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AR104716A1 - Agonistas de triazol del receptor apj - Google Patents

Agonistas de triazol del receptor apj

Info

Publication number
AR104716A1
AR104716A1 ARP160101478A ARP160101478A AR104716A1 AR 104716 A1 AR104716 A1 AR 104716A1 AR P160101478 A ARP160101478 A AR P160101478A AR P160101478 A ARP160101478 A AR P160101478A AR 104716 A1 AR104716 A1 AR 104716A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
perhaloalkyl
haloalkyl
heterocyclyl
Prior art date
Application number
ARP160101478A
Other languages
English (en)
Inventor
Yeh Wen
Chen - Yang Kevin
Wang Xiaodong
Swaminath Gayathri
Pattaropong Vatee
H Olson Steven
Nishimura Nobuko
T Mihalic Jeffrey
C Medina Julio
R Mgee Lawrence
Ma Zhihua
Lai Su
John Jen - Kopecky David
Yusuf Khakoo Aarif
Kayser Frank
R Kaller Matthew
C Judd Ted
Houze Jonathan
B Horne Daniel
Anne Heath Julie
J Hedley Simon
Fu Zice
P Farrell Robert
Du Xiaohui
John Dransfield Paul
Deignan Jeffrey
V Debenedetto Mikkel
V Connors Richard
C Cheng Alan
Chen Yinhong
Chen Xiaoqi
Chen Ning
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AR104716A1 publication Critical patent/AR104716A1/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Se describen compuestos de la fórmula (1) y fórmula (2), sal farmacéuticamente aceptable del mismo, estereoisómeros de cualquiera de los anteriores, o mezclas de los mismos que son agonistas del receptor APJ y tienen uso en tratar afecciones cardiovasculares y otras. Reivindicación 1: Un compuesto de la fórmula (1) o la fórmula (2), o una sal farmacéuticamente aceptable del mismo, un tautómero del mismo, una sal farmacéuticamente aceptable del tautómero, un estereoisómero de cualquiera de los anteriores, o una mezcla de los mismos, caracterizado porque: R¹ es un piridilo, piridonilo, o piridina N-óxido no sustituido, o es un piridilo, piridonilo, o piridina N-óxido sustituido con 1, 2, 3, ó 4 sustituyentes R¹ᵃ; R¹ᵃ en cada caso es seleccionado independientemente de -F, -Cl, -Br, -I, -CN, -alquilo C₁₋₆, -haloalquilo C₁₋₆, -perhaloalquilo C₁₋₆, -OH, -O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆), -alquenilo C₁₋₆, -O-(alquilo C₁₋₆)-OH, -O-(alquilo C₁₋₆)-O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆)-OH, -O-(haloalquilo C₁₋₆)-O-(alquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆)-OH, -O-(perhaloalquilo C₁₋₆)-O-(alquilo C₁₋₆), -NH₂, -NH(alquilo C₁₋₆), -N(alquilo C₁₋₆)₂, -C(=O)-(alquilo C₁₋₆), -C(=O)OH, -C(=O)-O-(alquilo C₁₋₆), -C(=O)NH₂, -C(=O)NH(alquilo C₁₋₆), -C(=O)N(alquilo C₁₋₆)₂, fenilo, -C(=O)-(heterociclilo), o un grupo heterociclilo, en donde el grupo heterociclilo del -C(=O)-(heterociclilo) o grupo heterociclilo es un anillo de 3 hasta 7 miembros que contiene 1, 2, ó 3 heteroátomos seleccionados de N, O, o S; R² se selecciona de -H, o alquilo C₁₋₄ o está ausente en los compuestos de la fórmula (2); R³ se selecciona de un alquilo C₁₋₁₀ no sustituido, un