AR084001A1 - Monobactamas y su uso en el tratamiento de infecciones bacterianas - Google Patents
Monobactamas y su uso en el tratamiento de infecciones bacterianasInfo
- Publication number
- AR084001A1 AR084001A1 ARP110104404A ARP110104404A AR084001A1 AR 084001 A1 AR084001 A1 AR 084001A1 AR P110104404 A ARP110104404 A AR P110104404A AR P110104404 A ARP110104404 A AR P110104404A AR 084001 A1 AR084001 A1 AR 084001A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- bacterial infections
- phenylalkyl
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de monobactama y su uso para tratar infecciones bacterianas.Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en la que cada uno de R1 y R2 es independientemente hidrógeno, alquilo C1-6 o fenilalquilo C1-6 opcionalmente sustituido, en los que los restos fenilo y alquilo C1-6 del fenilalquilo C1-6 están opcionalmente sustituidos; o R1 y R2 juntos, con el átomo de carbono a que están unidos, forman un cicloalquilo C3-6 opcionalmente sustituido o un heterociclo de 4 - 6 miembros opcionalmente sustituido; E es C(H), C(F), C(Cl) o N; X es -O-C(=O)-, -NH-C(=O)-, -NH-SO2-, -NH-C(=N-CN)-, -NH-T- o triazol; L está ausente, -(CH2)p-, -(CH2)p-NH-(CH2)q-, (CH2)p-O-(CH2)q-, -(CH2)p-C(=O)-NH-(CH2)q-, -(CH2)p-NH-C(=O)-(CH2)q-, -CH(CH3)-NH-C(=O)-(CH2)q-, -(CH2)p-NH-C(=O)-NH-(CH2)q-, -CH(CH3)-NH-C(=O)-NH-(CH2)q-, -(CH2)p-T-SO2-NH-(CH2)q-, -(CH2)p-T-(CH2)q, -(CH2)p-T-C(=O)-NH-(CH2)q-, -(CH2)p-T-(CH2)q-NH-C(=O)-, -NH-(CH2)p-T-, -O-(CH2)p-T-, -(CH2)p-Y-C(=O)-(CH2)q- o -(CH2)p-Y-(CH2)q-; T es un fenilo opcionalmente sustituido o un heteroarilo de 5 ó 6 miembros opcionalmente sustituido; Y es un heterociclo de 4 - 6 miembros opcionalmente sustituido; cada uno de p y q es independientemente 0, 1, 2 ó 3; A es un resto seleccionado del grupo de formulas (2); y R3 es hidrógeno, alquilo C1-3 o OH; con la condición de que la fórmula (1) no incluya ácido 2-(((1-(2-aminotiazol-4-il)-2-(((2S,3R)-2-((3-((1,5-dihidroxi-4-oxo-1,4-dihidropiridin-2-il)metil)ureido)metil)-4-oxo-1-sulfoazetidin-3-il)amino)-2-oxoetilideno)amino)oxi)-2-metilpropanoico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41757510P | 2010-11-29 | 2010-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084001A1 true AR084001A1 (es) | 2013-04-17 |
Family
ID=45315854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104404A AR084001A1 (es) | 2010-11-29 | 2011-11-25 | Monobactamas y su uso en el tratamiento de infecciones bacterianas |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20120302542A1 (es) |
| EP (1) | EP2646436B1 (es) |
| JP (1) | JP5777725B2 (es) |
| KR (1) | KR101514587B1 (es) |
| CN (1) | CN103228652B (es) |
| AR (1) | AR084001A1 (es) |
| AU (1) | AU2011336209B2 (es) |
| CA (1) | CA2815821C (es) |
| DK (1) | DK2646436T3 (es) |
| ES (1) | ES2542431T3 (es) |
| IL (1) | IL226052A0 (es) |
| MX (1) | MX2013005994A (es) |
| SG (1) | SG190007A1 (es) |
| TW (1) | TW201247661A (es) |
| UY (1) | UY33754A (es) |
| WO (1) | WO2012073138A1 (es) |
| ZA (1) | ZA201304479B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9988373B2 (en) | 2013-12-26 | 2018-06-05 | Shionogi & Co., Ltd. | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same |
| WO2015148379A1 (en) | 2014-03-24 | 2015-10-01 | Novartis Ag | Monobactam organic compounds for the treatment of bacterial infections |
| EA202092620A1 (ru) | 2015-09-23 | 2021-06-30 | Новартис Аг | Соли и твердые формы монобактамного антибиотика |
| CN105481812B (zh) * | 2015-11-30 | 2020-04-21 | 重庆天奕恒化科技有限公司 | 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法 |
| CA3008006C (en) | 2015-12-15 | 2024-04-09 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
| KR102408800B1 (ko) | 2016-03-07 | 2022-06-13 | 머크 샤프 앤드 돔 코포레이션 | 비시클릭 아릴 모노박탐 화합물 및 박테리아 감염의 치료를 위한 그의 사용 방법 |
| US10047077B2 (en) | 2016-04-13 | 2018-08-14 | Skyline Antiinfectives, Inc. | Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams |
| CN107641119B (zh) | 2016-07-21 | 2019-11-08 | 中国科学院上海药物研究所 | 单环β-内酰胺-铁载体轭合物及其制备方法和用途 |
| CN111094281B (zh) | 2017-08-02 | 2023-08-29 | 诺华股份有限公司 | 用于制备单内酰胺抗生素的化学方法及其中间体 |
| SG11202002575UA (en) | 2017-10-02 | 2020-04-29 | Merck Sharp & Dohme | Chromane monobactam compounds for the treatment of bacterial infections |
| US10513504B2 (en) | 2018-03-08 | 2019-12-24 | Apotex Inc. | Processes for the preparation of apalutamide and intermediates thereof |
| KR102786898B1 (ko) * | 2019-11-22 | 2025-03-25 | 쑤저우 얼예 파마슈티칼 컴퍼니 리미티드 | 설포닐우레아 고리 치환 모노시클릭 β-락탐계 항생제 |
| LT4069691T (lt) | 2019-12-06 | 2024-12-10 | Vertex Pharmaceuticals Incorporated | Pakeistieji tetrahidrofuranai kaip natrio kanalų moduliatoriai |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
| JP7551186B2 (ja) | 2021-03-31 | 2024-09-17 | フェドラ・ファーマシューティカルズ・インコーポレイテッド | ラクチビシン化合物、その調製、および抗菌剤としての使用 |
| WO2022235077A1 (ko) * | 2021-05-07 | 2022-11-10 | 한국생명공학연구원 | 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체 |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| KR20240105442A (ko) | 2021-11-18 | 2024-07-05 | 머크 샤프 앤드 돔 엘엘씨 | 크로만 아미딘 모노박탐 항생제 |
| JP7671398B2 (ja) * | 2021-11-18 | 2025-05-01 | メルク・シャープ・アンド・ドーム・エルエルシー | クロマンアミジンモノバクタム抗生物質 |
| CN115304594B (zh) * | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | 磺酰脲环取代的化合物的盐型及其晶型 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01502660A (ja) * | 1986-05-23 | 1989-09-14 | ジ・アップジョン・カンパニー | Ｎ―１置換スルホニルアミノカルボニル、ｃ―４置換モノバクタム類 |
| ES2373461T3 (es) * | 2005-12-07 | 2012-02-03 | Basilea Pharmaceutica Ag | Antibióticos útiles de monobactama. |
| TWI404533B (zh) | 2007-03-28 | 2013-08-11 | Apotex Technologies Inc | 去鐵酮（ｄｅｆｅｒｉｐｒｏｎｅ）之氟化衍生物 |
| CN102325769A (zh) * | 2008-12-19 | 2012-01-18 | 美国辉瑞有限公司 | 单卡波姆 |
-
2011
- 2011-11-15 DK DK11794237.5T patent/DK2646436T3/en active
- 2011-11-15 EP EP11794237.5A patent/EP2646436B1/en not_active Not-in-force
- 2011-11-15 KR KR1020137016718A patent/KR101514587B1/ko not_active Expired - Fee Related
- 2011-11-15 JP JP2013541445A patent/JP5777725B2/ja not_active Expired - Fee Related
- 2011-11-15 SG SG2013031752A patent/SG190007A1/en unknown
- 2011-11-15 CA CA2815821A patent/CA2815821C/en not_active Expired - Fee Related
- 2011-11-15 CN CN201180057264.5A patent/CN103228652B/zh not_active Expired - Fee Related
- 2011-11-15 ES ES11794237.5T patent/ES2542431T3/es active Active
- 2011-11-15 MX MX2013005994A patent/MX2013005994A/es active IP Right Grant
- 2011-11-15 WO PCT/IB2011/055104 patent/WO2012073138A1/en not_active Ceased
- 2011-11-15 AU AU2011336209A patent/AU2011336209B2/en not_active Ceased
- 2011-11-24 TW TW100143172A patent/TW201247661A/zh unknown
- 2011-11-25 AR ARP110104404A patent/AR084001A1/es not_active Application Discontinuation
- 2011-11-28 UY UY0001033754A patent/UY33754A/es not_active Application Discontinuation
- 2011-11-29 US US13/306,581 patent/US20120302542A1/en not_active Abandoned
-
2013
- 2013-02-27 US US13/778,670 patent/US20130252935A1/en not_active Abandoned
- 2013-04-29 IL IL226052A patent/IL226052A0/en unknown
- 2013-06-18 ZA ZA2013/04479A patent/ZA201304479B/en unknown
-
2015
- 2015-01-29 US US14/608,826 patent/US20150148326A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2815821A1 (en) | 2012-06-07 |
| AU2011336209A1 (en) | 2013-05-30 |
| US20150148326A1 (en) | 2015-05-28 |
| WO2012073138A1 (en) | 2012-06-07 |
| CN103228652B (zh) | 2015-02-18 |
| UY33754A (es) | 2012-06-29 |
| IL226052A0 (en) | 2013-06-27 |
| JP5777725B2 (ja) | 2015-09-09 |
| TW201247661A (en) | 2012-12-01 |
| DK2646436T3 (en) | 2015-06-29 |
| KR20130112054A (ko) | 2013-10-11 |
| CA2815821C (en) | 2015-07-07 |
| HK1184462A1 (en) | 2014-01-24 |
| EP2646436B1 (en) | 2015-05-27 |
| US20120302542A1 (en) | 2012-11-29 |
| KR101514587B1 (ko) | 2015-04-22 |
| CN103228652A (zh) | 2013-07-31 |
| AU2011336209B2 (en) | 2015-03-19 |
| EP2646436A1 (en) | 2013-10-09 |
| MX2013005994A (es) | 2013-07-15 |
| US20130252935A1 (en) | 2013-09-26 |
| ZA201304479B (en) | 2014-03-26 |
| SG190007A1 (en) | 2013-06-28 |
| JP2013544276A (ja) | 2013-12-12 |
| ES2542431T3 (es) | 2015-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |