AR084940A1 - Un crofelemer con un indice de polidispersidad dentro de un rango entre 0,9 y 1,2 - Google Patents

Un crofelemer con un indice de polidispersidad dentro de un rango entre 0,9 y 1,2

Info

Publication number: AR084940A1
Authority: AR; Argentina
Prior art keywords: crofelemer; range; water; sepharose; partially purified
Prior art date: 2011-01-27

Application number

ARP120100277A

Other languages

English (en)

Spanish (es)

Inventor

Vikas Parashar

Mubeen Ahmad Khan

Snehal Shah

Sukumar Sinha

Vipin Kumar Pandey

Original Assignee

Glenmark Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-01-27

Filing date

2012-01-27

Publication date

2013-07-10

2012-01-27 Application filed by Glenmark Pharmaceuticals Ltd filed Critical Glenmark Pharmaceuticals Ltd

2013-07-10 Publication of AR084940A1 publication Critical patent/AR084940A1/es

Links

229920001393 Crofelemer Polymers 0.000 title abstract 12
229940047615 crofelemer Drugs 0.000 title abstract 12
ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 title abstract 12
238000000034 method Methods 0.000 abstract 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 8
229920002684 Sepharose Polymers 0.000 abstract 7
239000000203 mixture Substances 0.000 abstract 7
239000004816 latex Substances 0.000 abstract 6
229920000126 latex Polymers 0.000 abstract 6
235000013311 vegetables Nutrition 0.000 abstract 6
239000002904 solvent Substances 0.000 abstract 4
XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 3
239000000843 powder Substances 0.000 abstract 3
238000003756 stirring Methods 0.000 abstract 3
229920000936 Agarose Polymers 0.000 abstract 2
206010012735 Diarrhoea Diseases 0.000 abstract 2
239000007788 liquid Substances 0.000 abstract 2
239000007791 liquid phase Substances 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
239000006188 syrup Substances 0.000 abstract 2
235000020357 syrup Nutrition 0.000 abstract 2
MTAWKURMWOXCEO-UHFFFAOYSA-N taspine Chemical compound O1C(=O)C2=C(CCN(C)C)C=C(OC)C3=C2C2=C1C(OC)=CC=C2C(=O)O3 MTAWKURMWOXCEO-UHFFFAOYSA-N 0.000 abstract 2
XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 abstract 1
JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 abstract 1
208000030507 AIDS Diseases 0.000 abstract 1
229920001991 Proanthocyanidin Polymers 0.000 abstract 1
CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 abstract 1
MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
238000005119 centrifugation Methods 0.000 abstract 1
238000004440 column chromatography Methods 0.000 abstract 1
239000012141 concentrate Substances 0.000 abstract 1
235000008504 concentrate Nutrition 0.000 abstract 1
238000010908 decantation Methods 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
238000004255 ion exchange chromatography Methods 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
230000014759 maintenance of location Effects 0.000 abstract 1
239000000178 monomer Substances 0.000 abstract 1
HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 abstract 1
229920002414 procyanidin Polymers 0.000 abstract 1
238000013094 purity test Methods 0.000 abstract 1
238000004062 sedimentation Methods 0.000 abstract 1
RKEBJJCZAOFMLH-UHFFFAOYSA-N taspine Natural products COc1ccc2OC(=O)c3c(OC)cc(CN(C)C)c4OC(=O)c1c2c34 RKEBJJCZAOFMLH-UHFFFAOYSA-N 0.000 abstract 1
238000000108 ultra-filtration Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medical Informatics (AREA)
Biotechnology (AREA)
Alternative & Traditional Medicine (AREA)
Botany (AREA)
Mycology (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Plant Substances (AREA)

ARP120100277A 2011-01-27 2012-01-27 Un crofelemer con un indice de polidispersidad dentro de un rango entre 0,9 y 1,2 AR084940A1 (es)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date
IN233MU2011		2011-01-27
IN245MU2011		2011-01-28
US201161444803P	2011-02-21	2011-02-21
US201161445046P	2011-02-22	2011-02-22
IN569MU2011		2011-03-01
US201161452730P	2011-03-15	2011-03-15

Publications (1)

Publication Number	Publication Date
AR084940A1 true AR084940A1 (es)	2013-07-10

Family

ID=45562974

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP120100277A AR084940A1 (es)	2011-01-27	2012-01-27	Un crofelemer con un indice de polidispersidad dentro de un rango entre 0,9 y 1,2

Country Status (4)

Country	Link
AR (1)	AR084940A1 (ru)
BR (1)	BR112013018688B1 (ru)
RU (1)	RU2593014C2 (ru)
WO (1)	WO2012101008A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT2632550T (pt)	2010-10-31	2017-08-02	Napo Pharmaceuticals Inc	Métodos e composições para tratar diarreia associada a vih
WO2020191383A1 (en) *	2019-03-20	2020-09-24	Alphyn Biologics	Croton lechleri compositions for use in the treatment of skin cancer
WO2022066803A1 (en) *	2020-09-22	2022-03-31	Alphyn Biologics, Llc	Topical croton lechleri compositions and their use in the treatment of a bacterial colonization or primary or secondary bacterial infection of an underlying skin disorder
WO2022066812A1 (en) *	2020-09-22	2022-03-31	Alphyn Biologics, Llc	Croton lechleri compositions and their use in the treatment of cystic fibrosis
JP2024508454A (ja)	2021-02-25	2024-02-27	アルフィンバイオロジックス、エルエルシー	局所皮膚細菌性皮膚疾患治療用組成物
WO2024073007A2 (en) *	2022-09-28	2024-04-04	Napo Pharmaceuticals, Inc.	Lyophilized formulation of crofelemer and methods of treatment using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5211944A (en) *	1990-10-12	1993-05-18	Shaman Pharmaceuticals, Inc.	Proanthocyanidin polymers having antiviral activity and methods of obtaining same
IN179200B (ru) *	1994-02-21	1997-09-13	Werner Dr Med Nawrocki
ATE430477T1 (de)	1996-10-16	2009-05-15	Napo Pharmaceuticals Inc	Enteral-formulierungen von proanthocyanidzusammensetzungen gegen diarrhöe
US7325195B1 (en)	1998-10-20	2008-01-29	Arant Gene W	Adjustable-speed electronic method of composing information
WO2000047062A2 (en) *	1999-02-01	2000-08-17	Shaman Pharmaceuticals, Inc.	Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
RU2381245C1 (ru) *	2008-07-10	2010-02-10	Государственное образовательное учреждение высшего профессионального образования "Белгородский государственный университет"	Способ получения концентрированного красителя
EA023814B1 (ru) *	2009-08-26	2016-07-29	Гленмарк Фармасьютикалс Лтд.	Способ получения полимерных композиций на основе проантоцианидина для фармацевтических форм

2012
- 2012-01-17 RU RU2013134704/15A patent/RU2593014C2/ru active
- 2012-01-17 WO PCT/EP2012/050658 patent/WO2012101008A1/en not_active Ceased
- 2012-01-17 BR BR112013018688-7A patent/BR112013018688B1/pt active IP Right Grant
- 2012-01-27 AR ARP120100277A patent/AR084940A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
RU2013134704A (ru)	2015-03-10
WO2012101008A1 (en)	2012-08-02
BR112013018688A2 (pt)	2016-10-18
BR112013018688B1 (pt)	2021-08-24
RU2593014C2 (ru)	2016-07-27

Publication	Publication Date	Title
AR084940A1 (es)	2013-07-10	Un crofelemer con un indice de polidispersidad dentro de un rango entre 0,9 y 1,2
UA112140C2 (uk)	2016-07-25	Нуклеозидні похідіні (варіанти), фармацевтична композиція на їх основі, спосіб лікування вірусної інфекції та застосування сполуки для виробництва лікарського засобу
ES2769627T3 (es)	2020-06-26	Extracción sólida/líquida
WO2011075534A3 (en)	2012-04-12	Purification of isoprene from renewable resources
AU2013261267A8 (en)	2015-01-22	Carboxylic acid compounds
WO2010147686A3 (en)	2011-02-24	Methods of purifying small modular immunopharmaceutical proteins
BR112014012358A2 (pt)	2017-06-06	2-oxo-1,3-dioxolano-4-carboxamidas, sua preparação e uso
WO2010039762A3 (en)	2010-07-15	Pharmaceutical compositions comprising boronic acid compounds
ES2535625T3 (es)	2015-05-13	Método para fabricar ácido hialurónico de bajo peso molecular
BR112014011327A2 (pt)	2017-04-25	copolímeros em tribloco de estireno-siloxano como membranas para transporte seletivo de álcoois e outros compostos orgânicos em misturas aquosas
BRPI0409928A (pt)	2006-04-25	compostos, enantiÈmeros, composição farmacêutica, uso de compostos, processo para a fabricação de compostos, e, modificação dos processos
WO2011042860A3 (en)	2011-06-03	New derivatives of thieno[2,3-b]pyridine and 5,6,7,8-tetrahydrothieno[2,3-b]quinoline in particular useful in the treatment of malaria
ES2593453T3 (es)	2016-12-09	Extracción líquido/líquido
CN103087079B (zh)	2014-12-10	一种哌拉西林的结晶方法
WO2012099952A3 (en)	2013-01-24	Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-ht6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
CN104231044B (zh)	2017-03-22	那西肽过柱纯化工艺
GT200000072A (es)	2001-11-08	Nuevas formas cristalinas de un antibiotico macrolido.
RU2012153394A (ru)	2014-06-27	Способ отделения триптофана
CN107936069A (zh)	2018-04-20	一种促凝血苹果花有效成分及其提取分离方法、应用
Li et al.	2012	Study on chemical constituents of Carthamus tinctorius
BRPI0515695A (pt)	2008-03-04	processo para isolamento de tacrolimus cristalino
CN113081975B (zh)	2022-11-29	注射用克林霉素磷酸酯冻干粉针剂的制备方法
MX2010007923A (es)	2010-08-10	Forma cristalina de abacavir que esta esencialmente libre de disolvente.
MY180951A (en)	2020-12-14	Process and apparatus for purification of acrylic acid
CN104382899B (zh)	2021-02-12	一种美洛西林钠舒巴坦钠的复方药物组合物

Legal Events

Date	Code	Title	Description
2022-02-25	FC	Refusal