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AR087418A1 - Inhibidores de replica de virus de influenza - Google Patents

Inhibidores de replica de virus de influenza

Info

Publication number
AR087418A1
AR087418A1 ARP120102809A ARP120102809A AR087418A1 AR 087418 A1 AR087418 A1 AR 087418A1 AR P120102809 A ARP120102809 A AR P120102809A AR P120102809 A ARP120102809 A AR P120102809A AR 087418 A1 AR087418 A1 AR 087418A1
Authority
AR
Argentina
Prior art keywords
independently
alkyl
structural formula
inhibitors
influenza virus
Prior art date
Application number
ARP120102809A
Other languages
English (en)
Inventor
Paul S Charifson
Michael P Clark
Upul K Bandarage
Randy S Bethiel
Michael J Boyd
Ioana Davies
Hongbo Deng
Huai Gao
Wenxin Gu
Luc J Farmer
John P Duffy
Joseph M Kennedy
Brian Redford
Mark W Ledeboer
Francois Maltais
Emanuele Perola
Tiansheng Wang
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46650922&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR087418(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR087418A1 publication Critical patent/AR087418A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Proceso de elaboración e intermediario.Reivindicación 1: Un compuesto representado por la fórmula estructural (1), o una de sus sales farmacéuticamente aceptables, en donde: X1 es -F, -Cl, -CF3, -CN o CH3; X2 es -H, -F o -Cl; Z1 es N o CH; Z2 es N o CR0; Z3 es CH o N; Y es -C(R4R5)-[C(R6R7)]n-Q o -C(R4)=C(R6)-Q; R0 es -H, -F o CN; R1, R2 y R3 son, cada uno y de modo independiente, -CH3, -CH2F, -CF3, -C2H5, -CH2CH2F, -CH2CF3; o, de modo opcional, R2 y R3 o R1, R2 y R3, junto con el átomo de carbono al que están unidos, forman un anillo carbocíclico de 3 - 10 miembros; R4 y R5 son, cada uno y de modo independiente, -H; R6 y R7 son, cada uno y de modo independiente, -H, -OH, -CH3 o -CF3; o de modo opcional, R5 y R7, junto con los átomos de carbono a los que están unidos, forman un anillo ciclopropano; y cada Q es, de modo independiente, -C(O)OR, -OH, -CH2OH, -S(O)R’, -P(O)(OH)2, -S(O)2R’, -S(O)2-NR’’R’’’ o un heterociclo de 5 miembros seleccionado del grupo de formulas (2); JQ es -H, -OH o -CH2OH; R es -H o alquilo C1-4; R’ es -OH, alquilo C1-4 o -CH2C(O)OH; R’’ es -H o -CH3; R’’’ es -H, un anillo carbocíclico de 3 - 6 miembros o alquilo C1-4 sustituido, de modo opcional, con uno o varios sustituyentes seleccionados del grupo que consiste en halógeno, -ORa y -C(O)ORa; Ra es -H o alquilo C1-4; y n es 0 ó 1. Reivindicación 50: Un compuesto representado por la fórmula estructural (3) o una de sus sales farmacéuticamente aceptables, en donde las variables de la fórmula estructural (3) son, cada uno y de modo independiente, tal como se definen en cualquiera de las reivindicaciones 1 - 38; y cuando Z1 es N, G es tritilo; cuando Z1 es CH, G es tosilo o tritilo.
ARP120102809A 2011-08-01 2012-08-01 Inhibidores de replica de virus de influenza AR087418A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161513793P 2011-08-01 2011-08-01

Publications (1)

Publication Number Publication Date
AR087418A1 true AR087418A1 (es) 2014-03-19

Family

ID=46650922

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120102809A AR087418A1 (es) 2011-08-01 2012-08-01 Inhibidores de replica de virus de influenza

Country Status (37)

Country Link
US (5) US9051319B2 (es)
EP (2) EP2739623B1 (es)
JP (3) JP5917692B2 (es)
KR (1) KR101967172B1 (es)
CN (3) CN105503862B (es)
AP (1) AP3867A (es)
AR (1) AR087418A1 (es)
AU (2) AU2012290127B2 (es)
CA (1) CA2844054C (es)
CL (1) CL2014000245A1 (es)
CO (1) CO6940412A2 (es)
CY (1) CY1118726T1 (es)
DK (1) DK2739623T3 (es)
EA (3) EA037372B1 (es)
EC (1) ECSP14013189A (es)
ES (2) ES2618919T3 (es)
GE (2) GEP201706698B (es)
HK (1) HK1223915A1 (es)
HR (1) HRP20170421T1 (es)
HU (1) HUE033752T2 (es)
IL (2) IL230618A (es)
IN (1) IN2014CN00562A (es)
LT (1) LT2739623T (es)
ME (1) ME02638B (es)
MX (1) MX339149B (es)
PE (1) PE20141209A1 (es)
PH (1) PH12014500257A1 (es)
PL (1) PL2739623T3 (es)
PT (1) PT2739623T (es)
RS (1) RS55858B1 (es)
SG (2) SG10201503835TA (es)
SI (1) SI2739623T1 (es)
TW (3) TWI537268B (es)
UA (2) UA118010C2 (es)
UY (1) UY34234A (es)
WO (1) WO2013019828A1 (es)
ZA (2) ZA201400604B (es)

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CN109641868B (zh) * 2016-08-30 2021-12-03 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
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EA201692506A2 (ru) 2017-06-30
CO6940412A2 (es) 2014-05-09
KR101967172B1 (ko) 2019-04-09
US10875855B2 (en) 2020-12-29
EA037372B1 (ru) 2021-03-22
CN103764654B (zh) 2016-01-20
EA201500265A1 (ru) 2015-10-30
CN103764654A (zh) 2014-04-30
LT2739623T (lt) 2017-04-10
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UY34234A (es) 2013-02-28
SG10201503833SA (en) 2015-06-29
PL2739623T3 (pl) 2017-07-31
SG10201503835TA (en) 2015-06-29
CN105503862B (zh) 2018-02-02
MX2014001067A (es) 2014-03-27
AU2012290127A1 (en) 2013-05-02
EA027210B1 (ru) 2017-06-30
EA201490396A1 (ru) 2014-06-30
EA023423B1 (ru) 2016-06-30
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GEP201706698B (en) 2017-07-10
US20160355512A1 (en) 2016-12-08
ZA201409246B (en) 2016-05-25
US9051319B2 (en) 2015-06-09
JP6259855B2 (ja) 2018-01-10
PE20141209A1 (es) 2014-09-19
HK1194736A1 (zh) 2014-10-24
JP2014521688A (ja) 2014-08-28
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WO2013019828A1 (en) 2013-02-07
MX339149B (es) 2016-05-13
EP3147284A1 (en) 2017-03-29
DK2739623T3 (en) 2017-04-24
US9394302B2 (en) 2016-07-19
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IL230618A (en) 2016-04-21
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