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PE20080895A1 - Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas - Google Patents

Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas

Info

Publication number
PE20080895A1
PE20080895A1 PE2007001451A PE2007001451A PE20080895A1 PE 20080895 A1 PE20080895 A1 PE 20080895A1 PE 2007001451 A PE2007001451 A PE 2007001451A PE 2007001451 A PE2007001451 A PE 2007001451A PE 20080895 A1 PE20080895 A1 PE 20080895A1
Authority
PE
Peru
Prior art keywords
hydroxylases
dihydropirazolones
hif
inhibitors
ona
Prior art date
Application number
PE2007001451A
Other languages
English (en)
Inventor
Kai Thede
Ingo Flamme
Felix Oehme
Jens-Kerim Erguden
Friederike Stoll
Joachim Schuhmacher
Hanno Wild
Peter Kolkhof
Hartmut Beck
Jorg Keldenich
Metin Akbaba
Mario Jeske
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20080895A1 publication Critical patent/PE20080895A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE DIHIDROPIRAZOLONAS DE FORMULA (I) DONDE R1 ES UN COMPUESTO DE FORMULA (i), (ii), ENTRE OTROS, DONDE A ES CR4 O N; E ES O, S O NR5; R2 ES UN COMPUESTO DE FORMULA (iii), (iv), ENTRE OTROS, DONDE G ES CR6 O N; L ES CR8 O N; R4, R6, R8 SON CADA UNO H, HALOGENO, CN, NITRO, ALQUILO(C1-C6), ENTRE OTROS; R5 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), FENILO, ENTRE OTROS; R3 ES H, ALQUILO(C1-C6) O CICLOALQUILO(C3-C7). SON COMPUESTOS PREFERIDOS: 2-PIRIDIN-2-IL-4-(1H-1,2,3-TRIAZOL-1-IL)-1,2-DIHIDRO-3H-PIRAZOL-3-ONA, 2-(6-MORFOLIN-4-ILPIRIMIDIN-4-IL)-4-[5-(TRIFLUOROMETIL)-1,3,4-TIADIAZOL-2-IL]-1,2-DIHIDRO-3H-PIRAZOL-3-ONA, 2-(6-PIPERIDIN-1-ILPIRIMIDIN-4-IL)-4-[5-(TRIFLUOROMETIL)-1,3,4-TIADIAZOL-2-IL]-1,2-DIHIDRO-3H-PIRAZOL-3-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL FACTOR DE TRANSCRIPCION INDUCIBLE POR HIPOXIA-PROPIL-4-HIDROXILASAS (HIF-PROPIL-4-HIDROXILASAS) SIENDO UTILES EN EL TRATAMIENTO DE INSUFICIENCIA CARDIACA, ANEMIA, INSUFICIENCIA RENAL
PE2007001451A 2006-10-26 2007-10-25 Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas PE20080895A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006050516A DE102006050516A1 (de) 2006-10-26 2006-10-26 Substituierte Dihydropyrazolone und ihre Verwendung

Publications (1)

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PE20080895A1 true PE20080895A1 (es) 2008-09-05

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ID=38734870

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2007001451A PE20080895A1 (es) 2006-10-26 2007-10-25 Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas
PE2011001768A PE20120620A1 (es) 2006-10-26 2007-10-25 Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas
PE2012000031A PE20120635A1 (es) 2006-10-26 2007-10-25 Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas

Family Applications After (2)

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PE2011001768A PE20120620A1 (es) 2006-10-26 2007-10-25 Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas
PE2012000031A PE20120635A1 (es) 2006-10-26 2007-10-25 Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas

Country Status (40)

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US (5) US8389520B2 (es)
EP (3) EP2383269B1 (es)
JP (2) JP5247712B2 (es)
KR (1) KR101455879B1 (es)
CN (2) CN101631785B (es)
AR (1) AR063392A1 (es)
AU (1) AU2007328052B2 (es)
BR (1) BRPI0717367B8 (es)
CA (1) CA2667382C (es)
CO (1) CO6170359A2 (es)
CR (2) CR10750A (es)
CU (2) CU23743B7 (es)
CY (1) CY1114272T1 (es)
DE (1) DE102006050516A1 (es)
DK (2) DK2084151T3 (es)
ES (3) ES2534872T3 (es)
GT (1) GT200900095A (es)
HN (1) HN2009000784A (es)
HR (2) HRP20130779T1 (es)
IL (2) IL198289A (es)
MA (1) MA30914B1 (es)
MX (1) MX2009004324A (es)
MY (1) MY169564A (es)
NO (1) NO343308B1 (es)
NZ (2) NZ596583A (es)
PE (3) PE20080895A1 (es)
PH (1) PH12013500578B1 (es)
PL (2) PL2546253T3 (es)
PT (2) PT2084151E (es)
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RU (2) RU2469031C2 (es)
SG (1) SG176421A1 (es)
SI (1) SI2084151T1 (es)
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UA (1) UA98125C2 (es)
UY (1) UY30663A1 (es)
WO (1) WO2008067871A1 (es)
ZA (1) ZA200902705B (es)

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DE102008020113A1 (de) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituierte Dihydropyrazolone und ihre Verwendung
DE102006050516A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
DE102006050515A1 (de) * 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dipyridiyl-dihydropyrazolone und ihre Verwendung
DE102006050513A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substitiuierte Dihydropyrazolone und ihre Verwendung
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GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
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