AR058110A1 - Derivados de piperidina - Google Patents
Derivados de piperidinaInfo
- Publication number
- AR058110A1 AR058110A1 ARP060105599A ARP060105599A AR058110A1 AR 058110 A1 AR058110 A1 AR 058110A1 AR P060105599 A ARP060105599 A AR P060105599A AR P060105599 A ARP060105599 A AR P060105599A AR 058110 A1 AR058110 A1 AR 058110A1
- Authority
- AR
- Argentina
- Prior art keywords
- membered heteroaryl
- phenyl
- group
- alkyl
- formula
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006163 5-membered heteroaryl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- -1 -O-phenyl Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Composiciones farmacéuticas; procedimientos, para tratar estados patologicos, enfermedades y trastornos como fibromialgia, ansiedad, depresion, esquizofrenia, déficit de atencion. Reivindicacion 1: Un compuesto de formula (1) o una de sus sales farmacéuticamente aceptables, en la que las posiciones del grupo piperidinilo de formula (1) están marcadas como 1, 2, 3, 4, 5 o 6; 10 es como se muestra en formula (2), un tienopiridinilo, un heteroarilo de 5 miembros o un heteroarilo de 6 miembros; R1, R2, R3, R4 y R5 se seleccionan independientemente del grupo consistente en H, -O-cicloalquilo C5-7, cicloalquilo C5-7, -O-heterocicloalquilo C5-7, -heterocicloalquilo C5-7, -O-fenilo, fenilo, alquileno C1-4-NR16R18, alquilo C1-4, alcoxi C1-4, halo, -C(O)NR12R14, -SO2-CH3, -SO2-CH2CH3, y CN; pudiendo estar dichos tienopiridinilo, heteroarilo de 5 miembros o heteroarilo de 6 miembros opcionalmente sustituidos con 1 a 3 sustituyentes seleccionados independientemente del grupo consistente en H, -O-cicloalquilo C5-7, cicloalquilo C5-7, -O-heterocicloalquilo C5-7, -heterocicloalquilo C5-7, -O-fenilo, -O-(CH2)n-fenilo, -(CH2)n-fenilo, fenilo, -O-(heteroarilo de 5- o 6-miembros), -O-(CH2)n-(heteroarilo de 5- o 6-miembros), - (CH2)n-(heteroarilo de 5- o 6-miembros), alquileno C1-4-NR16R18, alquilo C1-4, alcoxi C1-4, halo, -C(O)NR12R14, -SO2-CH3, -SO2-CH2CH3, y CN; n es 1,2 o 3; R12 y R14 se seleccionan independientemente del grupo consistente en H y alquilo C1-4; R16 y R18 se seleccionan independientemente del grupo consistente en H y alquilo C1-4, y R6 es H o 1 a 3 sustituyentes seleccionados independientemente del grupo consistente en alquilo C1-4, alcoxi C1-4 y halo; con la condicion de que cuando R10 es como en formula (2), y R1, R2, R4 y R5 son H, entonces R3 no es alcoxi C1-4; y cuando R10 es como en formula (2), entonces uno de R1, R2, R3, R4, R5 y R6 no es H.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75184505P | 2005-12-20 | 2005-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058110A1 true AR058110A1 (es) | 2008-01-23 |
Family
ID=38015373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105599A AR058110A1 (es) | 2005-12-20 | 2006-12-18 | Derivados de piperidina |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20070142389A1 (es) |
| EP (1) | EP1966137A2 (es) |
| JP (1) | JP2009520018A (es) |
| AR (1) | AR058110A1 (es) |
| CA (1) | CA2634172A1 (es) |
| DO (1) | DOP2006000287A (es) |
| GT (1) | GT200600516A (es) |
| NL (2) | NL2000376C2 (es) |
| PE (1) | PE20071005A1 (es) |
| TW (1) | TW200732304A (es) |
| UY (1) | UY30029A1 (es) |
| WO (1) | WO2007072150A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010059393A1 (en) * | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| WO2010059390A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| HRP20120920T1 (hr) | 2008-11-14 | 2013-01-31 | Theravance, Inc. | Spojevi 4-[2-(2 fluorofenoksimetil)fenil]piperidina |
| EP2523945A1 (en) | 2010-01-11 | 2012-11-21 | Theravance, Inc. | 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors |
| CA2861479C (en) * | 2012-01-31 | 2017-10-10 | Eisai R&D Management Co., Ltd. | Paroxetine derivative |
| JP6898310B2 (ja) * | 2015-09-02 | 2021-07-07 | トレベナ・インコーポレイテッドＴｒｅｖｅｎａ， Ｉｎｃ． | ６員アザヘテロ環を含有するデルタ−オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
| EP3582783B1 (en) | 2017-02-17 | 2023-06-07 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CA3052480A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CN111533682B (zh) * | 2020-05-29 | 2022-03-01 | 清华大学 | 帕罗西汀及其类似物的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| IE45511B1 (en) * | 1976-09-01 | 1982-09-08 | Ciba Geigy Ag | New derivatives of perhydro-aza-heterocycles and processesfor the production thereof |
| US4585777A (en) * | 1984-02-07 | 1986-04-29 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT |
| EP0190496A3 (en) * | 1984-12-13 | 1987-05-27 | Beecham Group Plc | Piperidine derivatives having a gastro-intestinal activity |
| IE66332B1 (en) * | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
| US5227379A (en) * | 1986-11-03 | 1993-07-13 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
| DK231088D0 (da) * | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
| US5017585A (en) * | 1986-11-03 | 1991-05-21 | Novo Nordisk A/S | Method of treating calcium overload |
| IL98757A (en) * | 1990-07-18 | 1997-01-10 | Novo Nordisk As | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
| US5808139A (en) * | 1992-04-21 | 1998-09-15 | Ligand Pharmaceuticals Incorporated | Non-steroid progesterone receptor agonist and antagonist and compounds and methods |
| US5914328A (en) * | 1992-10-09 | 1999-06-22 | Abbott Laboratories | Heterocyclic ether compounds useful in controlling neurotransmitter release |
| KR100384979B1 (ko) * | 1995-09-07 | 2003-10-17 | 에프. 호프만-라 로슈 아게 | 심부전증및신부전증치료용의신규한4-(옥시알콕시페닐)-3-옥시-피페리딘 |
| US20020151712A1 (en) * | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| WO2001032178A1 (en) * | 1999-10-29 | 2001-05-10 | Novo Nordisk A/S | Use of 3,4-substituted piperidines |
| AU2001270858A1 (en) * | 2000-07-17 | 2002-01-30 | Smithkline Beecham Plc | Novel processes for the preparation of 4-phenylpiperidine derivatives |
| EP1417174A2 (en) * | 2001-08-08 | 2004-05-12 | Neurosearch A/S | Substituted amine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
-
2006
- 2006-12-14 US US11/610,696 patent/US20070142389A1/en not_active Abandoned
- 2006-12-15 NL NL2000376A patent/NL2000376C2/nl not_active IP Right Cessation
- 2006-12-16 EP EP06831727A patent/EP1966137A2/en not_active Withdrawn
- 2006-12-16 WO PCT/IB2006/003639 patent/WO2007072150A2/en not_active Ceased
- 2006-12-16 CA CA002634172A patent/CA2634172A1/en not_active Abandoned
- 2006-12-16 JP JP2008546664A patent/JP2009520018A/ja not_active Withdrawn
- 2006-12-18 AR ARP060105599A patent/AR058110A1/es unknown
- 2006-12-18 DO DO2006000287A patent/DOP2006000287A/es unknown
- 2006-12-18 PE PE2006001623A patent/PE20071005A1/es not_active Application Discontinuation
- 2006-12-19 UY UY30029A patent/UY30029A1/es not_active Application Discontinuation
- 2006-12-19 TW TW095147655A patent/TW200732304A/zh unknown
- 2006-12-19 GT GT200600516A patent/GT200600516A/es unknown
-
2007
- 2007-10-15 NL NL2000937A patent/NL2000937C2/nl not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009520018A (ja) | 2009-05-21 |
| NL2000937C2 (nl) | 2008-07-22 |
| NL2000937A1 (nl) | 2008-01-11 |
| CA2634172A1 (en) | 2007-06-28 |
| GT200600516A (es) | 2007-08-21 |
| PE20071005A1 (es) | 2007-10-24 |
| TW200732304A (en) | 2007-09-01 |
| DOP2006000287A (es) | 2007-11-30 |
| NL2000376C2 (nl) | 2007-10-24 |
| NL2000376A1 (nl) | 2007-06-21 |
| US20070142389A1 (en) | 2007-06-21 |
| EP1966137A2 (en) | 2008-09-10 |
| UY30029A1 (es) | 2007-07-31 |
| WO2007072150A3 (en) | 2008-05-29 |
| WO2007072150A2 (en) | 2007-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |