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AR061311A1 - Procesos para preparar clorhidrato de cinacalcet y formas polimorficas del mismo - Google Patents

Procesos para preparar clorhidrato de cinacalcet y formas polimorficas del mismo

Info

Publication number
AR061311A1
AR061311A1 ARP070102514A ARP070102514A AR061311A1 AR 061311 A1 AR061311 A1 AR 061311A1 AR P070102514 A ARP070102514 A AR P070102514A AR P070102514 A ARP070102514 A AR P070102514A AR 061311 A1 AR061311 A1 AR 061311A1
Authority
AR
Argentina
Prior art keywords
chlorhydrate
processes
same
polymorphic forms
cinacalcet
Prior art date
Application number
ARP070102514A
Other languages
English (en)
Inventor
Tibor Szekeres
Jozsef Repasi
Andres Szabo
Velez Monica Benito
Bernardino Mangion
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR061311A1 publication Critical patent/AR061311A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Clorhidrato de cinacalcet, formas cristalinas polimorficas novedosas de clorhidrato de cinacalcet, clorhidrato de cinacalcet amorfo y procedimientos sintéticos para su preparacion.
ARP070102514A 2006-06-08 2007-06-08 Procesos para preparar clorhidrato de cinacalcet y formas polimorficas del mismo AR061311A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81178206P 2006-06-08 2006-06-08

Publications (1)

Publication Number Publication Date
AR061311A1 true AR061311A1 (es) 2008-08-20

Family

ID=39327252

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102514A AR061311A1 (es) 2006-06-08 2007-06-08 Procesos para preparar clorhidrato de cinacalcet y formas polimorficas del mismo

Country Status (8)

Country Link
US (1) US20110295037A1 (es)
EP (1) EP2041065A2 (es)
JP (1) JP2009539824A (es)
CN (1) CN101522606A (es)
AR (1) AR061311A1 (es)
CA (1) CA2654757A1 (es)
IL (1) IL195758A0 (es)
WO (1) WO2008068625A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010071689A2 (en) * 2008-05-05 2010-06-24 Medichem, S.A. Process for controlling the particle size of a 3-(trifluoromethyl)phenyl]-1-aminopropane derivative
EP2321256B1 (en) 2008-06-18 2014-11-12 ERREGIERRE S.p.A. Process for the synthesis of cinacalcet hydrochloride
JP2012503613A (ja) * 2008-09-25 2012-02-09 ラシオファルム ゲーエムベーハー コンパクト化シナカルセット
WO2010067204A1 (en) 2008-12-08 2010-06-17 Actavis Group Ptc Ehf Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
WO2010128388A2 (en) 2009-05-08 2010-11-11 Aurobindo Pharma Limited An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
US8759586B2 (en) 2009-09-16 2014-06-24 Ranbaxy Laboratories Limited Processes for the preparation of cinacalcet
IT1396623B1 (it) * 2009-11-26 2012-12-14 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet e suoi intermedi
US8921606B2 (en) 2010-07-16 2014-12-30 Hetero Research Foundation Process for cinacalcet hydrochloride
WO2012051737A1 (zh) * 2010-10-18 2012-04-26 上海永颐生物科技有限公司 西那卡塞及其药用盐的制备方法
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
BR112015014430B1 (pt) 2012-12-21 2022-08-30 Synthon B.V. Composição em comprimido
WO2014178068A2 (en) * 2013-04-08 2014-11-06 Cadila Healthcare Limited An improved process for preparation of n-[1-(1-naphthyl)ethyl] -3- [3-(trifluoromethyl)phenyl]propan-1-amine and pharmaceutically acceptable salts thereof
CN103193655B (zh) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 盐酸西那卡塞晶型ⅰ的制备方法
CN103467304A (zh) * 2013-08-07 2013-12-25 南京生命能科技开发有限公司 一种盐酸西那卡塞的制备方法
SG11201804811WA (en) * 2015-12-22 2018-07-30 Zogenix International Ltd Fenfluramine compositions and methods of preparing the same
US11331283B2 (en) * 2017-08-16 2022-05-17 Unichem Laboratories Ltd Pharmaceutical compositions comprising cinacalcet hydrochloride and one or more binders
CN107966511A (zh) * 2017-11-23 2018-04-27 中山奕安泰医药科技有限公司 检测(r)-1-(1-萘基)乙胺手性异构体的方法

Also Published As

Publication number Publication date
CN101522606A (zh) 2009-09-02
CA2654757A1 (en) 2008-06-12
WO2008068625A2 (en) 2008-06-12
WO2008068625A3 (en) 2008-11-20
WO2008068625A9 (en) 2009-03-26
EP2041065A2 (en) 2009-04-01
IL195758A0 (en) 2009-09-01
JP2009539824A (ja) 2009-11-19
US20110295037A1 (en) 2011-12-01

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