AR035821A1 - Composiciones que contienen un compuesto imidazotriazinona y al menos un anestesico local para administracion nasal, el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de la disfuncion erectil masculina , un aplicador de pulverizacion nasal y un insuflador de polvo - Google Patents
Composiciones que contienen un compuesto imidazotriazinona y al menos un anestesico local para administracion nasal, el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de la disfuncion erectil masculina , un aplicador de pulverizacion nasal y un insuflador de polvoInfo
- Publication number
- AR035821A1 AR035821A1 ARP020101322A ARP020101322A AR035821A1 AR 035821 A1 AR035821 A1 AR 035821A1 AR P020101322 A ARP020101322 A AR P020101322A AR P020101322 A ARP020101322 A AR P020101322A AR 035821 A1 AR035821 A1 AR 035821A1
- Authority
- AR
- Argentina
- Prior art keywords
- straight
- carbon atoms
- branched chain
- optionally substituted
- same
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003589 local anesthetic agent Substances 0.000 title abstract 3
- 208000010228 Erectile Dysfunction Diseases 0.000 title abstract 2
- 201000001881 impotence Diseases 0.000 title abstract 2
- 238000009413 insulation Methods 0.000 title 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- IJYHVZICHKCLMQ-UHFFFAOYSA-N imidazo[4,5-d]triazin-4-one Chemical compound O=C1N=NN=C2N=CN=C12 IJYHVZICHKCLMQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10118306A DE10118306A1 (de) | 2001-04-12 | 2001-04-12 | Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035821A1 true AR035821A1 (es) | 2004-07-14 |
Family
ID=7681379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101322A AR035821A1 (es) | 2001-04-12 | 2002-04-10 | Composiciones que contienen un compuesto imidazotriazinona y al menos un anestesico local para administracion nasal, el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de la disfuncion erectil masculina , un aplicador de pulverizacion nasal y un insuflador de polvo |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6740306B2 (sk) |
| EP (1) | EP1381368A2 (sk) |
| JP (1) | JP2004525968A (sk) |
| KR (1) | KR20030087072A (sk) |
| CN (1) | CN1537004A (sk) |
| AR (1) | AR035821A1 (sk) |
| BG (1) | BG108245A (sk) |
| BR (1) | BR0208813A (sk) |
| CA (1) | CA2443639A1 (sk) |
| CZ (1) | CZ20032752A3 (sk) |
| DE (1) | DE10118306A1 (sk) |
| DO (1) | DOP2002000373A (sk) |
| EC (1) | ECSP034795A (sk) |
| EE (1) | EE200300501A (sk) |
| GT (1) | GT200200070A (sk) |
| HU (1) | HUP0303877A3 (sk) |
| IL (1) | IL158255A0 (sk) |
| MX (1) | MXPA03009314A (sk) |
| NO (1) | NO20034556L (sk) |
| PE (1) | PE20021035A1 (sk) |
| PL (1) | PL363033A1 (sk) |
| RU (1) | RU2003133143A (sk) |
| SK (1) | SK12682003A3 (sk) |
| UY (1) | UY27256A1 (sk) |
| WO (1) | WO2002083674A2 (sk) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4540295B2 (ja) * | 2001-05-09 | 2010-09-08 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | ２−フェニル置換イミダゾトリアジノンの新しい用途 |
| DE102004023069A1 (de) * | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| JP4966204B2 (ja) * | 2004-12-23 | 2012-07-04 | ロックスロ ファーマ， インコーポレイテッド | ケトロラクの鼻腔内投与のための治療用組成物 |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| DE102005009241A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit kontrollierter Bioverfügbarkeit |
| DE102005009240A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
| US20070031349A1 (en) * | 2005-06-23 | 2007-02-08 | David Monteith | Rapidly absorbing oral formulations of PDE 5 inhibitors |
| US20090186896A1 (en) * | 2005-09-29 | 2009-07-23 | Bayer Healthcare Ag | PDE Inhibitors and Combinations Thereof for the Treatment of Urological Disorders |
| KR20100029762A (ko) * | 2007-06-13 | 2010-03-17 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 청력 장애 치료용 ｐｄｅ 억제제 |
| CN102137656A (zh) * | 2008-06-13 | 2011-07-27 | 罗克斯罗制药公司 | 用于鼻内投予的酮咯酸医药调配物 |
| US8277781B2 (en) * | 2009-03-13 | 2012-10-02 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
| US8551454B2 (en) * | 2009-03-13 | 2013-10-08 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| WO2020006606A1 (en) * | 2018-07-05 | 2020-01-09 | Helium 3 Resources Pty Ltd | A pharmaceutical composition and method of use of same |
| SE542968C2 (en) * | 2018-10-26 | 2020-09-22 | Lindahl Anders | Treatment of osteoarthritis |
| IL298432A (en) * | 2020-05-26 | 2023-01-01 | Strategic Drug Solutions Inc | Formulations and methods for treating erectile dysfunction |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4602099A (en) * | 1973-04-02 | 1986-07-22 | Merrell Dow Pharmaceuticals Inc. | Antirhinovirus agents |
| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| GB9514465D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| GB9514473D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| CA2256889A1 (en) | 1996-05-31 | 1997-12-04 | Mochida Pharmaceutical Co., Ltd. | Pyridocarbazole derivatives having cgmp-pde inhibitory effect |
| GB2315673A (en) * | 1996-08-01 | 1998-02-11 | Merck & Co Inc | Treatment of migraine |
| CA2291256A1 (en) * | 1997-05-29 | 1998-12-03 | Mochida Pharmaceutical Co., Ltd. | Therapeutic agent for erection dysfunction |
| CA2304112A1 (en) | 1997-09-23 | 1999-04-01 | John Harrison Heiligenstein | Treatment of attention-deficit/hyperactivity disorder |
| IL135462A0 (en) | 1997-11-12 | 2001-05-20 | Bayer Ag | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| TWI223598B (en) * | 1998-06-22 | 2004-11-11 | Pfizer Ireland Pharmaceuticals | An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate |
| WO2000000199A1 (en) * | 1998-06-26 | 2000-01-06 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of sildenafil citrate |
| JP2002542147A (ja) * | 1998-12-14 | 2002-12-10 | セレジィ ファーマシューティカルス， インコーポレイテッド | 肛門直腸障害の処置のための組成物および方法 |
-
2001
- 2001-04-12 DE DE10118306A patent/DE10118306A1/de not_active Withdrawn
-
2002
- 2002-04-03 CN CNA028114574A patent/CN1537004A/zh active Pending
- 2002-04-03 RU RU2003133143/15A patent/RU2003133143A/ru not_active Application Discontinuation
- 2002-04-03 EE EEP200300501A patent/EE200300501A/xx unknown
- 2002-04-03 CA CA002443639A patent/CA2443639A1/en not_active Abandoned
- 2002-04-03 EP EP02732548A patent/EP1381368A2/de not_active Withdrawn
- 2002-04-03 PL PL02363033A patent/PL363033A1/xx not_active Application Discontinuation
- 2002-04-03 CZ CZ20032752A patent/CZ20032752A3/cs unknown
- 2002-04-03 JP JP2002581429A patent/JP2004525968A/ja active Pending
- 2002-04-03 MX MXPA03009314A patent/MXPA03009314A/es unknown
- 2002-04-03 SK SK1268-2003A patent/SK12682003A3/sk unknown
- 2002-04-03 IL IL15825502A patent/IL158255A0/xx unknown
- 2002-04-03 BR BR0208813-4A patent/BR0208813A/pt not_active Application Discontinuation
- 2002-04-03 WO PCT/EP2002/003663 patent/WO2002083674A2/de not_active Ceased
- 2002-04-03 KR KR10-2003-7013280A patent/KR20030087072A/ko not_active Withdrawn
- 2002-04-03 HU HU0303877A patent/HUP0303877A3/hu unknown
- 2002-04-04 DO DO2002000373A patent/DOP2002000373A/es unknown
- 2002-04-10 AR ARP020101322A patent/AR035821A1/es not_active Application Discontinuation
- 2002-04-11 GT GT200200070A patent/GT200200070A/es unknown
- 2002-04-11 UY UY27256A patent/UY27256A1/es not_active Application Discontinuation
- 2002-04-11 US US10/122,694 patent/US6740306B2/en not_active Expired - Fee Related
- 2002-04-11 PE PE2002000303A patent/PE20021035A1/es not_active Application Discontinuation
-
2003
- 2003-10-08 EC EC2003004795A patent/ECSP034795A/es unknown
- 2003-10-09 BG BG108245A patent/BG108245A/xx unknown
- 2003-10-10 NO NO20034556A patent/NO20034556L/no not_active Application Discontinuation
-
2004
- 2004-03-30 US US10/813,801 patent/US20040248891A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20021035A1 (es) | 2002-11-29 |
| SK12682003A3 (sk) | 2004-03-02 |
| CA2443639A1 (en) | 2002-10-24 |
| BG108245A (en) | 2005-01-31 |
| DOP2002000373A (es) | 2002-11-30 |
| CZ20032752A3 (cs) | 2004-01-14 |
| WO2002083674A3 (de) | 2003-01-09 |
| US20040248891A1 (en) | 2004-12-09 |
| CN1537004A (zh) | 2004-10-13 |
| MXPA03009314A (es) | 2004-03-10 |
| KR20030087072A (ko) | 2003-11-12 |
| RU2003133143A (ru) | 2005-04-10 |
| US20030022894A1 (en) | 2003-01-30 |
| IL158255A0 (en) | 2004-05-12 |
| PL363033A1 (en) | 2004-11-15 |
| NO20034556L (no) | 2003-12-10 |
| WO2002083674A2 (de) | 2002-10-24 |
| BR0208813A (pt) | 2004-03-09 |
| EP1381368A2 (de) | 2004-01-21 |
| US6740306B2 (en) | 2004-05-25 |
| GT200200070A (es) | 2003-01-31 |
| JP2004525968A (ja) | 2004-08-26 |
| UY27256A1 (es) | 2002-11-29 |
| ECSP034795A (es) | 2003-12-01 |
| NO20034556D0 (no) | 2003-10-10 |
| HUP0303877A3 (en) | 2005-05-30 |
| EE200300501A (et) | 2003-12-15 |
| HUP0303877A2 (hu) | 2004-03-29 |
| DE10118306A1 (de) | 2002-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |