[go: up one dir, main page]

AR086249A1 - COMPOSITIONS OF VAGINAL ADMINISTRATION FAST DISSOLUTION TABLETS - Google Patents

COMPOSITIONS OF VAGINAL ADMINISTRATION FAST DISSOLUTION TABLETS

Info

Publication number
AR086249A1
AR086249A1 ARP120101551A ARP120101551A AR086249A1 AR 086249 A1 AR086249 A1 AR 086249A1 AR P120101551 A ARP120101551 A AR P120101551A AR P120101551 A ARP120101551 A AR P120101551A AR 086249 A1 AR086249 A1 AR 086249A1
Authority
AR
Argentina
Prior art keywords
vaginal administration
compositions
rapidly
vaginal
fast dissolution
Prior art date
Application number
ARP120101551A
Other languages
Spanish (es)
Inventor
Gopi Venkatesh
Vijaya Swaminathan
Jin-Wang Lai
Original Assignee
Aptalis Pharmatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptalis Pharmatech Inc filed Critical Aptalis Pharmatech Inc
Publication of AR086249A1 publication Critical patent/AR086249A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)

Abstract

Reivindicación 1: Una composición farmacéutica en la forma de microgránulos de disolución rápida de administración vaginal que incluye: (a) una cantidad terapéuticamente efectiva de una droga vaginalmente activa; (b) un excipiente polimérico con la propiedad dual de actuar como aglutinante, al igual que como material bioadhesivo; (c) un alcohol de azúcar, un sacárido o una combinación de los mismos; y (d) un disgregante; donde la composición farmacéutica se desintegra rápidamente luego de su inserción en la cavidad vaginal de un paciente o sujeto y forma una suspensión viscosa que contiene la droga que se esparce rápida y ampliamente y recubre la mucosa vaginal.Claim 1: A pharmaceutical composition in the form of rapidly dissolving vaginal administration microgranules that includes: (a) a therapeutically effective amount of a vaginally active drug; (b) a polymeric excipient with the dual property of acting as a binder, as well as as a bioadhesive material; (c) a sugar alcohol, a saccharide or a combination thereof; and (d) a disintegrant; where the pharmaceutical composition disintegrates rapidly after insertion into the vaginal cavity of a patient or subject and forms a viscous suspension containing the drug that spreads rapidly and widely and covers the vaginal mucosa.

ARP120101551A 2011-05-02 2012-05-02 COMPOSITIONS OF VAGINAL ADMINISTRATION FAST DISSOLUTION TABLETS AR086249A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161481582P 2011-05-02 2011-05-02

Publications (1)

Publication Number Publication Date
AR086249A1 true AR086249A1 (en) 2013-11-27

Family

ID=47108022

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120101551A AR086249A1 (en) 2011-05-02 2012-05-02 COMPOSITIONS OF VAGINAL ADMINISTRATION FAST DISSOLUTION TABLETS

Country Status (16)

Country Link
EP (1) EP2704694A4 (en)
JP (1) JP6154803B2 (en)
KR (2) KR20140014264A (en)
CN (1) CN103596556A (en)
AP (1) AP2013007268A0 (en)
AR (1) AR086249A1 (en)
AU (1) AU2012250862B2 (en)
CA (1) CA2839790A1 (en)
CL (1) CL2013003161A1 (en)
CO (1) CO6940408A2 (en)
IL (1) IL229170A0 (en)
MX (1) MX2013012745A (en)
RU (1) RU2013150323A (en)
SG (1) SG194725A1 (en)
TW (1) TW201247240A (en)
WO (1) WO2012151237A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA115876C2 (en) 2012-06-13 2018-01-10 Івофем, Інк. COMPOSITION AND METHOD OF IMPROVING THE EFFECTIVENESS OF BACTERICIDAL CONTRACEPTION
AP2015008726A0 (en) * 2013-03-15 2015-09-30 Conrad Low-glycerin-formulations for hiv treatment and prevention
WO2015070072A1 (en) * 2013-11-07 2015-05-14 Evofem, Inc. Methods for manufacturing contraceptive microbicides with antiviral properties
RU2691950C1 (en) * 2013-12-19 2019-06-19 Ивофем, Инк. Compositions and methods for inhibiting inflammation and diseases using alginic acid-based antimicrobial compound
CN110179801B (en) * 2014-04-11 2021-08-06 上海宣泰医药科技股份有限公司 Posaconazole medicine composition, preparation method and medicine preparation thereof
AU2015302059B2 (en) 2014-08-12 2020-02-06 Nextgen Jane, Inc. System and method for monitoring health based on collected bodily fluid
CN104434992B (en) * 2014-12-21 2018-06-08 昆明赛诺制药股份有限公司 A kind of American-cockroach-extract bioadhesive vaginal tablets and preparation method thereof
WO2016196653A1 (en) 2015-06-01 2016-12-08 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof
WO2017180909A1 (en) 2016-04-13 2017-10-19 Nextgen Jane, Inc. Sample collection and preservation devices, systems and methods
WO2018067568A1 (en) 2016-10-04 2018-04-12 Evofem Biosciences, Inc. Method of treatment and prevention of bacterial vaginosis
MX384337B (en) 2016-10-13 2025-03-14 Catalent Uk Swindon Zydis Ltd LYOPHILIZED PHARMACEUTICAL COMPOSITIONS FOR VAGINAL DELIVERY.
HUE070746T2 (en) 2017-10-06 2025-07-28 Gedea Biotech Ab Gluconic acid derivatives for use in the treatment and/or prevention of microbial infections
MX2021004553A (en) * 2018-10-23 2021-07-16 Eastern Virginia Medical School Pharmaceutical compositions and methods of making on demand solid dosage formulations.
WO2020128525A1 (en) * 2018-12-21 2020-06-25 The University Of Liverpool Nrti therapies
KR102357795B1 (en) * 2019-04-19 2022-02-04 한양대학교 산학협력단 Thermosensitive composition comprising phosphatidic acid and the use thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US20050276836A1 (en) 1997-06-11 2005-12-15 Michelle Wilson Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
US6899890B2 (en) 2002-03-20 2005-05-31 Kv Pharmaceutical Company Bioadhesive drug delivery system
US20040228932A1 (en) * 2003-05-12 2004-11-18 Pilgaonkar Pratibha S. Pharmaceutical excipient
US8545881B2 (en) 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
JP2006022039A (en) * 2004-07-08 2006-01-26 Towa Yakuhin Kk Simvastatin solid preparation having high stability
UA93354C2 (en) 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Topical antiviral formulations
CN1257715C (en) * 2004-08-02 2006-05-31 程月发 Clindamycin metronidazole vagina effervescent tablet and its preparing method and use
WO2006082596A2 (en) * 2005-01-19 2006-08-10 Kamalinder Kaur Singh Neem oil contraceptive formulations
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
US8252329B2 (en) * 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
CN1970079A (en) * 2006-12-08 2007-05-30 陕西沃普森制药有限公司 Vagina effervescence tablet of recombinant human interferon alpha-2a and preparation process thereof
CA2671938C (en) * 2006-12-10 2017-10-17 Chongxi Yu Transdermal delivery systems of beta-lactam antibiotics
AU2008256689A1 (en) * 2007-05-24 2008-12-04 New York Blood Center Inc. Rapidly dispersible vaginal tablet that provides a bioadhesive gel
US20090169620A1 (en) * 2007-12-21 2009-07-02 Venkatesh Gopi M Orally disintegrating tablet compositions of temazepam
CN101406463B (en) * 2008-02-28 2012-04-25 陕西君碧莎制药有限公司 Metronidazole, clotrimazole and chlorhexidine acetate vaginal effervescent tablet and preparation method thereof
CN101283989A (en) * 2008-02-28 2008-10-15 何文健 Metronidazole vaginal tablet process and quality control method
WO2010048389A2 (en) * 2008-10-23 2010-04-29 Henkel Corporation Pharmaceutical pellets comprising modified starch and therapeutic applications therefor
CN101780203B (en) * 2010-03-16 2012-09-05 刘仁杰 Lubrication effervescent agent for yin nourishing, nest warming, body deodorizing and youth keeping and preparation method thereof

Also Published As

Publication number Publication date
CA2839790A1 (en) 2012-11-08
KR20160112012A (en) 2016-09-27
AU2012250862A1 (en) 2013-05-02
SG194725A1 (en) 2013-12-30
EP2704694A4 (en) 2014-11-19
AP2013007268A0 (en) 2013-11-30
MX2013012745A (en) 2014-12-05
AU2012250862B2 (en) 2015-07-09
IL229170A0 (en) 2013-12-31
KR20140014264A (en) 2014-02-05
RU2013150323A (en) 2015-06-10
CL2013003161A1 (en) 2014-08-01
EP2704694A1 (en) 2014-03-12
CO6940408A2 (en) 2014-05-09
CN103596556A (en) 2014-02-19
JP2014513124A (en) 2014-05-29
NZ617376A (en) 2016-03-31
TW201247240A (en) 2012-12-01
JP6154803B2 (en) 2017-06-28
WO2012151237A1 (en) 2012-11-08

Similar Documents

Publication Publication Date Title
AR086249A1 (en) COMPOSITIONS OF VAGINAL ADMINISTRATION FAST DISSOLUTION TABLETS
CL2013001586A1 (en) Rapid dispersion microgranular composition comprising at least one sugar alcohol, a saccharide, or a mixture thereof, at least one super disintegrant and at least one multifunctional additive; oral disintegration tablet comprising the microgranular composition and at least one active ingredient; and manufacturing methods.
AR069875A1 (en) TEMAZEPAM COMPOSITIONS FOR ORAL DISINTEGRATION TABLETS AND PREPARATION METHOD
NZ727975A (en) Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa
UY33062A (en) TABLETS AND COMPOSITIONS PHARMACEUTICAL COMPRESSIBLE COATINGS AND MANUFACTURING METHODS
GT200600445A (en) SOLID PHARMACEUTICAL PRESENTATION FORMS OF ORAL ADMINISTRATION WITH QUICK RELEASE OF THE ACTIVE PRINCIPLE.
DK2032123T3 (en) Use of a hydrophilic matrix containing a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for the treatment of female STDs
BR112012007412A2 (en) orally transformable tablets.
AR062167A1 (en) GASTRORRETENTIVE ADMINISTRATION SYSTEM
CO6400186A2 (en) ULIPRISTAL ACETATE TABLETS
EA200801926A1 (en) TABLETS OF PARACETAMOL WITH FAST DELIVERY
CL2016001411A1 (en) Solid pharmaceutical dosage unit of oral disintegration comprising an estetrol component; Preparation method; use for female contraception and in female hormone replacement therapy.
PL1998762T3 (en) Solid dosage forms containing the active ingredient with taste masked
WO2009063222A3 (en) Solid compositions
UA116334C2 (en) SOLID FORMS OF BENDAMUSTINE DOSAGE
MX382255B (en) IMPLANTABLE DRUG DELIVERY COMPOSITIONS AND METHODS OF USING THE SAME.
WO2011111027A3 (en) Oral dispersible delayed release tablet formulation
BRPI0925315B8 (en) pharmaceutical composition of fixed dosage, oral, solid, stable in the form of a monolayer tablet, process for its preparation and use of irbesartan and amlodipine besylate
AR061790A1 (en) SOLID PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION, FORMULATIONS OF IMMEDIATE RELEASE TABLETS OF A THROMBIN RECEIVER ANTAGONIST, AND ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT
AR061166A1 (en) PHARMACEUTICAL COMPOSITIONS FOR SUSTAINED RELEASE OF PHENYLPHERINE
Jha et al. Formulation and evaluation of melt-in-mouth tablets of haloperidol
AR062925A1 (en) METHOD FOR MANUFACTURING TABLETS CONTAINING PHARMACOLOGICALLY ACTIVE AGENTS
AR060869A1 (en) SOLID PHARMACEUTICAL COMPOSITION OF GABAPENTINA
PE20110925A1 (en) GALENIC FORMULATION INCLUDING ALISQUIRENE AND PROCESS FOR ITS PREPARATION THROUGH FELTED EXTRUSION GRANULATION
MX2012010707A (en) Water-soluble pharmaceut.

Legal Events

Date Code Title Description
FB Suspension of granting procedure