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AR064353A1 - Compuestos y composiciones como inhibidores de la actividad del receptor cannabinoide 1. procesos de obtencion. - Google Patents

Compuestos y composiciones como inhibidores de la actividad del receptor cannabinoide 1. procesos de obtencion.

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Publication number
AR064353A1
AR064353A1 ARP070105623A ARP070105623A AR064353A1 AR 064353 A1 AR064353 A1 AR 064353A1 AR P070105623 A ARP070105623 A AR P070105623A AR P070105623 A ARP070105623 A AR P070105623A AR 064353 A1 AR064353 A1 AR 064353A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
halo
alkoxy
aryl
Prior art date
Application number
ARP070105623A
Other languages
English (en)
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of AR064353A1 publication Critical patent/AR064353A1/es

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    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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Abstract

La presente provee composiciones farmacéuticas que comprenden tales compuestos.y métodos para utilizar dichos compuestos para tratar o prevenir enfermedades o trastornos asociados con la actividad del Receptor Cannabinoide 1 (CB1). Procesos de obtencion. Reivindicacion 1: Un compuesto de Formula (1): en la cual: Y1 se selecciona de N y CR11; Y2 se selecciona de N y CR8; Z1 se selecciona de S, O, NH, CH-NO2, NS(O)2NH2, NC(O)NH2, NS(O)2CH3, N(OH) y N(CN); o C=Z1 de Formula 1 se reemplaza con CH2 o S(O)2; Z2 se selecciona de O, -CH2CHR1a-, -OCHR1a-, -CR1aR1b y -NR1a; R1a se selecciona de hidrogeno, ciano, alquilo C1-6, alquilo C1-6 ciano-sustituido, alquenilo C2-6, -X1R12, -X1NR13S(O)2R13, -X1OS(O)2R13, -X1NR13X1OR13, -X1OR13, - X1C(O)0R13, -X1S(O)2R12, -X1S(O)2NR13C(O)R13, -X1S(O)2R13, -X1C(O)R12, -X1NR13R13, -X1S(O)2NR13R13, -X1OC(O)NR13R13, -X1C(O)NR12R13, -X1NR13X1C(O)NR12, -X1NR13X1C(O)NR13R13, -X1C(O)NR13X1C(O)OR13, -X1C(O)NR13X1NR13R13, -X1C(O)NR13X1OR13 y - X1C(O)NR13R13 donde R12 se selecciona de arilo C6-10, heteroarilo C5-10, cicloalquilo C3-12 y heterocicloalquilo C3-10; donde dicho arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R12 está opcionalmente sustituido con 1 hasta 3 radicales independientemente seleccionados de hidroxi, bis-hidroxi-alquil C1-6-amino, alquil C1-6-amino, alquilo C1-6, alcoxi C1-6, alcoxi C1-6-carbonilo, alquil C1-6-sulfoxi, alquil C1-6-carboxi, alquil C1-6-sulfonilo, alquilo C1-6 halo-sustituido, alcoxi C1- 6 halo-sustituido, cicloalquilo C3-12, heterocicloalquilo C3-10, heteroarilo C5-10 y arilo C6-10 opcionalmente sustituido con 1 hasta 3 radicales halo; donde dichos sustituyentes cicloalquilo, heterocicloalquilo, heteroarilo y arilo de R12 puede estar además opcionalmente sustituidos con 1 hasta 3 radicales alquilo C1-6; donde cada R13 se selecciona independientemente de hidrogeno, alquilo C1-6, hidroxialquilo C1-6, arilo C6-10, heterocicloalquilo C3-10; donde dicho arilo o heterocicloalquilo de R13 está opcionalmente sustituido con un grupo seleccionado de alquilo C1-6 y alcoxi C1-6 donde cada X1 se selecciona independientemente de un enlace y alquileno C1-4; R1b se selecciona de hidrogeno, alquilo C1-6 y alquenilo C2- 6; R2a se selecciona de hidrogeno, alquilo