AR039319A1 - Imidazolinilmetil aralquilsulfonamidas - Google Patents
Imidazolinilmetil aralquilsulfonamidasInfo
- Publication number
- AR039319A1 AR039319A1 ARP030101352A ARP030101352A AR039319A1 AR 039319 A1 AR039319 A1 AR 039319A1 AR P030101352 A ARP030101352 A AR P030101352A AR P030101352 A ARP030101352 A AR P030101352A AR 039319 A1 AR039319 A1 AR 039319A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- formula
- compound
- methods
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006239 protecting group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos de la fórmula (1) donde R1-R6 son aquellos definidos aquí y los métodos para producirlo. También se proporcionan composiciones farmacéuticas que comprenden un compuesto de fórmula (1) y los métodos para su uso como agentes terapéuticos. Reivindicación 1: Un compuesto de la fórmula (1), una sal aceptable farmacéuticamente o un profármaco del mismo, en donde R1 es alquilo o -NR7R8, donde cada una de R7 y R8 es independientemente H o alquilo; R2 es H o alquilo; cada uno de R3, R4, R5, y R6 es independientemente H, haluro, alquilo, -OR9 (donde R9 es H, alquilo, un grupo protector hidroxi, o cicloalquilalquilo),-SR10 (donde R10 es H o alquilo), o -NR11R12 (donde cada uno de R11 y R12 es independientemente H, alquilo, o un grupo protector de N), siempre que R3, R4, R5, y R6 no sean todos simultáneamente alquilo; o R3 y R4 junto con los átomos a los que están unidos formen heterociclilo, heteroarilo, o cicloalquilo; y R14 es H, alquilo inferior o -OR15, donde R15 es H, alquilo inferior, o un grupo protector hidroxi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37470002P | 2002-04-23 | 2002-04-23 | |
| US37877502P | 2002-05-08 | 2002-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039319A1 true AR039319A1 (es) | 2005-02-16 |
Family
ID=29273005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101352A AR039319A1 (es) | 2002-04-23 | 2003-04-21 | Imidazolinilmetil aralquilsulfonamidas |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6756395B2 (es) |
| EP (1) | EP1501817A1 (es) |
| JP (1) | JP4362379B2 (es) |
| KR (1) | KR100696561B1 (es) |
| CN (1) | CN1296365C (es) |
| AR (1) | AR039319A1 (es) |
| AU (1) | AU2003227623B2 (es) |
| BR (1) | BR0309668A (es) |
| CA (1) | CA2483345C (es) |
| HR (1) | HRP20040951A2 (es) |
| IL (1) | IL164676A0 (es) |
| MX (1) | MXPA04010315A (es) |
| MY (1) | MY139228A (es) |
| NO (1) | NO20044531L (es) |
| NZ (1) | NZ535823A (es) |
| PA (1) | PA8571401A1 (es) |
| PE (1) | PE20040172A1 (es) |
| PL (1) | PL373322A1 (es) |
| RU (1) | RU2318814C2 (es) |
| TW (1) | TW200306807A (es) |
| UY (1) | UY27770A1 (es) |
| WO (1) | WO2003091236A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100696561B1 (ko) * | 2002-04-23 | 2007-03-19 | 에프. 호프만-라 로슈 아게 | 이미다졸린일메틸 아르알킬설폰아마이드 |
| WO2005063678A1 (ja) * | 2003-12-26 | 2005-07-14 | Daiichi Pharmaceutical Co., Ltd | フェニル酢酸誘導体の製造方法 |
| JP2011511025A (ja) * | 2008-02-04 | 2011-04-07 | エフ．ホフマン−ラ ロシュ アーゲー | 新規イミダゾリニルメチルアリールスルホンアミド |
| CA2711871A1 (en) * | 2008-02-04 | 2009-08-13 | F. Hoffmann-La Roche Ag | N-[3-bromo-2-chloro-4-(4, 5-dihydro-1h-imidazol-2-ylmethyl)-phenyl] -methanesulfoamide as alpha-1 a adrenergic partial agonist for the treatment of incontinence |
| BRPI0906632A2 (pt) * | 2008-02-04 | 2015-07-14 | Hoffmann La Roche | Imidazolinil metil aril sulfonamidas |
| WO2009100120A2 (en) | 2008-02-04 | 2009-08-13 | Neurogen Corporation | Pyridinyl-substituted piperazinyl oxoethyl tetrahydropyrazolopyridines |
| KR20100096266A (ko) * | 2008-02-04 | 2010-09-01 | 에프. 호프만-라 로슈 아게 | 신규한 이미다졸리닐메틸 아릴 설폰아미드 |
| JP4168086B1 (ja) * | 2008-04-16 | 2008-10-22 | 国立大学法人福井大学 | イミダゾリン誘導体 |
| CN103664845B (zh) * | 2013-12-27 | 2016-02-10 | 湖南欧亚生物有限公司 | 一种Plk激酶抑制剂药物中间体7-氨基-2,3-二氢苯并呋喃-4-甲酸的制备方法 |
| CN103853429B (zh) * | 2014-03-14 | 2018-01-23 | 联想(北京)有限公司 | 信息处理方法、信息处理装置及电子设备 |
| CN105693524A (zh) * | 2014-11-28 | 2016-06-22 | 浙江省化工研究院有限公司 | 一种硝基化合物的制备方法 |
| US11590107B2 (en) * | 2019-10-25 | 2023-02-28 | Curasen Therapeutics, Inc. | Methods for treating neurological disorders with α1A-AR partial agonists |
| AU2021334327A1 (en) * | 2020-08-27 | 2023-05-04 | Curasen Therapeutics, Inc. | α1A-ADRENERGIC RECEPTOR AGONISTS AND METHODS OF USE |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3660423A (en) * | 1970-02-13 | 1972-05-02 | Dow Chemical Co | 2-(substituted benzyl)methyl-2-imidazolines |
| AU3115471A (en) | 1970-07-22 | 1973-01-18 | Merck & Co Inc | Chemical processes and products |
| DK0786455T3 (da) * | 1994-09-26 | 2004-03-29 | Shionogi & Co | Imidazolderivater |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| TW405272B (en) | 1997-06-25 | 2000-09-11 | Sony Corp | Method and apparatus for growth of a nitride III-V compound semiconductor |
| GB9910110D0 (en) * | 1999-04-30 | 1999-06-30 | Glaxo Group Ltd | Chemical compounds |
| US6323231B1 (en) * | 2000-02-17 | 2001-11-27 | Abbott Laboratories | Use of α1A adrenoceptor agonists with α1B and α1D antagonism for the treatment of stress urinary incontinence |
| US6602897B2 (en) * | 2000-10-14 | 2003-08-05 | Boehringer Ingelheim Pharma Kg | m-Amino-phenylimino-imidazolidine derivatives for treating urinary incontinence |
| US20020169193A1 (en) * | 2001-02-10 | 2002-11-14 | Pascale Pouzet | Alkylphenyliminoimidazolidine derivatives for treating urinary incontinence |
| KR100696561B1 (ko) * | 2002-04-23 | 2007-03-19 | 에프. 호프만-라 로슈 아게 | 이미다졸린일메틸 아르알킬설폰아마이드 |
-
2003
- 2003-04-15 KR KR1020047016958A patent/KR100696561B1/ko not_active Expired - Fee Related
- 2003-04-15 RU RU2004134326/04A patent/RU2318814C2/ru not_active IP Right Cessation
- 2003-04-15 PL PL03373322A patent/PL373322A1/xx not_active Application Discontinuation
- 2003-04-15 BR BR0309668-8A patent/BR0309668A/pt not_active IP Right Cessation
- 2003-04-15 AU AU2003227623A patent/AU2003227623B2/en not_active Ceased
- 2003-04-15 NZ NZ535823A patent/NZ535823A/en not_active IP Right Cessation
- 2003-04-15 CN CNB038089238A patent/CN1296365C/zh not_active Expired - Fee Related
- 2003-04-15 CA CA2483345A patent/CA2483345C/en not_active Expired - Fee Related
- 2003-04-15 EP EP03725029A patent/EP1501817A1/en not_active Withdrawn
- 2003-04-15 MX MXPA04010315A patent/MXPA04010315A/es active IP Right Grant
- 2003-04-15 WO PCT/EP2003/003904 patent/WO2003091236A1/en not_active Ceased
- 2003-04-15 HR HR20040951A patent/HRP20040951A2/hr not_active Application Discontinuation
- 2003-04-15 JP JP2003587796A patent/JP4362379B2/ja not_active Expired - Fee Related
- 2003-04-16 TW TW092108802A patent/TW200306807A/zh unknown
- 2003-04-16 PE PE2003000388A patent/PE20040172A1/es not_active Application Discontinuation
- 2003-04-21 PA PA20038571401A patent/PA8571401A1/es unknown
- 2003-04-21 AR ARP030101352A patent/AR039319A1/es unknown
- 2003-04-22 MY MYPI20031496A patent/MY139228A/en unknown
- 2003-04-22 UY UY27770A patent/UY27770A1/es not_active Application Discontinuation
- 2003-04-22 US US10/421,119 patent/US6756395B2/en not_active Expired - Fee Related
-
2004
- 2004-04-13 US US10/823,012 patent/US7407980B2/en not_active Expired - Fee Related
- 2004-10-18 IL IL16467604A patent/IL164676A0/xx unknown
- 2004-10-21 NO NO20044531A patent/NO20044531L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6756395B2 (en) | 2004-06-29 |
| PL373322A1 (en) | 2005-08-22 |
| CA2483345A1 (en) | 2003-11-06 |
| CN1646516A (zh) | 2005-07-27 |
| MY139228A (en) | 2009-08-28 |
| AU2003227623B2 (en) | 2010-05-20 |
| MXPA04010315A (es) | 2005-06-08 |
| CN1296365C (zh) | 2007-01-24 |
| IL164676A0 (en) | 2005-12-18 |
| BR0309668A (pt) | 2005-03-01 |
| US20040214875A1 (en) | 2004-10-28 |
| RU2318814C2 (ru) | 2008-03-10 |
| NO20044531L (no) | 2004-11-19 |
| KR100696561B1 (ko) | 2007-03-19 |
| WO2003091236A1 (en) | 2003-11-06 |
| TW200306807A (en) | 2003-12-01 |
| PE20040172A1 (es) | 2004-04-08 |
| HK1080463A1 (en) | 2006-04-28 |
| US7407980B2 (en) | 2008-08-05 |
| KR20040102151A (ko) | 2004-12-03 |
| US20030229130A1 (en) | 2003-12-11 |
| JP4362379B2 (ja) | 2009-11-11 |
| PA8571401A1 (es) | 2004-02-07 |
| HRP20040951A2 (hr) | 2006-06-30 |
| CA2483345C (en) | 2010-12-21 |
| JP2005534628A (ja) | 2005-11-17 |
| NZ535823A (en) | 2007-07-27 |
| RU2004134326A (ru) | 2006-01-27 |
| UY27770A1 (es) | 2003-10-31 |
| AU2003227623A1 (en) | 2003-11-10 |
| EP1501817A1 (en) | 2005-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |