[go: up one dir, main page]

AR089310A1 - Proceso para la preparacion de magnolol y derivados del mismo - Google Patents

Proceso para la preparacion de magnolol y derivados del mismo

Info

Publication number
AR089310A1
AR089310A1 ARP120104803A ARP120104803A AR089310A1 AR 089310 A1 AR089310 A1 AR 089310A1 AR P120104803 A ARP120104803 A AR P120104803A AR P120104803 A ARP120104803 A AR P120104803A AR 089310 A1 AR089310 A1 AR 089310A1
Authority
AR
Argentina
Prior art keywords
biphenyl
diol
diallyl
dimethoxy
magnolol
Prior art date
Application number
ARP120104803A
Other languages
English (en)
Inventor
Proctor Gordon
Zaidel Lynette
Miller Steven
Carpenter Guy
Bartlett David
Moazzez Rebecca
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of AR089310A1 publication Critical patent/AR089310A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/003—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by hydrogenation of an unsaturated part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/05—Preparation of ethers by addition of compounds to unsaturated compounds
    • C07C41/06—Preparation of ethers by addition of compounds to unsaturated compounds by addition of organic compounds only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

En la presente se describen métodos de elevado rendimiento para la preparación de magnolol (5,5-dialil-bifenil-2,2-diol) y tetrahidromagnolol (5,5-dipropil-bifenil-2,2-diol). Reivindicación 1: Un método para la preparación de magnolol (5,5-dialil-bifenil-2,2-diol) o tetrahidromagnolol (5,5-dipropil-bifenil-2,2-diol), que comprende i) la metilación de bifenil-2,2-diol utilizando sulfato de dimetilo, para obtener 2,2-dimetoxi-bifenilo; ii) la bromuración del 2,2-dimetoxi-bifenilo para obtener 2,2-dimetoxi-5,5-dibromo-bifenilo; iii) la alquilación del 2,2-dimetoxi-5,5-dibromo-bifenilo con bromuro de alilo para obtener 2,2-dimetoxi-5,5-dialil-bifenilo; iv) la desmetilación del 2,2-dimetoxi-5,5-dialil-bifenilo mediante la reacción con cloruro de aluminio y tiourea; v) la recuperación del 5,5-dialil-bifenil-2,2-diol obtenido de esta forma; y vi) opcionalmente la hidrogenación del 5,5-dialil-bifenil-2,2-diol en presencia de un catalizador metálico y la recuperación del 5,5-dipropil-bifenil-2,2-diol obtenido de esta forma.
ARP120104803A 2011-12-20 2012-12-18 Proceso para la preparacion de magnolol y derivados del mismo AR089310A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/066045 WO2013095361A1 (en) 2011-12-20 2011-12-20 Processes for making magnolol and derivatives thereof

Publications (1)

Publication Number Publication Date
AR089310A1 true AR089310A1 (es) 2014-08-13

Family

ID=45498119

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104803A AR089310A1 (es) 2011-12-20 2012-12-18 Proceso para la preparacion de magnolol y derivados del mismo

Country Status (15)

Country Link
US (1) US9000231B2 (es)
EP (1) EP2794534B1 (es)
JP (1) JP2015500874A (es)
CN (1) CN103987684A (es)
AR (1) AR089310A1 (es)
AU (1) AU2011383722B2 (es)
BR (1) BR112014014255A2 (es)
CA (1) CA2858954A1 (es)
MX (1) MX2014007555A (es)
PH (1) PH12014501367A1 (es)
RU (1) RU2014129826A (es)
SG (1) SG11201402848YA (es)
TW (1) TWI504585B (es)
WO (1) WO2013095361A1 (es)
ZA (1) ZA201404277B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX351329B (es) 2013-01-23 2017-10-11 Colgate Palmolive Co Proceso para elaborar derivados de magnolol.
CN105622603A (zh) * 2015-05-28 2016-06-01 广州牌牌生物科技有限公司 多核化合物、其制备方法以及其应用
CN109053387B (zh) * 2018-09-19 2021-07-09 九江学院 一种厚朴酚的合成方法
WO2020126347A1 (en) 2018-12-18 2020-06-25 Unilever N.V. An antimicrobial composition
CN113717683B (zh) * 2021-09-27 2023-05-09 武汉纺织大学 一种光固化水下生物基抗菌胶粘剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5959157A (en) * 1995-06-26 1999-09-28 Alliedsignal, Inc. Process for making hydroxy-substituted ethynylated biphenyl compounds
CN1106391C (zh) 1999-04-12 2003-04-23 李安荣 厚朴酚系列化合物及其合成方法和以该化合物为活性成分的药物组合物
US6500409B1 (en) 2000-05-10 2002-12-31 Colgate Palmolive Company Synergistic antiplaque/antigingivitis oral composition
JP4851940B2 (ja) 2004-11-19 2012-01-11 宮城県 がんまたは糖尿病治療のための医薬組成物
WO2006061666A2 (en) 2004-12-08 2006-06-15 Richter Gedeon Vegyészeti Gyár Rt. A new process for the preparation of phenolic hydroxy-substituted compounds
WO2006129898A1 (en) 2005-05-30 2006-12-07 Korea Institute Of Oriental Medicine A mass separation method of magnolol from magnoliae cortex ormagnoliae radix
EP2040696B1 (en) 2006-07-14 2017-01-25 DSM IP Assets B.V. Compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders
CN101293816B (zh) 2008-06-24 2011-09-28 江南大学 厚朴酚的合成方法
JP5265282B2 (ja) * 2008-09-19 2013-08-14 花王株式会社 皮膚化粧料
TWI422382B (zh) 2010-02-24 2014-01-11 Colgate Palmolive Co 加強木蘭活性物之溶解度及傳送的組成物
TWI459957B (zh) 2010-02-24 2014-11-11 Colgate Palmolive Co 口腔保健組成物
US8519197B2 (en) 2010-02-25 2013-08-27 Colgate-Palmolive Company Synthesis of magnolol and its analogue compounds

Also Published As

Publication number Publication date
JP2015500874A (ja) 2015-01-08
WO2013095361A1 (en) 2013-06-27
SG11201402848YA (en) 2014-10-30
RU2014129826A (ru) 2016-02-10
CA2858954A1 (en) 2013-06-27
AU2011383722A1 (en) 2014-06-19
ZA201404277B (en) 2016-05-25
EP2794534B1 (en) 2016-11-30
US20140357902A1 (en) 2014-12-04
US9000231B2 (en) 2015-04-07
BR112014014255A2 (pt) 2017-06-13
AU2011383722B2 (en) 2015-03-12
MX2014007555A (es) 2014-08-01
TW201339129A (zh) 2013-10-01
TWI504585B (zh) 2015-10-21
EP2794534A1 (en) 2014-10-29
CN103987684A (zh) 2014-08-13
PH12014501367A1 (en) 2014-09-22

Similar Documents

Publication Publication Date Title
AR089310A1 (es) Proceso para la preparacion de magnolol y derivados del mismo
CO6280525A2 (es) Metodo y sistema con base de bromo para convertir alcanos gaseosos en hidrocarburos liquidos con el uso de electrolisis para la recuperacion de bromo
MY169347A (en) Process for producing brominated butyl rubber
CO7101249A2 (es) Prevencion de espuma en el proceso de flotacion inversa para la purificacion de carbonato de calcio
GB201217266D0 (en) Performing aggressive code optimization with an ability to rollback changes made by the aggressive optimizations
BR112014004930A2 (pt) processo para a produção de olefinas, e, uso das olefinas
AR088209A1 (es) Proceso para producir 2,3,3,3-tetrafluoropropeno
CL2012002464A1 (es) Proceso para la preparación de compuestos pesticidas que contienen un grupo tio-triazolo, que comprende hacer reaccionar un compuesto triazolo con un reactivo de grignard; compuestos pesticidas que contienen un grupo tio-triazolo; y su uso.
BR112013033729A2 (pt) método para reduzir o uso de água em um processo de conversão celulósica
BR112013006287A2 (pt) uso de um sistema de reação de espuma de poliuretano, e, processo para produzir compósitos
AR090642A1 (es) Metodo para elaborar una composicion con sales de aluminio
BR112016014006A2 (pt) Processos para a diazotização de 2,5-dicloroanilinas
BR112015014994A2 (pt) processo integrado para a produção de acetato de metila e metanol a partir de gás de síntese e éter dimetílico
CL2013002814A1 (es) Sistema para la recuperacion continua de metales que comprende sistema de lavado continuo, sistema de elucion continua, sistema de electroextraccion los que estan configurados para operar simultaneamente con procesos convencionales de recuperacion de metales; y proceso de recuperacion continua de un metal.
PH12014502779B1 (en) Preparation method for perfluoro-2-methyl-3-pentanone and intermediate
AR089311A1 (es) Procesos para la preparacion de analogos de magnolol
CL2014003565A1 (es) Uso de 2-metileno-19-nor-(20s)-1alpha,25-dihidroxivitamina d3 para tratar el hiperparatiroidismo secundario.
AR084543A1 (es) Sistema catalitico y su uso para la fabricacion de cloruro de vinilo por adicion de cloruro de hidrogeno al acetileno
MX392233B (es) Método para preparar bromuros.
MX2017000023A (es) Proceso para preparar fenilalcanos sustituidos.
Somorová Facility management
BR112013009619A2 (pt) método para purificação de misturas que compreende mtbe, bem como para produção de isobuteno por meio da divisão de misturas que compreendem mtbe
GB201210256D0 (en) Improved butanol recovery process
BR112014031391A2 (pt) catalisador para a conversão de oxigenados em olefinas, processo para a preparação de um catalizador, processo para converter oxigenados em olefinas e uso de catalizador.
AR086860A1 (es) Proceso para la produccion de propenos clorados y/o fluorados

Legal Events

Date Code Title Description
FB Suspension of granting procedure