AR062603A1 - Derivados del acido indol-2-carboxilico, composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la modulacion del receptor ppargamma. - Google Patents
Derivados del acido indol-2-carboxilico, composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la modulacion del receptor ppargamma.Info
- Publication number
- AR062603A1 AR062603A1 ARP070103857A ARP070103857A AR062603A1 AR 062603 A1 AR062603 A1 AR 062603A1 AR P070103857 A ARP070103857 A AR P070103857A AR P070103857 A ARP070103857 A AR P070103857A AR 062603 A1 AR062603 A1 AR 062603A1
- Authority
- AR
- Argentina
- Prior art keywords
- carbon atoms
- alkyl
- heterocyclyl
- aryl
- optionally substituted
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 23
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- -1 Ra-Rb-Rc Chemical group 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Derivados de indol que son moduladores de PPARalfa, composiciones farmacéuticas que los contienen, y a su uso en medicina para el tratamiento de enfermedades mediadas por PPARalfa Reivindicacion 1: Un compuesto de la formula (1) o una sal o solvato del mismo, en donde: R1 es -O-Ph-alquilo de 1 a 6 átomos de carbono, -NH-Ph-alquilo de 1 a 6 átomos de carbono, -CH2-Ph-halo-alquilo de 1 a 6 átomos de carbono, arilo o heterociclilo, en donde este arilo o heterociclilo está opcionalmente mono- sustituido con R7; R2 es halo-alquilo de 1 a 6 átomos de carbono, Ra-Rb-Rc, heterociclilo o arilo, en donde el arilo está opcionalmente sustituido con R8 y el heterociclilo está opcionalmente sustituido con R9; R3 es H, halo-alquilo de 1 a 6 átomos de carbono, o Ra-Rb-Rc; Ra es -O-; Rb es un enlace alquileno de 1 a 6 átomos de carbono, o -C(O)-; Rc es H, alquilo de 1 a 6 átomos de carbono, arilo, cicloalquilo de 3 a 6 átomos de carbono, alcoxilo de 1 a 6 átomos de carbono, -NR5R6, - O(CH2)2OCH3, o heterociclilo opcionalmente sustituido con 0=, o alquilo de 1 a 6 átomos de carbono; en donde : cuando Rb es un enlace, Rc es H o alquilo de 1 a 6 átomos de carbono; R4 y R5 son cada uno independientemente H o alquilo de 1 a 6 átomos de carbono; en donde cuando R3 y R4 son ambos H, R2 es arilo opcionalmente sustituido o heterociclilo opcionalmente sustituido; R6 es alquilo de 1 a 6 átomos de carbono, o tienil-alquileno de 1 a 6 átomos de carbono; R7 es alquilo de 1 a 6 átomos de carbono, -C(O)CH3, alcoxilo de 1 a 6 átomos de carbono, o halo-alquilo de 1 a 6 átomos de carbono; R8 es -OH, -CO2H, -O-alquilleno de 1 a 6 átomos de carbono-fenilo, alcoxilo de 1 a 6 átomos de carbono, -S-alquilo de 1 a 6 átomos de carbono, - S(O)2- alquilo de 1 a 6 átomos de carbono, -C(O)NR5R6, u -OC(CH3)2CO2H; y R9 es -C(O)CH3, -C(O)O-alquilo de 1 a 6 átomos de carbono, -C(O)O(CH2)2OCH3, -C(O)NH2, S-(O)2-alquilo de 1 a 6 átomos de carbono, -S(O)2NH2, o -S(O)2NC(O)o-alquilo de 1 a 6 átomos de carbono.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82412006P | 2006-08-31 | 2006-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062603A1 true AR062603A1 (es) | 2008-11-19 |
Family
ID=38830380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103857A AR062603A1 (es) | 2006-08-31 | 2007-08-30 | Derivados del acido indol-2-carboxilico, composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la modulacion del receptor ppargamma. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100240642A1 (es) |
| EP (1) | EP2081894A1 (es) |
| JP (1) | JP2010502648A (es) |
| KR (1) | KR20090074179A (es) |
| CN (1) | CN101563322A (es) |
| AR (1) | AR062603A1 (es) |
| AU (1) | AU2007289108A1 (es) |
| BR (1) | BRPI0716250A2 (es) |
| CA (1) | CA2662274A1 (es) |
| CL (1) | CL2007002516A1 (es) |
| EA (1) | EA200900254A1 (es) |
| MX (1) | MX2009002283A (es) |
| PE (1) | PE20080767A1 (es) |
| TW (1) | TW200819447A (es) |
| WO (1) | WO2008028118A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2951295C (en) * | 2007-04-16 | 2020-04-28 | Abbvie Inc. | 7-nonsubstituted indole mcl-1 inhibitors |
| WO2017149493A1 (en) * | 2016-03-02 | 2017-09-08 | The University Of Chicago | Small molecules inhibitors of rad51 |
| MX2019015475A (es) | 2017-06-30 | 2020-02-19 | Univ California | Composiciones y metodos para modular el crecimiento del cabello. |
| US11690824B2 (en) | 2018-04-10 | 2023-07-04 | The General Hospital Corporation | Antibacterial compounds |
| EP4077327A4 (en) * | 2019-12-20 | 2024-02-07 | The Regents of the University of California | Synthesis of compounds to promote hair growth |
| CN112479941B (zh) * | 2020-11-30 | 2023-01-13 | 沧州维智达美制药有限公司 | 一种2-取代-3-芳基卤苄衍生物的制备方法 |
| CN117486777B (zh) * | 2023-09-25 | 2025-11-28 | 浙江中医药大学 | 一种吲哚乙胺衍生物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684032A (en) * | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| WO2001030343A1 (en) * | 1999-10-22 | 2001-05-03 | Merck & Co., Inc. | Pharmaceuticals for treating obesity |
| AU2002211901A1 (en) * | 2000-10-10 | 2002-04-22 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents |
| UA95788C2 (en) * | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
-
2007
- 2007-08-29 TW TW096132114A patent/TW200819447A/zh unknown
- 2007-08-29 CL CL200702516A patent/CL2007002516A1/es unknown
- 2007-08-29 PE PE2007001175A patent/PE20080767A1/es not_active Application Discontinuation
- 2007-08-30 AR ARP070103857A patent/AR062603A1/es not_active Application Discontinuation
- 2007-08-31 EA EA200900254A patent/EA200900254A1/ru unknown
- 2007-08-31 US US12/438,024 patent/US20100240642A1/en not_active Abandoned
- 2007-08-31 JP JP2009526929A patent/JP2010502648A/ja active Pending
- 2007-08-31 EP EP07841701A patent/EP2081894A1/en not_active Withdrawn
- 2007-08-31 KR KR1020097006676A patent/KR20090074179A/ko not_active Withdrawn
- 2007-08-31 AU AU2007289108A patent/AU2007289108A1/en not_active Abandoned
- 2007-08-31 CN CNA2007800404569A patent/CN101563322A/zh active Pending
- 2007-08-31 MX MX2009002283A patent/MX2009002283A/es not_active Application Discontinuation
- 2007-08-31 BR BRPI0716250-2A2A patent/BRPI0716250A2/pt not_active Application Discontinuation
- 2007-08-31 WO PCT/US2007/077365 patent/WO2008028118A1/en not_active Ceased
- 2007-08-31 CA CA002662274A patent/CA2662274A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200819447A (en) | 2008-05-01 |
| CA2662274A1 (en) | 2008-03-06 |
| BRPI0716250A2 (pt) | 2013-10-08 |
| PE20080767A1 (es) | 2008-08-08 |
| AU2007289108A1 (en) | 2008-03-06 |
| EP2081894A1 (en) | 2009-07-29 |
| CN101563322A (zh) | 2009-10-21 |
| US20100240642A1 (en) | 2010-09-23 |
| KR20090074179A (ko) | 2009-07-06 |
| MX2009002283A (es) | 2009-03-20 |
| CL2007002516A1 (es) | 2008-05-16 |
| JP2010502648A (ja) | 2010-01-28 |
| EA200900254A1 (ru) | 2009-08-28 |
| WO2008028118A1 (en) | 2008-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR062603A1 (es) | Derivados del acido indol-2-carboxilico, composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la modulacion del receptor ppargamma. | |
| ECSP21004787A (es) | Inhibidores de inflamasoma nlrp3 | |
| AR067051A1 (es) | Indazoles sustituidos, su preparacion y su utilizacion terapeutica | |
| AR127309A2 (es) | Derivados de piridazinona | |
| AR047890A1 (es) | Derivados de azabiciclo[3.1.0]hexano como moduladores de los receptores de dopamina d3 | |
| AR061101A1 (es) | Compuesto de fenil-triazolil- metoxi- arilo, su uso para la manufactura de un medicamento y composicion farmaceutica que lo comprende | |
| BRPI0608732A2 (pt) | composto ou um sal, hidrato, solvato, complexo ou pró-droga farmaceuticamente aceitável do mesmo, sal de um composto, processo para a preparação de um composto, uso de um composto, composição farmacêutica, e, produto | |
| AR060237A1 (es) | Compuesto de 3-azabiciclo[3.1.0]hexano como moduladores del receptor de dopamina d3, su uso para la preparacion de un medicamento para el tratamiento de afecciones psicoticas y composicion farmaceutica que lo comprende. | |
| PE20200834A1 (es) | Derivados acetamida de biciclo[1.1.1]pentano sustituidos como moduladores del factor de iniciacion eucariota 2b y composiciones farmaceuticas de las mismas | |
| AR066882A1 (es) | Derivados de oxadiazol, una composicion farmaceutica que los comprende y su uso en la preparacion de medicamentos para el tratamiento de trastornos asociados con la disfuncion del glutamato. | |
| AR063022A1 (es) | Derivados de indol antagonistas del receptor de glucagon, composiciones farmaceuticas que los contienen y usos para tratar diabetes mellitus tipo 2 y estados patologicos relacionados. | |
| AR072952A1 (es) | Compuestos de 2-imino-3-metilpirrolopirimidinona fenilo-sustituida como inhibidores de bace-1, composiciones y su uso | |
| AR082994A1 (es) | Derivados de pirazina como bloqueadores del canal epitelial de sodio | |
| AR083367A1 (es) | Compuestos de tipo quinazolinona como antagonistas de crth | |
| CR10250A (es) | Derivados de amida y su aplicación para el tratamiento de enfermedades relacionadas con proteína-g | |
| AR078884A1 (es) | Antagonistas del receptor crth2 basados en indol | |
| AR062360A1 (es) | Derivados heterociclicos que modulan la actividad de la estearoil-coa-desaturasa | |
| AR069490A1 (es) | Agonistas de los receptores de glucocorticoides | |
| AR051431A1 (es) | Compuestos de pirazolina substituidos, su preparacion y su uso como medicamentos | |
| AR111281A1 (es) | Compuestos de pirimidinil-piridiloxi-naftil y métodos para tratar enfermedades y trastornos relacionados con ire1 | |
| AR053710A1 (es) | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos | |
| BR0308146A (pt) | Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto | |
| AR064253A1 (es) | Compuestos de biciclocarboxiamida sustituidos composiciones farmaceuticas y una combinacion que los incluye y su uso en fabaricacion de un medicamento para el tratamiento de enfermedades mediadas por la actividad del receptor vr1 | |
| CL2003002769A1 (es) | Compuestos derivados de carboxamida de tiazolilpirrol; procedimiento para su preparacion; composiciones farmaceuticas que los comprenden; y su uso para el tratamiento y/o profilaxis de enfermedades asociadas con la modulacion de receptores canabinoid | |
| ATE431345T1 (de) | Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |