AR061825A1 - Analogos del peptido intestinal vasoactivo (vip) - Google Patents
Analogos del peptido intestinal vasoactivo (vip)Info
- Publication number
- AR061825A1 AR061825A1 ARP070102996A ARP070102996A AR061825A1 AR 061825 A1 AR061825 A1 AR 061825A1 AR P070102996 A ARP070102996 A AR P070102996A AR P070102996 A ARP070102996 A AR P070102996A AR 061825 A1 AR061825 A1 AR 061825A1
- Authority
- AR
- Argentina
- Prior art keywords
- lys
- ala
- thr
- leu
- asn
- Prior art date
Links
- 102000055135 Vasoactive Intestinal Peptide Human genes 0.000 title abstract 3
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 title abstract 3
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 title abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 208000011623 Obstructive Lung disease Diseases 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- -1 carboxyl hydroxyl Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Para el tratamiento de las enfermedades obstructivas pulmonares, por ejemplo la EPOC, administrado, por ejemplo, por inhalacion. Reivindicacion 1: Un análogo cíclico del péptido intestinal vasoactivo de formula (1) X-His-R2-Asp-Ala-R5- Phe-Thr-Glu- Asn-Tyr-Thr-Lys-Leu-Arg-Lys-R16-Nle-R18-Ala-Lys-Lys21-Tyr-Leu-Asn-Asp25-Leu-R27-R28-Gly-Gly-Thr-Y [X-(Id. de Sec. N°:2)-Y] en la que X es un H del amino N-terminal de la Histidina que puede estar opcionalmente sustituida por un grupo protector amino hidrolizable, más preferiblemente por un grupo acetilo, Y es el hidroxilo del carboxilo C-terminal de la Treonina que puede estar opcionalmente sustituida por un grupo protector carboxilo hidrolizable, más preferiblemente por NH2, los residuos subrayados indican una union covalente de cadena lateral a cadena lateral del primer aminoácido (Lys21) y el ultimo (Asp25) dentro del segmento, R2 es Ser o Ala, R5 es Thr, Ser, Asp, Gln, Pro o CalfaMeVal, R16 es Gln, Ala o Arg, R18 es Ala, Lys o Glu, R27 es Lys o Leu con la excepcion de que R27 debe ser Lys cuando R5 es CalfaMeVal y R16 es Arg, R28 es Lys o Asn, o una sal farmacéuticamente aceptable de la misma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81880506P | 2006-07-06 | 2006-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061825A1 true AR061825A1 (es) | 2008-09-24 |
Family
ID=38786842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102996A AR061825A1 (es) | 2006-07-06 | 2007-07-05 | Analogos del peptido intestinal vasoactivo (vip) |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20080096807A1 (es) |
| EP (1) | EP2041168A2 (es) |
| JP (1) | JP2009542593A (es) |
| KR (1) | KR20090027239A (es) |
| CN (1) | CN101484468A (es) |
| AR (1) | AR061825A1 (es) |
| AU (1) | AU2007271274A1 (es) |
| BR (1) | BRPI0714306A2 (es) |
| CA (1) | CA2656757A1 (es) |
| CL (1) | CL2007001956A1 (es) |
| CR (1) | CR10518A (es) |
| EC (1) | ECSP099029A (es) |
| IL (1) | IL196122A0 (es) |
| MA (1) | MA30590B1 (es) |
| MX (1) | MX2009000013A (es) |
| NO (1) | NO20090027L (es) |
| PE (1) | PE20081000A1 (es) |
| RU (1) | RU2009103811A (es) |
| TW (1) | TW200819139A (es) |
| WO (1) | WO2008003612A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5827218B2 (ja) | 2010-04-30 | 2015-12-02 | 株式会社三和化学研究所 | 生理活性物質等の生体内安定性向上のためのペプチド及び生体内安定性が向上した生理活性物質 |
| CN102827268B (zh) * | 2011-06-13 | 2016-08-24 | 中肽生化有限公司 | 新型血管肠肽类似物及其制备方法和用途 |
| US8866872B2 (en) | 2011-06-21 | 2014-10-21 | Mitel Networks Corporation | Conferencing and collaboration system and methods thereof |
| US9789164B2 (en) * | 2013-03-15 | 2017-10-17 | Longevity Biotech, Inc. | Peptides comprising non-natural amino acids and methods of making and using the same |
| ES2818824T3 (es) * | 2014-05-08 | 2021-04-14 | Phasebio Pharmaceuticals Inc | Composiciones que comprenden una proteína de fusión de VIP-ELP para su uso en el tratamiento de fibrosis quística |
| ITUB20159175A1 (it) * | 2015-12-23 | 2017-06-23 | Materie Plastiche Pisane S R L | Composizione polimerica antibatterica |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879371A (en) * | 1971-09-17 | 1975-04-22 | Sami I Said | Isolation of vasoactive intestinal peptide |
| GB8427651D0 (en) * | 1984-11-01 | 1984-12-05 | Beecham Group Plc | Compounds |
| GB8525852D0 (en) * | 1985-10-19 | 1985-11-20 | Beecham Group Plc | Compounds |
| JPS62246595A (ja) * | 1986-04-17 | 1987-10-27 | Eisai Co Ltd | 気菅支拡張作用・降圧作用ペプタイド |
| US4835252A (en) * | 1987-02-26 | 1989-05-30 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Vasoactive intestinal peptide analogs |
| AU656230B2 (en) * | 1991-10-11 | 1995-01-27 | F. Hoffmann-La Roche Ag | Cyclic vasoactive peptides |
| WO1997029126A1 (en) * | 1996-02-09 | 1997-08-14 | F. Hoffmann-La Roche Ag | Synthesis of vip analog |
| US20050203009A1 (en) * | 2004-03-12 | 2005-09-15 | Bayer Pharmaceuticals Corporation | VPAC1 selective antagonists and their pharmacological methods of use |
| CA2576217A1 (en) * | 2004-08-18 | 2006-03-02 | Eli Lilly And Company | Selective vpac2 receptor peptide agonists |
| EP1804820A4 (en) * | 2004-10-08 | 2009-12-02 | Transition Therapeutics Inc | PHARMACEUTICAL PRODUCTS BASED ON VASOACTIVE INTESTINAL POLYPEPTIDES |
-
2007
- 2007-06-26 RU RU2009103811/10A patent/RU2009103811A/ru unknown
- 2007-06-26 MX MX2009000013A patent/MX2009000013A/es not_active Application Discontinuation
- 2007-06-26 CA CA002656757A patent/CA2656757A1/en not_active Abandoned
- 2007-06-26 WO PCT/EP2007/056351 patent/WO2008003612A2/en not_active Ceased
- 2007-06-26 AU AU2007271274A patent/AU2007271274A1/en not_active Abandoned
- 2007-06-26 CN CNA2007800254947A patent/CN101484468A/zh active Pending
- 2007-06-26 KR KR1020097000221A patent/KR20090027239A/ko not_active Ceased
- 2007-06-26 JP JP2009517165A patent/JP2009542593A/ja active Pending
- 2007-06-26 EP EP07765625A patent/EP2041168A2/en not_active Withdrawn
- 2007-06-26 BR BRPI0714306-0A patent/BRPI0714306A2/pt not_active IP Right Cessation
- 2007-07-03 US US11/825,105 patent/US20080096807A1/en not_active Abandoned
- 2007-07-04 TW TW096124342A patent/TW200819139A/zh unknown
- 2007-07-05 PE PE2007000873A patent/PE20081000A1/es not_active Application Discontinuation
- 2007-07-05 AR ARP070102996A patent/AR061825A1/es unknown
- 2007-07-05 CL CL200701956A patent/CL2007001956A1/es unknown
-
2008
- 2008-12-17 CR CR10518A patent/CR10518A/es not_active Application Discontinuation
- 2008-12-22 IL IL196122A patent/IL196122A0/en unknown
-
2009
- 2009-01-05 NO NO20090027A patent/NO20090027L/no not_active Application Discontinuation
- 2009-01-05 EC EC2009009029A patent/ECSP099029A/es unknown
- 2009-01-13 MA MA31568A patent/MA30590B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2007001956A1 (es) | 2008-04-18 |
| WO2008003612A2 (en) | 2008-01-10 |
| RU2009103811A (ru) | 2010-08-20 |
| KR20090027239A (ko) | 2009-03-16 |
| CN101484468A (zh) | 2009-07-15 |
| JP2009542593A (ja) | 2009-12-03 |
| TW200819139A (en) | 2008-05-01 |
| MA30590B1 (fr) | 2009-07-01 |
| IL196122A0 (en) | 2011-08-01 |
| MX2009000013A (es) | 2009-01-23 |
| BRPI0714306A2 (pt) | 2014-05-20 |
| US20080096807A1 (en) | 2008-04-24 |
| WO2008003612A3 (en) | 2008-02-28 |
| EP2041168A2 (en) | 2009-04-01 |
| AU2007271274A1 (en) | 2008-01-10 |
| NO20090027L (no) | 2009-01-15 |
| CR10518A (es) | 2009-01-27 |
| ECSP099029A (es) | 2009-02-27 |
| PE20081000A1 (es) | 2008-08-06 |
| CA2656757A1 (en) | 2008-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |