[go: up one dir, main page]

AR061886A1 - Compuestos derivados de 3-oxo-isoindolina-1-carboxamida, composicion farmaceutica y uso - Google Patents

Compuestos derivados de 3-oxo-isoindolina-1-carboxamida, composicion farmaceutica y uso

Info

Publication number
AR061886A1
AR061886A1 ARP070103082A ARP070103082A AR061886A1 AR 061886 A1 AR061886 A1 AR 061886A1 AR P070103082 A ARP070103082 A AR P070103082A AR P070103082 A ARP070103082 A AR P070103082A AR 061886 A1 AR061886 A1 AR 061886A1
Authority
AR
Argentina
Prior art keywords
aryl
alkyl
halogen
cyano
optionally substituted
Prior art date
Application number
ARP070103082A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR061886A1 publication Critical patent/AR061886A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Los compuestos de la presente son de utilidad en la profilaxis y en el tratamiento de las arritmias, en particular las arritmias auriculares y ventriculares. Reivindicacion 1: Un compuesto de la formula (1) en la cual R1 representa alquilo C1-12 (grupo alquilo que está optativamente sustituido o fusionado con uno o más grupos seleccionados entre halogeno, alquenilo C2-6, cicloalquilo C3-8, ciano, oxo, -OR8, -COR9, -SR10, -COXR11, -N(R12a)(R12b), -N(R13a)C(O)OR13b, -OC(O)N(R14a)(R14b), - SO2R15, arilo o Het1); además, R1 representa cicloalquilo C3-8, arilo o Het2; R8 a R11, R13a, R13b, R15 representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het9 (grupos alquilo C1-6, arilo y Het9 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het10); R12a y R12b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het11 (grupos alquilo C1-6, arilo y Het11 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het12), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R14a y R14b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het13 (grupos alquilo C1-6, arilo y Het13 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het14), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R2 representa alquilo C1-12 (grupo alquilo que está optativamente sustituido con uno o más grupos seleccionados entre halogeno, -OR16, -COR17, alquenilo C2-6, cicloalquilo C3-8, ciano, trialquilsililo, -COXR18, arilo o Het3); además, R2 representa (CH2)kN(R19a)(R19b), -(CH2)kNR20aC(O)N(R20b)(R20c), -(CH2)nNR21aSO2R21b, -(CH2)nSO2R22, -(CH2)kN(R23a)C(O)OR23b, -OC(O)N(R24a)(R24b), cicloalquilo C3-8, arilo o Het4; R16 a R18, R21, R22, R23a, R23b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het15 (grupos alquilo C1-6, arilo y Het15 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het16); R19a y R19b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het19 (grupos alquilo C1-6, arilo y Het19 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het20) o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R20a, R20b y R20c representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het21 (grupos alquilo C1-6, arilo y Het21 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het22); R20b y R20c juntos, pueden representar alquileno C3-6, optativamente interrumpido por un átomo de O; R3 representa hidrogeno, alquilo C1-12 (grupo alquilo que está optativamente sustituido con uno o más grupos seleccionados entre halogeno, -OR25, -COR26, alquenilo C2- 6, cicloalquilo C3-8, trialquilsililo,-COXR27, arilo o Het5); además R3 representa (CH2)kN(R28a)(R28b), -(CH2)kN(R29a)C(O)N(R29b)(R29c), -(CH2)nNR30aSO2R30b, -(CH2)nSO2R31, -(CH2)kN(R32a)C(O)OR32b, OC(O)N(R33a)(R33b), cicloalquilo C3-8, arilo o Het6; R25 a R27, R30, R31, R32a, R32b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het23 (grupos alquilo C1-6, arilo y Het23 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het24); R28a y R28b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het25 (grupos alquilo C1-6, arilo y Het25 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het26), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R33a y R33b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het27 (grupos alquilo C1-6, arilo y Het27 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het28) o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R29a, R29b, y R29c representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het29 (grupos alquilo C1-6, arilo y Het29 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het30); R29b y R29c juntos pueden representar alquileno C3-6, optativamente interrumpido por un átomo de O; R4 representa hidrogeno, -OH, arilo, alquilo C1-6 (grupo alquilo que está optativamente sustituido con uno o más grupos seleccionados entre halogeno, hidroxi, alquenilo C2-4, trialquilsililo), -OR34, -(CH2)mR35; R34 representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het31 (grupos alquilo C1-6, arilo y Het31 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het32); R35 representa independientemente arilo o Het33 (grupos arilo y Het33 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het34); R5 a R7 representan independientemente, en cada caso, hidrogeno, -OH, halogeno, ciano, nitro, alquilo C1-6, -OR36, - N(R37a)(R37b), -C(O)R38, -C(O)OR39, -C(O)N(R40a)(R40b), -NC(O)OR41, -OC(O)N(R42a)(R42b), -N(R43a)C(O)R43b, -N(R44a)S(O)2R44b, -S(O)2R45, -OS(O)2R46, -(CH2)nN(R47a)(R47b), -(CH2)nNR48aC(O)N(R48b)(R48c), -(CH2)nNR49aSO2R49b, trialquilsililo, arilo o Het7; R36, R38, R39, R41, R43, R44a, R44b, R45, R46, R49a y R49b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het35 (grupos alquilo C1-6, arilo y Het35 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het36); R37a y R37b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het37 (grupos alquilo C1-6, arilo y Het37 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het38), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R40a y R40b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het39 (grupos alquilo C1-6, arilo y Het39 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het40), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R42a y R42b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het41 (grupos alquilo C1-6, arilo y Het41 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het42), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R47a y R47b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het43 (grupos alquilo C1-6, arilo y Het43 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het44), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R48a, R48b y R48c representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het45 (grupos alquilo C1-6, arilo y Het45 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het46); R48b y R48c juntos pueden representar alquileno C3-6, optativamente interrumpido por un átomo de O; arilo está, encada caso, optativamente sustituido con -OH, halogeno, ciano, nitro, alquilo C1-6, cicloalquilo C3-8, alquenilo C2-6, arilo, Het8, -OR50, -(CH2)mR51, -SR52, -C(O)R53, -COXR54, -N(R55a)(R55b), -SO2R56, -OS(O)2R57, -(CH2)mN(R58a)(R58b), -(CH2)mNR59aC(O)N(R59b)(R59c), -C(O)OR60, -C(O)N(R61a)(R61b), -N(R62a)C(O)R62b, - N(R63a)C(O)OR63b, -OC(O)N(R64a)(R64b), -N(R65a)S(O)2R65b y OC(O)R66; R50 a R54, R56, R57, R60, R62a, R62b, R63a, R63b, R65a, R65b y R66 representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het47 (grupos alquilo C1-6, arilo y Het47 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het48); R51 representa independientemente arilo o Het49 (grupos arilo y Het49 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het50); R55a y R55b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het51 (grupos alquilo C1-6, arilo y Het51 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het52), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R58a y R58b representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het53 (grupos alquilo C1-6, arilo y Het53 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het54), o juntos representan alquileno C3-6, optativamente interrumpido por un átomo de O; R59a, representan independientemente, en cada caso, hidrogeno, alquilo C1-6, arilo o Het55 (grupos alquilo C1-6, arilo y Het55 que están optativamente sustituidos con uno o más sustituyentes seleccionados entre -OH, halogeno, ciano, nitro, alquilo C1-6, arilo y Het56); R59b y R59c juntos p
ARP070103082A 2006-07-12 2007-07-11 Compuestos derivados de 3-oxo-isoindolina-1-carboxamida, composicion farmaceutica y uso AR061886A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83024306P 2006-07-12 2006-07-12
US91336707P 2007-04-23 2007-04-23

