AR036131A1 - Derivados de benzo (g) quinolina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la fabricacion de un medicamento - Google Patents
Derivados de benzo (g) quinolina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la fabricacion de un medicamentoInfo
- Publication number
- AR036131A1 AR036131A1 ARP020102532A ARP020102532A AR036131A1 AR 036131 A1 AR036131 A1 AR 036131A1 AR P020102532 A ARP020102532 A AR P020102532A AR P020102532 A ARP020102532 A AR P020102532A AR 036131 A1 AR036131 A1 AR 036131A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- benzo
- manufacture
- quinolina
- preparation
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- RFQDDXWZZVRLKO-UHFFFAOYSA-N benzo[g]quinoline Chemical class N1=CC=CC2=CC3=CC=CC=C3C=C21 RFQDDXWZZVRLKO-UHFFFAOYSA-N 0.000 abstract 1
- 208000001491 myopia Diseases 0.000 abstract 1
- 230000004379 myopia Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de benzo[g]quinolina que comprenden un compuesto de la fórmula (1) en donde: A y B son cada uno H, o forman juntos un enlace adicional; X es CH2 ó CO; Y es O, S, NR2 [R2 siendo H o alquilo C1-4], CH2, u O-CH2, y R1 es H o alquilo C1-4, en forma de base libre o de sal de adición de ácido. Los compuestos de la fórmula (1) son útiles como productos farmacéuticos. El uso de un compuesto en forma de base libre o de sal de adición de ácido farmacéuticamente aceptable, para la fabricación de un medicamento para el tratamiento de glaucoma y miopía.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01116553 | 2001-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036131A1 true AR036131A1 (es) | 2004-08-11 |
Family
ID=8177978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102532A AR036131A1 (es) | 2001-07-09 | 2002-07-05 | Derivados de benzo (g) quinolina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la fabricacion de un medicamento |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7105528B2 (es) |
| EP (1) | EP1419149B1 (es) |
| JP (2) | JP5006505B2 (es) |
| KR (2) | KR101069948B1 (es) |
| CN (1) | CN1293071C (es) |
| AR (1) | AR036131A1 (es) |
| AT (1) | ATE443060T1 (es) |
| AU (1) | AU2002328856B2 (es) |
| BR (1) | BR0210894A (es) |
| CA (1) | CA2452920C (es) |
| DE (1) | DE60233740D1 (es) |
| EC (1) | ECSP024377A (es) |
| ES (1) | ES2330732T3 (es) |
| HU (1) | HUP0400833A3 (es) |
| IL (2) | IL159255A0 (es) |
| MX (1) | MXPA03012039A (es) |
| MY (1) | MY130656A (es) |
| NO (1) | NO327549B1 (es) |
| NZ (1) | NZ530314A (es) |
| PE (1) | PE20030240A1 (es) |
| PL (1) | PL208284B1 (es) |
| PT (1) | PT1419149E (es) |
| RU (1) | RU2300532C2 (es) |
| WO (1) | WO2003006458A1 (es) |
| ZA (1) | ZA200309642B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG24415A (en) * | 2002-03-07 | 2009-05-25 | Novartis Ag | Quinoline derivatives |
| WO2005023258A1 (en) * | 2003-09-05 | 2005-03-17 | Novartis Ag | Compositions comprising benzo (g) quinoline derivatives and prostaglandin derivatives |
| RU2438670C1 (ru) * | 2010-12-24 | 2012-01-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО "РостГМУ" Минздравсоцразвития России) | Способ лечения ишемического варианта первичной открытоугольной глаукомы у лиц с миопической рефракцией |
| TWI816716B (zh) | 2017-11-24 | 2023-10-01 | 丹麥商Ｈ 朗德貝克公司 | 用於治療帕金森病之新兒茶酚胺前驅藥 |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US12384765B2 (en) | 2019-05-21 | 2025-08-12 | H. Lundbeck A/S | Catecholamine prodrugs for use in the treatment of Parkinson's Disease |
| EP3972959A1 (en) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
| US12319710B2 (en) | 2019-05-21 | 2025-06-03 | H. Lundbeck A/S | Catecholamine prodrugs for use in the treatment of Parkinson's diseases |
| CN113727712B (zh) | 2019-05-21 | 2024-11-15 | H.隆德贝克有限公司 | 用于治疗帕金森病的儿茶酚胺氨基甲酸酯前药 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4114325A1 (de) * | 1991-05-02 | 1992-11-05 | Sandoz Ag | Octahydrobenzo(g)chinolin, seine herstellung und verwendung |
| US5262422A (en) * | 1991-05-02 | 1993-11-16 | Sandoz Ltd. | Octahydrobenzo[g]quinoline |
| GB9326010D0 (en) * | 1993-12-21 | 1994-02-23 | Sandoz Ltd | Improvements in or relating to organic compounds |
| TW357143B (en) * | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
| TW378209B (en) * | 1996-07-08 | 2000-01-01 | Novartis Ag | Benzo[g]quinoline derivatives, their preparation and the pharmaceutical composition containing them |
-
2002
- 2002-07-03 PE PE2002000598A patent/PE20030240A1/es not_active Application Discontinuation
- 2002-07-05 AR ARP020102532A patent/AR036131A1/es active IP Right Grant
- 2002-07-08 KR KR1020047000232A patent/KR101069948B1/ko not_active Expired - Fee Related
- 2002-07-08 AT AT02764648T patent/ATE443060T1/de active
- 2002-07-08 PT PT02764648T patent/PT1419149E/pt unknown
- 2002-07-08 RU RU2004102398/04A patent/RU2300532C2/ru not_active IP Right Cessation
- 2002-07-08 US US10/483,310 patent/US7105528B2/en not_active Expired - Fee Related
- 2002-07-08 WO PCT/EP2002/007594 patent/WO2003006458A1/en not_active Ceased
- 2002-07-08 KR KR1020097025779A patent/KR20100007983A/ko not_active Ceased
- 2002-07-08 ES ES02764648T patent/ES2330732T3/es not_active Expired - Lifetime
- 2002-07-08 CN CNB028138619A patent/CN1293071C/zh not_active Expired - Fee Related
- 2002-07-08 AU AU2002328856A patent/AU2002328856B2/en not_active Ceased
- 2002-07-08 JP JP2003512230A patent/JP5006505B2/ja not_active Expired - Fee Related
- 2002-07-08 IL IL15925502A patent/IL159255A0/xx unknown
- 2002-07-08 DE DE60233740T patent/DE60233740D1/de not_active Expired - Lifetime
- 2002-07-08 MY MYPI20022579A patent/MY130656A/en unknown
- 2002-07-08 PL PL365254A patent/PL208284B1/pl not_active IP Right Cessation
- 2002-07-08 HU HU0400833A patent/HUP0400833A3/hu unknown
- 2002-07-08 NZ NZ530314A patent/NZ530314A/en not_active IP Right Cessation
- 2002-07-08 EP EP02764648A patent/EP1419149B1/en not_active Expired - Lifetime
- 2002-07-08 MX MXPA03012039A patent/MXPA03012039A/es active IP Right Grant
- 2002-07-08 CA CA2452920A patent/CA2452920C/en not_active Expired - Fee Related
- 2002-07-08 BR BR0210894-1A patent/BR0210894A/pt not_active Application Discontinuation
- 2002-12-11 EC EC2002004377A patent/ECSP024377A/es unknown
-
2003
- 2003-12-08 IL IL159255A patent/IL159255A/en not_active IP Right Cessation
- 2003-12-11 ZA ZA200309642A patent/ZA200309642B/xx unknown
-
2004
- 2004-01-07 NO NO20040059A patent/NO327549B1/no not_active IP Right Cessation
-
2009
- 2009-10-30 JP JP2009250333A patent/JP2010024243A/ja not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FG | Grant, registration |