AR065873A1 - Procedimiento para preparar derivados porfirina tales como protoporfirina (ix) y sintesis de intermediarios - Google Patents
Procedimiento para preparar derivados porfirina tales como protoporfirina (ix) y sintesis de intermediariosInfo
- Publication number
- AR065873A1 AR065873A1 ARP080101296A ARP080101296A AR065873A1 AR 065873 A1 AR065873 A1 AR 065873A1 AR P080101296 A ARP080101296 A AR P080101296A AR P080101296 A ARP080101296 A AR P080101296A AR 065873 A1 AR065873 A1 AR 065873A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- formula
- propyl
- protoporphirine
- intermediaries
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000004033 porphyrin derivatives Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- PBTPREHATAFBEN-UHFFFAOYSA-N dipyrromethane Chemical compound C=1C=CNC=1CC1=CC=CN1 PBTPREHATAFBEN-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 150000004032 porphyrins Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Reivindicacion 1: Un procedimiento para preparar una porfirina de formula (1), opcionalmente en la forma de una sal, en la cual: R es un átomo de hidrogeno o un grupo seleccionado de: -CH=CH2, -CH2-CH3, -CH(OH)CH3, -C(O)CH3 y -CH2CH2COOR'a, dondeR'a es un átomo de hidrogeno o un grupo metilo, etilo, n-propilo o i-propilo, R' es un átomo de hidrogeno o un grupo R'b seleccionado entre metilo, etilo, n-propilo o i-propilo, que comprende: una etapa de condensacion, en un medio ácido, entre undipirrometano de formula (2) en la cual R'b es tal como se ha definido anteriormente para (1), y un dipirrometano de formula (3): en la cual Rö es R tal como se ha definido anteriormente para (1) o un grupo que es un precursor de R, de manera deformar la porfirina de formula (4): en la cual Rö y R'b son tal como se ha definido anteriormente para (2) y (3) seguido de: cuando Rö es distinto de R, mediante conversion del grupo Rö a R, cuando R'=H, mediante eliminacion del grupo R'b de manerade formar una funcion -COOH, opcionalmente en la forma de una sal. Reivindicacion 34: Un compuesto seleccionado de los compuestos de formulas (5), (6) y (7).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0702334A FR2914302A1 (fr) | 2007-03-30 | 2007-03-30 | Procede de preparation de derives de porphyrine, telle que la protoporphyrine (ix) et intermediaire de synthese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065873A1 true AR065873A1 (es) | 2009-07-08 |
Family
ID=38722680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101296A AR065873A1 (es) | 2007-03-30 | 2008-03-28 | Procedimiento para preparar derivados porfirina tales como protoporfirina (ix) y sintesis de intermediarios |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8026358B2 (es) |
| EP (1) | EP2142501B1 (es) |
| JP (1) | JP5427169B2 (es) |
| KR (1) | KR101496216B1 (es) |
| CN (2) | CN103641763A (es) |
| AR (1) | AR065873A1 (es) |
| AU (1) | AU2008252764B2 (es) |
| BR (1) | BRPI0809942B8 (es) |
| CA (1) | CA2680264C (es) |
| FR (1) | FR2914302A1 (es) |
| IL (1) | IL200214A (es) |
| MX (1) | MX2009008802A (es) |
| TW (1) | TWI428341B (es) |
| WO (1) | WO2008142250A2 (es) |
| ZA (1) | ZA200905953B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007307111B2 (en) | 2006-10-04 | 2012-03-08 | Mallinckrodt Hospital Products IP Limited | High-purity large-scale preparation of stannsoporfin |
| PT2691398T (pt) | 2011-03-30 | 2017-01-02 | Infacare Pharmaceutical Corp | Métodos para sintetizar mesoporfirinas de metal |
| CN102697182B (zh) * | 2012-06-15 | 2014-07-30 | 川渝中烟工业有限责任公司 | 一种降低卷烟烟气中氨的滤嘴添加剂制备方法及应用 |
| FR2992656B1 (fr) * | 2012-07-02 | 2016-10-07 | Sanofi Pasteur | Procede de production d'antigenes haemophilus influenzae type b |
| KR101894575B1 (ko) * | 2017-01-03 | 2018-09-04 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 화학적 방법 |
| KR20180079846A (ko) * | 2017-01-03 | 2018-07-11 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 생물학적 방법 |
| KR102429286B1 (ko) * | 2017-01-03 | 2022-08-04 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 생물학적 방법 |
| CN108822144B (zh) * | 2018-08-16 | 2020-01-21 | 湖南师范大学 | 氟硼扩环卟啉化合物、芳香性或反芳香性扩环卟啉化合物及合成方法 |
| JP2024528092A (ja) * | 2021-08-11 | 2024-07-26 | ビリックス カンパニー リミテッド | ビリルビンの合成方法 |
| CN114790161B (zh) * | 2022-05-16 | 2023-12-01 | 百顺药业有限公司 | 4-甲氧基羰基乙基-3-甲基-2-吡咯醛的合成方法及其中间体 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675338A (en) * | 1984-07-18 | 1987-06-23 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| JPS61186385A (ja) * | 1985-02-13 | 1986-08-20 | Sato Yakugaku Kenkyusho:Kk | デユウテロポルフイリン誘導体及びその塩 |
| JPH01203385A (ja) * | 1988-02-08 | 1989-08-16 | Tosoh Corp | プロトポルフィリンジエステルの製造方法 |
| US5659029A (en) * | 1995-12-22 | 1997-08-19 | Sun Company, Inc. (R&M) | Preparation of porphyrins and their metal complexes |
| WO1998033503A1 (en) * | 1997-02-05 | 1998-08-06 | Board Of Regents, The University Of Texas System | Porphyrin compounds as telomerase inhibitors |
| WO2000041689A1 (en) * | 1999-01-12 | 2000-07-20 | Kyowa Hakko Kogyo Co., Ltd. | Telomerase inhibitors |
| US6827926B2 (en) * | 2001-05-31 | 2004-12-07 | Miravant Pharmaceuticals, Inc. | Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy |
| CN1418880A (zh) * | 2001-11-14 | 2003-05-21 | 上海金赤生物制品有限公司 | 一种原卟啉二钠盐的制备方法 |
| CN1193034C (zh) * | 2001-11-14 | 2005-03-16 | 上海金赤生物制品有限公司 | 一种铁卟啉钠盐的制备方法 |
| CN1238355C (zh) * | 2003-11-21 | 2006-01-25 | 湖南大学 | 一种金属卟啉的合成方法 |
| CA2573927A1 (en) * | 2004-07-15 | 2006-01-19 | The University Of Sydney | Porphyrin linked metronidazole against gum disease: porphyromonas gingivalis |
-
2007
- 2007-03-30 FR FR0702334A patent/FR2914302A1/fr not_active Ceased
-
2008
- 2008-03-21 TW TW097110238A patent/TWI428341B/zh active
- 2008-03-28 AR ARP080101296A patent/AR065873A1/es unknown
- 2008-03-28 US US12/057,574 patent/US8026358B2/en active Active
- 2008-03-31 CA CA2680264A patent/CA2680264C/en active Active
- 2008-03-31 WO PCT/FR2008/000440 patent/WO2008142250A2/fr not_active Ceased
- 2008-03-31 CN CN201310576677.5A patent/CN103641763A/zh active Pending
- 2008-03-31 KR KR20097019733A patent/KR101496216B1/ko active Active
- 2008-03-31 BR BRPI0809942A patent/BRPI0809942B8/pt active IP Right Grant
- 2008-03-31 CN CN2008800099274A patent/CN101657420B/zh active Active
- 2008-03-31 JP JP2010501549A patent/JP5427169B2/ja active Active
- 2008-03-31 EP EP08787880.7A patent/EP2142501B1/fr active Active
- 2008-03-31 AU AU2008252764A patent/AU2008252764B2/en active Active
- 2008-03-31 MX MX2009008802A patent/MX2009008802A/es active IP Right Grant
-
2009
- 2009-08-03 IL IL200214A patent/IL200214A/en active IP Right Grant
- 2009-08-27 ZA ZA2009/05953A patent/ZA200905953B/en unknown
-
2011
- 2011-08-25 US US13/218,149 patent/US8420805B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010523532A (ja) | 2010-07-15 |
| BRPI0809942B1 (pt) | 2020-09-24 |
| WO2008142250A2 (fr) | 2008-11-27 |
| AU2008252764A1 (en) | 2008-11-27 |
| EP2142501B1 (fr) | 2014-10-08 |
| WO2008142250A3 (fr) | 2009-04-16 |
| KR101496216B1 (ko) | 2015-02-26 |
| US20080242857A1 (en) | 2008-10-02 |
| BRPI0809942B8 (pt) | 2021-05-25 |
| KR20090127139A (ko) | 2009-12-09 |
| BRPI0809942A2 (pt) | 2014-10-07 |
| MX2009008802A (es) | 2009-08-25 |
| CA2680264A1 (en) | 2008-11-27 |
| CA2680264C (en) | 2016-08-16 |
| FR2914302A1 (fr) | 2008-10-03 |
| TWI428341B (zh) | 2014-03-01 |
| CN101657420A (zh) | 2010-02-24 |
| US20110306761A1 (en) | 2011-12-15 |
| TW200902536A (en) | 2009-01-16 |
| US8026358B2 (en) | 2011-09-27 |
| IL200214A0 (en) | 2010-04-29 |
| CN101657420B (zh) | 2013-12-18 |
| AU2008252764B2 (en) | 2013-10-31 |
| ZA200905953B (en) | 2010-11-24 |
| EP2142501A2 (fr) | 2010-01-13 |
| JP5427169B2 (ja) | 2014-02-26 |
| IL200214A (en) | 2015-06-30 |
| US8420805B2 (en) | 2013-04-16 |
| CN103641763A (zh) | 2014-03-19 |
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Legal Events
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| FB | Suspension of granting procedure |