C1-6, alquilo C1-6 halo-sustituido, arilo C6-10, -X2NR14X2NR14R14, -X2NR14C(O)X2NR14C(O)OR14, -X2NR14X2R15, -X2OC(O)NR14R14, -X2OC(O)NR14R15, -X2NR14R14, -X2NR14S(O)2R14, -X2NR14S(O)2R15, -X2S(O)0-2R15, - X2NR14C(O)R14, -X2NR14C(O)R15, -X2NR14C(O)X2NR14R14, -X2OSi(R14)3, -X2OC(O)NR14R15, -X2C(O)OR14, -X2OR14, -X2OX2R15, -X2R15 y -X2C(O)R15 donde cada R14 se selecciona independientemente de hidrogeno y alquilo C1-6; R15 se selecciona de ciano, arilo C6-10, heteroarilo C5-10, cicloalquilo C3-12 y heterocicloalquilo C3-10 donde dicho arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R15 está opcionalmente sustituido con 1 hasta 3 radicales independientemente seleccionados de hidroxi, alquilo C1-6, alcoxi C1-6, alquil C1-6-sulfoxi, alquilo C1-6 halo-sustituido, alcoxi C1-6 halo-sustituido, -X3NR16R16, -X3ONR16R16, -X3OR16, -X3NR16C(O)OR16, -X3NR16S(O)0-2R16, -X3R16, -X3C(O)OR16, -X3C(O)NR16R16, -X3OC(O)NR16R16, -X3S(O)0-2NR16R16, -X3C(O)R16, arilo C6-10 y heteroarilo C5-10; donde dichos sustituyentes arilo y heteroarilo de R15 están opcionalmente sustituidos con 1 hasta 3 radicales halo; cada X2 y X3 se selecciona independientemente de un enlace y alquileno C1-4 y cada R16 se selecciona independientemente de hidrogeno, alquilo C1-6, arilo C6-10, heteroarilo C5-10, cicloalquilo C3-8 y heterocicloalquilo C3-12 donde cualquier arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R16 está opcionalmente sustituido con 1 hasta 3 radicales independientemente seleccionados de halo, ciano, alquilo C1-6, alquil C1-6-carbonil-amino y alcoxi C1-6; R2b se selecciona de hidrogeno y alquilo C1-6; o R2a y R2b junto con el átomo de carbono al cual R2a y R2b están unidos forman carbonilo; R3, R5, R6 y R7 se seleccionan cada uno independientemente de hidrogeno, halo y amino; R4 se selecciona de hidrogeno, halo, hidroxi, alquilo C1-6, alcoxi C1-6, alquilo C1-6 halo-sustituido, alcoxi C1-6 halo-sustituido, alquilo C1-6 hidroxi-sustituido, alcoxi C1-6 hidroxi-sustituido, alquilo C1-6 ciano-sustituido con, alcoxi C1-6 ciano-sustituido, -OX5R4a y OX5R4a; donde X5 se selecciona de un enlace y alquileno C1-4; R4a se selecciona de alquilo C1-6, cicloalquilo C3-8, arilo C6-10 y C5-10; donde cualquier cicloalquilo, arilo o heteroarilo de R4a está opcionalmente sustituido con 1 hasta 3 radicales independientemente seleccionados de halo, ciano, amino, alquilo C1-6, alcoxi C1-6, alquilo C1-6 halo-sustituido, alcoxi C1- 6 halo-sustituido, alquilo C1-6 hidroxi-sustituido, alcoxi C1-6 hidroxi-sustituido, alquilo C1-6 ciano-sustituido y alcoxi C1-6 ciano-sustituido; R8, R9, R11 y R12a se seleccionan cada uno independientemente de hidrogeno, halo, alquilo C1-6, alcoxi C1-6, alquilo C1-6 halo-sustituido y alcoxi C1-6 halo-sustituido; R10 se selecciona de halo, ciano, alquilo C1-6, alcoxi C1-6, alquilo C1-6 halosustituido, alcoxi C1-6 halo-sustituido, -X4OR17, -X4S(O)0-2R17 y -X4R17; donde X4 se selecciona de un enlace y alquileno C1-4; y R17 se selecciona de arilo C6-10 y heteroarilo C5-10; donde R17 está opcionalmente sustituido con 1 hasta 3 radicales halo; o su sal aceptable para uso farmacéutico.
ARP070105623A 2006-12-15 2007-12-14 Compuestos y composiciones como inhibidores de la actividad del receptor cannabinoide 1. procesos de obtencion. AR064353A1 (es)

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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103936690B (zh) 2005-10-25 2016-06-08 盐野义制药株式会社 氨基二氢噻嗪衍生物
WO2008130616A2 (en) * 2007-04-19 2008-10-30 Schering Corporation Diaryl morpholines as cb1 modulators
WO2008133273A1 (ja) * 2007-04-24 2008-11-06 Shionogi & Co., Ltd. アルツハイマー症治療用医薬組成物
RU2476430C2 (ru) 2007-04-24 2013-02-27 Сионоги Энд Ко., Лтд. Производные аминодигидротиазина, замещенные циклической группой
CA2725680A1 (en) 2008-05-30 2009-12-03 Takeda Pharmaceutical Company Limited Heterocyclic compound
ES2738123T3 (es) 2008-06-13 2020-01-20 Shionogi & Co Derivado heterocíclico que contiene azufre que tiene actividad inhibitoria de ß-secretasa
WO2010026212A1 (en) 2008-09-04 2010-03-11 Probiodrug Ag Novel inhibitors
WO2010047372A1 (ja) * 2008-10-22 2010-04-29 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体
FR2938538B1 (fr) * 2008-11-17 2011-08-05 Univ Nice Sophia Antipolis Procede de preparation d'acides et d'esters boroniques en presence de magnesium metallique
US20110263580A1 (en) * 2008-12-11 2011-10-27 Thomas Miller Method for treating alzheimer's disease and related conditions
FR2941696B1 (fr) * 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
WO2011071135A1 (ja) 2009-12-11 2011-06-16 塩野義製薬株式会社 オキサジン誘導体
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
US8927721B2 (en) 2010-10-29 2015-01-06 Shionogi & Co., Ltd. Naphthyridine derivative
WO2012057247A1 (ja) 2010-10-29 2012-05-03 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
JPWO2012147763A1 (ja) 2011-04-26 2014-07-28 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
MX352672B (es) 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
US9340549B2 (en) * 2012-03-05 2016-05-17 Amgen Inc. Oxazolidinone compounds and derivatives thereof
EP2912035A4 (en) 2012-10-24 2016-06-15 Shionogi & Co DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
EP2961735B1 (en) 2013-02-28 2017-09-27 Amgen Inc. A benzoic acid derivative mdm2 inhibitor for the treatment of cancer
EP2970237B1 (en) 2013-03-14 2017-09-27 Amgen Inc. Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
ES2694375T3 (es) * 2013-09-17 2018-12-20 Vectus Biosystems Limited Composiciones para el tratamiento de la hipertensión y/o de la fibrosis
TW201609710A (zh) * 2013-12-10 2016-03-16 杜邦股份有限公司 除草用經取代嘧啶氧基苯化合物
WO2015108779A1 (en) 2014-01-16 2015-07-23 E. I. Du Pont De Nemours And Company Pyrimidinyloxy benzene derivatives as herbicides
EP3153166B1 (en) * 2014-06-09 2022-08-03 Chugai Seiyaku Kabushiki Kaisha Hydantoin derivative-containing pharmaceutical composition
TW202400564A (zh) 2015-06-05 2024-01-01 美商艾佛艾姆希公司 作為除草劑之嘧啶氧基苯衍生物
EP3619206B1 (en) 2017-05-02 2024-02-14 FMC Corporation Pyrimidinyloxy benzo-fused compounds as herbicides
KR102803660B1 (ko) 2018-03-05 2025-05-02 브리스톨-마이어스 스큅 컴퍼니 페닐피롤리디논 포르밀 펩티드 2 수용체 효능제
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
CA3121199A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN111434655A (zh) 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 溶血磷脂酸受体拮抗剂及其制备方法
CN113173916A (zh) * 2021-03-31 2021-07-27 翟洪 一种托匹司他的制备方法
WO2025217248A1 (en) * 2024-04-11 2025-10-16 Corteva Agriscience Llc Formulations containing substituted 5-membered ring pesticides and methods of use

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129228A (en) * 1964-04-14 -chj-n h
FR1516714A (fr) * 1962-11-07 1968-02-05 Bayer Ag Procédé de préparation de dérivés de l'imidazolidine
FR2097038A1 (en) * 1970-07-29 1972-03-03 Bellon Labor Sa Roger 1-(substd phenyl)-2-oxo-4-piperazinocarbonyl pyrrolidines - analgesic
NL7312944A (nl) * 1973-09-20 1975-03-24 Akzo Nv Werkwijze ter bereiding van nieuwe imidazolidino-deri- vaten en de toepassing hiervan.
FI875101A7 (fi) * 1986-12-03 1988-06-04 Tanabe Seiyaku Co Laktaamijohdannaiset ja niitä sisältävät valmisteet.
JPS63264458A (ja) * 1986-12-03 1988-11-01 Tanabe Seiyaku Co Ltd ラクタム誘導体
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4426757A1 (de) * 1994-07-28 1996-02-01 Bayer Ag 2-Imidazolidinon-Derivate
EP1144373B1 (en) * 1999-01-13 2005-10-19 Genentech, Inc. Serine protease inhibitors
UA74781C2 (en) 1999-04-02 2006-02-15 Abbott Lab Antiinflammatory and immumosuppressive compounds inhibiting cell adhesion
AU2003279442A1 (en) * 2002-10-04 2004-04-23 Laboratoires Fournier S.A. 2-thiohydantoine derivative compounds and use thereof for the treatment of diabetes
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
GB0230088D0 (en) 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
US20040209928A1 (en) * 2002-12-30 2004-10-21 Ravi Kurukulasuriya Glucagon receptor antagonists/inverse agonists
CN101115726A (zh) 2004-12-03 2008-01-30 先灵公司 作为cb1拮抗剂的取代哌嗪
CN101087775A (zh) * 2004-12-23 2007-12-12 奇斯药制品公司 具有抗毒蕈碱活性的吡咯衍生物
WO2006124447A2 (en) * 2005-05-13 2006-11-23 Eli Lilly And Company Substituted n-arylpyrrolidines as selective androgen receptor modulators
WO2007020502A2 (en) * 2005-08-16 2007-02-22 Pharmacia & Upjohn Company Llc Cannabinoid receptor ligands and uses thereof
US20070203183A1 (en) 2006-01-13 2007-08-30 Schering Corporation Diaryl piperidines as CB1 modulators

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WO2008076754A2 (en) 2008-06-26
KR101245918B1 (ko) 2013-03-20
CA2672271C (en) 2013-01-22
TW200831080A (en) 2008-08-01
EA017696B1 (ru) 2013-02-28
MX2009006339A (es) 2009-08-21
AU2007333992B2 (en) 2012-05-17
PE20081512A1 (es) 2009-01-04
EP2121598A2 (en) 2009-11-25
CL2007003629A1 (es) 2008-08-08
JP2013014596A (ja) 2013-01-24
WO2008076754A3 (en) 2008-12-24
CA2672271A1 (en) 2008-06-26
KR20120054106A (ko) 2012-05-29
US20100234365A1 (en) 2010-09-16
US20130210769A1 (en) 2013-08-15
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AU2007333992A1 (en) 2008-06-26
EA200900828A1 (ru) 2009-12-30

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