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AR058755A1 - Formas polimorfas cristalinas de clorhidrato de olopatadina y procesos para su preparacion - Google Patents

Formas polimorfas cristalinas de clorhidrato de olopatadina y procesos para su preparacion

Info

Publication number
AR058755A1
AR058755A1 ARP060105802A ARP060105802A AR058755A1 AR 058755 A1 AR058755 A1 AR 058755A1 AR P060105802 A ARP060105802 A AR P060105802A AR P060105802 A ARP060105802 A AR P060105802A AR 058755 A1 AR058755 A1 AR 058755A1
Authority
AR
Argentina
Prior art keywords
olopatadine
chlorhydrate
processes
preparation
crystalline polymorph
Prior art date
Application number
ARP060105802A
Other languages
English (en)
Inventor
Monica Benito
I Elies Molins
Iolanda Chamorro
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR058755A1 publication Critical patent/AR058755A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente se relaciona con formas polimorficas de clorhidrato de olopatadina, denominadas formas A y B de clorhidrato de olopatadina, y con métodos para prepararlas, purificarlas y tratarlas. Reivindicacion 2: Una forma A de clorhidrato de olopatadina de acuerdo con la reivindicacion 1, caracterizada porque dicha forma A de clorhidrato de olopatadina se caracteriza por un espectro XRD (2theta) que tiene picos característicos a aproximadamente 6,28°, 10,92°, 12,72°, 15,55°, 17,58°, 18,26°, 18,94°, 19,39°, 20,64°, 24,14°, 25,49° y 28,32°. Reivindicacion 9: Una forma B de clorhidrato de olopatadina de acuerdo con la reivindicacion 8, caracterizada porque dicha forma B de clorhidrato de olopatadina se caracteriza por un espectro XRD (2theta) que tiene picos característicos a aproximadamente 10,44°, 12,93°, 14,81°, 18,53°, 19,20°, 19,44°, 20,96°, 22,99° y 28,76°.
ARP060105802A 2005-12-22 2006-12-26 Formas polimorfas cristalinas de clorhidrato de olopatadina y procesos para su preparacion AR058755A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75258705P 2005-12-22 2005-12-22

Publications (1)

Publication Number Publication Date
AR058755A1 true AR058755A1 (es) 2008-02-20

Family

ID=38606489

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105802A AR058755A1 (es) 2005-12-22 2006-12-26 Formas polimorfas cristalinas de clorhidrato de olopatadina y procesos para su preparacion

Country Status (6)

Country Link
US (1) US20100137619A1 (es)
EP (2) EP1971590A2 (es)
AR (1) AR058755A1 (es)
CA (1) CA2634665A1 (es)
IL (1) IL192360A0 (es)
WO (1) WO2007119120A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687646B2 (en) 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
CH698773B1 (de) * 2007-02-16 2011-06-30 Sumitomo Chemical Co Verfahren zur Herstellung einer Dibenzoxepin-Verbindung.
JP5325517B2 (ja) * 2007-10-12 2013-10-23 住友化学株式会社 ジベンゾオキセピン化合物の精製方法
AU2010211085B2 (en) * 2009-02-05 2016-08-25 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for preparing olopatadine and/or a pharmaceutically acceptable salt thereof
IT1397503B1 (it) 2009-04-21 2013-01-16 F S I Fabbrica Italiana Sint Processo per la preparazione di olopatadina
WO2011033532A1 (en) 2009-09-17 2011-03-24 Indoco Remedies Limited Process for preparation of olopatadine hydrochloride
WO2011128911A2 (en) * 2010-04-12 2011-10-20 Msn Laboratories Limited Improved process for ll-[(z)-3-(dimethylamino)propyiidenel-6-ll- dihydrodibenz[b,el oxepin-2-aceticacid
ITMI20131820A1 (it) * 2013-11-04 2015-05-05 Laboratorio Chimico Int Spa Procedimento per la preparazione di olopatadina
CN110865130B (zh) * 2018-08-27 2023-08-22 北京海晶生物医药科技有限公司 一种盐酸奥洛他定及其有关物质的检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354155A (en) * 1963-10-14 1967-11-21 Pfizer & Co C Aminoalkylphosphonium compounds and process for the use thereof
GB8520662D0 (en) 1985-08-17 1985-09-25 Wellcome Found Tricyclic aromatic compounds
JPS6310784A (ja) 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
ES2253996B1 (es) * 2004-07-28 2007-08-16 Urquima, S.A. Procedimiento para la preparacion del acido 11-((z)-3-(dimetilamino)propiliden)-6,11-dihidrodibenz(b,e)oxepinacetico.
WO2007105234A2 (en) * 2006-03-14 2007-09-20 Usv Limited A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6, 11-DIHYDRODIBENZ [b, e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE AND POLYMORPHS THEREOF
US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof

Also Published As

Publication number Publication date
CA2634665A1 (en) 2007-10-25
WO2007119120A2 (en) 2007-10-25
EP1971590A2 (en) 2008-09-24
EP2228371A1 (en) 2010-09-15
IL192360A0 (en) 2009-08-03
WO2007119120A3 (en) 2008-02-14
US20100137619A1 (en) 2010-06-03

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