DK1838718T3 - Pyrrolopyrazoler, potente kinase inhibitorer - Google Patents

Pyrrolopyrazoler, potente kinase inhibitorer

Info

Publication number: DK1838718T3
Authority: DK; Denmark
Prior art keywords: pyrrolopyrazoles; kinase inhibitors; potent kinase; potent; inhibitors
Prior art date: 2005-01-10

Application number

DK05850734.4T

Other languages

English (en)

Inventor

Djamal Bouzida

Liming Dong

Chuangxing Guo

Yufeng Hong

Haitao Li

Joseph T Marakovits

Anle Yang

Junhu Zhang

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-10

Filing date

2005-12-28

Publication date

2011-07-25

2005-12-28 Application filed by Pfizer filed Critical Pfizer

2011-07-25 Application granted granted Critical

2011-07-25 Publication of DK1838718T3 publication Critical patent/DK1838718T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Enzymes And Modification Thereof (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

DK05850734.4T 2005-01-10 2005-12-28 Pyrrolopyrazoler, potente kinase inhibitorer DK1838718T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US64290005P	2005-01-10	2005-01-10
US73377005P	2005-11-04	2005-11-04
PCT/IB2005/003975 WO2006072831A1 (en)	2005-01-10	2005-12-28	Pyrrolopyrazoles, potent kinase inhibitors

Publications (1)

Publication Number	Publication Date
DK1838718T3 true DK1838718T3 (da)	2011-07-25

Family

ID=36463340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05850734.4T DK1838718T3 (da)	2005-01-10	2005-12-28	Pyrrolopyrazoler, potente kinase inhibitorer

Country Status (29)

Country	Link
US (2)	US8067591B2 (da)
EP (1)	EP1838718B1 (da)
JP (1)	JP4250195B2 (da)
KR (1)	KR100919343B1 (da)
CN (1)	CN101115760B (da)
AP (1)	AP2007004061A0 (da)
AT (1)	ATE512972T1 (da)
AU (1)	AU2005323797B2 (da)
BR (1)	BRPI0518509A2 (da)
CA (1)	CA2593428C (da)
CU (1)	CU23778B7 (da)
CY (1)	CY1111752T1 (da)
DK (1)	DK1838718T3 (da)
EA (1)	EA011815B1 (da)
ES (1)	ES2365245T3 (da)
GE (1)	GEP20094785B (da)
HR (1)	HRP20110485T1 (da)
IL (1)	IL184275A0 (da)
MA (1)	MA29141B1 (da)
MX (1)	MX2007008385A (da)
NO (1)	NO20073859L (da)
NZ (1)	NZ556273A (da)
PL (1)	PL1838718T3 (da)
PT (1)	PT1838718E (da)
RS (1)	RS51891B (da)
SI (1)	SI1838718T1 (da)
TN (1)	TNSN07254A1 (da)
WO (1)	WO2006072831A1 (da)
ZA (1)	ZA200705628B (da)

