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MX2017000023A - Proceso para preparar fenilalcanos sustituidos. - Google Patents

Proceso para preparar fenilalcanos sustituidos.

Info

Publication number
MX2017000023A
MX2017000023A MX2017000023A MX2017000023A MX2017000023A MX 2017000023 A MX2017000023 A MX 2017000023A MX 2017000023 A MX2017000023 A MX 2017000023A MX 2017000023 A MX2017000023 A MX 2017000023A MX 2017000023 A MX2017000023 A MX 2017000023A
Authority
MX
Mexico
Prior art keywords
preparing substituted
phenylalkanes
substituted phenylalkanes
processes
compound
Prior art date
Application number
MX2017000023A
Other languages
English (en)
Other versions
MX395643B (es
Inventor
Liao Subo
Trawick Bobby
Mcclurg Joseph
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of MX2017000023A publication Critical patent/MX2017000023A/es
Publication of MX395643B publication Critical patent/MX395643B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención provee métodos para la preparación de fenilalcanos sustituidos. En particular, los procesos comprenden hacer reaccionar un compuesto fenilborónico con un compuesto que contiene carbonilo a-ß insaturado a través de una reacción de adición 1,4 asimétrica. Los procesos pueden ser útiles en la síntesis de tapentadol.
MX2017000023A 2014-07-10 2015-07-10 Proceso para preparar fenilalcanos sustituidos. MX395643B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462022815P 2014-07-10 2014-07-10
US201562155913P 2015-05-01 2015-05-01
PCT/US2015/039884 WO2016007823A1 (en) 2014-07-10 2015-07-10 Process for preparing substituted phenylalkanes

Publications (2)

Publication Number Publication Date
MX2017000023A true MX2017000023A (es) 2017-05-01
MX395643B MX395643B (es) 2025-03-25

Family

ID=55064941

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017000023A MX395643B (es) 2014-07-10 2015-07-10 Proceso para preparar fenilalcanos sustituidos.

Country Status (11)

Country Link
US (1) US9556108B2 (es)
EP (1) EP3166923B1 (es)
JP (1) JP6502397B2 (es)
AU (1) AU2015287663B2 (es)
BR (1) BR112017000417B1 (es)
CA (1) CA2954642C (es)
DK (1) DK3166923T3 (es)
ES (1) ES2940904T3 (es)
MX (1) MX395643B (es)
PT (1) PT3166923T (es)
WO (1) WO2016007823A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3166923B1 (en) 2014-07-10 2023-03-15 SpecGx LLC Process for preparing substituted phenylalkanes
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
GB2539442A (en) * 2015-06-16 2016-12-21 Azad Pharmaceutical Ingredients Ag New synthesis of tapentadol-HCI intermediates
JP6463854B2 (ja) * 2015-07-10 2019-02-06 マリンクロッド エルエルシー ３‐置換フェニルアルキルアミンを製造するための二段法
WO2018009856A1 (en) 2016-07-08 2018-01-11 Cody Laboratories, Inc. Method for catalytic preparation of hydromorphone, hydrocodone and other opiates
CN116496496B (zh) * 2023-04-27 2024-11-05 中国石油大学(华东) 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法
GB2636346A (en) * 2023-11-29 2025-06-18 Airbus Operations Ltd Elongate aircraft structural component and method of fabricating an elongate aircraft structural component

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DE2340812C2 (de) 1973-08-11 1982-05-27 Basf Ag, 6700 Ludwigshafen Phenylpropanale sowie ein Verfahren zu deren Herstellung
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
CA2404464C (en) * 2000-04-20 2008-03-11 F. Hoffmann-La Roche Ag Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders
PL369655A1 (en) * 2001-10-16 2005-05-02 Dr.Reddy's Laboratories Ltd. Novel-beta-phenyl-alpha-oxysubstituted propionic derivatives, process for its preparation and their use in the preparation of pharmaceutically important compounds
US7323565B2 (en) 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7399858B2 (en) 2002-11-11 2008-07-15 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US7321038B2 (en) 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
JP4351859B2 (ja) * 2003-04-14 2009-10-28 三菱レイヨン株式会社 光学活性β−アリ−ル化合物の製造法
DE10328316A1 (de) * 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
US7608709B2 (en) 2005-07-25 2009-10-27 National University Corporation Chiba University 2, 3-bis(dialkylphosphino)pyrazine derivative, process of producing the same, and metal complex having the same as ligand
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
US7399859B1 (en) 2007-02-06 2008-07-15 Cody Laboratories Inc. Method for catalytic preparation of hydromorphone and hydrocodone
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
WO2010057099A1 (en) 2008-11-14 2010-05-20 University Of Kansas Polymer-supported transition metal catalyst complexes and methods of use
WO2010144641A1 (en) 2009-06-11 2010-12-16 Mallinckrodt Inc. Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
CN102002065B (zh) 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
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WO2011092719A2 (en) * 2010-02-01 2011-08-04 Ind-Swift Laboratories Limited Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives
EP2542521A2 (en) 2010-03-05 2013-01-09 Actavis Group Ptc Ehf Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
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WO2012146978A2 (en) * 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
WO2013090161A1 (en) * 2011-12-12 2013-06-20 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
JP2013221025A (ja) 2012-04-19 2013-10-28 Dainippon Sumitomo Pharma Co Ltd ビフェニルアセトアミド誘導体の製造方法及びその中間体
EP2852439A1 (en) 2012-05-23 2015-04-01 Stemergie Biotechnology SA Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof
CN102936205B (zh) * 2012-11-12 2014-06-18 合肥市新星医药化工有限公司 一种他喷他多的合成方法
EP3166923B1 (en) 2014-07-10 2023-03-15 SpecGx LLC Process for preparing substituted phenylalkanes

Also Published As

Publication number Publication date
US9556108B2 (en) 2017-01-31
AU2015287663A1 (en) 2017-01-12
JP2017520566A (ja) 2017-07-27
EP3166923B1 (en) 2023-03-15
BR112017000417B1 (pt) 2021-06-08
CA2954642C (en) 2023-04-11
DK3166923T3 (da) 2023-04-11
EP3166923A1 (en) 2017-05-17
WO2016007823A1 (en) 2016-01-14
CA2954642A1 (en) 2016-01-14
MX395643B (es) 2025-03-25
JP6502397B2 (ja) 2019-04-17
EP3166923A4 (en) 2018-02-21
PT3166923T (pt) 2023-06-02
AU2015287663B2 (en) 2019-02-28
US20160009635A1 (en) 2016-01-14
BR112017000417A2 (pt) 2017-11-07
ES2940904T3 (es) 2023-05-12

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