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AR092563A1 - PROCESO PARA LA PREPARACION DE 2-AMINO-5,8-DIMETOXI[1,2,4]TRIAZOL[1,5-c]PIRIMIDINA A PARTIR DE 4-CLORO-2,5-DIMETOXIPIRIMIDINA - Google Patents

PROCESO PARA LA PREPARACION DE 2-AMINO-5,8-DIMETOXI[1,2,4]TRIAZOL[1,5-c]PIRIMIDINA A PARTIR DE 4-CLORO-2,5-DIMETOXIPIRIMIDINA

Info

Publication number
AR092563A1
AR092563A1 ARP130103289A ARP130103289A AR092563A1 AR 092563 A1 AR092563 A1 AR 092563A1 AR P130103289 A ARP130103289 A AR P130103289A AR P130103289 A ARP130103289 A AR P130103289A AR 092563 A1 AR092563 A1 AR 092563A1
Authority
AR
Argentina
Prior art keywords
dialkoxy
formula
pyrimidine
amino
triazol
Prior art date
Application number
ARP130103289A
Other languages
English (en)
Inventor
C Bland Douglas
Roth Gary
Bott Craig
T Hamilton Christopher
Neuman Joseph
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of AR092563A1 publication Critical patent/AR092563A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F10/04—Monomers containing three or four carbon atoms
    • C08F10/06—Propene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • C08F4/62—Refractory metals or compounds thereof
    • C08F4/64—Titanium, zirconium, hafnium or compounds thereof
    • C08F4/65—Pretreating the metal or compound covered by group C08F4/64 before the final contacting with the metal or compound covered by group C08F4/44
    • C08F4/651—Pretreating with non-metals or metal-free compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • C08F4/62—Refractory metals or compounds thereof
    • C08F4/64—Titanium, zirconium, hafnium or compounds thereof
    • C08F4/65—Pretreating the metal or compound covered by group C08F4/64 before the final contacting with the metal or compound covered by group C08F4/44
    • C08F4/652—Pretreating with metals or metal-containing compounds
    • C08F4/657—Pretreating with metals or metal-containing compounds with metals or metal-containing compounds, not provided for in groups C08F4/653 - C08F4/656

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se elaboraron 2-amino-5,8-dialcoxi[1,2,4]-triazol[1,5-c]pirimidinas a partir de 4-cloro-2,5-dialcoxipirimidinas en un proceso que evita la hidracina y el haluro de cianógeno. Reivindicación 1: Un proceso para la preparación de 2-amino-5,8-dialcoxi[1,2,4]triazol[1,5-c]-pirimidinas de la fórmula (1), en el cual R es un alquilo C₁₋₄ que comprende: i) poner en contacto 4-cloro-2,5-dialcoxi pirimidina de la fórmula (2) en donde R se presenta como se ha definido anteriormente con una sal de cianamida en un solvente aprótico polar para obtener un 2,5-dialcoxi-4-cianoamino pirimidina de la fórmula (3) en la cual R se presenta como se la ha definido anteriormente; ii) en contacto con la 2,5-dialcoxi-4-cianoaminopirimidina con cualquier hidroxilamino en la forma de base libre o sal de hidroxilamino en presencia de una base para producir una 2,5-dialcoxi-4-hidroxiguanidinilpirimidina de la fórmula (4) en donde R se presenta como se la ha definido anteriormente; y iii) ciclización la piridimidina 2,5-dialcoxi-4-hidroxiguanidinilo tratándola con un cloroformato de alquilo para obtener la 2-amino-5,8-dialcoxi[1,2,4]triazol[1,5-c]pirimidina. Reivindicación 18: Un proceso para la preparación de 2-amino-5,8-dialcoxi[1,2,4]triazol[1,5-c]-pirimidinas de la fórmula (1), en donde R es un alquilo C₁₋₄ que comprende: la ciclización de 2,5-dialcoxi-4-hidroxiguanidinil pirimidina de la fórmula (4) en donde R se presenta como se la ha descripto anteriormente; tratándola con un cloroformato de alquilo para obtener la 2-amino-5,8-dialcoxi[1,2,4]triazol[1,5-c]pirimidina. Reivindicación 21: Un compuesto de la fórmula (3) en la cual R representa un alquilo C₁₋₄. Reivindicación 22: Un compuesto de la fórmula (4) en la cual R representa un alquilo C₁₋₄.
ARP130103289A 2012-09-14 2013-09-13 PROCESO PARA LA PREPARACION DE 2-AMINO-5,8-DIMETOXI[1,2,4]TRIAZOL[1,5-c]PIRIMIDINA A PARTIR DE 4-CLORO-2,5-DIMETOXIPIRIMIDINA AR092563A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261701250P 2012-09-14 2012-09-14

Publications (1)

Publication Number Publication Date
AR092563A1 true AR092563A1 (es) 2015-04-22

Family

ID=50275133

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130103289A AR092563A1 (es) 2012-09-14 2013-09-13 PROCESO PARA LA PREPARACION DE 2-AMINO-5,8-DIMETOXI[1,2,4]TRIAZOL[1,5-c]PIRIMIDINA A PARTIR DE 4-CLORO-2,5-DIMETOXIPIRIMIDINA

Country Status (19)

Country Link
US (1) US9000160B2 (es)
EP (1) EP2895486B1 (es)
JP (1) JP6293758B2 (es)
KR (1) KR20150056590A (es)
CN (1) CN104768953A (es)
AR (1) AR092563A1 (es)
AU (1) AU2013315734B2 (es)
BR (1) BR102013023482A8 (es)
CA (1) CA2884106A1 (es)
HK (1) HK1212334A1 (es)
IL (1) IL237677B (es)
IN (1) IN2015DN01972A (es)
MX (1) MX2015003314A (es)
NZ (1) NZ705676A (es)
PL (1) PL2895486T3 (es)
RU (1) RU2635352C2 (es)
TW (1) TWI617563B (es)
UY (1) UY35034A (es)
WO (1) WO2014043087A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112730689B (zh) * 2020-12-29 2023-04-07 营口昌成新材料科技有限公司 2-氨基-5,8-二甲氧基[1,2,4]三唑并[1,5-c]嘧啶液相色谱分析方法
CN115417875B (zh) * 2022-09-19 2024-05-31 山东华升新材料有限公司 一种5,8-二甲氧基-[1,2,4]三唑并[1,5-c]嘧啶-2-胺的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA001064B1 (ru) * 1996-09-24 2000-10-30 Дау Агросайенсез Ллс N-([1,2,4]триазолазинил)бензолсульфонамиды и пиридинсульфонамиды и их применение в качестве гербицидов
AU2001268497B2 (en) 2000-06-16 2005-08-11 Dow Agrosciences Llc Process for the preparation of 2-Amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine
MX2012013648A (es) * 2010-05-25 2013-02-11 Dow Agrosciences Llc Proceso para la preparacion de 8-alcoxi [1, 2, 4] triazol [1, 5-c]pirimidin-2-aminas substituidas-5.

Also Published As

Publication number Publication date
RU2635352C2 (ru) 2017-11-13
US9000160B2 (en) 2015-04-07
PL2895486T3 (pl) 2018-08-31
HK1212334A1 (en) 2016-06-10
IL237677B (en) 2018-07-31
TWI617563B (zh) 2018-03-11
RU2015113560A (ru) 2016-11-10
US20140081023A1 (en) 2014-03-20
AU2013315734B2 (en) 2016-03-17
NZ705676A (en) 2016-10-28
CN104768953A (zh) 2015-07-08
MX2015003314A (es) 2016-01-20
JP6293758B2 (ja) 2018-03-14
BR102013023482A8 (pt) 2016-07-12
AU2013315734A1 (en) 2015-03-26
EP2895486B1 (en) 2018-03-07
WO2014043087A1 (en) 2014-03-20
CA2884106A1 (en) 2014-03-20
IN2015DN01972A (es) 2015-08-14
KR20150056590A (ko) 2015-05-26
JP2015531783A (ja) 2015-11-05
EP2895486A1 (en) 2015-07-22
UY35034A (es) 2014-04-30
EP2895486A4 (en) 2016-01-27
TW201414739A (zh) 2014-04-16
IL237677A0 (en) 2015-04-30
BR102013023482A2 (pt) 2015-08-11

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