AR078606A1 - Derivados de piperidina para prevenir y/o tratar trastornos degenerativos del sistema nervioso central - Google Patents
Derivados de piperidina para prevenir y/o tratar trastornos degenerativos del sistema nervioso centralInfo
- Publication number
- AR078606A1 AR078606A1 ARP100103715A ARP100103715A AR078606A1 AR 078606 A1 AR078606 A1 AR 078606A1 AR P100103715 A ARP100103715 A AR P100103715A AR P100103715 A ARP100103715 A AR P100103715A AR 078606 A1 AR078606 A1 AR 078606A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- hydrogen
- halogen
- prevent
- Prior art date
Links
- 210000003169 central nervous system Anatomy 0.000 title abstract 2
- 230000003412 degenerative effect Effects 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- -1 -OH Inorganic materials 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de piperidina, así como también composiciones y su uso para prevenir y/o tratar trastornos degenerativos del sistema nervioso central. En particular, estos compuestos son utilizados para prevenir y/o tratar la enfermedad de Parkinson. Reivindicacion 1: Un compuesto de formula (1) en donde R1 es C(R2)(R3)(R4); R2 es hidrogeno, -OH o halogeno; R3 es hidrogeno, -OH, halogeno o alquilo C1-8; R4 es halogeno, alquilo C1-8, alquilo C1-8 sustituido, arilo, arilo sustituido, alquilcicloalquilo o alquilcicloalquilo sustituido; R3 y R4 pueden juntarse con el carbono al que están unidos para formar un anillo cicloalquilo, que puede estar opcionalmente sustituido, preferiblemente por halogeno y más preferiblemente por uno o más átomos de fluor; R6 es hidrogeno, alquilo C1-8, alquilo C1-8 sustituido, arilalquilo, arilalquilo sustituido, alquilarilo o alquilarilo sustituido; Z es opcional, cuando está presente Z es -(CH2)1-8-, -C(=O)-, - S(=O)2NH-, -S(=O)2-, -C(=S)NH-, -S(=O)2-CH3, C(=O)-NH-, -S(=O)2-NR9R10, -C(=O)alquilo C1-8 o -C(=O)CH(NH2)CH3; R9 es hidrogeno, alquilo C1-8 o alquilo C1-8 sustituido; R10 es hidrogeno, alquilo C1-8 o alquilo C1-8 sustituido; R5 es hidrogeno, alquilo C1-8, alquilo C1-8 sustituido, arilo, arilo sustituido, alquenilo C1-8, alquenilo C1-8 sustituido, arilalquilo, arilalquilo sustituido, alquilarilo, alquilarilo sustituido, aminoarilalquilo o aminoarilalquilo sustituido; R7 es -OH o halogeno; y R8 es hidrogeno, halogeno o alquilo C1-8; siempre que R2 y R3 no sean ambos hidrogeno cuando R4 sea un halogeno, Z no esté presente, R7 sea -OH, R5, R6 y R8 sean hidrogeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25280309P | 2009-10-19 | 2009-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078606A1 true AR078606A1 (es) | 2011-11-23 |
Family
ID=43879775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103715A AR078606A1 (es) | 2009-10-19 | 2010-10-12 | Derivados de piperidina para prevenir y/o tratar trastornos degenerativos del sistema nervioso central |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US8604206B2 (es) |
| EP (2) | EP2490532B1 (es) |
| JP (2) | JP5805649B2 (es) |
| KR (3) | KR101880411B1 (es) |
| CN (2) | CN102655747A (es) |
| AR (1) | AR078606A1 (es) |
| AU (3) | AU2010308396B2 (es) |
| BR (1) | BR112012009121A2 (es) |
| CA (1) | CA2778348C (es) |
| CY (1) | CY1118966T1 (es) |
| DK (1) | DK2490532T3 (es) |
| ES (2) | ES2814178T3 (es) |
| HR (1) | HRP20170236T1 (es) |
| HU (1) | HUE033116T2 (es) |
| IL (1) | IL219160B (es) |
| LT (1) | LT2490532T (es) |
| MX (2) | MX368459B (es) |
| PL (1) | PL2490532T3 (es) |
| PT (1) | PT2490532T (es) |
| RS (1) | RS55679B1 (es) |
| RU (2) | RU2015147509A (es) |
| SG (1) | SG10201507159XA (es) |
| SI (1) | SI2490532T1 (es) |
| SM (2) | SMT201700105T1 (es) |
| TW (1) | TWI642434B (es) |
| WO (1) | WO2011049736A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101880411B1 (ko) | 2009-10-19 | 2018-07-19 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 중추신경계의 퇴행성 질환을 예방 및/또는 치료하는 신규 조성물 |
| CN102647905B (zh) | 2009-10-19 | 2015-09-09 | 阿米库斯治疗学公司 | 用于预防和/或治疗溶酶体贮积失调的新颖组合物 |
| EP2591823A1 (en) * | 2011-11-11 | 2013-05-15 | Biologische Heilmittel Heel GmbH | Composition for treating or preventing neurodegenerative disorders |
| ES2924829T3 (es) | 2012-03-27 | 2022-10-11 | Amicus Therapeutics Inc | Compuestos novedosos para prevenir y/o tratar tesaurismosis lisosómicas y/o trastornos degenerativos del sistema nervioso central |
| EP3087056A4 (en) * | 2013-12-23 | 2017-07-19 | Alectos Therapeutics Inc. | Glucocerebrosidase modulators and uses thereof |
| US10179128B2 (en) * | 2015-08-31 | 2019-01-15 | Amicus Therapeutics, Inc. | Regimens for treating and preventing lysosomal disorders and degenerative disorders of the central nervous system |
| JP7250698B2 (ja) * | 2017-04-25 | 2023-04-03 | アミカス セラピューティックス インコーポレイテッド | 中枢神経系の変性疾患及び／又はリソソーム蓄積疾患を予防及び／又は治療するための新規組成物 |
| RU2676956C1 (ru) * | 2017-08-25 | 2019-01-11 | Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" | Антитела для связывания имиглюцеразы и их применение в аффинной хроматографии |
| KR101991276B1 (ko) | 2018-01-19 | 2019-06-21 | 전남대학교산학협력단 | 신규 균주 페니실리움 아쿠아티쿰 및 이를 이용한 퇴행성 뇌질환 치료제 |
| WO2020023390A1 (en) | 2018-07-25 | 2020-01-30 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
| US20220226357A1 (en) * | 2019-04-29 | 2022-07-21 | Thomas Jefferson University | Methods for treating neurodegenerative disorders |
| WO2022232383A1 (en) * | 2021-04-30 | 2022-11-03 | Vanqua Bio, Inc. | Small molecule modulators of glucocerebrosidase activity and uses thereof |
| CA3218510A1 (en) * | 2021-04-30 | 2022-11-03 | Vanqua Bio, Inc. | Small molecule modulators of glucocerebrosidase activity and uses thereof |
| WO2024163532A1 (en) * | 2023-01-31 | 2024-08-08 | Bioeutectics Corporation | Use of additives (adjuvants, anti freezing agents, antimicrobial and antioxidants) in natural deep eutectic solvents and mixtures |
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| US4407957A (en) | 1981-03-13 | 1983-10-04 | Damon Corporation | Reversible microencapsulation of a core material |
| EP0585368B1 (en) | 1991-04-25 | 1997-08-06 | Brown University Research Foundation | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
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| US5863903A (en) * | 1994-03-09 | 1999-01-26 | Novo Nordisk A/S | Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes |
| ATE243196T1 (de) | 1994-03-09 | 2003-07-15 | Novo Nordisk As | Piperidine und pyrrolidine |
| FR2718357B1 (fr) | 1994-04-06 | 1997-10-03 | Defarges Alain Moreau | Perfectionnements apportés à un dispositif d'injection par jet sans aiguille. |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5780014A (en) | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
| US5654007A (en) | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
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| US6274597B1 (en) * | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
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| US20040082641A1 (en) * | 2002-10-28 | 2004-04-29 | Rytved Klaus Asger | Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases |
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| MXPA06007378A (es) * | 2003-12-23 | 2007-01-26 | Musc Found For Res Dev | Metodos y composiciones para la prevencion y tratamiento de enfermedades o condiciones inflamatorias. |
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| JP5303458B2 (ja) * | 2006-06-23 | 2013-10-02 | アミークス セラピューティックス インコーポレイテッド | β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法 |
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| WO2010015816A2 (en) | 2008-08-06 | 2010-02-11 | Summit Corporation Plc | Treatment of lysosomal storage disorders and other proteostatic diseases |
| JP5634498B2 (ja) * | 2009-04-09 | 2014-12-03 | アミカス セラピューティックス インコーポレイテッド | 中枢神経系の変性障害の予防および／または治療方法 |
| CA2758271C (en) | 2009-04-09 | 2018-06-05 | Robert Boyd | Methods for preventing and/or treating lysosomal storage disorders |
| CN102647905B (zh) | 2009-10-19 | 2015-09-09 | 阿米库斯治疗学公司 | 用于预防和/或治疗溶酶体贮积失调的新颖组合物 |
| PL2490712T3 (pl) * | 2009-10-19 | 2015-12-31 | Amicus Therapeutics Inc | Sposób leczenia choroby Alzheimera przy zastosowaniu chaperonów farmakologicznych dla zwiększenia aktywności gangliozydaz |
| KR101880411B1 (ko) | 2009-10-19 | 2018-07-19 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 중추신경계의 퇴행성 질환을 예방 및/또는 치료하는 신규 조성물 |
| KR102023720B1 (ko) | 2012-09-03 | 2019-09-20 | 엘지이노텍 주식회사 | 보이스 코일 모터 |
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2010
- 2010-10-05 KR KR1020177037220A patent/KR101880411B1/ko not_active Expired - Fee Related
- 2010-10-05 KR KR1020177022493A patent/KR101813988B1/ko not_active Expired - Fee Related
- 2010-10-05 SM SM20170105T patent/SMT201700105T1/it unknown
- 2010-10-05 SI SI201031401A patent/SI2490532T1/sl unknown
- 2010-10-05 ES ES16191218T patent/ES2814178T3/es active Active
- 2010-10-05 BR BR112012009121A patent/BR112012009121A2/pt not_active Application Discontinuation
- 2010-10-05 DK DK10825396.4T patent/DK2490532T3/en active
- 2010-10-05 US US12/898,112 patent/US8604206B2/en active Active
- 2010-10-05 KR KR1020127012936A patent/KR101769396B1/ko not_active Expired - Fee Related
- 2010-10-05 RU RU2015147509A patent/RU2015147509A/ru unknown
- 2010-10-05 HU HUE10825396A patent/HUE033116T2/en unknown
- 2010-10-05 SG SG10201507159XA patent/SG10201507159XA/en unknown
- 2010-10-05 PT PT108253964T patent/PT2490532T/pt unknown
- 2010-10-05 LT LTEP10825396.4T patent/LT2490532T/lt unknown
- 2010-10-05 WO PCT/US2010/051447 patent/WO2011049736A1/en not_active Ceased
- 2010-10-05 MX MX2016000153A patent/MX368459B/es unknown
- 2010-10-05 MX MX2012004548A patent/MX340807B/es active IP Right Grant
- 2010-10-05 RS RS20170153A patent/RS55679B1/sr unknown
- 2010-10-05 EP EP10825396.4A patent/EP2490532B1/en active Active
- 2010-10-05 AU AU2010308396A patent/AU2010308396B2/en not_active Ceased
- 2010-10-05 PL PL10825396T patent/PL2490532T3/pl unknown
- 2010-10-05 EP EP16191218.3A patent/EP3143875B1/en active Active
- 2010-10-05 CA CA2778348A patent/CA2778348C/en active Active
- 2010-10-05 CN CN2010800566279A patent/CN102655747A/zh active Pending
- 2010-10-05 HR HRP20170236TT patent/HRP20170236T1/hr unknown
- 2010-10-05 RU RU2012120759/04A patent/RU2581058C2/ru active
- 2010-10-05 ES ES10825396.4T patent/ES2617192T3/es active Active
- 2010-10-05 JP JP2012535221A patent/JP5805649B2/ja active Active
- 2010-10-05 CN CN201510783936.0A patent/CN105367485B/zh not_active Expired - Fee Related
- 2010-10-12 TW TW099134782A patent/TWI642434B/zh not_active IP Right Cessation
- 2010-10-12 AR ARP100103715A patent/AR078606A1/es unknown
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2012
- 2012-04-15 IL IL219160A patent/IL219160B/en not_active IP Right Cessation
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2013
- 2013-11-19 US US14/084,131 patent/US9409862B2/en active Active
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2015
- 2015-03-30 JP JP2015069784A patent/JP6258245B2/ja active Active
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2016
- 2016-06-08 AU AU2016203817A patent/AU2016203817B2/en not_active Ceased
- 2016-07-22 US US15/217,217 patent/US20160326114A1/en not_active Abandoned
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2017
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- 2017-02-22 CY CY20171100240T patent/CY1118966T1/el unknown
- 2017-12-07 AU AU2017272296A patent/AU2017272296B2/en not_active Ceased
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2018
- 2018-06-01 US US15/995,813 patent/US10421724B2/en active Active
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