AR086422A1 - Metodo para el tratamiento de tumores solidos avanzados, volasertib - Google Patents
Metodo para el tratamiento de tumores solidos avanzados, volasertibInfo
- Publication number
- AR086422A1 AR086422A1 ARP120101734A ARP120101734A AR086422A1 AR 086422 A1 AR086422 A1 AR 086422A1 AR P120101734 A ARP120101734 A AR P120101734A AR P120101734 A ARP120101734 A AR P120101734A AR 086422 A1 AR086422 A1 AR 086422A1
- Authority
- AR
- Argentina
- Prior art keywords
- volasertib
- solid tumors
- treatment
- hydrate
- salt
- Prior art date
Links
- SXNJFOWDRLKDSF-STROYTFGSA-N volasertib Chemical compound C1CN([C@H]2CC[C@@H](CC2)NC(=O)C2=CC=C(C(=C2)OC)NC=2N=C3N(C(C)C)[C@@H](C(N(C)C3=CN=2)=O)CC)CCN1CC1CC1 SXNJFOWDRLKDSF-STROYTFGSA-N 0.000 title abstract 4
- 229950003081 volasertib Drugs 0.000 title abstract 4
- 208000037844 advanced solid tumor Diseases 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 4
- 208000037843 metastatic solid tumor Diseases 0.000 abstract 2
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 abstract 1
- 229960004562 carboplatin Drugs 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Uso de Volasertib o una sal del mismo o un hidrato del mismo en combinación con Cisplatino o Carboplatino o una sal de los mismos o un hidrato de los mismos para tratar pacientes que sufren de tumores sólidos avanzados y/o metastásicos.Reivindicación 1: Volasertib o una sal del mismo o un hidrato del mismo aceptables para uso farmacéutico para el uso en el tratamiento de tumores sólidos avanzados y/o metastásicos caracterizado por la administración de 300 a 500 mg de Volasertib o una sal del mismo o un hidrato del mismo aceptables para uso farmacéutico en un día durante un ciclo de tratamiento de 14, 15, 16, 17,18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 ó 31 días.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166365 | 2011-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086422A1 true AR086422A1 (es) | 2013-12-11 |
Family
ID=46149422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101734A AR086422A1 (es) | 2011-05-17 | 2012-05-16 | Metodo para el tratamiento de tumores solidos avanzados, volasertib |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9370535B2 (es) |
| EP (1) | EP2709626A1 (es) |
| JP (1) | JP2014513705A (es) |
| KR (1) | KR20140025461A (es) |
| CN (1) | CN103533940A (es) |
| AR (1) | AR086422A1 (es) |
| AU (1) | AU2012257760A1 (es) |
| BR (1) | BR112013029484A2 (es) |
| CA (1) | CA2836385A1 (es) |
| CL (1) | CL2013003230A1 (es) |
| EA (1) | EA201301269A1 (es) |
| IL (1) | IL228908A0 (es) |
| MX (1) | MX2013013014A (es) |
| PH (1) | PH12013502334A1 (es) |
| UY (1) | UY34076A (es) |
| WO (1) | WO2012156380A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US20060035903A1 (en) | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
| WO2015011236A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
| WO2015116696A1 (en) * | 2014-01-28 | 2015-08-06 | Massachusetts Institute Of Technology | Combination therapies and methods of use thereof for treating cancer |
| US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
| EP4319729A4 (en) * | 2021-04-09 | 2025-02-26 | Cardiff Oncology, Inc. | CANCER TREATMENT WITH PARP INHIBITORS AND PLK1 INHIBITORS |
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| DE3537761A1 (de) | 1985-10-24 | 1987-04-30 | Bayer Ag | Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure |
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| US5043270A (en) | 1989-03-31 | 1991-08-27 | The Board Of Trustees Of The Leland Stanford Junior University | Intronic overexpression vectors |
| CA2029651C (en) | 1989-11-17 | 2000-06-06 | David D. Davey | Tricyclic pteridinones and a process for their preparation |
| US5198547A (en) | 1992-03-16 | 1993-03-30 | South Alabama Medical Science Foundation, Usa | Process for N5-formylating tetrahydropteridines |
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| JP5841548B2 (ja) | 2010-02-17 | 2016-01-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン、その製造方法及び使用 |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| US20130131069A1 (en) | 2011-05-13 | 2013-05-23 | Boehringer Ingelheim International Gmbh | Method for treatment of solid malignancies including advanced or metastatic solid malignancies |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
-
2012
- 2012-05-09 US US13/467,147 patent/US9370535B2/en active Active
- 2012-05-15 BR BR112013029484A patent/BR112013029484A2/pt not_active IP Right Cessation
- 2012-05-15 WO PCT/EP2012/058959 patent/WO2012156380A1/en not_active Ceased
- 2012-05-15 EP EP12723424.3A patent/EP2709626A1/en not_active Ceased
- 2012-05-15 AU AU2012257760A patent/AU2012257760A1/en not_active Abandoned
- 2012-05-15 MX MX2013013014A patent/MX2013013014A/es not_active Application Discontinuation
- 2012-05-15 CN CN201280023176.8A patent/CN103533940A/zh active Pending
- 2012-05-15 JP JP2014510769A patent/JP2014513705A/ja active Pending
- 2012-05-15 KR KR1020137030105A patent/KR20140025461A/ko not_active Withdrawn
- 2012-05-15 CA CA2836385A patent/CA2836385A1/en not_active Abandoned
- 2012-05-15 PH PH1/2013/502334A patent/PH12013502334A1/en unknown
- 2012-05-15 EA EA201301269A patent/EA201301269A1/ru unknown
- 2012-05-16 AR ARP120101734A patent/AR086422A1/es unknown
- 2012-05-17 UY UY0001034076A patent/UY34076A/es unknown
-
2013
- 2013-10-16 IL IL228908A patent/IL228908A0/en unknown
- 2013-11-11 CL CL2013003230A patent/CL2013003230A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2709626A1 (en) | 2014-03-26 |
| EA201301269A1 (ru) | 2014-05-30 |
| PH12013502334A1 (en) | 2019-03-22 |
| IL228908A0 (en) | 2013-12-31 |
| BR112013029484A2 (pt) | 2017-01-17 |
| CA2836385A1 (en) | 2012-11-22 |
| US9370535B2 (en) | 2016-06-21 |
| UY34076A (es) | 2012-11-30 |
| CL2013003230A1 (es) | 2014-08-01 |
| AU2012257760A1 (en) | 2013-10-31 |
| CN103533940A (zh) | 2014-01-22 |
| JP2014513705A (ja) | 2014-06-05 |
| MX2013013014A (es) | 2014-01-31 |
| KR20140025461A (ko) | 2014-03-04 |
| WO2012156380A1 (en) | 2012-11-22 |
| US20130122111A1 (en) | 2013-05-16 |
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