AR060977A1 - Aminotiazoles y sus usos - Google Patents
Aminotiazoles y sus usosInfo
- Publication number
- AR060977A1 AR060977A1 ARP070102300A ARP070102300A AR060977A1 AR 060977 A1 AR060977 A1 AR 060977A1 AR P070102300 A ARP070102300 A AR P070102300A AR P070102300 A ARP070102300 A AR P070102300A AR 060977 A1 AR060977 A1 AR 060977A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- cycloalkyl
- absent
- substituted
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
La presente solicitud describe compuestos orgánicos que son utiles para el tratamiento, prevencion y/o alivio de enfermedades. Reivindicacion 1: Un compuesto de formula (1) y sales aceptables para uso farmacéutico, enantiomeros, estereoisomeros, rotámeros, tautomeros, diastereomeros, atropisomeros o racematos del mismo, que incluyen el N-oxido de piridina del mismo; donde A se selecciona del grupo que consiste en un enlace, H, -(CH2)-, -C(alquil)2, -(CH2)1-8-, -[C(alquil)2]1-8-, - (cicloalquil)-, -(aril)-, -(heteroaril)-, -C(O)-, -C(O)C(O)-, -C(O)O-, -C(O)N(R8a)-, -S(O)2-, -S(O)-, -S(O)2N(R8a)-, -S(O)N(R8a)-, -C(=NR8)N(R8a), -C(=NR8)N(R8a)C(O)-, -C(=NR8)-, -C=C-C(O)-, -C=C-C(O)O-, -C=C-C(O)N(R8a)-; G está ausente, o se selecciona del grupo que consiste en H, -[C(Ra)(Rb)]x, -[C(Ra)(Rb)]x-O-[C(Ra)(Rb)]y-, -[C(Ra)(Rb)]x-N(R8a)-[C(Ra)(Rb)]y-, -(cicloalquil)-, -(heterociclil)-, -(aril)-, -(heteroaril)-; J se selecciona del grupo que consiste en H, F, O-alquilo, N(R8a)2, N+(R8a)3, N(R8a)C(O)alquilo, CO2H, C(=O)N(R8a)2, CO2-alquilo, P(O)(OH)2, P(O)(O-alquil)2, y un heterociclilo sustituido que contiene nitrogeno; Ra se selecciona del grupo que consiste en H, alquilo, F, CO2H, CO2-alquilo, -N(R1)2, -OR1, - (CH2)0-4-J y -R4b; Rb se selecciona del grupo que consiste en H, alquilo y F; x e y son cada uno, independientemente, enteros de 0-10; R1 se selecciona de -H, -C(alquil)2-J, -R4b; R2a se selecciona del grupo que consiste en H, alquilo sustituido o no sustituido, OH, OR4a, OC(O)R4a, OC(O)N(R8a)2 y N(R8a)2; R2b se selecciona del grupo que consiste en: ausente, H y alquilo, o R2a y R2b pueden formar en conjunto =O o =NH; R3 y R12 se seleccionan cada uno, en forma independiente, del grupo que consiste en H, halogeno, OR4b, -G-J, y N(R8a)2; R4a se selecciona del grupo que consiste en H y alquilo; R4b se selecciona del grupo que consiste en alquilo y -(CH2-CH2-O-)n-R9, donde n es un entero de 1-500, 1000, 2000, 3000, 4000, 5000, 10000 20000, 30000, 40000, 50000 o 60000 o es una media de una pluralidad de enteros que tiene un valor de 1-500, 1000, 2000, 3000, 4000, 5000, 10000, 20000, 30000, 40000, 50000 o 60000; R5 se selecciona del grupo que consiste en H, alquilo y R4b; R8 se selecciona del grupo que consiste en H, CN, NO2, alquilo, cicloalquilo y SO2-alquilo; R8a está ausente, o se selecciona del grupo que consiste en H, -(alquil)-, -(cicloalquil)-, C(alquil)2-J, -R4b, donde R8a puede también ciclarse con el átomo al cual se une R8a para formar un anillo de 3, 4, 5, 6 o 7 miembros que es aromático o no aromático y que puede contener uno o más heteroátomos, donde el anillo puede además sustituirse en una o más oportunidades con sustituyentes que son iguales o diferentes; y R9 se selecciona del grupo que consiste en H, alquilo y CH2CO2H. Reivindicacion 33: Un método para tratar una infeccion bacteriana que comprende administrar a un sujeto necesitado de dicho tratamiento una cantidad aceptable para uso farmacéutico de un compuesto de cualquiera de las reivindicaciones 1-32, de modo tal que se trate la infeccion bacteriana.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80969306P | 2006-05-31 | 2006-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060977A1 true AR060977A1 (es) | 2008-07-23 |
Family
ID=38645676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102300A AR060977A1 (es) | 2006-05-31 | 2007-05-29 | Aminotiazoles y sus usos |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7851439B2 (es) |
| EP (2) | EP2322536A3 (es) |
| JP (1) | JP5351014B2 (es) |
| KR (1) | KR101061658B1 (es) |
| CN (2) | CN102399260B (es) |
| AR (1) | AR060977A1 (es) |
| AU (1) | AU2007255025B2 (es) |
| BR (1) | BRPI0711885A2 (es) |
| CA (1) | CA2650133A1 (es) |
| CL (1) | CL2007001542A1 (es) |
| CR (1) | CR10430A (es) |
| DK (1) | DK2044101T3 (es) |
| EC (1) | ECSP088922A (es) |
| ES (1) | ES2441993T3 (es) |
| HR (1) | HRP20140055T1 (es) |
| IL (1) | IL194880A (es) |
| MA (1) | MA30485B1 (es) |
| MX (1) | MX2008015216A (es) |
| MY (1) | MY146920A (es) |
| NO (1) | NO20085032L (es) |
| NZ (1) | NZ572154A (es) |
| PE (2) | PE20121011A1 (es) |
| PL (1) | PL2044101T3 (es) |
| PT (1) | PT2044101E (es) |
| RU (1) | RU2450015C2 (es) |
| SI (1) | SI2044101T1 (es) |
| TN (1) | TNSN08496A1 (es) |
| TW (2) | TW201107337A (es) |
| UA (1) | UA95627C2 (es) |
| WO (1) | WO2007142986A2 (es) |
| ZA (1) | ZA200808449B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR060977A1 (es) | 2006-05-31 | 2008-07-23 | Novartis Ag | Aminotiazoles y sus usos |
| JP5230647B2 (ja) * | 2006-12-20 | 2013-07-10 | ノバルティス アーゲー | アミノチアゾール大環状分子、抗菌化合物としてのその使用およびその製造法 |
| PE20090318A1 (es) * | 2007-06-04 | 2009-04-17 | Novartis Ag | Macrociclos y sus usos |
| AU2012261611B2 (en) * | 2007-12-12 | 2014-05-15 | Novartis Ag | Aminothiazoles and their uses |
| WO2009074605A1 (en) * | 2007-12-12 | 2009-06-18 | Novartis Ag | Aminothiazoles and their uses |
| WO2014167371A1 (en) * | 2013-04-12 | 2014-10-16 | Naicons S.C.A.R.L. | Analogs of the antibiotic aminothiazole ge2270 |
| CN106366168B (zh) * | 2016-08-26 | 2020-09-15 | 上海交通大学 | 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法 |
| CN107243008B (zh) * | 2017-04-13 | 2021-03-30 | 中国科学院广州生物医药与健康研究院 | 吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的组合物 |
| CN113219078B (zh) * | 2021-03-25 | 2022-12-16 | 广东产品质量监督检验研究院（国家质量技术监督局广州电气安全检验所、广东省试验认证研究院、华安实验室） | 一种生活用纸制品中17种有机抗菌剂快速筛查方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202241A (en) * | 1988-09-09 | 1993-04-13 | Gruppo Lepetit S.P.A. | Antibiotic GE 2270 |
| DK0406745T3 (da) * | 1989-07-04 | 1995-02-27 | Lepetit Spa | Antibiotiske GE 2270 faktorer A1, A2, A3 og H |
| DE69108972T2 (de) * | 1990-03-08 | 1995-10-19 | Lepetit Spa | Antibiotika GE 2270 Faktoren B1, B2, C1, D1, D2, E und T. |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| DK0529410T3 (da) * | 1991-08-30 | 1998-05-11 | Biosearch Italia Spa | Antibiotikum GE 2270 faktor C2a |
| US5882900A (en) * | 1992-09-10 | 1999-03-16 | Gruppo Lepetit S.P.A. | Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium |
| DK0675900T3 (da) | 1992-12-22 | 1998-03-09 | Biosearch Italia Spa | Antibiotika GE 37468 A, B og C |
| AU3805295A (en) * | 1994-11-08 | 1996-05-31 | Gruppo Lepetit S.P.A. | Microbial transformation process for obtaining antibiotic ge 2270 factor d2 |
