AR054082A1 - Sintesis de una benzoxazinona - Google Patents
Sintesis de una benzoxazinonaInfo
- Publication number
- AR054082A1 AR054082A1 ARP050103697A ARP050103697A AR054082A1 AR 054082 A1 AR054082 A1 AR 054082A1 AR P050103697 A ARP050103697 A AR P050103697A AR P050103697 A ARP050103697 A AR P050103697A AR 054082 A1 AR054082 A1 AR 054082A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- synthesis
- hiv
- contacting
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- -1 C1-6 alkyl chloroformate Chemical compound 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000012044 organic layer Substances 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Este compuesto es util como un inhibidor de la transcriptasa inversa del virus de inmunodeficiencia humana (VIH). Por lo tanto es util en el tratamiento del VIH, que es el retrovirus que produce la destruccion progresista del sistema inmune humano. Reivindicacion 1: Un proceso para la síntesis de un compuesto de la formula (1), dicho proceso caracterizado porque comprende: a) poner en contacto un compuesto de la formula (2), o una sal del mismo; con el cloroformiato de alquilo C1-6 en presencia de una primera base, en un primer solvente, a una temperatura de aproximadamente 20 a 56sC bajo atmosfera ambiental, para dar un compuesto de la formula (3), en donde R es alquilo C1-6; b) separar la capa orgánica y concentrar hasta obtener el compuesto de la formula (3) en solucion; poner en contacto el compuesto de la formula (3) en solucion con una segunda base aproximadamente a 47-52sC para obtener el compuesto de la formula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60670204P | 2004-09-02 | 2004-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054082A1 true AR054082A1 (es) | 2007-06-06 |
Family
ID=36036924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103697A AR054082A1 (es) | 2004-09-02 | 2005-09-02 | Sintesis de una benzoxazinona |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7205402B2 (es) |
| EP (1) | EP1786791A4 (es) |
| JP (1) | JP4980910B2 (es) |
| KR (1) | KR20070061850A (es) |
| CN (1) | CN101010307B (es) |
| AR (1) | AR054082A1 (es) |
| AU (1) | AU2005282576B2 (es) |
| BR (1) | BRPI0514842A (es) |
| CA (1) | CA2578966A1 (es) |
| IL (1) | IL181678A (es) |
| MX (1) | MX2007002235A (es) |
| NO (1) | NO20071414L (es) |
| PE (1) | PE20060587A1 (es) |
| RU (1) | RU2385868C2 (es) |
| TW (1) | TWI354667B (es) |
| WO (1) | WO2006029079A2 (es) |
| ZA (1) | ZA200701873B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7740693B2 (en) * | 2007-10-01 | 2010-06-22 | Honeywell International Inc. | Organic fluorescent sulfonyl ureido benzoxazinone pigments |
| WO2011005871A1 (en) | 2009-07-07 | 2011-01-13 | Pgxhealth, Llc | Substituted 8-[6-carbonylamine-3-pyridyl]xanthines as adenosine a2b antagonists |
| US8080655B2 (en) * | 2009-07-20 | 2011-12-20 | Apotex Pharmachem Inc. | Methods of making efavirenz and intermediates thereof |
| DE102009041443A1 (de) | 2009-09-16 | 2011-03-31 | Archimica Gmbh | Salze des 6-Chlor-4-(cyclopropylethinyl)-1,4-dihydro-4-(trifluormethyl)-2H-3,1-benzoxazin-2-ons und deren Synthese, Aufreinigung und Anwendung als Vorstufen für Efavirenz |