Publications (1)

Publication Number Publication Date
AR061886A1 true AR061886A1 (es) 2008-10-01

Family

ID=38923495

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103082A AR061886A1 (es) 2006-07-12 2007-07-11 Compuestos derivados de 3-oxo-isoindolina-1-carboxamida, composicion farmaceutica y uso

Country Status (15)

Country Link
US (2) US20080015237A1 (es)
EP (1) EP2049484A1 (es)
JP (1) JP2009542804A (es)
KR (1) KR20090039722A (es)
AR (1) AR061886A1 (es)
AU (1) AU2007273275A1 (es)
BR (1) BRPI0713457A2 (es)
CA (1) CA2657151A1 (es)
CL (1) CL2007002021A1 (es)
IL (1) IL196206A0 (es)
MX (1) MX2009000420A (es)
NO (1) NO20090031L (es)
TW (1) TW200812962A (es)
UY (1) UY30476A1 (es)
WO (1) WO2008008022A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201000462A (en) * 2008-05-30 2010-01-01 Astrazeneca Ab New compounds useful in pain therapy
TW201000461A (en) * 2008-05-30 2010-01-01 Astrazeneca Ab New compounds useful in pain therapy
TW201000447A (en) * 2008-05-30 2010-01-01 Astrazeneca Ab New compounds useful in pain therapy
TW201000446A (en) * 2008-05-30 2010-01-01 Astrazeneca Ab New compounds useful in pain therapy
FR2932483A1 (fr) * 2008-06-13 2009-12-18 Cytomics Systems Composes utiles pour le traitement des cancers.
EP2161259A1 (de) 2008-09-03 2010-03-10 Bayer CropScience AG 4-Halogenalkylsubstituierte Diaminopyrimidine als Fungizide
CN103664973B (zh) * 2008-10-17 2017-04-19 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
FI20105806A0 (fi) 2010-07-15 2010-07-15 Medeia Therapeutics Ltd Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia
US8895571B2 (en) 2011-10-14 2014-11-25 Incyte Corporation Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors
WO2013104829A1 (en) 2012-01-13 2013-07-18 Medeia Therapeutics Ltd Novel arylamide derivatives having antiandrogenic properties
KR101947976B1 (ko) 2015-12-15 2019-02-13 아스트라제네카 아베 이소인돌 화합물
WO2018229155A1 (en) 2017-06-14 2018-12-20 Astrazeneca Ab 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849441A (en) * 1986-12-25 1989-07-18 Kyowa Hakko Kogyo Co., Ltd. Isoindolin-1-one derivative and antiarrhythmic agent
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
DE60132606T2 (de) * 2000-09-20 2009-02-19 Merck & Co., Inc. Isochinolinone als kalium-kanal-inhibitoren
FR2840302B1 (fr) * 2002-06-03 2004-07-16 Aventis Pharma Sa Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
DE10341233A1 (de) * 2003-09-08 2005-03-24 Aventis Pharma Deutschland Gmbh Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
DE10356717A1 (de) * 2003-12-02 2005-07-07 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten
WO2007053503A1 (en) * 2005-11-01 2007-05-10 Janssen Pharmaceutica N.V. Substituted dihydroisoindolones as allosteric modulators of glucokinase
EP2044019A1 (en) * 2006-07-12 2009-04-08 Astra Zeneca AB 3-oxoisoindoline-1-carboxamide derivatives as analgesic agents

Also Published As

Publication number Publication date
CL2007002021A1 (es) 2008-02-08
US20100298392A1 (en) 2010-11-25
AU2007273275A1 (en) 2008-01-17
BRPI0713457A2 (pt) 2012-03-13
MX2009000420A (es) 2009-01-27
TW200812962A (en) 2008-03-16
US20080015237A1 (en) 2008-01-17
CA2657151A1 (en) 2008-01-17
KR20090039722A (ko) 2009-04-22
JP2009542804A (ja) 2009-12-03
NO20090031L (no) 2009-01-27
UY30476A1 (es) 2008-02-29
IL196206A0 (en) 2009-09-22
WO2008008022A1 (en) 2008-01-17
EP2049484A1 (en) 2009-04-22

Similar Documents

Publication Publication Date Title
AR061886A1 (es) Compuestos derivados de 3-oxo-isoindolina-1-carboxamida, composicion farmaceutica y uso
PE20080361A1 (es) Compuestos derivados de purina como activadores del receptor de adenosina a2a
ES2948312T3 (es) Derivado de purinona como inhibidor de Btk quinasa
AR042192A1 (es) Derivados antivirales de nucleosidos de pirimidina
KR102284938B1 (ko) 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법
PE20080992A1 (es) Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c
CO5271655A1 (es) Nuevos compuestos oxabispidinas utiles en el tratamiento de arritmias cardiacas
PE20080704A1 (es) Inhibidores ns5b del virus hepatitis c de indolobenzazepina fusionados a ciclopropilo
RU2008133856A (ru) Карбоциклические и гетероциклические арилсульфоны в качестве ингибиторов гамма-секретазы
PE20091424A1 (es) Nucleosidos 2',4'-sustituidos como agentes antivirales
AR060125A1 (es) Derivados de la malonamida
PE20171449A1 (es) Derivados de nucleosidos sustituidos utiles como agentes antineoplasicos
PE20060837A1 (es) COMPUESTOS DE 3H-OXAZOLO Y 3H-TIAZOLO[4,5-d]PIRIMIDIN-2-ONA 3,5-DISUSTITUIDA Y 3,5,7-TRISUSTITUIDA Y PROFARMACOS DE LOS MISMOS
BR122012009489B8 (pt) processo para produzir 2-etóxi-1-{[2’-(5-oxo-4,5-diidro-1,2,4-oxadiazol-3-il)bifenil-4-il]metil}-1h-benzimidazol-7-carboxilato de (5-metil-2-oxo-1,3-dioxol-4-il)metila ou um sal do mesmo, composição farmacéutica, e, uso
AR050699A1 (es) Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan
NO20092399L (no) Kjemiske forbindelser
AR079400A1 (es) Cianobutiratos sustituidos con efecto herbicida
UY27638A1 (es) Compuesto inhibidor de la hepatitis c
AR061548A1 (es) 3-aminopirrolidino-4-lactamas sustituidas como inhibidoras de dipeptidilpeptidasa iv (dpp-iv), composiciones farmaceuticas que las comprenden y el uso de las mismas en el tratamiento de la diabetes ii.
ECSP003828A (es) Antagonistas de neurokinina selectivos
PE20160120A1 (es) Derivados de nucleosido 4'-fluoro-2'-metilo sustituido
PE20071326A1 (es) Inhibidores de la polimerasa viral
PE20090478A1 (es) Compuestos de indol macrociclicos como inhibidores de la proteasa del virus de la hepatitis c
AR065628A1 (es) Compuestos triciclicos de utilidad en el tratamiento de trastornos por carencia de hierro en el organismo
ES2236006T3 (es) Esteres de acido benzoico de oxazolidinonas con un sustituyente de hidroxiacetilpiperazina.

Legal Events

Date Code Title Description
FB Suspension of granting procedure