| KR100381688B1 (ko) * | 1995-02-07 | 2003-12-11 | 바이오써치 이탈리아 에스.피.에이. | Ge2270및ge2270-유사항생제의염기성프롤린-아미드유도체 |
| DK0808326T3 (da) * | 1995-02-07 | 2001-10-01 | Biosearch Italia Spa | Basiske oxazolinamidderivater af GE2270 og GE2270-lignende antibiotika |
| EP0880541B1 (en) * | 1996-02-14 | 2003-01-15 | Biosearch Italia S.p.A. | Derivatives of antibiotic ge2270 factors |
| JPH1059997A (ja) * | 1996-08-22 | 1998-03-03 | Microbial Chem Res Found | アミチアマイシンアミド誘導体 |
| SI1553967T1 (sl) * | 2002-06-17 | 2011-07-29 | Naicons S C A R L | Uporaba amid derivata GE 2270 faktorja A3 za zdravljenje aken |
| EP1793812A4 (en) | 2004-09-22 | 2009-08-26 | Merck & Co Inc | ANTIBIOTIC CONNECTION |
| AR060977A1 (es) * | 2006-05-31 | 2008-07-23 | Novartis Ag | Aminotiazoles y sus usos |
| WO2009074605A1 (en) * | 2007-12-12 | 2009-06-18 | Novartis Ag | Aminothiazoles and their uses |
-
2007
- 2007-05-29 AR ARP070102300A patent/AR060977A1/es unknown
- 2007-05-29 PE PE2012000528A patent/PE20121011A1/es not_active Application Discontinuation
- 2007-05-29 PE PE2007000664A patent/PE20080103A1/es not_active Application Discontinuation
- 2007-05-30 DK DK07795502.9T patent/DK2044101T3/da active
- 2007-05-30 HR HRP20140055TT patent/HRP20140055T1/hr unknown
- 2007-05-30 CN CN201110384145.2A patent/CN102399260B/zh not_active Expired - Fee Related
- 2007-05-30 US US11/755,481 patent/US7851439B2/en active Active
- 2007-05-30 TW TW099141102A patent/TW201107337A/zh unknown
- 2007-05-30 TW TW096119338A patent/TWI342310B/zh not_active IP Right Cessation
- 2007-05-30 CA CA002650133A patent/CA2650133A1/en not_active Abandoned
- 2007-05-30 RU RU2008150785/04A patent/RU2450015C2/ru not_active IP Right Cessation
- 2007-05-30 PL PL07795502T patent/PL2044101T3/pl unknown
- 2007-05-30 AU AU2007255025A patent/AU2007255025B2/en not_active Ceased
- 2007-05-30 PT PT77955029T patent/PT2044101E/pt unknown
- 2007-05-30 MX MX2008015216A patent/MX2008015216A/es active IP Right Grant
- 2007-05-30 WO PCT/US2007/012768 patent/WO2007142986A2/en not_active Ceased
- 2007-05-30 CN CNA2007800198364A patent/CN101454337A/zh active Pending
- 2007-05-30 KR KR1020087029296A patent/KR101061658B1/ko not_active Expired - Fee Related
- 2007-05-30 BR BRPI0711885-6A patent/BRPI0711885A2/pt not_active Application Discontinuation
- 2007-05-30 NZ NZ572154A patent/NZ572154A/en not_active IP Right Cessation
- 2007-05-30 MY MYPI20084727A patent/MY146920A/en unknown
- 2007-05-30 EP EP10179066A patent/EP2322536A3/en not_active Withdrawn
- 2007-05-30 CL CL200701542A patent/CL2007001542A1/es unknown
- 2007-05-30 JP JP2009513260A patent/JP5351014B2/ja not_active Expired - Fee Related
- 2007-05-30 EP EP07795502.9A patent/EP2044101B1/en active Active
- 2007-05-30 SI SI200731371T patent/SI2044101T1/sl unknown
- 2007-05-30 UA UAA200811756A patent/UA95627C2/ru unknown
- 2007-05-30 ES ES07795502.9T patent/ES2441993T3/es active Active
-
2008
- 2008-10-03 ZA ZA2008/08449A patent/ZA200808449B/en unknown
- 2008-10-23 IL IL194880A patent/IL194880A/en active IP Right Grant
- 2008-11-10 CR CR10430A patent/CR10430A/es unknown
- 2008-11-28 EC EC2008008922A patent/ECSP088922A/es unknown
- 2008-11-28 TN TNP2008000496A patent/TNSN08496A1/en unknown
- 2008-12-01 MA MA31428A patent/MA30485B1/fr unknown
- 2008-12-02 NO NO20085032A patent/NO20085032L/no unknown
-
2010
- 2010-07-01 US US12/828,737 patent/US20100267757A1/en not_active Abandoned
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