AR066345A1 - Glucopeptidos semisinteticos con actividad antibacteriana - Google Patents

Glucopeptidos semisinteticos con actividad antibacteriana

Info

Publication number: AR066345A1
Authority: AR; Argentina
Prior art keywords: amino; compounds; groups; amino acid; antibacterial activity
Prior art date: 2007-05-08

Application number

ARP080101809A

Other languages

English (en)

Spanish (es)

Original Assignee

Lead Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-08

Filing date

2008-04-29

Publication date

2009-08-12

2008-04-29 Application filed by Lead Therapeutics Inc filed Critical Lead Therapeutics Inc

2009-08-12 Publication of AR066345A1 publication Critical patent/AR066345A1/es

Links

230000000844 anti-bacterial effect Effects 0.000 title abstract 2
102000002068 Glycopeptides Human genes 0.000 abstract 4
108010015899 Glycopeptides Proteins 0.000 abstract 4
125000003277 amino group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
150000002772 monosaccharides Chemical class 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
208000035143 Bacterial infection Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000002016 disaccharides Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000002336 glycosamine derivatives Chemical class 0.000 abstract 1
150000002337 glycosamines Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

ARP080101809A 2007-05-08 2008-04-29 Glucopeptidos semisinteticos con actividad antibacteriana AR066345A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US91670107P	2007-05-08	2007-05-08

Publications (1)

Publication Number	Publication Date
AR066345A1 true AR066345A1 (es)	2009-08-12

Family

ID=39494067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP080101809A AR066345A1 (es)	2007-05-08	2008-04-29	Glucopeptidos semisinteticos con actividad antibacteriana

Country Status (4)

Country	Link
AR (1)	AR066345A1 (fr)
GB (1)	GB2449156B8 (fr)
TW (1)	TW200848062A (fr)
WO (1)	WO2008140973A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010048340A2 (fr) *	2008-10-24	2010-04-29	Lead Therapeutics, Inc.	Nouveaux glycopeptides semi-synthétiques en tant qu'agents antibactériens
GB2465863A (en) *	2008-12-05	2010-06-09	Lead Therapeutics Inc	Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
WO2011140009A1 (fr) *	2010-05-04	2011-11-10	Biomarin Pharmaceutical Inc.	Procédés d'utilisation de glycopeptides semi-synthétiques en tant qu'agents antibactériens
CN105585617A (zh) *	2016-03-24	2016-05-18	中国医学科学院医药生物技术研究所	去甲万古霉素衍生物及其制备纯化方法
WO2018102890A1 (fr) *	2016-12-09	2018-06-14	The University Of Queensland	Constructions de visualisation
CN110312518A (zh) *	2016-12-09	2019-10-08	昆士兰大学	糖蛋白抗生物素构建体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0273727A3 (fr) *	1986-12-30	1990-01-17	Smithkline Beecham Corporation	Glycopeptides glycosyle's
CA1339808C (fr) *	1988-10-19	1998-04-07	Manuel Debono	Antibiotiques aux glycopeptides
EP1095058A4 (fr) *	1998-07-14	2003-07-16	Univ Princeton	Antibiotiques glycopeptidiques, bibliotheques combinatoires d'antibiotiques glycopeptidiques, et procedes de production correspondants
WO2003070756A2 (fr) *	2002-02-18	2003-08-28	Combinature Biopharm Ag	Nouveaux antibiotiques glycopeptidiques et leur procede de synthese
EP1534316A2 (fr) *	2002-08-30	2005-06-01	K.U. Leuven Research and Development	Antibiotiques glycopeptidiques, leurs derrives semi-synthetiques et leur utilisation tant qu'agent antiviral
JP4330169B2 (ja) *	2004-11-29	2009-09-16	国立大学法人名古屋大学	グリコペプチド抗生物質モノマー誘導体
US7368422B2 (en) *	2005-02-28	2008-05-06	Novartis Vaccines And Diagnostics Inc.	Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity

2008
- 2008-04-23 GB GB0807351A patent/GB2449156B8/en not_active Expired - Fee Related
- 2008-04-25 TW TW097115488A patent/TW200848062A/zh unknown
- 2008-04-29 AR ARP080101809A patent/AR066345A1/es not_active Application Discontinuation
- 2008-05-02 WO PCT/US2008/062483 patent/WO2008140973A1/fr not_active Ceased

Also Published As

Publication number	Publication date
HK1125114A1 (zh)	2009-07-31
GB0807351D0 (en)	2008-05-28
WO2008140973A1 (fr)	2008-11-20
GB2449156B (en)	2010-04-28
GB2449156A (en)	2008-11-12
GB2449156B8 (en)	2010-06-02
TW200848062A (en)	2008-12-16

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Legal Events

Date	Code	Title	Description
2014-12-03	FA	Abandonment or withdrawal