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KR101060892B1 (ko) *	2007-02-07	2011-08-31	화이자 인코포레이티드	Ｐｋｃ 억제제로서의 3-아미노-피롤로[3,4-ｃ] 피라졸-5(1ｈ,4ｈ,6ｈ) 카브알데하이드 유도체
UA96618C2 (en) *	2007-02-07	2011-11-25	Пфайзер Инк.	3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors
EP2195321B1 (en) *	2007-04-12	2016-10-19	Pfizer Inc.	3-amido-pyrrolo[3,4-c]pyrazole-5(1h, 4h,6h) carbaldehyde derivatives as inhibitors of protein kinase c
KR20100038108A (ko) *	2007-07-25	2010-04-12	브리스톨-마이어스 스큅 컴퍼니	트리아진 키나제 억제제
FR2928150A1 (fr)	2008-02-29	2009-09-04	Vetoquinol Sa Sa	Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
JPWO2009130900A1 (ja) *	2008-04-24	2011-08-11	日本曹達株式会社	オキシム誘導体、中間体化合物および植物病害防除剤
EP2145891A1 (en)	2008-07-09	2010-01-20	Vetoquinol S.A.	9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
WO2011044264A2 (en) *	2009-10-06	2011-04-14	Afraxis, Inc.	Pyrrolopyrazoles for treating cns disorders
KR101483215B1 (ko)	2010-01-29	2015-01-16	한미약품 주식회사	단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
EP2640369A1 (en)	2010-11-17	2013-09-25	F.Hoffmann-La Roche Ag	Methods of treating tumors
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WO2013113781A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds i
WO2013113776A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113791A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113716A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113778A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113782A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113719A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds ii
EP2825533B1 (en)	2012-03-13	2016-10-19	Basf Se	Fungicidal pyrimidine compounds
WO2013135672A1 (en)	2012-03-13	2013-09-19	Basf Se	Fungicidal pyrimidine compounds
CN104168898A (zh) *	2012-03-16	2014-11-26	霍夫曼-拉罗奇有限公司	以pak1抑制剂治疗黑色素瘤的方法
JP6186440B2 (ja)	2012-09-19	2017-08-23	ノバルティスアーゲー	キナーゼ阻害剤としてのジヒドロピロリジノピリミジン
DK2906555T3 (da) *	2012-10-15	2017-02-06	Pfizer Ireland Pharmaceuticals	Fremgangsmåde til fremstilling af voriconazol og analoger deraf
CA2923101A1 (en)	2013-09-16	2015-03-19	Basf Se	Fungicidal pyrimidine compounds
WO2015036059A1 (en)	2013-09-16	2015-03-19	Basf Se	Fungicidal pyrimidine compounds
EP3236959B1 (en)	2014-12-23	2025-09-24	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (cdk7)
CA2978518C (en)	2015-03-27	2023-11-21	Nathanael S. Gray	Inhibitors of cyclin-dependent kinases
CN107735401B (zh)	2015-06-15	2021-08-31	宇部兴产株式会社	取代二氢吡咯并吡唑衍生物
CN104926735A (zh) *	2015-06-16	2015-09-23	上海合全药物研发有限公司	4-氯-5-氟-2-甲基嘧啶的工业化制备方法
AU2016378723B2 (en)	2015-12-22	2021-09-30	SHY Therapeutics LLC	Compounds for the treatment of cancer and inflammatory disease
WO2017144546A1 (en)	2016-02-23	2017-08-31	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
JP7258748B2 (ja)	2016-11-22	2023-04-17	ダナ－ファーバーキャンサーインスティテュート，インコーポレイテッド	サイクリン依存性キナーゼ１２（ｃｄｋ１２）の阻害剤およびその使用
MA49458A (fr)	2017-06-21	2020-04-29	SHY Therapeutics LLC	Composés interagissant avec la superfamille ras destinés à être utilisés dans le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladies fibrotiques
EP3781168A4 (en) *	2018-04-16	2022-10-05	The Regents of the University of California	PAK4 INHIBITORS AND METHODS OF USE
WO2020005807A1 (en)	2018-06-25	2020-01-02	Dana-Farber Cancer Institute, Inc.	Taire family kinase inhibitors and uses thereof
EP3898609A1 (en)	2018-12-19	2021-10-27	Shy Therapeutics LLC	Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
EP3902542A4 (en) *	2018-12-28	2022-09-07	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof
US20220220480A1 (en)	2019-04-17	2022-07-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
EP4073102A4 (en)	2019-12-12	2024-05-08	Ting Therapeutics LLC	Compositions and methods for the prevention and treatment of hearing loss
WO2021198511A1 (en)	2020-04-03	2021-10-07	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for treatment of sars-cov-2 infection
CN111454278B (zh) *	2020-05-15	2021-03-19	四川大学	Pak1抑制剂及其合成和在制备抗肿瘤药物中的应用
WO2022008597A1 (en)	2020-07-08	2022-01-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical composition for the treatment of infectious diseases
KR20230128085A (ko) *	2020-12-31	2023-09-01	시노허브 파마슈티컬 씨오., 엘티디	플라스민 억제제, 이를 제조하는 방법 및 이의 용도
WO2024261302A1 (en)	2023-06-22	2024-12-26	Institut National de la Santé et de la Recherche Médicale	Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders
WO2025078334A1 (en)	2023-10-09	2025-04-17	Institut National de la Santé et de la Recherche Médicale	Combination of pak1 inhibitors and clk inhibitors for preventing resistance to chemotherapy in patients suffering from acute myeloid leukemia

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2005
- 2005-12-28 KR KR1020077018110A patent/KR100919343B1/ko not_active Expired - Fee Related
- 2005-12-28 ES ES05850734T patent/ES2365245T3/es active Active
- 2005-12-28 CN CN2005800480012A patent/CN101115760B/zh not_active Expired - Fee Related
- 2005-12-28 WO PCT/IB2005/003975 patent/WO2006072831A1/en not_active Ceased
- 2005-12-28 AT AT05850734T patent/ATE512972T1/de active
- 2005-12-28 PT PT05850734T patent/PT1838718E/pt unknown
- 2005-12-28 PL PL05850734T patent/PL1838718T3/pl unknown
- 2005-12-28 AP AP2007004061A patent/AP2007004061A0/xx unknown
- 2005-12-28 US US11/813,658 patent/US8067591B2/en not_active Expired - Fee Related
- 2005-12-28 EA EA200701257A patent/EA011815B1/ru not_active IP Right Cessation
- 2005-12-28 MX MX2007008385A patent/MX2007008385A/es active IP Right Grant
- 2005-12-28 JP JP2007549962A patent/JP4250195B2/ja not_active Expired - Fee Related
- 2005-12-28 NZ NZ556273A patent/NZ556273A/en not_active IP Right Cessation
- 2005-12-28 AU AU2005323797A patent/AU2005323797B2/en not_active Ceased
- 2005-12-28 DK DK05850734.4T patent/DK1838718T3/da active
- 2005-12-28 EP EP05850734A patent/EP1838718B1/en active Active
- 2005-12-28 SI SI200531320T patent/SI1838718T1/sl unknown
- 2005-12-28 RS RS20110352A patent/RS51891B/sr unknown
- 2005-12-28 HR HR20110485T patent/HRP20110485T1/hr unknown
- 2005-12-28 GE GEAP200510173A patent/GEP20094785B/en unknown
- 2005-12-28 CA CA2593428A patent/CA2593428C/en not_active Expired - Fee Related
- 2005-12-28 BR BRPI0518509-2A patent/BRPI0518509A2/pt not_active Application Discontinuation
2007
- 2007-06-28 IL IL184275A patent/IL184275A0/en unknown
- 2007-07-04 TN TNP2007000254A patent/TNSN07254A1/en unknown
- 2007-07-09 CU CU20070160A patent/CU23778B7/es not_active IP Right Cessation
- 2007-07-09 ZA ZA200705628A patent/ZA200705628B/xx unknown
- 2007-07-10 MA MA30059A patent/MA29141B1/fr unknown
- 2007-07-23 NO NO20073859A patent/NO20073859L/no not_active Application Discontinuation
2011
- 2011-07-20 CY CY20111100716T patent/CY1111752T1/el unknown
- 2011-10-06 US US13/267,302 patent/US8530652B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MA29141B1 (fr)	2008-01-02
PT1838718E (pt)	2011-08-17
CU23778B7 (es)	2012-02-15
US8067591B2 (en)	2011-11-29
BRPI0518509A2 (pt)	2008-11-25
HRP20110485T1 (hr)	2011-07-31
NO20073859L (no)	2007-10-03
HK1114380A1 (en)	2008-10-31
US20120264751A1 (en)	2012-10-18
CA2593428A1 (en)	2006-07-13
JP4250195B2 (ja)	2009-04-08
EP1838718A1 (en)	2007-10-03
EA200701257A1 (ru)	2007-12-28
IL184275A0 (en)	2007-10-31
CA2593428C (en)	2012-04-17
EA011815B1 (ru)	2009-06-30
WO2006072831A1 (en)	2006-07-13
PL1838718T3 (pl)	2011-10-31
NZ556273A (en)	2010-01-29
AU2005323797B2 (en)	2009-07-09
KR100919343B1 (ko)	2009-09-25
EP1838718B1 (en)	2011-06-15
US8530652B2 (en)	2013-09-10
US20100222342A1 (en)	2010-09-02
JP2008526826A (ja)	2008-07-24
TNSN07254A1 (en)	2008-12-31
CN101115760B (zh)	2010-11-03
AU2005323797A1 (en)	2006-07-13
SI1838718T1 (sl)	2011-08-31
KR20070096007A (ko)	2007-10-01
MX2007008385A (es)	2007-08-21
ES2365245T3 (es)	2011-09-27
CU20070160A7 (es)	2009-03-16
CN101115760A (zh)	2008-01-30
CY1111752T1 (el)	2015-10-07
AP2007004061A0 (en)	2007-08-31
ZA200705628B (en)	2008-11-26
GEP20094785B (en)	2009-09-25
RS51891B (sr)	2012-02-29
ATE512972T1 (de)	2011-07-15

Publication	Publication Date	Title
DK1838718T3 (da)	2011-07-25	Pyrrolopyrazoler, potente kinase inhibitorer
CY2021013I1 (el)	2021-10-15	Δι-αρυλ μετα-πυριμιδινο αναστολεις κινασων
DK1979356T3 (da)	2013-11-18	Carbonylaminopyrrolopyrazoler, kraftige kinaseinhibitorer
DK1704145T3 (da)	2012-09-24	Selektive kinaseinhibitorer
DK1926722T3 (da)	2011-12-19	Substituerede benzimidazoler som kinaseinhibitorer
EP2015752A4 (en)	2010-03-31	P13 Kinase Antagonists
NO20082514L (no)	2008-07-18	Aminopyrimidiner anvendelige som kinaseinhibitorer
ATE518860T1 (de)	2011-08-15	Pyrroloä2,3-büpyridinderivate als proteinkinaseinhibitoren
IL190078A0 (en)	2008-08-07	Kinase inhibitors
NL1031741A1 (nl)	2006-11-07	Purinederivaten.
DK1846394T3 (da)	2012-01-16	Pyrazolylaminopyridinderivater, der er egnede som kinaseinhibitorer
AP2006003659A0 (en)	2006-06-30	Azabenzofuran substituted thioureas, inhibitors ofviral replication
DK1704797T3 (da)	2011-11-21	Arbejdsbord
EP1893607A4 (en)	2010-07-21	CHECKPOINT KINASE INHIBITORS
DK2035385T3 (da)	2010-03-22	Inhibitorer af akt (proteinkinase B)
ATE493403T1 (de)	2011-01-15	Kinaseinhibitoren
DE112005003586A5 (de)	2008-03-06	Bohrfutter
ATE433449T1 (de)	2009-06-15	Kinaseinhibitoren
ATE520664T1 (de)	2011-09-15	Tyrosinkinase-hemmer
BRPI0719883A2 (pt)	2015-05-05	Inibidores de quinase
ITMI20050051A1 (it)	2006-07-19	Fotodiodio organico di poli-9,9-diottil-fluorene
ZA200804667B (en)	2010-05-26	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
DE602006019301D1 (de)	2011-02-10	Kinaseinhibitoren
DE602005008061D1 (de)	2008-08-21	Kinaseinhibitoren
ZA200803287B (en)	2009-10-28	Kinase inhibitors