AR038762A1 - Derivados de indolina, un proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion y el uso de dichos derivados para la fabricacion de un medicamento - Google Patents
Derivados de indolina, un proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion y el uso de dichos derivados para la fabricacion de un medicamentoInfo
- Publication number
- AR038762A1 AR038762A1 ARP010104806A ARP010104806A AR038762A1 AR 038762 A1 AR038762 A1 AR 038762A1 AR P010104806 A ARP010104806 A AR P010104806A AR P010104806 A ARP010104806 A AR P010104806A AR 038762 A1 AR038762 A1 AR 038762A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- preparation
- ring
- alkynyl
- cycloalkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- -1 alkylsulfoxyl Chemical group 0.000 abstract 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005224 heteroarylcarbonylamino group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000005226 heteroaryloxycarbonyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Derivados de indolina, que comprenden compuestos de fórmula general (1) en la que R1 y R2 se seleccionan independientemente entre hidrógeno, alquilo, alquenilo, alquinilo, y cicloalquilo; R3 es alquilo, alquenilo, alquinilo, o cicloalquilo; R4, R5, R6 y R7 se seleccionan independientemente entre hidrógeno, alquilo, alquenilo, alquinilo, cicloalquilo, halógeno, haloalquilo, hidroxi, arilo, amino, mono- y dialquilamino, alcoxi, cicloalquiloxi, ariloxi, heteroariloxi, alquiltio, alquilsulfoxilo, alquilsulfonilo, nitro, ciano, alcoxicarbonilo, ariloxicarbonilo, heteroariloxicarbonilo, heteroarilo, alquilcarbonilamino, arilcarbonilamino, heteroarilcarbonilamino, y carboxilo; el anillo A representa un anillo heterocíclico de 5 a 6 miembros, parcialmente insaturado o saturado, carbocíclico o saturado o parcialmente instaurado, en donde los dos átomos del anillo de indolina al cual el anillo A está fusionado forman un enlace simple C-C saturado; y sales, ésteres y/o sus compuestos de adición farmacéuticamente aceptables. Estos compuestos son especialmente útiles para la prevención y tratamiento de trastornos del sistema nervioso central; dano al sistema nervioso central; trastornos cardiovasculares; trastornos gastrointestinales; diabetes, apnea del sueno y especialmente para el tratamiento y prevención de la obesidad. También se describe un proceso para la preparación de dichos derivados, una composición farmacéutica, un proceso para la preparación de dicha composición y el uso de dichos derivados para la fabricación de un medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00122539 | 2000-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038762A1 true AR038762A1 (es) | 2005-01-26 |
Family
ID=8170101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104806A AR038762A1 (es) | 2000-10-16 | 2001-10-12 | Derivados de indolina, un proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion y el uso de dichos derivados para la fabricacion de un medicamento |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6479534B1 (es) |
| EP (1) | EP1328515B1 (es) |
| JP (1) | JP4047723B2 (es) |
| KR (1) | KR100545435B1 (es) |
| CN (1) | CN100334076C (es) |
| AR (1) | AR038762A1 (es) |
| AT (1) | ATE403647T1 (es) |
| AU (2) | AU2002221670B2 (es) |
| BR (1) | BR0114708A (es) |
| CA (1) | CA2422698C (es) |
| DE (1) | DE60135239D1 (es) |
| ES (1) | ES2311563T3 (es) |
| MX (1) | MXPA03003246A (es) |
| WO (1) | WO2002044152A1 (es) |
| ZA (1) | ZA200302516B (es) |
Families Citing this family (70)
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| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CA2551037A1 (en) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
| WO2005097127A2 (en) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Method of treating men with metabolic and anthropometric disorders |
| US7081696B2 (en) | 2004-08-12 | 2006-07-25 | Exro Technologies Inc. | Polyphasic multi-coil generator |
| EP2248524A3 (en) | 2004-08-25 | 2011-03-09 | Takeda Pharmaceutical Company Limited | Preventives/remedies for stress urinary incontinence and method of screening the same |
| CA2584806C (en) | 2004-11-01 | 2014-06-17 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
| TW200640931A (en) | 2005-02-17 | 2006-12-01 | Wyeth Corp | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
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| US6004996A (en) | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| DE69916288T2 (de) | 1998-08-14 | 2005-03-24 | F. Hoffmann-La Roche Ag | Lipasehemmer und chitosan enthaltende arzneimittel |
| AU761351B2 (en) | 1998-08-14 | 2003-06-05 | Cheplapharm Arzneimittel Gmbh | Pharmaceutical compositions containing lipase inhibitors |
| GB9918962D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
-
2001
- 2001-10-12 AT AT01998144T patent/ATE403647T1/de not_active IP Right Cessation
- 2001-10-12 WO PCT/EP2001/011814 patent/WO2002044152A1/en not_active Ceased
- 2001-10-12 MX MXPA03003246A patent/MXPA03003246A/es active IP Right Grant
- 2001-10-12 AU AU2002221670A patent/AU2002221670B2/en not_active Ceased
- 2001-10-12 CN CNB018174434A patent/CN100334076C/zh not_active Expired - Fee Related
- 2001-10-12 DE DE60135239T patent/DE60135239D1/de not_active Expired - Lifetime
- 2001-10-12 BR BR0114708-0A patent/BR0114708A/pt not_active IP Right Cessation
- 2001-10-12 KR KR1020037005300A patent/KR100545435B1/ko not_active Expired - Fee Related
- 2001-10-12 AR ARP010104806A patent/AR038762A1/es unknown
- 2001-10-12 AU AU2167002A patent/AU2167002A/xx active Pending
- 2001-10-12 EP EP01998144A patent/EP1328515B1/en not_active Expired - Lifetime
- 2001-10-12 CA CA002422698A patent/CA2422698C/en not_active Expired - Fee Related
- 2001-10-12 ES ES01998144T patent/ES2311563T3/es not_active Expired - Lifetime
- 2001-10-12 JP JP2002546522A patent/JP4047723B2/ja not_active Expired - Fee Related
- 2001-10-15 US US09/977,783 patent/US6479534B1/en not_active Expired - Fee Related
-
2003
- 2003-03-31 ZA ZA200302516A patent/ZA200302516B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1328515A1 (en) | 2003-07-23 |
| JP2004527467A (ja) | 2004-09-09 |
| CN1630636A (zh) | 2005-06-22 |
| WO2002044152A1 (en) | 2002-06-06 |
| BR0114708A (pt) | 2003-07-01 |
| KR100545435B1 (ko) | 2006-01-24 |
| ATE403647T1 (de) | 2008-08-15 |
| EP1328515B1 (en) | 2008-08-06 |
| DE60135239D1 (de) | 2008-09-18 |
| ES2311563T3 (es) | 2009-02-16 |
| CA2422698C (en) | 2009-12-15 |
| US6479534B1 (en) | 2002-11-12 |
| AU2167002A (en) | 2002-06-11 |
| JP4047723B2 (ja) | 2008-02-13 |
| AU2002221670B2 (en) | 2006-11-02 |
| CN100334076C (zh) | 2007-08-29 |
| ZA200302516B (en) | 2004-06-30 |
| MXPA03003246A (es) | 2003-06-06 |
| US20020183349A1 (en) | 2002-12-05 |
| KR20030048437A (ko) | 2003-06-19 |
| CA2422698A1 (en) | 2002-06-06 |
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