[go: up one dir, main page]

AR035330A1 - Uso de metabolito de (-) -cis-6-fenil-5- (4-(2-pirrolidin-1-iletoxi) fenil)-5, 6, 7, 8-tetrahidronaftalen-2-ol, metabolitos y composiciones que los contienen - Google Patents

Uso de metabolito de (-) -cis-6-fenil-5- (4-(2-pirrolidin-1-iletoxi) fenil)-5, 6, 7, 8-tetrahidronaftalen-2-ol, metabolitos y composiciones que los contienen

Info

Publication number
AR035330A1
AR035330A1 ARP010101626A ARP010101626A AR035330A1 AR 035330 A1 AR035330 A1 AR 035330A1 AR P010101626 A ARP010101626 A AR P010101626A AR P010101626 A ARP010101626 A AR P010101626A AR 035330 A1 AR035330 A1 AR 035330A1
Authority
AR
Argentina
Prior art keywords
phenyl
disease
cancer
formula
metabolite
Prior art date
Application number
ARP010101626A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR035330A1 publication Critical patent/AR035330A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)

Abstract

Uso de un metabolito de (-)-cis-6-fenil-5-[4-(2-pirrolidin-1-iletoxi)fenil]-5,6,7,8-tetrahidronaftalen-2-ol de la fórmula (1) para la preparación de medicamentos caracterizado porque es para el tratamiento de osteoporosis, cáncer de mama, hiperlipidemia, arteriosclerosis, enfermedad de Alzheimer, cataratas, pérdida de libido, disfunción sexual masculina, cáncer de colon, verrugas dérmicas, enfermedad autoinmune, alopecia, acné, enfermedad cardiovascular, diabetes, endometriosis, disfunción sexual femenina, hiperglucemia, obesidad, trastorno obsesivo compulsivo, síndrome premenstrual, carcinoma prostático, hiperplasia prostática benigna, hipertensión pulmonar, dano por reperfusión, artritis reumatoide, osteoartritis, seborrea, ginecomastia senil, deficiencia de testosterona, síndrome de Turner, fibrosis uterina, vaginitis atrófica, incontinencia, cáncer de útero, hirsutismo, bulimia, anorexia, deseo sexual hipoactivo, trastorno de la excitación sexual, dispareunia, vaginismo, prolapso, infecciones del tracto urinario, apoplejía, infarto de miocardio, insuficiencia renal aguda o crónica, enfermedad oclusiva arterial periférica, fenómeno de Raynaud, cánceres de ovario, hígado y práncreas, así como de cáncer desmoide, glioma y carcinoma de células renales, o promover la curación de heridas, incrementar la frecuencia de los orgasmos o reducción del pH vaginal, fórmula (1), donde R1 se selecciona de fórmulas (2), (3) y (4) o -NH(CH2)3COR6; R5 se selecciona de H o CH3; R2, R3, R4 y R7 son iguales o diferentes y se seleccionan de H y OR5; y R6 se selecciona de -OH - -NHCH2COOH, siempre que: (a) si R1 es fórmula (2) o -NH(CH2)3COOH y (b) R2 es OH u OCH3 y R3 y R7 son H, o si R1 es como se definió (a) anteriormente, y (c) R2 y R7 son H y R3 es OH u OCH3, entonces R4 no es H o un isómero óptico, estereoisómero, regioisómero o isómero configuracional o isómero geométrico de éste o un tautómero o una sal farmacéuticamente aceptable de éste. Estos compuestos de la presente se pueden utilizar como patrones en ensayos analíticos o como intermedio para la síntesis química o biosíntesis posterior de entidades químicas. La presente se refiere también a composiciones farmacéuticas para el tratamiento de enfermedades y a su uso en la preparación de las mismas.
ARP010101626A 2000-04-07 2001-04-05 Uso de metabolito de (-) -cis-6-fenil-5- (4-(2-pirrolidin-1-iletoxi) fenil)-5, 6, 7, 8-tetrahidronaftalen-2-ol, metabolitos y composiciones que los contienen AR035330A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26719800P 2000-04-07 2000-04-07

Publications (1)

Publication Number Publication Date
AR035330A1 true AR035330A1 (es) 2004-05-12

Family

ID=23017734

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010101626A AR035330A1 (es) 2000-04-07 2001-04-05 Uso de metabolito de (-) -cis-6-fenil-5- (4-(2-pirrolidin-1-iletoxi) fenil)-5, 6, 7, 8-tetrahidronaftalen-2-ol, metabolitos y composiciones que los contienen

Country Status (38)

Country Link
US (2) US6455572B1 (es)
EP (1) EP1268453B1 (es)
JP (1) JP2004510693A (es)
KR (1) KR20020089434A (es)
CN (1) CN1209353C (es)
AP (1) AP2002002641A0 (es)
AR (1) AR035330A1 (es)
AT (1) ATE333450T1 (es)
AU (2) AU2001240985B2 (es)
BG (1) BG107137A (es)
BR (1) BR0109838A (es)
CA (1) CA2405070A1 (es)
CR (1) CR6766A (es)
CZ (1) CZ20023223A3 (es)
DE (1) DE60121557T2 (es)
DK (1) DK1268453T3 (es)
EA (1) EA004866B1 (es)
EE (1) EE200200580A (es)
ES (1) ES2266169T3 (es)
HK (1) HK1052511B (es)
HR (1) HRP20020802A2 (es)
HU (1) HUP0300419A3 (es)
IL (1) IL152082A0 (es)
IS (1) IS6549A (es)
MA (1) MA26890A1 (es)
MX (1) MXPA02009940A (es)
NO (1) NO20024767L (es)
OA (1) OA12325A (es)
PA (1) PA8514901A1 (es)
PE (1) PE20011183A1 (es)
PL (1) PL358593A1 (es)
PT (1) PT1268453E (es)
SK (1) SK14092002A3 (es)
TN (1) TNSN01052A1 (es)
TR (1) TR200202310T2 (es)
UY (1) UY26656A1 (es)
WO (1) WO2001077093A1 (es)
ZA (1) ZA200207995B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US7001926B2 (en) 2000-03-10 2006-02-21 Oxigene, Inc. Tubulin binding agents and corresponding prodrug constructs
US7091240B2 (en) 2000-03-10 2006-08-15 Oxigene, Inc. Tubulin binding ligands and corresponding prodrug constructs
CZ20002567A3 (cs) * 2000-07-11 2001-12-12 Léčiva, A.S. Tableta vyrobitelná přímým tabletováním, obsahující aktivní látku kyselinu 4-amino-1-hydroxybutyliden-1,1-bisfosfonovou, a způsob její výroby
EP1192945A3 (en) * 2000-09-21 2004-03-03 Pfizer Products Inc. Use of an estrogen agonist/antagonist for treating osteoarthritis
AU781168B2 (en) * 2001-01-26 2005-05-12 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
AU2003207567B2 (en) * 2002-01-18 2008-01-24 Merck Sharp & Dohme Corp. Edg receptor agonists
WO2003076930A1 (en) * 2002-03-14 2003-09-18 Warner-Lambert Company Llc Method for characterizing metabolites using hydrogen/deuterium exchange
CA2536946A1 (en) * 2003-08-26 2005-03-03 Board Of Regents, The University Of Texas System Estrogen receptor modulators and uses thereof
US7456214B2 (en) 2004-05-03 2008-11-25 Baylor University Chromene-containing compounds with anti-tubulin and vascular targeting activity
AU2012200714B2 (en) * 2004-08-13 2014-04-17 Wyeth Llc Tanaproget derivatives, metabolites, and uses thereof
MX2007001812A (es) * 2004-08-13 2007-03-26 Wyeth Corp Derivados de tanaproget, metabolitos, y usos de los mismos.
CA2611035C (en) * 2005-06-22 2010-09-14 Pfizer Products Inc. Stereoselective hydrogenation process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride
US7902147B2 (en) * 2007-11-05 2011-03-08 Duke University Chronic lymphocytic leukemia prognosis and treatment
TW201043595A (en) * 2009-03-13 2010-12-16 Organon Nv Tetrahydronaphthalen-2-ol derivatives
US9845291B2 (en) 2014-12-18 2017-12-19 Genentech, Inc. Estrogen receptor modulators and uses thereof
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522319A (en) * 1964-01-23 1970-07-28 Ciba Geigy Corp Phenol substituted tetrahydronaphthalenes useful as estrogenics
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
UA51676C2 (uk) 1995-11-02 2002-12-16 Пфайзер Інк. (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція
TW442286B (en) 1996-02-28 2001-06-23 Pfizer New therapeutic uses of estrogen agonists
IL120266A (en) 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
US6358951B1 (en) * 1998-08-21 2002-03-19 Pfizer Inc. Growth hormone secretagogues

Also Published As

Publication number Publication date
EA200200949A1 (ru) 2003-02-27
CZ20023223A3 (cs) 2003-12-17
HK1052511B (zh) 2005-09-30
US6455572B1 (en) 2002-09-24
WO2001077093A1 (en) 2001-10-18
IS6549A (is) 2002-09-17
EP1268453B1 (en) 2006-07-19
HRP20020802A2 (en) 2005-02-28
BR0109838A (pt) 2003-01-21
USRE39419E1 (en) 2006-12-05
PE20011183A1 (es) 2001-11-14
ZA200207995B (en) 2003-10-20
US20020042443A1 (en) 2002-04-11
AU4098501A (en) 2001-10-23
TR200202310T2 (tr) 2005-09-21
KR20020089434A (ko) 2002-11-29
CA2405070A1 (en) 2001-10-18
DK1268453T3 (da) 2006-10-23
SK14092002A3 (sk) 2004-01-08
EP1268453A1 (en) 2003-01-02
DE60121557T2 (de) 2007-07-12
ATE333450T1 (de) 2006-08-15
OA12325A (en) 2004-04-13
PT1268453E (pt) 2006-10-31
NO20024767D0 (no) 2002-10-03
CR6766A (es) 2004-01-14
MA26890A1 (fr) 2004-12-20
BG107137A (bg) 2003-05-30
AP2002002641A0 (en) 2002-12-31
IL152082A0 (en) 2003-05-29
EE200200580A (et) 2004-06-15
EA004866B1 (ru) 2004-08-26
DE60121557D1 (de) 2006-08-31
HUP0300419A3 (en) 2005-07-28
JP2004510693A (ja) 2004-04-08
CN1209353C (zh) 2005-07-06
HUP0300419A2 (hu) 2003-06-28
ES2266169T3 (es) 2007-03-01
NO20024767L (no) 2002-12-03
UY26656A1 (es) 2001-11-30
TNSN01052A1 (fr) 2005-11-10
AU2001240985B2 (en) 2005-08-04
HK1052511A1 (en) 2003-09-19
PA8514901A1 (es) 2002-08-29
MXPA02009940A (es) 2003-02-12
CN1422263A (zh) 2003-06-04
PL358593A1 (en) 2004-08-09

Similar Documents

Publication Publication Date Title
AR035330A1 (es) Uso de metabolito de (-) -cis-6-fenil-5- (4-(2-pirrolidin-1-iletoxi) fenil)-5, 6, 7, 8-tetrahidronaftalen-2-ol, metabolitos y composiciones que los contienen
JP7038712B2 (ja) ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤のｅ３リガーゼリガンドとのコンジュゲーションによるｂｔｋの分解および使用法
AU762735B2 (en) Nonsteroidal antiinflammatories
RU2320645C2 (ru) 2-(2,6-дихлорфенил)диарилимидазолы, способ их получения (варианты), промежуточные продукты и фармацевтическая композиция
JP2019535746A (ja) ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤のｅ３リガーゼリガンドとのコンジュゲーションによるｂｔｋの分解および使用法
RU2010107599A (ru) Ферментативный способ получения 17-моноэфиров кортексолона и/или их 9,11-дегидропроизводных
JP6917649B2 (ja) 新規化合物及びそれを有効成分として含有する、線維症または非アルコール性脂肪肝炎の予防、改善または治療用組成物
CA2478232A1 (en) Heterocyclic amide derivatives as cytokine inhibitors
McBriar et al. Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors
CN110229168A (zh) 11,20-二羰基济源冬凌草甲素及其l-氨基酸-14-酯三氟乙酸盐
JP2015504917A (ja) Ｍｏｇａｔ−２阻害剤として有用な新規モルホリニル誘導体
CN106565760A (zh) 氟硼二吡咯衍生物及其制备方法和在医药上的应用
RU2013109416A (ru) Композиция, включающая ретинол, его предшественник или продукт его реакции и экстракт из по меньшей мере одного растения chamomilla, для лечения рака
AU610131B2 (en) Chromone derivatives
CN108250094B (zh) 一种哌嗪二酮类化合物的制备方法
FR2712289A1 (fr) Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
ES2943011T3 (es) Procedimiento de preparación del compuesto imidazol dicetona deuterado
CN101798332A (zh) 胆酸类偶合物、其制备方法和用途
RU2006116631A (ru) Новые триарилимидазолы
CN105884706B (zh) 新利司他高效的合成方法
JP2004509899A (ja) トリアゾロ−エポチロン
RU2015125568A (ru) Производные прегненолона
NO20032407D0 (no) Anvendelse av 6-dimetylaminometyl-1-fenyl- cykloheksanforbindelser for behandling av urininkontinens
KR20100031211A (ko) 리코칼콘계 화합물의 제조방법
JP7697168B2 (ja) 含窒素脂肪族複素環を有するカルバモ（ジチオペルオキソ）チオレート化合物の製造方法とその悪液質に対する治療の応用

Legal Events

Date Code Title Description
FB Suspension of granting procedure