AR069569A1 - Derivados de benzoxazina, un intermediario para su preparacion, una composicion farmaceutica que los comprende y su uso para la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de renina. - Google Patents
Derivados de benzoxazina, un intermediario para su preparacion, una composicion farmaceutica que los comprende y su uso para la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de renina.Info
- Publication number
- AR069569A1 AR069569A1 ARP080105282A ARP080105282A AR069569A1 AR 069569 A1 AR069569 A1 AR 069569A1 AR P080105282 A ARP080105282 A AR P080105282A AR P080105282 A ARP080105282 A AR P080105282A AR 069569 A1 AR069569 A1 AR 069569A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heterocyclyl
- alkylated
- mono
- alkoxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical class C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- -1 nitrate ester Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- DEDUBNVYPMOFDR-RXMQYKEDSA-N (2r)-2-ethoxypropan-1-ol Chemical compound CCO[C@H](C)CO DEDUBNVYPMOFDR-RXMQYKEDSA-N 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000006598 aminocarbonylamino group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 239000002461 renin inhibitor Substances 0.000 abstract 1
- 229940086526 renin-inhibitors Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Uso de estos compuestos como medicamentos, en especial como inhibidores de renina y en composiciones farmacéuticas que los comprenden. Se provee además un intermediario para su preparacion. Reivindicacion 1: Un compuesto de formula (1) sus prodrogas, sus derivados nitrosados o de éster de nitrato o sus sales, preferentemente sus sales farmacéuticamente aceptables, en los cuales R1 es alcanoiloxi C1-8, alcanoiloxi C1-8-alquilo C1-8, alcoxi C1-8, alcoxi C1-8-alcoxiC1-8, alcoxi C1-8-alcoxi C1-8-alquilo C1-8, alcoxiC1-8-alquilo C1-8, alcoxicarbonilamino C1-8, alcoxicarbonilamino C1-8-alquilo C1-8, alquilcarbonilamino C0-8, alquilcarbonilamino C0-8-alquilo C1-8, O-carboxilo alquilado C1-8, O-carboxil-alquilo C1-8 alquilado C1-8, amino opcionalmente N-mono- o N,N-di-alquilado C1-8, amino-alquilo C1-8 opcionalmente N-mono- o N,N-di-alquilado C1-8, amino-carbonilamino opcionalmente N-mono- o N,N-di-alquilado C1-8, amino-carbonilamino-alquiIo C1-8 opcionalmente N-mono- o N,N-di-alquilado C1-8, heterociclilo, heterociclil-alquilo C1-8, heterociclil-aIquil C0-8-carbonil-alquilamino C0-8, heterociclil-alquil C0-8-carbonil-alquilamino C0-8-aIquilo C1-8, heterociclil-alquil C0-8-carbonil-alquilo C1-8, cicloalquil-aIquil C0-8-carbonil-alquilamino C0-8, cicloalquil-alquil C0-8-carbonil-alquilamino C0-8-alquilo C1-8, hidroxilo, alquilo C1-8 sustituido con hidroxi, ureido opcionalmente N-mono-, -di- o -tri-alquilado C1-8 o sustituido con heterociclilo, o ureido-alquilo C1-8 opcionalmente N-mono-, -di- o -tri-alquilado C1-8 o sustituido con heterociclilo, y donde los radicales heterociclilo y cicloalquilo mencionados anteriormente no están sustituidos o están sustituidos. Reivindicacion 10. El compuesto ( R )-2-etoxi-propan-1-ol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07122363 | 2007-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069569A1 true AR069569A1 (es) | 2010-02-03 |
Family
ID=39203128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105282A AR069569A1 (es) | 2007-12-05 | 2008-12-04 | Derivados de benzoxazina, un intermediario para su preparacion, una composicion farmaceutica que los comprende y su uso para la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de renina. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8003640B2 (es) |
| EP (1) | EP2229384A1 (es) |
| JP (1) | JP2011506287A (es) |
| KR (1) | KR20100112550A (es) |
| CN (1) | CN101918396A (es) |
| AR (1) | AR069569A1 (es) |
| AU (1) | AU2008333201A1 (es) |
| BR (1) | BRPI0820013A2 (es) |
| CA (1) | CA2705722A1 (es) |
| EA (1) | EA201000882A1 (es) |
| MX (1) | MX2010006218A (es) |
| TW (1) | TW200932241A (es) |
| WO (1) | WO2009071606A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR053836A1 (es) * | 2005-03-31 | 2007-05-23 | Speedel Experimenta Ag | Piperdinas 3,4,5-sustituidas |
| RU2010129690A (ru) | 2007-12-19 | 2012-01-27 | Дайниппон Сумитомо Фарма Ко., Лтд. (Jp) | Бициклические гетероциклические производные |
| CN102482256B (zh) | 2009-06-24 | 2014-11-26 | 大日本住友制药株式会社 | N-取代的环状氨基衍生物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63264573A (ja) | 1986-04-24 | 1988-11-01 | Toray Ind Inc | 光学活性６−置換−ピリジン−３−カルボン酸エステル化合物および液晶 |
| KR100384979B1 (ko) | 1995-09-07 | 2003-10-17 | 에프. 호프만-라 로슈 아게 | 심부전증및신부전증치료용의신규한4-(옥시알콕시페닐)-3-옥시-피페리딘 |
| TW200900399A (en) * | 2003-10-01 | 2009-01-01 | Speedel Experimenta Ag | Organic compounds |
| AR045950A1 (es) | 2003-10-09 | 2005-11-16 | Speedel Experimenta Ag | Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos. |
| TW200613274A (en) | 2004-07-09 | 2006-05-01 | Speedel Experimenta Ag | Organic compounds |
| AR053836A1 (es) | 2005-03-31 | 2007-05-23 | Speedel Experimenta Ag | Piperdinas 3,4,5-sustituidas |
| WO2007045551A2 (en) | 2005-10-18 | 2007-04-26 | Nicox S.A. | Renin inhibitors nitroderivatives |
| TW200804359A (en) * | 2006-01-19 | 2008-01-16 | Speedel Experimenta Ag | Substituted 4-phenylpiperidines |
| EP1911758A1 (en) * | 2006-10-04 | 2008-04-16 | Speedel Experimenta AG | Phenyl piperidine derivatives for use as renin inhibitors |
-
2008
- 2008-12-03 TW TW097146872A patent/TW200932241A/zh unknown
- 2008-12-04 KR KR1020107012384A patent/KR20100112550A/ko not_active Withdrawn
- 2008-12-04 AU AU2008333201A patent/AU2008333201A1/en not_active Abandoned
- 2008-12-04 MX MX2010006218A patent/MX2010006218A/es not_active Application Discontinuation
- 2008-12-04 US US12/745,100 patent/US8003640B2/en not_active Expired - Fee Related
- 2008-12-04 EP EP08858365A patent/EP2229384A1/en not_active Withdrawn
- 2008-12-04 BR BRPI0820013-0A patent/BRPI0820013A2/pt not_active IP Right Cessation
- 2008-12-04 WO PCT/EP2008/066747 patent/WO2009071606A1/en not_active Ceased
- 2008-12-04 JP JP2010536447A patent/JP2011506287A/ja active Pending
- 2008-12-04 CN CN200880118754XA patent/CN101918396A/zh active Pending
- 2008-12-04 EA EA201000882A patent/EA201000882A1/ru unknown
- 2008-12-04 AR ARP080105282A patent/AR069569A1/es unknown
- 2008-12-04 CA CA2705722A patent/CA2705722A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011506287A (ja) | 2011-03-03 |
| KR20100112550A (ko) | 2010-10-19 |
| CN101918396A (zh) | 2010-12-15 |
| US8003640B2 (en) | 2011-08-23 |
| BRPI0820013A2 (pt) | 2015-05-19 |
| TW200932241A (en) | 2009-08-01 |
| EP2229384A1 (en) | 2010-09-22 |
| EA201000882A1 (ru) | 2011-02-28 |
| CA2705722A1 (en) | 2009-06-11 |
| MX2010006218A (es) | 2010-06-23 |
| US20100303926A1 (en) | 2010-12-02 |
| WO2009071606A1 (en) | 2009-06-11 |
| AU2008333201A1 (en) | 2009-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |