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AR043579A1 - Procedimiento para la preparacion de ciclesonida cristalina con un tamano definido de particulas - Google Patents

Procedimiento para la preparacion de ciclesonida cristalina con un tamano definido de particulas

Info

Publication number
AR043579A1
AR043579A1 ARP040100815A ARP040100815A AR043579A1 AR 043579 A1 AR043579 A1 AR 043579A1 AR P040100815 A ARP040100815 A AR P040100815A AR P040100815 A ARP040100815 A AR P040100815A AR 043579 A1 AR043579 A1 AR 043579A1
Authority
AR
Argentina
Prior art keywords
crystalline
preparation
compound
formula
procedure
Prior art date
Application number
ARP040100815A
Other languages
English (en)
Inventor
Schmidt Beate Dr
Kaupp Stefan Dr
Sturm Ernst Dr
Eistetter Klaus Dr
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33099298&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR043579(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of AR043579A1 publication Critical patent/AR043579A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La ciclesonida cristalina obtenida de acuerdo con el nuevo procedimiento presenta ventajosas propiedades aerodinámicas, y se puede transformar ulteriormente, sin ninguna micronización adicional por medios mecánicos, en formulaciones farmacéuticas inhalables o que se administran por vía nasal. Reivindicación 1: Procedimiento para la preparación de un compuesto de la fórmula (1), en forma cristalina, con un tamano definido de partículas, que comprende las etapas de: a) preparación de una solución del compuesto de la fórmula (1) en un apropiado disolvente orgánico, miscible con agua; b) adición de la solución obtenida de acuerdo con a) al agua, y c) aislamiento del material precipitado formado del compuesto de fórmula (1).
ARP040100815A 2003-03-27 2004-03-12 Procedimiento para la preparacion de ciclesonida cristalina con un tamano definido de particulas AR043579A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03007007 2003-03-27
DE10314097 2003-03-27

Publications (1)

Publication Number Publication Date
AR043579A1 true AR043579A1 (es) 2005-08-03

Family

ID=33099298

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100815A AR043579A1 (es) 2003-03-27 2004-03-12 Procedimiento para la preparacion de ciclesonida cristalina con un tamano definido de particulas

Country Status (27)

Country Link
US (1) US9422327B2 (es)
EP (1) EP1611150B1 (es)
JP (1) JP4746535B2 (es)
KR (1) KR101102709B1 (es)
AR (1) AR043579A1 (es)
AT (1) ATE546459T1 (es)
AU (1) AU2004224092B2 (es)
BR (1) BRPI0408569B1 (es)
CA (1) CA2519752C (es)
CL (1) CL2004000636A1 (es)
CY (1) CY1112970T1 (es)
DK (1) DK1611150T3 (es)
EA (1) EA011157B1 (es)
ES (1) ES2382928T3 (es)
HR (1) HRP20050917B1 (es)
IL (1) IL170746A (es)
MX (1) MXPA05010041A (es)
MY (1) MY143936A (es)
NO (1) NO331984B1 (es)
NZ (1) NZ542827A (es)
PE (1) PE20050388A1 (es)
PL (1) PL1611150T3 (es)
PT (1) PT1611150E (es)
RS (1) RS52549B (es)
SI (1) SI1611150T1 (es)
TW (1) TWI328589B (es)
WO (1) WO2004085460A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CA2622640A1 (en) * 2005-11-02 2007-05-18 Sicor Inc. Improved process for the preparation of ciclesonide
WO2007092574A2 (en) * 2006-02-08 2007-08-16 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
EP2392584A1 (en) * 2006-09-19 2011-12-07 Cipla Limited Crystalline Ciclesonide Methanol Solvate Form C
EP2262823B1 (en) * 2008-03-13 2013-01-23 Farmabios S.p.A. Process for the preparation of pregnane derivatives
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
WO2010054158A2 (en) * 2008-11-07 2010-05-14 Auspex Pharmaceuticals, Inc. Steroid modulators of glucocorticoid receptor
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
WO2014007781A2 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions
WO2014007770A2 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising corticosteroid and sorbitol
US10111957B2 (en) 2012-07-05 2018-10-30 Arven Ilac Snayi ve Ticaret A.S. Inhalation compositions comprising glucose anhydrous
LT3464318T (lt) 2016-06-02 2021-06-25 Abbvie Inc. Gliukokortikoidų receptorių agonistas ir jo imunokonjugatai
PE20201286A1 (es) 2017-12-01 2020-11-24 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados de este

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328929D0 (en) * 1983-10-29 1983-11-30 Sterwin Ag Steroid compounds
WO1990003782A2 (en) 1988-10-05 1990-04-19 The Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DK0407028T4 (da) 1989-05-31 2000-01-31 Fisons Plc Anordning til inhalation af medikamenter og sammensætning af medikamenter
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
FR2668945B1 (fr) 1990-11-12 1993-02-19 Theramex Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus.
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
GB9306703D0 (en) 1993-03-31 1993-05-26 Fisons Plc Inhalation device
ATE172739T1 (de) * 1993-04-02 1998-11-15 Byk Gulden Lomberg Chem Fab Neue prednisolonderivate
IL111194A (en) 1993-10-08 1998-02-08 Fisons Plc Process for the production of medicament formulations
PT749438E (pt) * 1994-03-09 2001-05-31 Byk Gulden Lomberg Chem Fab Novos compostos sililo e sua utilizacao
DE19541689A1 (de) 1994-11-14 1996-05-15 Byk Gulden Lomberg Chem Fab Kombinationsarzneimittel
DE19635498A1 (de) 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung
US6120752A (en) * 1997-05-21 2000-09-19 3M Innovative Properties Company Medicinal aerosol products containing formulations of ciclesonide and related steroids
GB9722285D0 (en) 1997-10-23 1997-12-17 Rhone Poulenc Rorer Ltd Inhalation device
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
US6585958B1 (en) * 1998-07-24 2003-07-01 Jago Research Ag Medicinal aerosol formulations
GB9828721D0 (en) 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
ATE304799T1 (de) * 1999-06-25 2005-10-15 Cognis Ip Man Gmbh Verwendung von nanoskaligen sterolen und sterolestern
AR026073A1 (es) 1999-10-20 2002-12-26 Nycomed Gmbh Composicion farmaceutica acuosa que contiene ciclesonida
AR026072A1 (es) 1999-10-20 2002-12-26 Nycomed Gmbh Composicion farmaceutica que contiene ciclesonida para aplicacion a la mucosa
HU228432B1 (hu) * 2000-11-10 2013-03-28 Nycomed Gmbh Eljárás 16,17-(ciklohexilmetilén)-bisz(oxi)-11,21-dihidroxi-pregna-1,4-dién-3,20-dion elõállítására transz-ketálozással

Also Published As

Publication number Publication date
IL170746A0 (en) 2009-02-11
MY143936A (en) 2011-07-29
TWI328589B (en) 2010-08-11
EA200501391A1 (ru) 2006-06-30
KR101102709B1 (ko) 2012-01-05
JP4746535B2 (ja) 2011-08-10
PL1611150T3 (pl) 2012-07-31
EP1611150B1 (en) 2012-02-22
TW200418519A (en) 2004-10-01
PT1611150E (pt) 2012-05-07
EP1611150A1 (en) 2006-01-04
WO2004085460A8 (en) 2007-03-15
US20060128954A1 (en) 2006-06-15
ATE546459T1 (de) 2012-03-15
HRP20050917B1 (hr) 2014-02-14
CA2519752A1 (en) 2004-10-07
MXPA05010041A (es) 2005-11-17
JP2006521332A (ja) 2006-09-21
AU2004224092B2 (en) 2010-03-04
PE20050388A1 (es) 2005-05-30
SI1611150T1 (sl) 2012-06-29
RS52549B (sr) 2013-04-30
WO2004085460A1 (en) 2004-10-07
NO331984B1 (no) 2012-05-21
CY1112970T1 (el) 2016-04-13
CL2004000636A1 (es) 2005-02-04
BRPI0408569A (pt) 2006-03-21
DK1611150T3 (da) 2012-05-14
EA011157B1 (ru) 2009-02-27
BRPI0408569B1 (pt) 2017-08-29
HRP20050917A2 (en) 2006-12-31
AU2004224092A1 (en) 2004-10-07
CA2519752C (en) 2012-05-29
NZ542827A (en) 2008-02-29
US9422327B2 (en) 2016-08-23
RS20050704A (sr) 2007-06-04
KR20050114250A (ko) 2005-12-05
NO20054835L (no) 2005-10-19
IL170746A (en) 2012-06-28
ES2382928T3 (es) 2012-06-14
HK1088905A1 (zh) 2006-11-17

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