AR052580A1 - Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias - Google Patents
Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatoriasInfo
- Publication number
- AR052580A1 AR052580A1 ARP060100701A ARP060100701A AR052580A1 AR 052580 A1 AR052580 A1 AR 052580A1 AR P060100701 A ARP060100701 A AR P060100701A AR P060100701 A ARP060100701 A AR P060100701A AR 052580 A1 AR052580 A1 AR 052580A1
- Authority
- AR
- Argentina
- Prior art keywords
- monocyclic
- group
- bicyclic
- aromatic
- optionally substituted
- Prior art date
Links
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 title 1
- 101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 title 1
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 title 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000002619 bicyclic group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Pregnancy & Childbirth (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion No. 1:Un compuesto caracterizado porque está representado por la siguiente formula estructural (1) o una sal farmacéuticamente aceptable del mismo, donde : El anillo A es un anillo arilo o heteroarilo, de 5-6 miembros, condensado, opcionalmente sustituido; Y es >C(Rx)- o >N-; X1 es -C(=O)-, -SO2-, -CONR-, -C«2- o -CO2-, R1 es un grupo opcionalmente sustituido seleccionado entre un grupo alifático, un arilo monocíclico o bicíclico, un heteroarilo monocíclico o bicíclico, un heterociclilo monocíclico o bicíclico no aromático o un grupo carbociclilo monocíclico o bicíclico no aromático; R2 es un grupo alquilo C1-3, un grupo haloalquilo C1-3 o un grupo cicloalquilo C3-6, o un grupo opcionalmente sustituido seleccionado entre un grupo cicloalquilo C3-8, un grupo heterocíclico monocíclico no aromático, un arilo monocíclico o un grupo heteroarilo monocíclico; R4 es -[C(R7)2]m-B; o R3 y R4 se forman junto con el átomo de nitrogeno situado entre ellos para formar un grupo heteroarilo monocíclico o bicíclico, opcionalmente sustituido o un grupo heterocíclico no aromático; o Rx y R4 se toman junto con los átomos de carbono y nitrogeno situados entre ellos para formar un grupo heterocíclico que contiene nitrogeno, no aromático, monocíclico, opcionalmente sustituido; R5 es -OH, -O(grupo alifático C1-4)-COOR' o -N(R')2; R6 es -OH, -O(grupo alifático C1-4), N(R')2, -C(O)R', -COOR', C(O)N(R')2 o un grupo opcionalmente sustituido seleccionado ente un cicloalquilo monocíclico, un arilo monocíclico, un heteroarilo monocíclico o un grupo heterocíclico no aromático monocíclico; cada R7 es independientemente hidrogeno o un grupo alifático C1-4 o N(R')2 es un grupo heterocíclico que contiene nitrogeno, no aromático, monocíclico; m es cero o uno; y B es -H, -C(R7)3, -C(R7)3-C(R7)3 o un grupo opcionalmente sustituido seleccionado ente un cicloalquilo monocíclico o bicíclico, un arilo monocíclico o bicíclico, un heteroarilo monocíclico o bicíclico o un grupo heterocíclico no aromático, monocíclico o bicíclico, con la condicion de que los compuestos de formula(1) sean distintos de los compuestos en los que X1 es -COO- y R1 es etilo y el anillo A está sustituido con: a) dos apariciones de OMe, a) dos apariciones de Me, o c) una aparicion de CF3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65592705P | 2005-02-24 | 2005-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052580A1 true AR052580A1 (es) | 2007-03-21 |
Family
ID=36593677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100701A AR052580A1 (es) | 2005-02-24 | 2006-02-24 | Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7951950B2 (es) |
| EP (1) | EP1861372A1 (es) |
| JP (1) | JP2008543726A (es) |
| KR (1) | KR20070114762A (es) |
| CN (1) | CN101146776A (es) |
| AR (1) | AR052580A1 (es) |
| AU (1) | AU2006216713A1 (es) |
| BR (1) | BRPI0608553A2 (es) |
| CA (1) | CA2598133A1 (es) |
| CR (1) | CR9378A (es) |
| DO (1) | DOP2006000054A (es) |
| GT (1) | GT200600093A (es) |
| IL (1) | IL185422A0 (es) |
| MA (1) | MA29330B1 (es) |
| MX (1) | MX2007010215A (es) |
| NI (1) | NI200700221A (es) |
| NO (1) | NO20074388L (es) |
| PE (1) | PE20061013A1 (es) |
| RU (1) | RU2007135224A (es) |
| SV (1) | SV2007002429A (es) |
| TN (1) | TNSN07325A1 (es) |
| TW (1) | TW200640869A (es) |
| UA (1) | UA90706C2 (es) |
| UY (1) | UY29397A1 (es) |
| WO (1) | WO2006091674A1 (es) |
| ZA (1) | ZA200707498B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITVA20050050A1 (it) * | 2005-08-05 | 2007-02-06 | Lamberti Spa | Sistemi fotopolimerizzabili contenenti coiniziatori fotoreticolabili a bassa estraibilita' e volatilita' |
| WO2007130353A2 (en) * | 2006-05-01 | 2007-11-15 | Johns Hopkins University | Phase 2 inducers, ppar-alpha agonists and related signalling pathways protect cartilage against inflammation, apoptosis and stress |
| ATE502920T1 (de) | 2007-12-14 | 2011-04-15 | Pulmagen Therapeutics Asthma Ltd | Indole und ihre therapeutische verwendung |
| CA2728311A1 (en) | 2008-07-15 | 2010-01-21 | F. Hoffmann-La Roche Ag | Aminotetrahydroindazoloacetic acids |
| JP5394488B2 (ja) * | 2008-07-15 | 2014-01-22 | エフ．ホフマン−ラ ロシュ アーゲー | アミノテトラヒドロインダゾロ酢酸 |
| WO2010018109A2 (en) | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Substituted aminotetralines |
| WO2010018113A2 (en) | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Bi-aryl aminotetralines |
| EP2358677B1 (en) | 2008-11-17 | 2014-01-08 | F. Hoffmann-La Roche AG | Naphthylacetic acids used as crth2 antagonists or partial agonists |
| MX2011005120A (es) | 2008-11-17 | 2011-05-30 | Hoffmann La Roche | Acidos naftilaceticos. |
| MX2011005200A (es) | 2008-11-17 | 2011-06-01 | Hoffmann La Roche | Acidos naftilaceticos. |
| EP2590944B1 (en) | 2010-07-05 | 2015-09-30 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
| PE20140788A1 (es) * | 2011-06-17 | 2014-07-09 | Merck Sharp & Dohme | Tetrahidroquinolinas condensadas con cicloalquilo como moduladores de receptores de crth2 |
| EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
| EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
| US8470884B2 (en) | 2011-11-09 | 2013-06-25 | Hoffmann-La Roche Inc. | Alkenyl naphthylacetic acids |
| US8691993B2 (en) * | 2011-12-12 | 2014-04-08 | Hoffmann-La Roche Inc. | Piperidinyl naphthylacetic acids |
| JP2015500326A (ja) | 2011-12-16 | 2015-01-05 | アトピックス テラピューティクス リミテッド | 好酸球性食道炎の治療のためのｃｒｔｈ２拮抗薬およびプロトンポンプ阻害薬の組み合わせ |
| EP2794563B1 (en) | 2011-12-21 | 2017-02-22 | Actelion Pharmaceuticals Ltd | Heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| JP2015520752A (ja) * | 2012-05-11 | 2015-07-23 | アッヴィ・インコーポレイテッド | Ｎａｍｐｔ阻害薬としてのピリダジンおよびピリジン誘導体 |
| US9296723B2 (en) | 2012-05-11 | 2016-03-29 | Abbvie Inc. | NAMPT inhibitors |
| MX2014013758A (es) * | 2012-05-11 | 2015-02-05 | Abbvie Inc | Derivados de tiazolcarboxamida para usarse como inhibidores de nampt. |
| WO2014006585A1 (en) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| NZ720004A (en) | 2013-11-18 | 2020-03-27 | Forma Therapeutics Inc | Tetrahydroquinoline compositions as bet bromodomain inhibitors |
| CN106029076B (zh) | 2013-11-18 | 2019-06-07 | 福马疗法公司 | 作为bet溴域抑制剂的苯并哌嗪组合物 |
| US9727784B2 (en) * | 2014-06-03 | 2017-08-08 | Digitalglobe, Inc. | Some automated and semi-automated tools for linear feature extraction in two and three dimensions |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1991005549A1 (en) | 1989-10-20 | 1991-05-02 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
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-
2006
- 2006-02-23 JP JP2007557128A patent/JP2008543726A/ja active Pending
- 2006-02-23 CN CNA2006800096718A patent/CN101146776A/zh active Pending
- 2006-02-23 EP EP06735798A patent/EP1861372A1/en not_active Withdrawn
- 2006-02-23 AU AU2006216713A patent/AU2006216713A1/en not_active Withdrawn
- 2006-02-23 ZA ZA200707498A patent/ZA200707498B/xx unknown
- 2006-02-23 BR BRPI0608553-9A patent/BRPI0608553A2/pt not_active IP Right Cessation
- 2006-02-23 WO PCT/US2006/006287 patent/WO2006091674A1/en not_active Ceased
- 2006-02-23 MX MX2007010215A patent/MX2007010215A/es not_active Application Discontinuation
- 2006-02-23 GT GT200600093A patent/GT200600093A/es unknown
- 2006-02-23 CA CA002598133A patent/CA2598133A1/en not_active Abandoned
- 2006-02-23 US US11/360,885 patent/US7951950B2/en active Active
- 2006-02-23 UA UAA200710441A patent/UA90706C2/ru unknown
- 2006-02-23 RU RU2007135224/04A patent/RU2007135224A/ru not_active Application Discontinuation
- 2006-02-23 KR KR1020077021757A patent/KR20070114762A/ko not_active Withdrawn
- 2006-02-24 SV SV2006002429A patent/SV2007002429A/es unknown
- 2006-02-24 DO DO2006000054A patent/DOP2006000054A/es unknown
- 2006-02-24 AR ARP060100701A patent/AR052580A1/es unknown
- 2006-02-24 TW TW095106336A patent/TW200640869A/zh unknown
- 2006-02-24 UY UY29397A patent/UY29397A1/es not_active Application Discontinuation
- 2006-02-24 PE PE2006000220A patent/PE20061013A1/es not_active Application Discontinuation
-
2007
- 2007-08-21 IL IL185422A patent/IL185422A0/en unknown
- 2007-08-23 NI NI200700221A patent/NI200700221A/es unknown
- 2007-08-24 TN TNP2007000325A patent/TNSN07325A1/en unknown
- 2007-08-29 NO NO20074388A patent/NO20074388L/no not_active Application Discontinuation
- 2007-09-11 MA MA30215A patent/MA29330B1/fr unknown
- 2007-09-12 CR CR9378A patent/CR9378A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007010215A (es) | 2007-11-07 |
| IL185422A0 (en) | 2008-01-06 |
| UY29397A1 (es) | 2006-10-02 |
| EP1861372A1 (en) | 2007-12-05 |
| AU2006216713A1 (en) | 2006-08-31 |
| CN101146776A (zh) | 2008-03-19 |
| TNSN07325A1 (en) | 2008-12-31 |
| GT200600093A (es) | 2006-10-19 |
| US7951950B2 (en) | 2011-05-31 |
| UA90706C2 (ru) | 2010-05-25 |
| KR20070114762A (ko) | 2007-12-04 |
| US20060241109A1 (en) | 2006-10-26 |
| NI200700221A (es) | 2008-05-09 |
| PE20061013A1 (es) | 2006-10-13 |
| SV2007002429A (es) | 2007-02-19 |
| ZA200707498B (en) | 2008-11-26 |
| BRPI0608553A2 (pt) | 2010-01-12 |
| TW200640869A (en) | 2006-12-01 |
| RU2007135224A (ru) | 2009-03-27 |
| DOP2006000054A (es) | 2006-08-31 |
| WO2006091674A1 (en) | 2006-08-31 |
| CR9378A (es) | 2008-01-21 |
| JP2008543726A (ja) | 2008-12-04 |
| MA29330B1 (fr) | 2008-03-03 |
| CA2598133A1 (en) | 2006-08-31 |
| NO20074388L (no) | 2007-11-20 |
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