alquilo C₁₋₁₀ sustituido con 1, 2 ó 3 sustituyentes R³ᵃ, un grupo de la fórmula -(CR³ᵇR³ᶜ)-Q, un grupo de la fórmula -NH-(CR³ᵇR³ᶜ)-Q, un grupo de la fórmula -(CR³ᵇR³ᶜ)-C(=O)-Q, un grupo de la fórmula -(CR³ᵈR³ᵉ)-(CR³ᶠR³ᵍ)-Q, un grupo de la fórmula -(CR³ᵇ=CR³ᶜ)-Q, o un grupo de la fórmula -(heterociclilo)-Q, en donde el heterociclilo del -(heterociclilo)-Q tiene 5 hasta 7 miembros en el anillo de los cuales 1, 2, ó 3 son heteroátomos seleccionados de N, O, o S y está no sustituido o está sustituido con 1, 2, ó 3 sustituyentes R³ʰ; R³ᵃ en cada caso es seleccionado independientemente de -F, -Cl, -CN, -OH, -O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆), -O-(alquilo C₁₋₆)-OH, -O-(alquilo C₁₋₆)-O-(alquilo C₁₋₆), alquenilo C₂₋₆, alquinilo C₂₋₆, -NH₂, -NH(alquilo C₁₋₆), o -N(alquilo C₁₋₆)₂; R³ᵇ y R³ᶜ son seleccionados independientemente de -H, -F, -Cl, -CN, -alquilo C₁₋₆, -haloalquilo C₁₋₆, -perhaloalquilo C₁₋₆, -OH, -O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆), -O-(alquilo C₁₋₆)-OH, -O-(alquilo C₁₋₆)-O-(alquilo C₁₋₆), -NH₂, -NH(alquilo C₁₋₆), o -N(alquilo C₁₋₆)₂; R³ᵈ y R³ᵉ son seleccionados independientemente de -H, -F, -Cl, -CN, -alquilo C₁₋₆, -haloalquilo C₁₋₆, -perhaloalquilo C₁₋₆, -OH, -O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆), -O-(alquilo C₁₋₆)-OH, -O-(alquilo C₁₋₆)-O-(alquilo C₁₋₆), -NH₂, -NH(alquilo C₁₋₆), o -N(alquilo C₁₋₆)₂; R³ᶠ y R³ᵍ son seleccionados independientemente de -H, -F, -Cl, -CN, -alquilo C₁₋₆, -haloalquilo C₁₋₆, -perhaloalquilo C₁₋₆, -OH, -O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆), -O-(alquilo C₁₋₆)-OH, -O-(alquilo C₁₋₆)-O-(alquilo C₁₋₆), -NH₂, -NH(alquilo C₁₋₆), o -N(alquilo C₁₋₆)₂; R³ʰ en cada caso es seleccionado independientemente de -F, -Cl, -CN, -alquilo C₁₋₆, -haloalquilo C₁₋₆, -perhaloalquilo C₁₋₆, -OH, -O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆), -O-(alquilo C₁₋₆)-OH, -O-(alquilo C₁₋₆)-O-(alquilo C₁₋₆), -NH₂, -NH(alquilo C₁₋₆), -N(alquilo C₁₋₆)₂, u oxo; Q es un grupo arilo C₆₋₁₀ monocíclico o bicíclico, un grupo heteroarilo monocíclico o bicíclico con 5 hasta 10 miembros en el anillo que contiene 1, 2, ó 3 heteroátomos seleccionados de N, O, o S, un grupo cicloalquilo C₃₋₈, o un grupo heterociclilo de 3 hasta 7 miembros que contiene 1, 2, ó 3 heteroátomos seleccionados de N, O, o S, en donde el grupo arilo C₆₋₁₀, el grupo heteroarilo, el grupo cicloalquilo, y el grupo heterociclilo están no sustituidos o están sustituidos con 1, 2, 3, ó 4 sustituyente RQ; RQ en cada caso es seleccionado independientemente de -F, -Cl, -Br, -I, -CN, -alquilo C₁₋₆, -haloalquilo C₁₋₆, -perhaloalquilo C₁₋₆, -alquenilo C₂₋₆, -alquinilo C₂₋₆, -OH, -O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆), -NH₂, -NH(alquilo C₁₋₆), -N(alquilo C₁₋₆)₂, -C(=O)-(alquilo C₁₋₆), -C(=O)OH, -C(=O)-O-(alquilo C₁₋₆), -C(=O)NH₂, -C(=O)NH(alquilo C₁₋₆), C(=O)N (alquilo C₁₋₆)₂, -S(=O)₂-(alquilo C₁₋₆), fenilo, o un grupo heteroarilo, y el grupo heterociclilo Q puede estar sustituido con 1 oxo sustituyente RQ; R⁴ se selecciona de un grupo arilo C₆₋₁₀ monocíclico o bicíclico, un grupo heteroarilo monocíclico o bicíclico con 5 hasta 10 miembros en el anillo que contiene 1, 2, ó 3 heteroátomos seleccionados independientemente de N, O, o S, o un grupo heterociclilo monocíclico o bicíclico con 5 hasta 10 miembros en el anillo que contiene 1, 2, 3, ó 4 heteroátomos seleccionados independientemente de N, O, o S, en donde el grupo arilo C₆₋₁₀, el grupo heteroarilo, o el grupo heterociclilo están no sustituidos o están sustituidos con 1, 2, ó 3 sustituyentes R⁴ᵃ; R⁴ᵃ en cada caso es seleccionado independientemente de -F, -Cl, -Br, -I, -CN, -alquilo C₁₋₆, -haloalquilo C₁₋₆, -perhaloalquilo C₁₋₆, -OH, -O-(alquilo C₁₋₆), -O-(haloalquilo C₁₋₆), -O-(perhaloalquilo C₁₋₆), -NH₂, -NH(alquilo C₁₋₆), -N(alquilo C₁₋₆)₂, -C(=O)-(alquilo C₁₋₆), -C(=O)OH, -C(=O)-O-(alquilo C₁₋₆), C(=O)NH₂, -C(=O)NH(alquilo C₁₋₆), o -C(=O)N(alquilo C₁₋₆)₂, y el grupo heterociclilo R⁴ puede estar sustituido además con 1 oxo sustituyente; y en donde además: si R⁴ es un anillo fenilo no sustituido o sustituido y R³ es un grupo de la fórmula -(CR³ᵇ=CR³ᶜ)-Q, entonces al menos uno de los siguientes es cierto: a) R⁴ es sustituido con al menos un grupo -O-(alquilo C₁₋₆); b) Q no es un oxadiazol; c) R³ᵇ no es -H; d) R³ᶜ no es -H; e) R¹ no es un grupo 2-piridilo; o f) R⁴ es sustituido con dos o más grupos -O-(alquilo C₁₋₆).
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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1143120A (ja) * 1997-07-28 1999-02-16 Ishikawajima Harima Heavy Ind Co Ltd 容器の後処理装置
HUE050317T2 (hu) * 2015-05-20 2020-11-30 Amgen Inc APJ receptor triazol agonistái
LT3303330T (lt) 2015-06-03 2019-08-12 Bristol-Myers Squibb Company 4-hidroksi-3-(heteroaril)piridin-2-ono apj agonistai, skirti panaudoti širdies ir kraujagyslių sutrikimų gydymui
CA3001974A1 (en) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as apj agonists
EA037162B1 (ru) 2016-03-24 2021-02-12 Бристол-Маерс Сквибб Компани 6-гидрокси-4-оксо-1,4-дигидропиримидин-5-карбоксамиды в качестве агонистов apj
WO2017192485A1 (en) 2016-05-03 2017-11-09 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor
EP3541802B1 (en) 2016-11-16 2025-01-01 Amgen Inc. Alkyl substituted triazole compounds as agonists of the apj receptor
EP3541803B1 (en) * 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
WO2018097945A1 (en) 2016-11-16 2018-05-31 Amgen Inc. Heteroaryl-substituted triazoles as apj receptor agonists
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
WO2018093577A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the apj receptor
KR20200041337A (ko) * 2017-08-15 2020-04-21 인플라좀 리미티드 신규한 설폰아마이드 카복스아마이드 화합물
MA50509A (fr) 2017-11-03 2021-06-02 Amgen Inc Agonistes de triazole fusionnés du récepteur apj
US11724997B2 (en) 2018-03-01 2023-08-15 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor
CN108728408B (zh) * 2018-05-28 2021-08-24 天津博雅秀岩生物技术有限公司 犬胎膜间充质干细胞及制备方法和使用的培养基
CN108795853B (zh) * 2018-05-28 2021-08-24 天津博雅秀岩生物技术有限公司 制备犬胎膜间充质干细胞的方法和犬胎膜间充质干细胞
KR20230165832A (ko) * 2021-04-06 2023-12-05 바이오에이지 랩스, 인코포레이티드 노화-관련 근육 질병 치료용 아펠린 수용체 조절제
JP2025533774A (ja) 2022-09-27 2025-10-09 バイオエイジ ラブス， インコーポレイテッド 筋肉状態を処置するためのアペリン受容体アゴニスト
TW202438513A (zh) 2023-01-03 2024-10-01 美商百愛及生物醫藥公司 用於治療與體重增加相關之疾病或病症之愛帕琳(apelin)受體促效劑及glp-1受體促效劑之組合療法
CN117417325B (zh) * 2023-12-19 2024-10-22 药康众拓(北京)医药科技有限公司 氘代1,2,4-三唑类Apelin受体激动剂药物及用途
WO2025171812A1 (zh) * 2024-02-18 2025-08-21 苏州浦合医药科技有限公司 一类取代的唑类化合物作为apj受体激动剂
WO2025180467A1 (zh) * 2024-02-28 2025-09-04 上海拓界生物医药科技有限公司 一种羰基取代的三唑类化合物及其制备方法和用途
WO2025213190A1 (en) 2024-04-05 2025-10-09 BioAge Labs, Inc. Methods of treating a disease or condition associated with weight gain
WO2025251084A1 (en) 2024-05-31 2025-12-04 BioAge Labs, Inc. Methods of treating a disease or condition associated with weight gain

Family Cites Families (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4681943A (en) * 1984-11-30 1987-07-21 The Dow Chemical Company 1-acyl-1-(2-pyridinyl)semicarbazides
JPS62149673A (ja) * 1985-09-05 1987-07-03 Sumitomo Chem Co Ltd ピリジン誘導体、その製造法およびそれを有効成分とする植物病害防除剤
DE3825867A1 (de) 1988-03-04 1989-09-14 Bayer Ag Heterocyclisch substituierte sulfonylaminoazole und ihre verwendung als herbizide
EP0409332A3 (en) 1989-07-19 1991-08-07 Merck & Co. Inc. Substituted triazoles as angiotensin ii antagonists
DE3928605A1 (de) 1989-08-30 1991-03-07 Bayer Ag Substituierte sulfonylaminoazole
JP2726563B2 (ja) 1990-02-13 1998-03-11 メルク・エンド・カムパニー・インコーポレーテツド 置換ベンジル要素を含むトリアゾールアンギオテンシン▲ｉｉ▼拮抗物質
JPH0511439A (ja) 1990-09-13 1993-01-22 Fuji Photo Film Co Ltd 光重合性組成物
DE4035141A1 (de) 1990-11-06 1992-05-07 Bayer Ag Substituierte sulfonylaminotriazolylpyrimidine
CZ283018B6 (cs) 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
SE9103397D0 (sv) 1991-11-18 1991-11-18 Kabi Pharmacia Ab Nya substituerade salicylsyror
JP3217846B2 (ja) * 1992-03-04 2001-10-15 クミアイ化学工業株式会社 トリアゾール誘導体及び殺虫剤
US5510362A (en) 1992-03-13 1996-04-23 Merck, Sharp And Dohme Limited Imidazole, triazole and tetrazole derivatives
US5411839A (en) 1993-01-15 1995-05-02 Eastman Kodak Company Image formation in color reversal materials using strong inhibitors
BR9607017A (pt) 1995-02-03 1997-10-28 Upjohn Co Composto e uso do mesmo
US5563026A (en) 1995-04-28 1996-10-08 Eastman Kodak Company Color negative element having improved green record printer compatibility
DE19725450A1 (de) 1997-06-16 1998-12-17 Hoechst Schering Agrevo Gmbh 4-Haloalkyl-3-heterocyclylpyridine und 4-Haloalkyl-5-heterocyclylpyrimidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
JP3788676B2 (ja) 1997-11-11 2006-06-21 富士写真フイルム株式会社 有機エレクトロルミネツセンス素子材料およびそれを使用した有機エレクトロルミネツセンス素子
ES2182485T3 (es) 1998-02-13 2003-03-01 Upjohn Co Derivados de aminofenil isosazolina sustituidos utiles como agentes antimicrobianos.
JP2002504550A (ja) 1998-02-25 2002-02-12 ファルマシア・アンド・アップジョン・カンパニー 抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体
CN1390215A (zh) 1999-09-10 2003-01-08 麦克公司 酪氨酸激酶抑制剂
KR20030043785A (ko) 2000-03-16 2003-06-02 젠소프트, 인크. 핵산 결합 부위를 포함하는 하전된 화합물 및 이의 용도
CA2403447A1 (en) 2000-03-23 2001-09-27 Takeda Chemical Industries, Ltd. Peptide derivative
JP3873746B2 (ja) 2000-05-19 2007-01-24 アステラス製薬株式会社 トリアゾール誘導体
EP1353674A1 (en) 2000-12-29 2003-10-22 Alteon, Inc. Method for treating glaucoma ivb
WO2002053101A2 (en) 2000-12-29 2002-07-11 Alteon, Inc. Method for treating fibrotic diseases or other indications
CA2445568A1 (en) * 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Triazole-derived kinase inhibitors and uses thereof
US6727364B2 (en) 2001-04-30 2004-04-27 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
US6787555B2 (en) 2001-04-30 2004-09-07 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
US6790846B2 (en) 2001-05-24 2004-09-14 The Procter & Gamble Company Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
JP2003005356A (ja) 2001-06-20 2003-01-08 Fuji Photo Film Co Ltd 電子線又はｘ線用ネガ型レジスト組成物
DE10138569A1 (de) 2001-08-06 2003-04-30 Bayer Ag Regulation des APJ-Rezeptors
JP2003321456A (ja) 2002-04-30 2003-11-11 Fuji Photo Film Co Ltd ５−アミノ−４−含窒素芳香族ヘテロ環置換ピラゾール類の製造方法
AU2003295324B2 (en) 2002-08-23 2008-08-28 Ardea Biosciences,Inc. Non-nucleoside reverse transcriptase inhibitors
US7084145B2 (en) 2002-10-25 2006-08-01 Pfizer Inc. Triazole compounds useful in therapy
AU2003300099A1 (en) 2003-01-02 2004-07-29 Millennium Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR INHIBITING TGF-Beta
US7169797B2 (en) 2003-02-14 2007-01-30 Abbott Laboratories Protein-tyrosine phosphatase inhibitors and uses thereof
US20040167188A1 (en) 2003-02-14 2004-08-26 Zhili Xin Protein-tyrosine phosphatase inhibitors and uses thereof
US20050170431A1 (en) 2003-02-28 2005-08-04 Plexxikon, Inc. PYK2 crystal structure and uses
US20090048301A1 (en) 2003-07-09 2009-02-19 Imclone Systems Incorporated Heterocyclic compounds and their use as anticancer agents
EP1664052B1 (en) 2003-08-15 2009-02-18 AstraZeneca AB Fused heterocycles as inhibitors of glutamate racemase (muri)
WO2005039569A1 (en) 2003-10-18 2005-05-06 Bayer Healthcare Ag 5-substituted 2-(phenylmethyl) thio-4-phenyl-4h-1,2,4-triazole derivatives and related compounds as gaba-agonists for the treatment of urinary incontinence and related diseases
JP2005170939A (ja) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd 糖尿病の予防・治療剤
US20050165015A1 (en) 2004-01-23 2005-07-28 Ncube Mghele V. Vanilloid receptor ligands and their use in treatments
US7297168B2 (en) 2004-02-02 2007-11-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
DE102004008141A1 (de) 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
EP1730124A4 (en) 2004-03-26 2009-04-01 Amphora Discovery Corp Certain compounds based on triazole, compositions and applications thereof
WO2005123672A2 (en) 2004-06-14 2005-12-29 Takeda San Diego, Inc. Kinase inhibitors
US7399317B2 (en) 2004-08-26 2008-07-15 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
EP1790641A4 (en) 2004-09-16 2009-08-26 Astellas Pharma Inc DERIVATIVE OF TRIAZOLE OR SALT OF SAID DERIVATIVE
ME01498B (me) 2004-11-18 2014-04-20 Synta Pharmaceuticals Corp Jedinjenja triazola koja modulišu aktivnost hsp90
US20060156480A1 (en) 2005-01-14 2006-07-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
WO2006080533A1 (ja) 2005-01-31 2006-08-03 Mochida Pharmaceutical Co., Ltd. ３－アミノ－１,２,４－トリアゾール誘導体
WO2006095783A1 (ja) 2005-03-09 2006-09-14 Nippon Kayaku Kabushiki Kaisha 新規なｈｓｐ９０阻害剤
US8399464B2 (en) 2005-03-09 2013-03-19 Nippon Kayaku Kabushiki Kaisha HSP90 inhibitor
EP1863484A1 (en) 2005-03-21 2007-12-12 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
US8101618B2 (en) 2005-04-06 2012-01-24 Msd K.K. 1,4-substituted piperazine derivatives
JPWO2007007688A1 (ja) 2005-07-08 2009-01-29 持田製薬株式会社 ３，５−ジアミノ−１，２，４−トリアゾール誘導体
EP1922068A4 (en) 2005-08-16 2010-08-11 Icagen Inc INHIBITORS OF VOLTAGE-CONTROLLED SODIUM CHANNELS
US8921406B2 (en) 2005-08-21 2014-12-30 AbbVie Deutschland GmbH & Co. KG 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
KR20090005195A (ko) 2006-04-19 2009-01-12 라보라뚜와르 세로노 에스. 에이. Ｍｅｋ 저해제로서 신규한 헤테로아릴-치환된 아릴아미노피리딘 유도체
WO2007139951A2 (en) 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with protooncogene products
AU2012200157B2 (en) 2006-05-25 2014-08-21 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with protooncogene products
TW200806637A (en) 2006-05-25 2008-02-01 Synta Pharmaceuticals Corp Synthesis of triazole compounds that modulate HSP90 activity
CA2653329C (en) 2006-05-25 2018-01-16 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
EP2026797A2 (en) 2006-05-25 2009-02-25 Synta Pharmaceuticals Corporation Method for treating non-hodgkin's lymphoma
US8318790B2 (en) 2006-05-25 2012-11-27 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US8778977B2 (en) 2006-06-30 2014-07-15 Sunesis Pharmaceuticals, Inc. Pyridinonyl PDK1 inhibitors
WO2008008375A2 (en) 2006-07-14 2008-01-17 Chemocentryx, Inc. Triazolyl pyridyl benzenesulfonamides as ccr2 or ccr9 modulators for the treatment of inflammation
US7718683B2 (en) 2006-07-14 2010-05-18 Chemocentryx, Inc. Triazolyl phenyl benzenesulfonamides
EP2054059A2 (en) 2006-08-17 2009-05-06 Synta Pharmaceuticals Corporation Triazole compounds that modulate hsp90 activity
US20110046125A1 (en) 2006-10-19 2011-02-24 Synta Pharmaceuticals Corp. Method for treating infections
US20100280032A1 (en) 2006-10-26 2010-11-04 Synta Pharmaceuticals Corp. Method for treating inflammatory disorders
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
WO2008097640A2 (en) 2007-02-08 2008-08-14 Synta Pharmaceuticals Corp. Triazole compounds that are useful in the treatment of proliferative disorders, such as cancer
US7909187B2 (en) 2007-02-20 2011-03-22 Lonzell Montgomery Modular baby bottle system
US8993608B2 (en) 2007-03-12 2015-03-31 Synta Pharmaceuticals Corp. Method for inhibiting topoisomerase II
US8648104B2 (en) 2007-05-25 2014-02-11 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with mutations in c-Met
WO2009023402A2 (en) 2007-07-17 2009-02-19 Acea Biosciences Inc. Heterocyclic compounds and uses as anticancer agents
EP2193135A1 (en) 2007-08-13 2010-06-09 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
WO2009075890A2 (en) 2007-12-12 2009-06-18 Synta Pharmaceuticals Corp. Method for synthesis of triazole compounds that modulate hsp90 activity
US7820665B2 (en) 2007-12-19 2010-10-26 Amgen Inc. Imidazopyridazine inhibitors of PI3 kinase for cancer treatment
DE102008013587A1 (de) 2008-03-11 2009-09-17 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung
EP2103602A1 (en) 2008-03-17 2009-09-23 AEterna Zentaris GmbH Novel 1,2,4-triazole derivatives and process of manufacturing thereof
MX338530B (es) 2008-06-03 2016-04-21 Siga Technologies Inc Inhibidores de molecula pequeña para el tratamiento o prevencion de infeccion de virus del dengue.
CA2727252A1 (en) 2008-07-01 2010-01-07 Genentech, Inc. Isoindolone derivatives as mek kinase inhibitors and methods of use
CN102137847B (zh) 2008-07-01 2015-06-10 健泰科生物技术公司 作为mek激酶抑制剂的二环杂环
US20100031237A1 (en) 2008-08-01 2010-02-04 International Business Machines Corporation Methods for Detecting Inter-Module Dependencies
TW201011003A (en) 2008-08-08 2010-03-16 Synta Pharmaceuticals Corp Triazole compounds that modulate HSP90 activity
DE102008038221A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh 7-Azaindolderivate
US9339480B2 (en) 2008-11-26 2016-05-17 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
DE102008059702A1 (de) 2008-12-01 2010-06-02 Byk-Chemie Gmbh Verfahren zur Herstellung rheologisch wirksamer Harnstoffurethane in organischen Salzen
AU2010255552A1 (en) 2009-06-05 2012-01-12 Oslo University Hospital Hf Azole derivatives as Wtn pathway inhibitors
BRPI1010881A2 (pt) 2009-06-08 2016-05-31 California Capital Equity Llc derivados de triazina e suas aplicações terapêuticas.
AR077851A1 (es) 2009-12-11 2011-09-28 Exelixis Inc Agonistas del tgr5
RU2639876C2 (ru) 2010-03-30 2017-12-25 Версеон Корпорейшн Мультизамещенные ароматические соединения в качестве ингибиторов тромбина
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
WO2011133521A2 (en) 2010-04-19 2011-10-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor
WO2011146801A1 (en) 2010-05-20 2011-11-24 Synta Pharmaceuticals Corp. Formulation and dosing of hsp90 inhibitory compounds
US20110294767A1 (en) 2010-05-26 2011-12-01 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
JP5996532B2 (ja) 2010-07-15 2016-09-21 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 有害生物防除剤としての新規複素環式化合物
US20130266636A1 (en) 2010-08-12 2013-10-10 The Regents Of The University Of California Methods for blocking cell proliferation and treating diseases and conditions responsive to cell growth inhibition
US20130158063A1 (en) * 2010-08-24 2013-06-20 Georgetown University Compounds, Compositions and Methods Related to PPAR Antagonists
JP5517890B2 (ja) * 2010-11-15 2014-06-11 サンデン株式会社 ショーケース及び照明モジュール
CA2820800A1 (en) * 2010-12-08 2012-06-14 Oslo University Hospital Hf Triazole derivatives as wnt signaling pathway inhibitors
US20140045908A1 (en) 2011-02-25 2014-02-13 Synta Pharmaceuticals Corp. Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers
CA2842707A1 (en) 2011-08-04 2013-02-07 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of pancreatitis
WO2013032939A1 (en) 2011-08-26 2013-03-07 Metabolex, Inc. Bicyclic agonists of gpr131 and uses thereof
EP2771003B1 (en) 2011-10-28 2017-04-19 Lumena Pharmaceuticals LLC Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
KR20190135545A (ko) 2011-10-28 2019-12-06 루메나 파마수티컬즈, 인코포레이티드 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제
WO2013067165A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
CA2853799A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors
EP2802596A1 (en) 2012-01-09 2014-11-19 Anchor Therapeutics, Inc. Apj receptor compounds
CN104169275B (zh) 2012-01-13 2017-06-09 百时美施贵宝公司 用作激酶抑制剂的三唑取代的吡啶化合物
JP2015515469A (ja) 2012-03-28 2015-05-28 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０阻害剤としてのトリアゾール誘導体
CA2875964C (en) 2012-06-07 2018-01-02 Georgia State University Research Foundation, Inc. Seca inhibitors and methods of making and using thereof
US20140005181A1 (en) * 2012-06-21 2014-01-02 Sanford-Burnham Medical Research Institute Small molecule antagonists of the apelin receptor for the treatment of disease
WO2014044738A1 (en) 2012-09-21 2014-03-27 Sanofi Benzoimidazole-carboxylic acid amide derivatives as apj receptor modulators
US20160067347A1 (en) 2012-12-20 2016-03-10 Amgen Inc. Apj receptor agonists and uses thereof
CN105228616B (zh) 2013-03-15 2019-05-03 实发生物医学公司 抗前蛋白转化酶枯草杆菌蛋白酶Kexin 9型（抗PCSK9）化合物及其用于治疗和/或预防心血管疾病的方法
UY35517A (es) 2013-04-04 2014-10-31 Mabxience S A Un procedimiento para aumentar la formación de ácido piroglutamico de una proteína
EP3003322B1 (en) 2013-05-30 2023-09-13 Washington University Mannose derivatives and their use in the treatment of bacterial infections
CA2942940A1 (en) 2014-03-20 2015-09-24 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of compounds inhibiting apelin / apj / gp130 signaling for treating cancer
EP3134427B1 (en) 2014-04-24 2020-06-03 Nanyang Technological University Asx-specific protein ligase
WO2015184011A2 (en) * 2014-05-28 2015-12-03 Sanford-Burnham Medical Research Institute Agonists of the apelin receptor and methods of use thereof
KR102509043B1 (ko) 2014-06-06 2023-03-09 리써치 트라이앵글 인스티튜트 아펠린 수용체(apj) 효능제 및 이의 용도
US20160058705A1 (en) 2014-08-28 2016-03-03 Jayakumar Rajadas Compositions and methods for treating cardiovascular and pulmonary diseases and disorders with apelin
HUE050317T2 (hu) * 2015-05-20 2020-11-30 Amgen Inc APJ receptor triazol agonistái
LT3303330T (lt) 2015-06-03 2019-08-12 Bristol-Myers Squibb Company 4-hidroksi-3-(heteroaril)piridin-2-ono apj agonistai, skirti panaudoti širdies ir kraujagyslių sutrikimų gydymui
EP3115826A1 (de) 2015-07-06 2017-01-11 Trumpf Laser Marking Systems AG Vorrichtung zur ablenkung eines laserstrahls
WO2017010058A1 (ja) 2015-07-14 2017-01-19 パナソニックＩｐマネジメント株式会社 識別媒体認識装置および識別媒体認識方法
CA3001974A1 (en) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as apj agonists
WO2017091513A1 (en) 2015-11-24 2017-06-01 Daiichi Sankyo Company, Limited Novel azole derivatives as apelin receptor agonist
JP6817305B2 (ja) 2015-12-04 2021-01-20 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アペリン受容体アゴニストおよびその使用方法
PE20190258A1 (es) 2015-12-09 2019-02-25 Res Triangle Inst Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos
WO2017192485A1 (en) * 2016-05-03 2017-11-09 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor

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