| EP2447255A1 (en) * | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of cyclic carbamates |
| EP2471783A1 (en) | 2010-12-23 | 2012-07-04 | Esteve Química, S.A. | Novel polymorphic form of efavirenz |
| CN103508973B (zh) * | 2012-06-25 | 2016-04-27 | 上海迪赛诺药业有限公司 | 制备依非韦伦i型结晶的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6081182A (ja) * | 1983-10-12 | 1985-05-09 | Kissei Pharmaceut Co Ltd | チオフエン誘導体及びその製造方法 |
| US5922864A (en) * | 1997-02-12 | 1999-07-13 | Merck & Co., Inc. | Efficient synthesis of a 1,4-dihydro2H-3,1-benzoxazin-2-one |
| HRP980056A2 (en) * | 1997-02-12 | 1998-12-31 | Edward J.J: Grabowski | Efficient synthesis of a 1,4-dihidro-2h-3,1-benzoxazin-2-one |
| DE69819538T2 (de) * | 1997-09-03 | 2004-09-30 | Merck & Co., Inc. | Verfahren zur verbesserung der optischen reinheit von 2r-[1-hydroxy-1-trifluormethyl-3-cyclopropylpropyn-2-yl]-4-chloranilin |
| HRP990182A2 (en) * | 1998-06-11 | 2000-02-29 | Du Pont Pharm Co | Crystalline efavirenz |
-
2005
- 2005-09-01 PE PE2005001003A patent/PE20060587A1/es not_active Application Discontinuation
- 2005-09-01 US US11/217,892 patent/US7205402B2/en not_active Expired - Lifetime
- 2005-09-02 RU RU2007112006/04A patent/RU2385868C2/ru not_active IP Right Cessation
- 2005-09-02 KR KR1020077007447A patent/KR20070061850A/ko not_active Ceased
- 2005-09-02 CA CA002578966A patent/CA2578966A1/en not_active Abandoned
- 2005-09-02 AU AU2005282576A patent/AU2005282576B2/en not_active Ceased
- 2005-09-02 AR ARP050103697A patent/AR054082A1/es unknown
- 2005-09-02 TW TW094130204A patent/TWI354667B/zh not_active IP Right Cessation
- 2005-09-02 BR BRPI0514842-1A patent/BRPI0514842A/pt not_active IP Right Cessation
- 2005-09-02 WO PCT/US2005/031541 patent/WO2006029079A2/en not_active Ceased
- 2005-09-02 CN CN2005800292352A patent/CN101010307B/zh not_active Expired - Fee Related
- 2005-09-02 MX MX2007002235A patent/MX2007002235A/es active IP Right Grant
- 2005-09-02 JP JP2007530448A patent/JP4980910B2/ja not_active Expired - Fee Related
- 2005-09-02 EP EP05794096A patent/EP1786791A4/en not_active Withdrawn
-
2007
- 2007-03-01 IL IL181678A patent/IL181678A/en not_active IP Right Cessation
- 2007-03-02 ZA ZA200701873A patent/ZA200701873B/xx unknown
- 2007-03-15 NO NO20071414A patent/NO20071414L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006029079A3 (en) | 2006-06-01 |
| WO2006029079A2 (en) | 2006-03-16 |
| AU2005282576A1 (en) | 2006-03-16 |
| CN101010307A (zh) | 2007-08-01 |
| PE20060587A1 (es) | 2006-07-09 |
| BRPI0514842A (pt) | 2008-06-24 |
| RU2007112006A (ru) | 2008-10-10 |
| JP2008511682A (ja) | 2008-04-17 |
| RU2385868C2 (ru) | 2010-04-10 |
| CN101010307B (zh) | 2011-10-19 |
| MX2007002235A (es) | 2007-04-23 |
| EP1786791A4 (en) | 2009-04-15 |
| TWI354667B (en) | 2011-12-21 |
| ZA200701873B (en) | 2008-09-25 |
| JP4980910B2 (ja) | 2012-07-18 |
| NO20071414L (no) | 2007-03-15 |
| IL181678A0 (en) | 2007-07-04 |
| US20060047115A1 (en) | 2006-03-02 |
| CA2578966A1 (en) | 2006-03-16 |
| AU2005282576B2 (en) | 2011-11-24 |
| TW200621735A (en) | 2006-07-01 |
| EP1786791A2 (en) | 2007-05-23 |
| US7205402B2 (en) | 2007-04-17 |
| IL181678A (en) | 2012-01-31 |
| KR20070061850A (ko) | 2007-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |