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AR022725A1 - ENZYMATIC HYDROLYSIS ENANTIOSELECTIVA OF ESTERES 3-SUBSTITUTES OF GLUTARIC ACID - Google Patents

ENZYMATIC HYDROLYSIS ENANTIOSELECTIVA OF ESTERES 3-SUBSTITUTES OF GLUTARIC ACID

Info

Publication number
AR022725A1
AR022725A1 ARP000100766A AR022725A1 AR 022725 A1 AR022725 A1 AR 022725A1 AR P000100766 A ARP000100766 A AR P000100766A AR 022725 A1 AR022725 A1 AR 022725A1
Authority
AR
Argentina
Prior art keywords
enantioselectiva
esteres
substitutes
glutaric acid
enzymatic hydrolysis
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR022725A1 publication Critical patent/AR022725A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se presenta un proceso un proceso para preparar un compuesto de enantiomero S de la formula (1) en exceso enantiomérico, o un compuesto del enantiomero Rcon la formula (2) en exceso enantiomérico, proceso que comprende hidrolizar un compuesto que tiene la formula (3) con: (a) una enzima apta para producir unexceso enantiomérico del compuesto del enantiomero S de la formula (1) de por lo menos 70% o (b) una enzima con capacidad para producir un excesoenantiomérico del compuesto del enantiomero Rde la formula (2) de por lo menos 70%, donde R1 es seleccionado entre el grupo que consiste en alquilo, arilo,aralquilo, cicloalquilo o cicloalquilalquilo.A process is presented a process for preparing an enantiomer compound S of the formula (1) in enantiomeric excess, or a compound of the R enantiomer with the formula (2) in enantiomeric excess, a process comprising hydrolyzing a compound having the formula (3 ) with: (a) an enzyme capable of producing an enantiomeric process of the compound of the S enantiomer of the formula (1) of at least 70% or (b) an enzyme capable of producing an enantiomeric excess of the compound of the enantiomer R of the formula ( 2) of at least 70%, where R1 is selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl.

ARP000100766 1999-02-26 2000-02-23 ENZYMATIC HYDROLYSIS ENANTIOSELECTIVA OF ESTERES 3-SUBSTITUTES OF GLUTARIC ACID AR022725A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25947299A 1999-02-26 1999-02-26

Publications (1)

Publication Number Publication Date
AR022725A1 true AR022725A1 (en) 2002-09-04

Family

ID=22985103

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100766 AR022725A1 (en) 1999-02-26 2000-02-23 ENZYMATIC HYDROLYSIS ENANTIOSELECTIVA OF ESTERES 3-SUBSTITUTES OF GLUTARIC ACID

Country Status (3)

Country Link
AR (1) AR022725A1 (en)
AU (1) AU3500500A (en)
WO (1) WO2000050628A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006271356A1 (en) * 2005-07-18 2007-01-25 Pfizer Limited Process for the preparation of sulfonamide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3224019C1 (en) * 1982-06-28 1984-02-16 Takara Shuzo Co., Ltd., Kyoto Process for the preparation of alkyl beta -(S)-aminoglutarates
WO1993004058A1 (en) * 1991-08-22 1993-03-04 Chiroscience Limited Chiral glutarate esters, their resolution and derived glutarimide compounds
DE19623142A1 (en) * 1996-06-10 1997-12-11 Huels Chemische Werke Ag Enantiomerically enriched malonic acid monoesters substituted by a tertiary hydrocarbon radical and their preparation

Also Published As

Publication number Publication date
WO2000050628A1 (en) 2000-08-31
AU3500500A (en) 2000-09-14

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