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AR052330A1 - Derivados de adamantano que comprenden quinoleinas sustituidas - Google Patents

Derivados de adamantano que comprenden quinoleinas sustituidas

Info

Publication number
AR052330A1
AR052330A1 ARP050104990A ARP050104990A AR052330A1 AR 052330 A1 AR052330 A1 AR 052330A1 AR P050104990 A ARP050104990 A AR P050104990A AR P050104990 A ARP050104990 A AR P050104990A AR 052330 A1 AR052330 A1 AR 052330A1
Authority
AR
Argentina
Prior art keywords
halogen
optionally substituted
represent
substituent
heterocyclic ring
Prior art date
Application number
ARP050104990A
Other languages
English (en)
Inventor
Richard Evans
Rhonan Ford
Toby Thompson
Paul Willis
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR052330A1 publication Critical patent/AR052330A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Molecular Biology (AREA)
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  • AIDS & HIV (AREA)
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Abstract

Procesos para su preparacion; composiciones farmacéuticas que los contienen; y su uso en terapia. Reivindicacion 1: Un compuesto caracterizado porque responda a la formula (1), o una sal aceptable para uso farmacéutico o un éster hidrolizable en vivo del mismo, donde: n representa 1, 2 o 3; cada R1 representa en forma independiente hidrogeno, hidroxi o un halogeno; A es C(O)NH o NHC(O); p es 0, 1 o 2; cada R2 representa en forma independiente halogeno o alquilo C1-6 opcionalmente sustituido por al menos un sustituyente seleccionado en forma independiente entre oxidrilo, halogeno y alcoxi C1-6; q es 0, 1 o 2; cada R4 representa en forma independiente halogeno o alquilo C1-6 opcionalmente sustituido por al menos un sustituyente seleccionado en forma independiente entre oxidrilo, halogeno y alcoxi C1-6; R3 representa un grupo Y1R6 o Z1R10; R6 representa un grupo R8 o un anillo carbocíclico o heterocíclico de 4 a 9 miembros, donde dicho anillo carbocíclico o heterocíclico está sustituido por al menos un sustituyente seleccionado en forma independiente entre Y2R9 y Z2R11, y donde dicho anillo carbocíclico o heterocíclico de 4 a 9 miembros puede estar además opcionalmente sustituido por al menos un sustituyente seleccionado en forma independiente entre halogeno, oxidrilo, alcoxi C1-6, alquilo C1-6, fenilo y un anillo heteroaromático de 5 o 6 miembros, donde dicho alquilo C1-6, fenilo o anillo heteroaromático de 5 o 6 miembros puede estar opcionalmente sustituido por al menos un sustituyente seleccionado entre halogeno, oxidrilo y alcoxi C1-6; R8 y R9 representa cada uno en forma independiente tetrazolilo, 1,2,3-triazolilo, 1,2,4-triazolilo o un anillo heterocíclico de 5 o 6 miembros que comprende entre 1 y 4 heteroátomos seleccionados en forma independiente entre nitrogeno, oxígeno y azufre, donde el anillo heterocíclico está sustituido por al menos un sustituyente seleccionado entre oxidrilo, =O y =S, y donde el anillo heterocíclico puede estar además opcionalmente sustituido por al menos un sustituyente seleccionado entre halogeno, nitro, amino, ciano, alquilsulfonilo C1-6, alcoxicarbonilo C1-6 y un grupo alquilo C1-6 en donde dicho grupo alquilo C1-6 puede estar opcionalmente sustituido por al menos un sustituyente seleccionado entre halogeno, oxidrilo y amino; R10 y R11 representa cada uno en forma independiente carboxilo, alquilsulfonilaminocarbonilo C1-6, C(O)NHOH o NHR12; R12 representa CN, alquilsulfonilo C1-6, alquilcarbonilo C1-6, alcoxicarbonilo C1-6, alquilaminosulfonilo C1-6 o di-alquilaminosulfoniloC1-6; Y1 e Y2 representa cada uno en forma independiente un enlace, O, S(O)0-2, NR7C(O), C(O)NR7, SO2NR7, NR7SO2, >NR7, O(CH2)1-6, S(O)0-2(CH2)1-6, NR7(CH2)1-6, (CH2) 1-3O(CH2)1-3, (CH2)1 3S(O)0-2(CH2)1-3, (CH2)1-3NR7(CH2)1-3, (CH2)1-3NR7C(O)(CH2)0-3, (CH2)1-3C(O)NR7(CH2)0-3, S(O)0-2(CH2) 1-6NR7 o a alquileno C1-6 en donde dicho alquileno C1-6 puede estar opcionalmente sustituido por al menos un sustituyente seleccionado en forma independiente entre oxidrilo, halogeno y alcoxi C1-6; Z1 y Z2 representa cada uno en forma independiente un enlace, O(CH2)1-6, S(O)0-2(CH2)1-6, NR7(CH2)1-6, (CH2)1-3O(CH2)1-3, (CH2)1-3S(O)0-2(CH2)1-3, (CH2)1- 3NR7(CH2)1-3, (CH2) 1-3NR7C(O)(CH2)1-3 , (CH2)1-3C(O)NR7(CH2)1-3 o a alquileno C1-6 en donde dicho alquileno C1-6 puede estar opcionalmente sustituido por al menos un sustituyente seleccionado en forma independiente entre oxidrilo, halogeno y alcoxi C1-6; y cada R7 representa en forma independiente hidrogeno o un grupo alquilo C1-6 que puede estar opcionalmente sustituido por al menos un sustituyente seleccionado en forma independiente entre oxidrilo, halogeno y alcoxi C1-6; con las siguientes salvedades: a) cuando R3 representa Y1R6 e Y1 representa NR7(CH2)1-6, S(CH2)1-6, O(CH2)1-6 o un alquileno C1-6 opcionalmente sustituido, entonces R6 no representa oxopirrolidinilo; b) cuando R3 representa Z1R10 y Z1 representa (CH2)1-3NR7(CH2)1-3, entonces R10 no representa carboxilo; c) cuando R3 representa Y1R6 e Y1 representa (CH2)1-3NR7(CH2)1-3 y R6 representa un grupo R8 entonces R8 no representa un anillo heterocíclico de 5 o 6 miembros sustituido con oxidrilo o =O; d) cuando R3 representa Y1R6 e Y1 representa (CH2)1-3NR7(CH2)1-3 y R6 representa un anillo carbocíclico o heterocíclico de 4 a 9 miembros sustituido con Z2R11 y Z2 representa un enlace, entonces R11 no representa carboxilo; e) cuando R3 representa Y1R6 e Y1 representa NR7(CH2)1-6, S(CH2)1-6, O(CH2)1-6 o un alquileno C1-6 opcionalmente sustituido y R6 representa fenilo sustituido con Z2R11 y Z2 representa un enlace, entonces R11 no representa alquilsulfonilamino C1-6; f) cuando R3 representa Z1R10 y Z1 representa O(CH2)1-6, S(CH2)1-6, NR7(CH2)1-6 o un alquileno C1-6 opcionalmente sustituido y R10 representa NHR12, entonces R12 no representa alquilcarbonilo C1-6; y g) el compuesto no se selecciona entre tert-butilo 1-{5-[(1-adamantilacetil)]-6- metilquinolin-2-il}piperidin-4-ilcarbamato y tert-butilo (3S)-1-{5-[(1-adamantilacetil) amino]-6-metilquinolin-2-il}pirrolidin-3-ilcarbamato.
ARP050104990A 2004-11-30 2005-11-29 Derivados de adamantano que comprenden quinoleinas sustituidas AR052330A1 (es)

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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
WO2008013494A1 (en) * 2006-07-27 2008-01-31 Astrazeneca Ab Quinoline derivatives as p2x7 receptor antagonist and their use in the treatment of rheumatoid arthritis, osteoarthritis, copd and ibd
CA2680761A1 (en) 2007-03-22 2008-09-25 Astrazeneca Ab Quinoline derivatives for the treatment of inflammatory diseases
US8106073B2 (en) 2007-11-30 2012-01-31 Astrazeneca Ab Quinoline derivatives 057
ES2357682T3 (es) 2008-03-25 2011-04-28 Affectis Pharmaceuticals Ag Antagonistas de p2x7r novedosos y su utilización.
DK2243772T3 (da) 2009-04-14 2012-02-13 Affectis Pharmaceuticals Ag Hidtil ukendte P2X7R-antagonister og deres anvendelse
CN102858741A (zh) 2010-05-14 2013-01-02 阿费克蒂斯制药股份公司 制备p2x7r拮抗剂的新方法
RS54369B1 (sr) * 2010-10-08 2016-04-28 Nivalis Therapeutics, Inc. Nova jedinjenja hinolina supstituisana kao inhibitori s-nitrosoglutathione reduktaze
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
ES2574840T3 (es) 2011-07-22 2016-06-22 Actelion Pharmaceuticals Ltd. Derivados de amidas heterocíclicas como antagonistas de receptores p2x7
KR102033190B1 (ko) 2012-01-20 2019-10-16 이도르시아 파마슈티컬스 리미티드 Ｐ２ｘ７ 수용체 길항제로서의 헤테로시클릭 아미드 유도체
EA029644B1 (ru) 2012-12-12 2018-04-30 Идорсиа Фармасьютиклз Лтд Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов
CA2891499C (en) 2012-12-18 2021-07-06 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
CA2896790C (en) 2013-01-22 2022-05-10 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
KR102220847B1 (ko) 2013-01-22 2021-02-26 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
AR100724A1 (es) * 2014-06-05 2016-10-26 Merck Patent Gmbh Derivados de quinolina y su uso en enfermedades neurodegenerativas
CN105601566A (zh) * 2016-02-02 2016-05-25 张敏 一种护理烧伤后感染的药物组合物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471491A (en) * 1967-08-28 1969-10-07 Squibb & Sons Inc Adamantyl-s-triazines
US3464998A (en) * 1968-03-04 1969-09-02 Searle & Co Adamantyl esters and amides of pyridinecarboxylic acids
US4349552A (en) * 1978-10-30 1982-09-14 Fujisawa Pharmaceutical Company, Ltd. 5-Fluorouracil derivatives, and their pharmaceutical compositions
US4751292A (en) * 1985-07-02 1988-06-14 The Plant Cell Research Institute, Inc. Adamantyl purines
US5399564A (en) * 1991-09-03 1995-03-21 Dowelanco N-(4-pyridyl or 4-quinolinyl) arylacetamide and 4-(aralkoxy or aralkylamino) pyridine pesticides
ATE406163T1 (de) * 1996-05-20 2008-09-15 Darwin Discovery Ltd Chinolincarboxamide als tnf-inhibitoren und als pde-iv inhibitoren
SE9704544D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704545D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
RU2254333C2 (ru) * 1999-04-09 2005-06-20 Астразенека Аб Производные адамантана, способ их получения, фармацевтическая композиция на их основе и способы лечения
SE9904505D0 (sv) * 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) * 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
GB0013737D0 (en) * 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds
KR100908468B1 (ko) * 2001-07-02 2009-07-21 엔.브이.오가논 테트라히드로퀴놀린 유도체
WO2003042190A1 (en) * 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
SE0103836D0 (sv) * 2001-11-16 2001-11-16 Astrazeneca Ab Novel compounds
US6908939B2 (en) * 2001-12-21 2005-06-21 Galderma Research & Development S.N.C. Biaromatic ligand activators of PPARγ receptors
SE0200920D0 (sv) * 2002-03-25 2002-03-25 Astrazeneca Ab Novel compounds
SE0300445D0 (sv) * 2003-02-18 2003-02-18 Astrazeneca Ab New combination
SE0300480D0 (sv) * 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
WO2004105796A1 (en) * 2003-05-29 2004-12-09 Astrazeneca Ab A pharmaceutical composition containing a p2x7 receptor antagonist and methotrexate
CA2526883A1 (en) * 2003-05-29 2004-12-09 Astrazeneca Ab A pharmaceutical composition comprising a p2x7-receptor antagonist and a tumour necrosis factor .alpha.
US20070010497A1 (en) * 2003-05-29 2007-01-11 Nigel Boughton-Smith Pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine
SE0302192D0 (sv) * 2003-08-08 2003-08-08 Astrazeneca Ab Novel compounds
SE0302488D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab New combination

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JP2008521894A (ja) 2008-06-26
SE0402925D0 (sv) 2004-11-30
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