AR035465A1 - Compuestos de imidazopiridina, procesos para su preparacion,formulacion farmaceutica, usos de estos compuestos para la fabricacion de medicamentos e intermediarios - Google Patents
Compuestos de imidazopiridina, procesos para su preparacion,formulacion farmaceutica, usos de estos compuestos para la fabricacion de medicamentos e intermediariosInfo
- Publication number
- AR035465A1 AR035465A1 ARP020103019A ARP020103019A AR035465A1 AR 035465 A1 AR035465 A1 AR 035465A1 AR P020103019 A ARP020103019 A AR P020103019A AR P020103019 A ARP020103019 A AR P020103019A AR 035465 A1 AR035465 A1 AR 035465A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- intermediaries
- medicines
- group
- manufacture
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos de imidazopirina que tienen la fórmula (1) o una sal farmacéuticamente aceptable del mismo, donde Het es un grupo heterocíclico alifático o aromático de 4, 5 o 6 miembros que contiene por lo menos un átomo de nitrógeno, oxígeno o azufre, sustituido con un grupo R3 y un grupo R4 en las posiciones orto; R1 es H, CH3, o CH2OH; R2 es CH3 o CH2CH3; R3 y R4 se seleccionan de manera independiente del grupo de H, alquilo C1-6 hidroxilado o halógeno; R5 y R6 son sustituyentes seleccionados de manera independiente que comprenden átomos de C, H, N, O, S, Se, P y halógeno, que proporcionan a los compuestos de fórmula (1) en peso molecular menor o igual a 600 y X es NH u O; que es NH u O; que inhiben la secreción de ácido gástrico estimulada de manera exógeno o endógena y que por lo tanto pueden usarse en la prevención y en el tratamiento de enfermedades inflamatorias gastrointestinales . Proceso para su preparación, formulación farmacéutica, usos de estos compuestos para la fabricación de medicamentos e intermediarios.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102808A SE0102808D0 (sv) | 2001-08-22 | 2001-08-22 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035465A1 true AR035465A1 (es) | 2004-05-26 |
Family
ID=20285105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103019A AR035465A1 (es) | 2001-08-22 | 2002-08-09 | Compuestos de imidazopiridina, procesos para su preparacion,formulacion farmaceutica, usos de estos compuestos para la fabricacion de medicamentos e intermediarios |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20040220209A1 (es) |
| EP (1) | EP1421083A1 (es) |
| JP (1) | JP2005501870A (es) |
| KR (1) | KR20040036723A (es) |
| CN (1) | CN100343252C (es) |
| AR (1) | AR035465A1 (es) |
| BR (1) | BR0211846A (es) |
| CA (1) | CA2456350A1 (es) |
| HU (1) | HUP0401350A3 (es) |
| IL (1) | IL160143A0 (es) |
| IS (1) | IS7159A (es) |
| MX (1) | MXPA04001402A (es) |
| NO (1) | NO20040760L (es) |
| NZ (1) | NZ531110A (es) |
| PL (1) | PL367971A1 (es) |
| RU (1) | RU2294935C2 (es) |
| SE (1) | SE0102808D0 (es) |
| WO (1) | WO2003018582A1 (es) |
| ZA (1) | ZA200401114B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301904D0 (sv) | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound II with therapeutic effect |
| EP1974730A1 (en) | 2003-11-03 | 2008-10-01 | AstraZeneca AB | Imidazo[1,2-a]pyridine derivatives for use in the treatment of sleep disturbance due to silent gastro-esophageal reflux |
| WO2005070927A2 (en) * | 2004-01-26 | 2005-08-04 | Altana Pharma Ag | 1,2,4-triazolo[1,5-a] pyridines as gastric acid secretion inhibitors |
| BRPI0519598A2 (pt) * | 2004-12-17 | 2009-03-10 | Pfizer | derivados de cromano éteis como antagonistas de bomba de Ácido, composiÇço farmacÊutica e uso dos mesmos |
| GB0513423D0 (en) * | 2005-06-30 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| WO2007107827A1 (en) * | 2006-03-17 | 2007-09-27 | Raqualia Pharma Inc. | Chromane derivatives |
| WO2008059373A1 (es) * | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Vacuna contra la malaria, basada en la subunidad 200l de la proteína msp1 de plasmodium vivax. |
| KR200449743Y1 (ko) * | 2008-03-11 | 2010-08-05 | 주식회사 보루네오가구 | 파티션용 상부 스크린의 고정구조 |
| FI20086158A0 (fi) | 2008-12-03 | 2008-12-03 | Mikael Dahlstroem | Imidatsopyridiinijohdannaiset |
| KR101605063B1 (ko) | 2009-07-09 | 2016-03-21 | 라퀄리아 파마 인코포레이티드 | 소화관 운동이상이 관여하는 질환의 치료용 산 펌프 길항제 |
| CA2770087C (en) * | 2009-09-24 | 2014-09-09 | F. Hoffmann-La Roche Ag | Imidazopyridine or imidazopyrimidine derivatives as phosphodiesterase 1oa inhibitors |
| FR2962437B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique |
| WO2014117274A1 (en) * | 2013-01-31 | 2014-08-07 | Neomed Institute | Imidazopyridine compounds and uses thereof |
| JP2016520047A (ja) * | 2013-04-30 | 2016-07-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピラゾールアミドのＰｄ触媒カップリング |
| CN106279151A (zh) * | 2015-06-26 | 2017-01-04 | 江苏太瑞生诺生物医药科技有限公司 | 5-(2-(8-((2,6-二甲基苄基)氨基)-2,3-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺基)乙氧基)-5-氧代戊酸的固体形式及其制备方法 |
| CN113727716A (zh) | 2019-02-25 | 2021-11-30 | 贝卢斯医疗咳嗽病公司 | 采用p2x3调节剂的治疗 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA81219B (en) * | 1980-01-23 | 1982-01-27 | Schering Corp | Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them |
| DE3269604D1 (en) * | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| EP0228006A1 (en) * | 1985-12-16 | 1987-07-08 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine compounds and processes for preparation thereof |
| IL108520A (en) * | 1993-02-15 | 1997-09-30 | Byk Gulden Lomberg Chem Fab | 2, 3, 8-TRISUBSTITUTED IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| UA48122C2 (uk) * | 1993-10-11 | 2002-08-15 | Бік Гульден Ломберг Хеміше Фабрік Гмбх | АЛКОКСІАЛКІЛКАРБАМАТИ ІМІДАЗО[1,2-а]ПІРИДИНІВ, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ |
| JPH10505333A (ja) * | 1994-07-28 | 1998-05-26 | ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | イミダゾピリジン−アゾリジノン |
| SE9801526D0 (sv) * | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
-
2001
- 2001-08-22 SE SE0102808A patent/SE0102808D0/xx unknown
-
2002
- 2002-08-09 AR ARP020103019A patent/AR035465A1/es not_active Application Discontinuation
- 2002-08-21 CA CA002456350A patent/CA2456350A1/en not_active Abandoned
- 2002-08-21 WO PCT/SE2002/001489 patent/WO2003018582A1/en not_active Ceased
- 2002-08-21 CN CNB028160177A patent/CN100343252C/zh not_active Expired - Fee Related
- 2002-08-21 IL IL16014302A patent/IL160143A0/xx unknown
- 2002-08-21 EP EP02759036A patent/EP1421083A1/en not_active Withdrawn
- 2002-08-21 RU RU2004103628/04A patent/RU2294935C2/ru not_active IP Right Cessation
- 2002-08-21 JP JP2003523243A patent/JP2005501870A/ja active Pending
- 2002-08-21 BR BR0211846-7A patent/BR0211846A/pt not_active IP Right Cessation
- 2002-08-21 US US10/487,149 patent/US20040220209A1/en not_active Abandoned
- 2002-08-21 NZ NZ531110A patent/NZ531110A/en unknown
- 2002-08-21 PL PL02367971A patent/PL367971A1/xx not_active Application Discontinuation
- 2002-08-21 KR KR10-2004-7002466A patent/KR20040036723A/ko not_active Ceased
- 2002-08-21 MX MXPA04001402A patent/MXPA04001402A/es unknown
- 2002-08-21 HU HU0401350A patent/HUP0401350A3/hu unknown
-
2004
- 2004-02-11 ZA ZA200401114A patent/ZA200401114B/en unknown
- 2004-02-20 NO NO20040760A patent/NO20040760L/no not_active Application Discontinuation
- 2004-02-20 IS IS7159A patent/IS7159A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IS7159A (is) | 2004-02-20 |
| RU2294935C2 (ru) | 2007-03-10 |
| PL367971A1 (en) | 2005-03-07 |
| NZ531110A (en) | 2005-10-28 |
| CA2456350A1 (en) | 2003-03-06 |
| US20040220209A1 (en) | 2004-11-04 |
| KR20040036723A (ko) | 2004-04-30 |
| IL160143A0 (en) | 2004-06-20 |
| BR0211846A (pt) | 2004-09-08 |
| ZA200401114B (en) | 2005-06-22 |
| MXPA04001402A (es) | 2004-05-27 |
| EP1421083A1 (en) | 2004-05-26 |
| HUP0401350A2 (hu) | 2004-12-28 |
| JP2005501870A (ja) | 2005-01-20 |
| CN1543464A (zh) | 2004-11-03 |
| CN100343252C (zh) | 2007-10-17 |
| NO20040760L (no) | 2004-02-20 |
| RU2004103628A (ru) | 2005-06-27 |
| WO2003018582A1 (en) | 2003-03-06 |
| SE0102808D0 (sv) | 2001-08-22 |
| HUP0401350A3 (en) | 2009-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| FA | Abandonment or withdrawal |