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MX395643B - Proceso para preparar fenilalcanos sustituidos. - Google Patents

Proceso para preparar fenilalcanos sustituidos.

Info

Publication number
MX395643B
MX395643B MX2017000023A MX2017000023A MX395643B MX 395643 B MX395643 B MX 395643B MX 2017000023 A MX2017000023 A MX 2017000023A MX 2017000023 A MX2017000023 A MX 2017000023A MX 395643 B MX395643 B MX 395643B
Authority
MX
Mexico
Prior art keywords
preparing substituted
phenylalkans
processes
tapentadol
phenylboronic
Prior art date
Application number
MX2017000023A
Other languages
English (en)
Other versions
MX2017000023A (es
Inventor
Bobby Trawick
Joseph Mcclurg
Subo Liao
Original Assignee
SpecGx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SpecGx LLC filed Critical SpecGx LLC
Publication of MX2017000023A publication Critical patent/MX2017000023A/es
Publication of MX395643B publication Critical patent/MX395643B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención provee métodos para la preparación de fenilalcanos sustituidos. En particular, los procesos comprenden hacer reaccionar un compuesto fenilborónico con un compuesto que contiene carbonilo a-ß insaturado a través de una reacción de adición 1,4 asimétrica. Los procesos pueden ser útiles en la síntesis de tapentadol.
MX2017000023A 2014-07-10 2015-07-10 Proceso para preparar fenilalcanos sustituidos. MX395643B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462022815P 2014-07-10 2014-07-10
US201562155913P 2015-05-01 2015-05-01
PCT/US2015/039884 WO2016007823A1 (en) 2014-07-10 2015-07-10 Process for preparing substituted phenylalkanes

Publications (2)

Publication Number Publication Date
MX2017000023A MX2017000023A (es) 2017-05-01
MX395643B true MX395643B (es) 2025-03-25

Family

ID=55064941

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017000023A MX395643B (es) 2014-07-10 2015-07-10 Proceso para preparar fenilalcanos sustituidos.

Country Status (11)

Country Link
US (1) US9556108B2 (es)
EP (1) EP3166923B1 (es)
JP (1) JP6502397B2 (es)
AU (1) AU2015287663B2 (es)
BR (1) BR112017000417B1 (es)
CA (1) CA2954642C (es)
DK (1) DK3166923T3 (es)
ES (1) ES2940904T3 (es)
MX (1) MX395643B (es)
PT (1) PT3166923T (es)
WO (1) WO2016007823A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3166923B1 (en) 2014-07-10 2023-03-15 SpecGx LLC Process for preparing substituted phenylalkanes
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
GB2539442A (en) * 2015-06-16 2016-12-21 Azad Pharmaceutical Ingredients Ag New synthesis of tapentadol-HCI intermediates
DK3995492T3 (da) * 2015-07-10 2024-08-19 SpecGx LLC Totrinsfremgangsmåde til fremstilling af 3-substituerede phenylalkylaminer
WO2018009856A1 (en) 2016-07-08 2018-01-11 Cody Laboratories, Inc. Method for catalytic preparation of hydromorphone, hydrocodone and other opiates
CN116496496B (zh) * 2023-04-27 2024-11-05 中国石油大学(华东) 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法
GB2636346A (en) * 2023-11-29 2025-06-18 Airbus Operations Ltd Elongate aircraft structural component and method of fabricating an elongate aircraft structural component

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DE2340812C2 (de) 1973-08-11 1982-05-27 Basf Ag, 6700 Ludwigshafen Phenylpropanale sowie ein Verfahren zu deren Herstellung
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
CA2404464C (en) 2000-04-20 2008-03-11 F. Hoffmann-La Roche Ag Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders
HRP20040349A2 (en) 2001-10-16 2005-06-30 Dr. Reddy's Laboratories Limited Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them
US7399858B2 (en) 2002-11-11 2008-07-15 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US7323565B2 (en) 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7321038B2 (en) 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
JP4351859B2 (ja) * 2003-04-14 2009-10-28 三菱レイヨン株式会社 光学活性β−アリ−ル化合物の製造法
DE10328316A1 (de) * 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
US7608709B2 (en) 2005-07-25 2009-10-27 National University Corporation Chiba University 2, 3-bis(dialkylphosphino)pyrazine derivative, process of producing the same, and metal complex having the same as ligand
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
US7399859B1 (en) 2007-02-06 2008-07-15 Cody Laboratories Inc. Method for catalytic preparation of hydromorphone and hydrocodone
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
AU2009313838B2 (en) 2008-11-14 2015-02-05 University Of Kansas Polymer-supported transition metal catalyst complexes and methods of use
JP5697215B2 (ja) 2009-06-11 2015-04-08 マリンクロッド エルエルシー 触媒的水素移動による６−α−アミノＮ−置換モルフィナンの合成
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AU2010337825A1 (en) * 2009-12-29 2012-07-05 Mapi Pharma Limited Intermediate compounds and processes for the preparation of tapentadol and related compounds
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US20130096346A1 (en) * 2010-03-05 2013-04-18 Actavis Group Ptc Ehf Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
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JP2013221025A (ja) 2012-04-19 2013-10-28 Dainippon Sumitomo Pharma Co Ltd ビフェニルアセトアミド誘導体の製造方法及びその中間体
AU2013265266A1 (en) 2012-05-23 2015-01-15 Stemergie Biotechnology Sa Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof
CN102936205B (zh) * 2012-11-12 2014-06-18 合肥市新星医药化工有限公司 一种他喷他多的合成方法
EP3166923B1 (en) 2014-07-10 2023-03-15 SpecGx LLC Process for preparing substituted phenylalkanes

Also Published As

Publication number Publication date
WO2016007823A1 (en) 2016-01-14
BR112017000417A2 (pt) 2017-11-07
CA2954642C (en) 2023-04-11
US20160009635A1 (en) 2016-01-14
PT3166923T (pt) 2023-06-02
EP3166923A4 (en) 2018-02-21
EP3166923B1 (en) 2023-03-15
EP3166923A1 (en) 2017-05-17
JP2017520566A (ja) 2017-07-27
ES2940904T3 (es) 2023-05-12
AU2015287663A1 (en) 2017-01-12
CA2954642A1 (en) 2016-01-14
JP6502397B2 (ja) 2019-04-17
US9556108B2 (en) 2017-01-31
DK3166923T3 (da) 2023-04-11
MX2017000023A (es) 2017-05-01
AU2015287663B2 (en) 2019-02-28
BR112017000417B1 (pt) 2021-06-08

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