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AR079248A1 - Microcapsulas de fexofenadina y composiciones que las contienen - Google Patents

Microcapsulas de fexofenadina y composiciones que las contienen

Info

Publication number
AR079248A1
AR079248A1 ARP100104459A ARP100104459A AR079248A1 AR 079248 A1 AR079248 A1 AR 079248A1 AR P100104459 A ARP100104459 A AR P100104459A AR P100104459 A ARP100104459 A AR P100104459A AR 079248 A1 AR079248 A1 AR 079248A1
Authority
AR
Argentina
Prior art keywords
microcapsules
fexofenadine
pharmaceutical composition
granulated
masked
Prior art date
Application number
ARP100104459A
Other languages
English (en)
Inventor
Luigi Boltri
Roberto Cassanmagnago
Paolo Gatti
Mauro Serratoni
Luigi Mapelli
Flavio Fabiani
Original Assignee
Eurand Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43989749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR079248(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eurand Pharmaceuticals Ltd filed Critical Eurand Pharmaceuticals Ltd
Publication of AR079248A1 publication Critical patent/AR079248A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composicion farmacéutica que comprende microcápsulas de liberacion inmediata con su sabor enmascarado que comprenden fexofenadina y un recubrimiento de polímero insoluble en agua. Dichas microcápsulas y las composiciones farmacéuticas que las comprenden tienen un contenido apropiado de droga y propiedades farmacéuticas deseables, incluyendo una rápida velocidad de disolucion de la fexofenadina combinada con un efecto de enmascaramiento del sabor. Reivindicacion 1: Una composicion farmacéutica caracterizada porque comprende microcápsulas que se seleccionan entre microcápsulas de liberacion inmediata con su sabor enmascarado o microcápsulas co-granuladas de liberacion inmediata con su sabor enmascarado, y mezclas de las mismas, donde dichas microcápsulas comprenden fexofenadina y un recubrimiento polimérico insoluble en agua. Reivindicacion 3: La composicion farmacéutica de las reivindicaciones 1-2, caracterizada porque dicha fexofenadina es fexofenadina cristalina. Reivindicacion 5: La composicion farmacéutica de las reivindicaciones 1-4, caracterizada porque dicho polímero insoluble en agua se selecciona entre el grupo que consiste en etilcelulosa, acetato de polivinilo, acetato de celulosa, butirato acetato de celulosa, acetato de polivinilo, copolímeros de amonio-metacrilato y mezclas de los mismos. Reivindicacion 13: La composicion farmacéutica de la reivindicacion 12, caracterizada porque dicha composicion libera por lo menos aproximadamente 95% de dicho clorhidrato de fexofenadina dentro de los 15 minutos en solucion amortiguadora de 2° fluido de JP para pH 6,8. Reivindicacion 19: La composicion farmacéutica de la reivindicacion 18, caracterizada porque dicho ingrediente inactivo se selecciona entre el grupo que consiste en sacárido azucar alcohol, azucar alcohol granulado, y sacárido granulado. Reivindicacion 21: La composicion farmacéutica de las reivindicaciones 1-20, caracterizada porque dicha composicion está en la forma de una tableta, cápsula o sachet. Reivindicacion 27: EI proceso de la reivindicacion 25, caracterizado porque dicha fexofenadina es clorhidrato de fexofenadina. Reivindicacion 33: Un método para tratar una condicion relacionada con la inflamacion en un sujeto caracterizado porque comprende administrar a un sujeto que lo necesita una composicion farmacéutica que comprende microcápsulas de liberacion inmediata con su sabor enmascarado o microcápsulas co-granuladas de liberacion inmediata con su sabor enmascarado, donde dichas microcápsulas comprenden fexofenadina y un recubrimiento polimérico insoluble en agua.
ARP100104459A 2009-12-02 2010-12-02 Microcapsulas de fexofenadina y composiciones que las contienen AR079248A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26582309P 2009-12-02 2009-12-02
US35457510P 2010-06-14 2010-06-14

Publications (1)

Publication Number Publication Date
AR079248A1 true AR079248A1 (es) 2012-01-04

Family

ID=43989749

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104459A AR079248A1 (es) 2009-12-02 2010-12-02 Microcapsulas de fexofenadina y composiciones que las contienen

Country Status (21)

Country Link
US (6) US8580313B2 (es)
EP (1) EP2506836B1 (es)
JP (3) JP5309262B2 (es)
KR (1) KR101765357B1 (es)
CN (2) CN102958515A (es)
AR (1) AR079248A1 (es)
AU (1) AU2010325746B2 (es)
CA (1) CA2782285A1 (es)
CL (1) CL2012001451A1 (es)
CO (1) CO6541583A2 (es)
ES (1) ES2668203T3 (es)
IL (1) IL220085A (es)
MX (1) MX2012006240A (es)
NZ (1) NZ600256A (es)
RU (1) RU2563623C2 (es)
SA (1) SA110310896B1 (es)
SG (1) SG10201407965XA (es)
TW (1) TWI471146B (es)
UY (1) UY33076A (es)
WO (1) WO2011067667A2 (es)
ZA (1) ZA201203983B (es)

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NZ600256A (en) 2009-12-02 2014-05-30 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them
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PL2976069T3 (pl) * 2013-03-22 2020-10-19 Adare Pharmaceuticals S.R.L. Mikrokapsułki piperachiny i zawierające je kompozycje
GB201308933D0 (en) * 2013-05-17 2013-07-03 Diurnal Ltd Paediatric composition
CN105358138A (zh) * 2013-07-03 2016-02-24 R.P.谢勒技术有限公司 包含非索非那定的胶囊制剂
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US20160051639A1 (en) * 2014-08-25 2016-02-25 Aimmune Therapeutics, Inc. Egg protein formulations and methods of manufacture thereof
WO2019204708A1 (en) * 2018-04-21 2019-10-24 Quest Products, Llc Bilayer adhering lozenge effective to mask undesirable flavor
EP4035733A4 (en) * 2019-09-25 2024-01-10 Nobelpharma Co., Ltd. Granule having masked unpleasant taste and method for producing same
WO2022175829A1 (en) * 2021-02-17 2022-08-25 Cellix Bio Private Limited Topical formulations and compositions
CN113197867A (zh) * 2021-05-07 2021-08-03 济川(上海)医学科技有限公司 一种非索非那定掩味颗粒，包含其的掩味组合物和掩味制剂，以及制备方法和用途
CN113522186A (zh) * 2021-07-19 2021-10-22 上海应用技术大学 一种香精微胶囊及其制备方法
WO2023126637A1 (en) * 2021-12-29 2023-07-06 Opella Healthcare Group Sas Compositions containing fexofenadine
CN114343230B (zh) * 2022-02-10 2023-05-12 湖北中烟工业有限责任公司 一种薄片添加剂、其制备方法及含有该薄片添加剂的烟草薄片
CN117503707B (zh) 2022-08-05 2024-08-23 哈尔滨市康隆药业有限责任公司 一种掩味微球及其制备工艺和应用

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