AR051626A1 - Compuestos de imidazo[1,2-a]piridina,procesos para preparar dichos compuestos,composiciones farmaceuticas que los contienen y usos como moduladores del receptor gaba a - Google Patents
Compuestos de imidazo[1,2-a]piridina,procesos para preparar dichos compuestos,composiciones farmaceuticas que los contienen y usos como moduladores del receptor gaba aInfo
- Publication number
- AR051626A1 AR051626A1 ARP050104693A ARP050104693A AR051626A1 AR 051626 A1 AR051626 A1 AR 051626A1 AR P050104693 A ARP050104693 A AR P050104693A AR P050104693 A ARP050104693 A AR P050104693A AR 051626 A1 AR051626 A1 AR 051626A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- alkynyl
- cycloalkyl
- alkenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 imidazo [1,2-a] pyridine compound Chemical class 0.000 abstract 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 125000001041 indolyl group Chemical group 0.000 abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 2
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 2
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 2
- 125000000335 thiazolyl group Chemical group 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000001326 naphthylalkyl group Chemical group 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1. Un compuesto de imidazo[1,2-a]piridina de formula (1) así como las correspondientes sales farmacéuticamente aceptables; caracterizado porque R1 y R2 se seleccionan independientemente del grupo que consiste en H alquil C1-6 lineal o ramificado, alquenil C2-6, alquinil C2-6, haloalquil C1-6, -O-alquil C1-6, F, Cl, y Br; R3 se selecciona del grupo que consiste en H, alquil C1-6 lineal o ramificado, cicloalquil C3-6, cicloalquil C3-6-alquil C1-6, alquenil C2-6, alquenil C2-6- alquil C1-6, alquinil C2-6, alquinil C2-6-alquil C1-6; R4 se selecciona del grupo que consiste e H, haloalquil C2-6, cicloalquil C3-5, cicloalquil C3-6-alquil C1-6, alquinil C2-6-alquil C1-6, alquil C1-6-O-alquil C1-6, alquil C1-6-NH-alquil C1-6, alquil C1-6-N(dialquil C1-6), -OR5, -NHR5, -NR5R6, como se muestra en el resto de formula (2) fenilalquil C2-6, fenialquenil C2-6, naftil, naftil monosustituido, naftil disustituido, naftilalquil C1-6, naftilalquenil C2-6, furil, furil sustituido, benzofuril, benzofuril sustituido, pirrolil, pirrolil sustituido, isoxazolil, isoxazolil sustituido, benzoisoxazolil, benzoisoxazolil sustituido, imidazolil, imidazolil sustituido, benzoimidazolil, benzoimidazolil sustituido, indolil, indolil sustituido, pirazolil, pirazolil sustituido, tienil, tienil sustituido, benzotienil, benzotienil sustituido, tiazolil, tiazolil sustituido, benzotiazolil, benzotiazolil sustituido, quinolinil, quinolinil sustituido, isoquinolinil, isoquinolinil sustituido, piridil, piridil sustituido, pirazinil, pirazinil sustituido, 6-oxo-1,4,5,6-tetrahidropiridazinil, 6-oxo-1,4,5,6-tetrahidropiridazinil sustituido, tiadiazolil, tiadiazolil sustituido, isotiazolil, isotiazolil sustituido, tienilmetil, 2- oxocromenil, 2-oxocromenol sustituido, 2-(furan-2-il)vinil, oxazolil, oxazolil sustituido, y benzisoxazolil; R5 y R6 se seleccionan independientemente del grupo que consiste en H, alquil C1-6 lineal o ramificado, fenilalquil C1-6, haloalquil C1-6, cicloalquil C3-6, cicloalquil C3-6-alquil C1-6, alquenil C2-6 y alquinil C2-6, alquenil C2-6-alquil C1-6, alquinil C2-6-alquil C1-6, fenil, fenil sustituido, heteroaril, heteroaril sustituido; y R7 y R8 se seleccionan independientemente del grupo que consiste en alquil C2-6 lineal o ramificado, cicloalquil C3-6, alquenil C2-6, alquinil C2-6, -OH, -O-alquil C1-6, -SH, -S-alquil C1-6, halo-alquil C1-6, omega, omega, omega-trifluoroalquil C1-6, -NHalquil C1-6, -Ndialquil C1-6, -NO2, -CN, - SO2alquil C1-6, -COalquil C1-6, -COOalquil C1-6, -CO-NHalquil C1-6, -CONdialquil C1-6, fenil, fenil sustituido, heteroaril y heteroaril sustituido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04105698 | 2004-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051626A1 true AR051626A1 (es) | 2007-01-24 |
Family
ID=34929843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104693A AR051626A1 (es) | 2004-11-11 | 2005-11-09 | Compuestos de imidazo[1,2-a]piridina,procesos para preparar dichos compuestos,composiciones farmaceuticas que los contienen y usos como moduladores del receptor gaba a |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20080200473A1 (es) |
| EP (1) | EP1814880B1 (es) |
| JP (1) | JP2008519805A (es) |
| KR (1) | KR20070084026A (es) |
| CN (1) | CN101065377B (es) |
| AR (1) | AR051626A1 (es) |
| AT (1) | ATE421962T1 (es) |
| AU (1) | AU2005303811A1 (es) |
| BR (1) | BRPI0517796A (es) |
| CA (1) | CA2585315A1 (es) |
| DE (1) | DE602005012598D1 (es) |
| DK (1) | DK1814880T3 (es) |
| ES (1) | ES2321858T3 (es) |
| IL (1) | IL182963A0 (es) |
| MX (1) | MX2007005611A (es) |
| NO (1) | NO20072831L (es) |
| PA (1) | PA8652101A1 (es) |
| PE (1) | PE20060967A1 (es) |
| PL (1) | PL1814880T3 (es) |
| PT (1) | PT1814880E (es) |
| RU (1) | RU2007121864A (es) |
| TW (1) | TWI357412B (es) |
| UY (1) | UY29204A1 (es) |
| WO (1) | WO2006051063A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003078448A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| US8221804B2 (en) | 2005-02-03 | 2012-07-17 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
| WO2007137954A1 (en) * | 2006-05-31 | 2007-12-06 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
| BRPI0716583A2 (pt) * | 2006-08-24 | 2013-10-01 | Australian Nuclear Science Tec | ligandos fluorados para marcar recptores de benzodiazepina perifÉricos |
| EP2282735B1 (en) | 2008-04-21 | 2019-01-16 | Signum Biosciences, Inc. | Pp2a modulators for treating alzheimer, parkinson, diabetes |
| WO2009143156A2 (en) * | 2008-05-19 | 2009-11-26 | Sepracor Inc. | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS |
| WO2010045615A2 (en) | 2008-10-16 | 2010-04-22 | Cenomed Biosciences, Llc | Treatment of organophosphate exposure with ocinaplon |
| DK2376490T3 (da) * | 2008-12-04 | 2013-04-15 | Proximagen Ltd | Imidazopyridinforbindelser |
| IN2012DN04917A (es) | 2009-11-05 | 2015-09-25 | Univ Notre Dame Du Lac | |
| US8729271B2 (en) | 2010-09-17 | 2014-05-20 | Taisho Pharmaceutical Co., Ltd | Glycine transporter inhibiting substances |
| IL257743B (en) | 2015-09-17 | 2022-08-01 | Marvin J Miller | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
| US12282014B2 (en) | 2015-11-19 | 2025-04-22 | Dana-Farber Cancer Institute, Inc. | Methods of identifying compounds that interfere with ERG-driven misguidance of BAF complexes in TMPRSS2-ERG driven prostate cancers |
| CN106906486B (zh) * | 2017-02-22 | 2018-12-11 | 华南理工大学 | 3-溴-2-苯基-咪唑并[1,2-α]吡啶类衍生物的电化学合成方法 |
| EP3746124A4 (en) | 2018-01-30 | 2021-10-27 | Foghorn Therapeutics Inc. | COMPOUNDS AND THEIR USES |
| US12473334B2 (en) | 2018-10-17 | 2025-11-18 | Dana-Farber Cancer Institute, Inc. | SWI/SNF family chromatin remodeling complexes and uses thereof |
| WO2020160196A1 (en) | 2019-01-29 | 2020-08-06 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| EP4096668A4 (en) * | 2020-01-29 | 2024-02-28 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| BR112022015004A2 (pt) | 2020-01-29 | 2022-09-20 | Foghorn Therapeutics Inc | Composto, composição farmacêutica, métodos para diminuir a atividade de um complexo baf, induzir apoptose, reduzir o crescimento tumoral, suprimir a progressão e a colonização metastática do câncer e reduzir o nível e/ou a atividade de brg1 e/ou brm em um câncer e métodos de tratamento e de inibição de brm e brg1 |
| US12383555B2 (en) | 2020-05-20 | 2025-08-12 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| AU2024262043A1 (en) * | 2023-04-24 | 2025-11-20 | Shanghai SIMR Biotechnology Co., Ltd | Imidazopyridine or imidazopyrazine compound, preparation method therefor, and pharmaceutical composition and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2568880B1 (fr) * | 1984-08-07 | 1986-12-12 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique |
| FR2593818B1 (fr) * | 1986-02-05 | 1988-04-29 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique |
| FR2593181B1 (fr) * | 1986-01-22 | 1988-04-01 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique |
| DE3769333D1 (de) * | 1986-01-22 | 1991-05-23 | Synthelabo | Acylaminomethylimidazo(1,2-a)pyrimidinderivate, ihre herstellung und therapeutische verwendung. |
| WO2004066930A2 (en) * | 2003-01-27 | 2004-08-12 | Arthur Zaks | Method for inducing pain relief using imidazo[1,2-a]pyridine derivatives |
-
2005
- 2005-11-04 EP EP05808135A patent/EP1814880B1/en not_active Expired - Lifetime
- 2005-11-04 CN CN2005800386913A patent/CN101065377B/zh not_active Expired - Fee Related
- 2005-11-04 MX MX2007005611A patent/MX2007005611A/es active IP Right Grant
- 2005-11-04 AU AU2005303811A patent/AU2005303811A1/en not_active Abandoned
- 2005-11-04 DE DE602005012598T patent/DE602005012598D1/de not_active Expired - Lifetime
- 2005-11-04 PT PT05808135T patent/PT1814880E/pt unknown
- 2005-11-04 WO PCT/EP2005/055753 patent/WO2006051063A1/en not_active Ceased
- 2005-11-04 ES ES05808135T patent/ES2321858T3/es not_active Expired - Lifetime
- 2005-11-04 BR BRPI0517796-0A patent/BRPI0517796A/pt not_active IP Right Cessation
- 2005-11-04 PL PL05808135T patent/PL1814880T3/pl unknown
- 2005-11-04 CA CA002585315A patent/CA2585315A1/en not_active Abandoned
- 2005-11-04 AT AT05808135T patent/ATE421962T1/de active
- 2005-11-04 RU RU2007121864/04A patent/RU2007121864A/ru not_active Application Discontinuation
- 2005-11-04 US US11/667,494 patent/US20080200473A1/en not_active Abandoned
- 2005-11-04 JP JP2007540634A patent/JP2008519805A/ja active Pending
- 2005-11-04 KR KR1020077010318A patent/KR20070084026A/ko not_active Ceased
- 2005-11-04 DK DK05808135T patent/DK1814880T3/da active
- 2005-11-07 PE PE2005001302A patent/PE20060967A1/es not_active Application Discontinuation
- 2005-11-08 TW TW094139042A patent/TWI357412B/zh not_active IP Right Cessation
- 2005-11-08 PA PA20058652101A patent/PA8652101A1/es unknown
- 2005-11-09 AR ARP050104693A patent/AR051626A1/es not_active Application Discontinuation
- 2005-11-10 UY UY29204A patent/UY29204A1/es not_active Application Discontinuation
-
2007
- 2007-05-03 IL IL182963A patent/IL182963A0/en unknown
- 2007-06-04 NO NO20072831A patent/NO20072831L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2585315A1 (en) | 2006-05-18 |
| KR20070084026A (ko) | 2007-08-24 |
| WO2006051063A1 (en) | 2006-05-18 |
| TW200624432A (en) | 2006-07-16 |
| ATE421962T1 (de) | 2009-02-15 |
| TWI357412B (en) | 2012-02-01 |
| NO20072831L (no) | 2007-08-01 |
| DK1814880T3 (da) | 2009-05-18 |
| PT1814880E (pt) | 2009-04-23 |
| PE20060967A1 (es) | 2006-09-20 |
| DE602005012598D1 (de) | 2009-03-19 |
| UY29204A1 (es) | 2006-01-31 |
| US20080200473A1 (en) | 2008-08-21 |
| CN101065377B (zh) | 2011-07-27 |
| MX2007005611A (es) | 2007-07-11 |
| ES2321858T3 (es) | 2009-06-12 |
| BRPI0517796A (pt) | 2008-10-28 |
| AU2005303811A1 (en) | 2006-05-18 |
| PL1814880T3 (pl) | 2009-07-31 |
| CN101065377A (zh) | 2007-10-31 |
| JP2008519805A (ja) | 2008-06-12 |
| RU2007121864A (ru) | 2008-12-20 |
| EP1814880B1 (en) | 2009-01-28 |
| IL182963A0 (en) | 2007-08-19 |
| PA8652101A1 (es) | 2006-10-13 |
| EP1814880A1 (en) | 2007-08-08 |
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