-30

Family

ID=87847809

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230102013A AR130079A1 (es) 2022-08-01 2023-07-31 Restos escindibles por proteasas, y métodos de uso de los mismos

Country Status (5)

Country Link
EP (1) EP4565261A1 (es)
JP (1) JP2025525867A (es)
AR (1) AR130079A1 (es)
TW (1) TW202423953A (es)
WO (1) WO2024030845A1 (es)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
CN117969827B (zh) * 2024-03-28 2024-07-02 北京大学人民医院 抗caspase 14抗体在制备类风湿关节炎补充诊断产品中的应用
WO2025240659A2 (en) 2024-05-14 2025-11-20 Cytomx Therapeutics, Inc. Activatable constructs, compositions and methods

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Also Published As

Publication number Publication date
TW202423953A (zh) 2024-06-16
WO2024030845A1 (en) 2024-02-08
EP4565261A1 (en) 2025-06-11
JP2025525867A (ja) 2025-08-07

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