[go: up one dir, main page]

AR067557A1 - Preparacion solida y metodo de preparacion - Google Patents

Preparacion solida y metodo de preparacion

Info

Publication number
AR067557A1
AR067557A1 ARP080103045A ARP080103045A AR067557A1 AR 067557 A1 AR067557 A1 AR 067557A1 AR P080103045 A ARP080103045 A AR P080103045A AR P080103045 A ARP080103045 A AR P080103045A AR 067557 A1 AR067557 A1 AR 067557A1
Authority
AR
Argentina
Prior art keywords
methyl
benzonitrile
dioxo
piperidinyl
pyrimidinyl
Prior art date
Application number
ARP080103045A
Other languages
English (en)
Inventor
Kazumichi Yamamoto
Hiroyoshi Koyama
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39930391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR067557(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR067557A1 publication Critical patent/AR067557A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicaciones 1. Una preparacion solida caracterizada porque comprende las siguientes primera parte y segunda parte; primera parte: una parte que comprende 2-[[6-[(3R)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2H)-pirimidinil]metil]benzonitrilo o una de sus sales y sustancialmente libre de clorhidrato de metformina; segunda parte: una parte que comprende clorhidrato de metformina y sustancialmente libre de 2-[[6-[(3R)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2H)-pirimidinil]metil]benzonitrilo y una de sus sales. Reivindicacion 15: Una preparacion solida caracterizada porque comprende los siguientes nucleo y cubierta: nucleo: un nucleo que comprende clorhidrato de metformina y sustancialmente libre de 2-[[6-[(3R)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2H)-pirimidinil]metil]-benzonitrilo y una de sus sales cubierta; una cubierta que comprende 2-[[6-[(3R)-3-amino-1- piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2H)-pirimidinil]metil)benzonitrilo o una de sus sales y sustancialmente libre de clorhidrato de metformina. Reivindicacion 16: Una preparacion solida caracterizada porque comprende los siguientes nucleo y cubierta: nucleo: un nucleo que comprende 2-[[6-[(3R)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2 4-dioxo-1(2H)-pirimidinil]metil]benzonitrilo o una de sus sales y sustancialmente libre de clorhidrato de metformina; cubierta: una cubierta que comprende clorhidrato de metformina y sustancialmente libre de 2-[[6-[(3R)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2H)-pirimidinil]metil]benzonitrilo y una de sus sales. Reivindicacion 17: La preparacion solida de la reivindicacion 15 o 16, caracterizada porque además comprende una capa intermedia entre dicho nucleo y dicha cubierta.
ARP080103045A 2007-07-19 2008-07-16 Preparacion solida y metodo de preparacion AR067557A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007188574 2007-07-19

Publications (1)

Publication Number Publication Date
AR067557A1 true AR067557A1 (es) 2009-10-14

Family

ID=39930391

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080103045A AR067557A1 (es) 2007-07-19 2008-07-16 Preparacion solida y metodo de preparacion

Country Status (27)

Country Link
US (1) US8900638B2 (es)
EP (1) EP2185138B1 (es)
JP (2) JP5479318B2 (es)
KR (1) KR101536786B1 (es)
CN (1) CN101801351B (es)
AR (1) AR067557A1 (es)
AU (1) AU2008276842C9 (es)
BR (1) BRPI0814299B8 (es)
CA (1) CA2694620C (es)
CO (1) CO6160301A2 (es)
CR (1) CR11267A (es)
DO (1) DOP2010000028A (es)
EA (1) EA020870B1 (es)
EC (1) ECSP109979A (es)
ES (1) ES2603879T3 (es)
GE (1) GEP20125672B (es)
IL (1) IL203171A (es)
JO (1) JO3272B1 (es)
MA (1) MA31592B1 (es)
MY (1) MY159203A (es)
NZ (1) NZ583346A (es)
PE (2) PE20090882A1 (es)
TN (1) TN2010000019A1 (es)
TW (1) TWI421102B (es)
UA (1) UA98799C2 (es)
WO (1) WO2009011451A1 (es)
ZA (1) ZA201000831B (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
AR067557A1 (es) * 2007-07-19 2009-10-14 Takeda Pharmaceutical Preparacion solida y metodo de preparacion
EP2251005B1 (en) * 2008-02-13 2012-10-10 Dainippon Sumitomo Pharma Co., Ltd. Orally disintegrating tablets
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
NZ604091A (en) 2008-08-15 2014-08-29 Boehringer Ingelheim Int Purin derivatives for use in the treatment of fab-related diseases
AR073380A1 (es) * 2008-09-25 2010-11-03 Takeda Pharmaceutical Composicion farmaceutica solida. comprimido multicapa
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
AR075204A1 (es) 2009-01-29 2011-03-16 Boehringer Ingelheim Int Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2
MX2011008416A (es) 2009-02-13 2011-09-08 Boehringer Ingelheim Int Medicaciones antidiabeticas que comprenden un inhibidor de dpp-4 (linagliptina) opcionalmente en combinacion con otros antidiabeticos.
WO2010109468A1 (en) 2009-03-26 2010-09-30 Mapi Pharma Hk Limited Process for the preparation of alogliptin
EP2429500B1 (en) * 2009-05-13 2015-01-14 Wyeth LLC Method to stabilize a dietary supplement comprising glucosamine
ES2693686T3 (es) 2009-11-13 2018-12-13 Astrazeneca Ab Formulaciones de comprimidos de liberación inmediata
JP5775522B2 (ja) 2009-11-13 2015-09-09 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ 二層錠製剤
PH12012501037A1 (en) 2009-11-27 2013-01-14 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
JP2013522279A (ja) 2010-03-18 2013-06-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連状態の治療で用いるｇｐｒ１１９作動薬とｄｄｐ−ｉｖ阻害薬リナグリプチンの組合せ
CA2797310C (en) 2010-05-05 2020-03-31 Boehringer Ingelheim International Gmbh Glp-1 receptor agonist and dpp-4 inhibitor combination therapy
CN103068392A (zh) * 2010-05-12 2013-04-24 Mapi医药公司 苯甲酸阿格列汀的多晶形物
KR20230051307A (ko) 2010-06-24 2023-04-17 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
JP2012051832A (ja) * 2010-08-31 2012-03-15 Fancl Corp 顆粒組成物及びそれを含有する食品又は医薬品
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
WO2013077825A1 (en) * 2011-11-23 2013-05-30 Mahmut Bilgic Preparation process for a formulation comprising metformin
EP4151218A1 (en) 2012-05-14 2023-03-22 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9750705B2 (en) 2012-08-31 2017-09-05 The Regents Of The University Of California Agents useful for treating obesity, diabetes and related disorders
CN103877054B (zh) * 2012-12-21 2016-05-25 北大方正集团有限公司 一种苯甲酸阿格列汀片剂及其制备方法
EP2769712A1 (en) * 2013-02-21 2014-08-27 Siegfried International AG Pharmaceutical formulation comprising DPP-IV inhibitor agglomerates and DPP-IV inhibitor particles
CN103353491B (zh) * 2013-06-29 2018-11-16 北京万全德众医药生物技术有限公司 一种用液相色谱法分离测定苯甲酸阿格列汀原料及其制剂的方法
JP5922310B2 (ja) * 2013-07-25 2016-05-24 株式会社三和化学研究所 医薬製剤
CN104749269B (zh) * 2013-12-31 2018-12-28 中美华世通生物医药科技（武汉）有限公司 一种利用hplc测定阿格列汀原料药及制剂中对映异构体杂质的方法
CN105527348B (zh) * 2014-09-28 2018-07-24 中美华世通生物医药科技（武汉）有限公司 分离分析苯甲酸阿格列汀制剂及其有关物质的方法
CN104569172A (zh) * 2014-11-05 2015-04-29 广东东阳光药业有限公司 一种用液相色谱检测苯甲酸阿格列汀片溶出度的方法
CN105675733B (zh) * 2014-11-17 2020-01-31 重庆医药工业研究院有限责任公司 一种用液相色谱法分离测定琥珀酸曲格列汀及其光学异构体的方法
PT3227204T (pt) * 2014-12-03 2020-03-26 Caffitaly System Spa Corpo de contenção para fabricar uma cápsula para preparar bebidas e método para fabricar cápsulas com diferentes quantidades de substância alimentar em pó utilizando um único tipo de corpo de contenção
CN107810005B (zh) 2015-06-17 2021-04-20 赫克萨尔股份公司 阿格列汀制剂
US10206923B2 (en) 2015-08-20 2019-02-19 Torrent Pharmaceuticals Limited Pharmaceutical composition of alogliptin and metformin
WO2017033115A1 (en) * 2015-08-21 2017-03-02 Alembic Pharmaceuticals Limited Stable pharmaceutical composition of alogliptin and metformin fixed dose combination
MX390899B (es) 2015-10-30 2025-03-21 Cancer Prevention Pharmaceuticals Inc Formulación de combinación de dosis fija, eflornitina y sulindaco.
WO2017211979A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
CN106008277A (zh) * 2016-06-12 2016-10-12 聊城大学 一种新型二甲双胍盐酸盐及其制备方法
CN106421794A (zh) * 2016-09-27 2017-02-22 黑龙江珍宝岛药业股份有限公司 一种用于治疗ⅱ型糖尿病的药物组合物及其制备方法
CN108318610A (zh) * 2017-12-29 2018-07-24 合肥拓锐生物科技有限公司 一种苯甲酸阿格列汀原料及其制剂中有关物质的分析方法
WO2020013777A2 (en) 2018-04-27 2020-01-16 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Tablet formulations comprising metformin and sitagliptin
CN108743611A (zh) * 2018-06-20 2018-11-06 常州制药厂有限公司 一种复方利血平片的制备方法
WO2020098904A1 (en) 2018-11-12 2020-05-22 Pharmaceutical Oriented Services Ltd Dosage form containing metformin and a dipeptidyl peptidase iv inhibitor
TR201907905A1 (tr) * 2019-05-24 2020-12-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Alogli̇pti̇n ve metformi̇n i̇çeren bi̇r kombi̇nasyon
CN111537622B (zh) * 2019-11-29 2021-11-26 杭州华东医药集团新药研究院有限公司 一种度格列汀及其盐的杂质的检测方法
KR20230051096A (ko) 2021-10-08 2023-04-17 (주)셀트리온 안정성이 개선된 당뇨병 치료용 약학 조성물

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3174901A (en) * 1963-01-31 1965-03-23 Jan Marcel Didier Aron Samuel Process for the oral treatment of diabetes
JPS49110814A (es) * 1973-03-02 1974-10-22
EP0862562B1 (en) 1995-09-13 2001-07-04 Takeda Chemical Industries, Ltd. Benzoxazepine compounds, their production and use as lipid lowering agents
US6803357B1 (en) 1998-02-02 2004-10-12 New England Medical Center Hospitals, Inc. Method of regulating glucose metabolism, and reagents related thereto
DK0974356T3 (da) * 1998-07-15 2003-10-27 Merck Sante Sas Tabletter omfattende en kombination af metformin og glibenclamid
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
RU2280447C2 (ru) 1999-09-17 2006-07-27 Новартис Аг Способ лечения нарушений метаболизма, прежде всего диабета или заболеваний или состояний, связанных с диабетом
US6559188B1 (en) * 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
SK287810B6 (sk) 1999-11-03 2011-10-04 Bristol-Myers Squibb Company Farmaceutický prostriedok obsahujúci nízkodávkovú kombináciu metformínu a glyburidu
EP1285651B1 (en) 2000-04-28 2010-09-01 Takeda Pharmaceutical Company Limited Melanin concentrating hormone antagonists
US6780432B1 (en) 2000-05-01 2004-08-24 Aeropharm Technology, Inc. Core formulation
US6403121B1 (en) * 2000-05-01 2002-06-11 Aeropharm Technology Incorporated Core formulation
AU2001256733A1 (en) 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
AU2002257582A1 (en) * 2001-02-14 2002-09-04 Glaxo Wellcome S.A. Pharmaceutical formulation
US6524618B1 (en) * 2001-06-12 2003-02-25 Vijai Kumar Directly compressible extended-release matrix formulation for metformin hydrochloride
WO2003007951A1 (en) 2001-07-17 2003-01-30 N-Gene Research Laboratories Inc. A synergistic pharmaceutical combination for the prevention or treatment of diabetes
EP1435931A2 (en) 2001-09-28 2004-07-14 Sun Pharmaceuticals Industries Ltd. Dosage form for treatment of diabetes mellitus
US20030187074A1 (en) * 2002-03-04 2003-10-02 Javed Hussain Oral compositions for treatment of diabetes
US20030224046A1 (en) * 2002-06-03 2003-12-04 Vinay Rao Unit-dose combination composition for the simultaneous delivery of a short-acting and a long-acting oral hypoglycemic agent
US20040125143A1 (en) 2002-07-22 2004-07-01 Kenneth Deaton Display system and method for displaying a multi-dimensional file visualizer and chooser
US20050176622A1 (en) 2002-09-18 2005-08-11 Kerstin Kuhn-Wache Secondary binding site of dipeptidyl peptidase IV (DPIV)
US20060094722A1 (en) * 2002-09-26 2006-05-04 Eisai Co., Ltd. Combination drug
UA80991C2 (en) * 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
EP1635832A2 (en) 2003-06-06 2006-03-22 Merck & Co., Inc. Combination therapy for the treatment of diabetes
MXPA06001601A (es) 2003-08-13 2006-08-25 Takeda Pharmaceutical Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa.
RU2367423C2 (ru) * 2003-12-19 2009-09-20 ОМЕГА БИО-ФАРМА (Ай.Пи. 3) ЛИМИТЕД Композиции и способы для лечения диабета
CN102127057A (zh) 2004-03-15 2011-07-20 武田药品工业株式会社 二肽基肽酶抑制剂
KR100760430B1 (ko) * 2004-12-31 2007-10-04 한미약품 주식회사 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법
MXPA05009633A (es) * 2005-09-08 2007-03-07 Silanes Sa De Cv Lab Composicion farmaceutica estable de glimepirida de liberacion inmediata y metformina de liberacion prolongada.
SI1931350T2 (sl) 2005-09-14 2021-11-30 Takeda Pharmaceutical Company Limited Uporaba inhibitorjev dipeptidil peptidaze
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
US8414921B2 (en) 2005-12-16 2013-04-09 Merck Sharp & Dohme Corp. Pharmaceutical compositions of combinations of dipeptidyl peptidase-4 inhibitors with metformin
GB0526291D0 (en) 2005-12-23 2006-02-01 Prosidion Ltd Therapeutic method
MEP7609A (en) * 2005-12-28 2011-12-20 Therapeutic agent for diabetes
RU2333760C2 (ru) 2006-05-16 2008-09-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Твердая дозированная лекарственная форма для лечения сахарного диабета
TW200826936A (en) * 2006-12-01 2008-07-01 Merck Frosst Canada Ltd Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
AR065096A1 (es) * 2007-02-01 2009-05-13 Takeda Pharmaceutical Preparacion solida
ME01239B (me) * 2007-02-01 2013-06-20 Takeda Pharmaceuticals Co Čvrsti preparat koji sadrži alogliptin i pioglitazon
AR067557A1 (es) * 2007-07-19 2009-10-14 Takeda Pharmaceutical Preparacion solida y metodo de preparacion
RU2380097C1 (ru) 2009-01-20 2010-01-27 Общество с ограниченной ответственностью "ИТЭРА" Твердая дозированная лекарственная форма для лечения сахарного диабета

Also Published As

Publication number Publication date
JP2010533643A (ja) 2010-10-28
WO2009011451A1 (en) 2009-01-22
AU2008276842C1 (en) 2013-11-28
EP2185138A1 (en) 2010-05-19
IL203171A (en) 2016-11-30
PE20090882A1 (es) 2009-08-03
CN101801351A (zh) 2010-08-11
EP2185138B1 (en) 2016-09-07
MY159203A (en) 2016-12-30
AU2008276842C9 (en) 2014-08-21
CN101801351B (zh) 2012-12-12
AU2008276842A1 (en) 2009-01-22
KR20100036367A (ko) 2010-04-07
CA2694620A1 (en) 2009-01-22
TN2010000019A1 (en) 2011-09-26
ZA201000831B (en) 2011-04-28
ECSP109979A (es) 2010-03-31
JO3272B1 (ar) 2018-09-16
BRPI0814299B8 (pt) 2021-05-25
NZ583346A (en) 2012-02-24
EA201070164A1 (ru) 2010-08-30
GEP20125672B (en) 2012-10-25
CO6160301A2 (es) 2010-05-20
TWI421102B (zh) 2014-01-01
CA2694620C (en) 2016-05-31
MA31592B1 (fr) 2010-08-02
JP5479318B2 (ja) 2014-04-23
CR11267A (es) 2010-05-03
BRPI0814299A2 (pt) 2015-02-03
ES2603879T3 (es) 2017-03-01
JP2014058547A (ja) 2014-04-03
US8900638B2 (en) 2014-12-02
US20100136127A1 (en) 2010-06-03
BRPI0814299B1 (pt) 2018-12-18
EA020870B1 (ru) 2015-02-27
DOP2010000028A (es) 2010-02-15
US20110014299A2 (en) 2011-01-20
TW200914066A (en) 2009-04-01
PE20140923A1 (es) 2014-08-11
AU2008276842B2 (en) 2013-07-04
UA98799C2 (ru) 2012-06-25
KR101536786B1 (ko) 2015-07-14

Similar Documents

Publication Publication Date Title
AR067557A1 (es) Preparacion solida y metodo de preparacion
IL280401A (en) Saline suppressor Janus kinas (R) - 3- (4- (H7-pyrrolo [D - 2,3] pyrimidin-4-yl) -1H-pyrazole-1-yl) -3-cyclopentylpropananitrile
CY1114925T1 (el) Χορηγηση αναστολεων διπεπτιδυλοπεπτιδασης
BRPI0812563A2 (pt) Metabólitos do inibidor de janus quinase de (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3 ciclopentilpropanonitrila
HRP20110094T8 (en) Solid preparation comprising alogliptin and pioglitazone
IS2779B (is) Tafla með breyttan losunarhraða á búprópíónhýdróklóríði
DK1838718T3 (da) Pyrrolopyrazoler, potente kinase inhibitorer
TW200736195A (en) Methods for preparing sulfonamide substituted alcohols and intermediates thereof
NO20081700L (no) Lagringsmedium for konfidensiell informasjon
NO20044727D0 (no) Enhet for informasjonsdisplay med diskontinuerlig virkende holdeinnsatser
JP2007055207A5 (es)
DK1720852T3 (da) Fremgangsmåde til fremstilling af enantiomerrene 1-substituerede 3-aminoalkoholer
ES2571834T3 (es) Alquilsulfonamida quinolinas
DE602005012164D1 (de) Magnetisches Aufzeichnungsmittel
DE50210860D1 (de) Abspielgerät für speichermedien
DE602005015338D1 (de) Hologramm-wiedergabekopf
DE602005003623D1 (de) Magnetisches Aufzeichnungsmittel
ITBO20020759A1 (it) Procedimento per lo stoccaggio di informazione ad
TH114424A (th) สารเตรียมชนิดของแข็ง
UA11437S (uk) Футляр для дискових носіїв інформації
ITMO20040341A1 (it) Apparato valvolare.
BR8101156Y1 (pt) disposição construtiva introduzida no suporte para o estudo do campo magnético.
DE602005008061D1 (de) Kinaseinhibitoren
ITTV20050022A1 (it) Supporto per manico di violini piccoli.
SE0402858D0 (sv) Lagring av media

Legal Events

Date Code Title Description
FC Refusal