AR029930A1 - Peptidos analogos de la sustancia p, procesos de sintesis de los mismos, composiciones y el uso de dichos peptidos para la manufactura de un medicamento para el tratamiento de cancer - Google Patents
Peptidos analogos de la sustancia p, procesos de sintesis de los mismos, composiciones y el uso de dichos peptidos para la manufactura de un medicamento para el tratamiento de cancerInfo
- Publication number
- AR029930A1 AR029930A1 ARP010102429A ARP010102429A AR029930A1 AR 029930 A1 AR029930 A1 AR 029930A1 AR P010102429 A ARP010102429 A AR P010102429A AR P010102429 A ARP010102429 A AR P010102429A AR 029930 A1 AR029930 A1 AR 029930A1
- Authority
- AR
- Argentina
- Prior art keywords
- alpha
- peptides
- acid
- substance
- ac6c
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- WOXWUZCRWJWTRT-UHFFFAOYSA-N 1-amino-1-cyclohexanecarboxylic acid Chemical compound OC(=O)C1(N)CCCCC1 WOXWUZCRWJWTRT-UHFFFAOYSA-N 0.000 abstract 2
- NILQLFBWTXNUOE-UHFFFAOYSA-N 1-aminocyclopentanecarboxylic acid Chemical compound OC(=O)C1(N)CCCC1 NILQLFBWTXNUOE-UHFFFAOYSA-N 0.000 abstract 2
- CZHCGMZJLLOYJW-UHFFFAOYSA-N 2-amino-2-propylpentanoic acid Chemical compound CCCC(N)(C(O)=O)CCC CZHCGMZJLLOYJW-UHFFFAOYSA-N 0.000 abstract 2
- 125000001431 2-aminoisobutyric acid group Chemical group [#6]C([#6])(N*)C(*)=O 0.000 abstract 2
- KWOMLHIFHFWBSB-UHFFFAOYSA-N 2-azaniumyl-2-ethylbutanoate Chemical compound CCC(N)(CC)C(O)=O KWOMLHIFHFWBSB-UHFFFAOYSA-N 0.000 abstract 2
- FUOOLUPWFVMBKG-UHFFFAOYSA-N alpha-amino-isobutyric acid Natural products CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical class C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
- 102400000096 Substance P Human genes 0.000 abstract 1
- 101800003906 Substance P Proteins 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Abarca análogos peptídicos sintéticos que son antagonistas de la Sustancia P, péptidos simil sustancia P y péptidos relacionados, que son utiles para el tratamiento del cáncer. Se relaciona especialmente con el diseno y la síntesis de los novedosos análogos antagonistas de la sustancia P que incorporan aminoácidos alfa, alfa-dialquilados en sitios específicos cuyas formulas son: X-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-R-NH2 en la cual X es acetilo o un grupo alcanoilo recto, ramificado o cíclico con 3 a 18 átomos de carbono, o ha sido suprimido; R es Aib, Deg, Dpg, Ac5c o Ac6c; o bien R es un grupo carboxi-protector hidrolizable o una sal farmacéuticamente aceptable del péptido en donde Aib es ácido alfa-aminoisobutírico. Deg es alfa, alfa-dietilglicina, Dpg es alfa, alfa-di-n-propilglicina. Ac5C es ácido 1-aminociclopentancarboxílico y Ac6C es ácido 1-aminociclohexano carboxílico, D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-R-NH2, en la cual, R es Aib, Deg, Dpg, Ac5c o Ac6c; o bien R es un grupo carboxi protector hidrolizable o una sal farmacéuticamente aceptable del péptido en donde Aib es ácido alfa-aminoisobutírico, Deg es alfa, alfa-dietilglicina, Dpg es alfa, alfa-di-n-propilglicina, Ac5C es ácido 1-aminociclopentancarboxílico y Ac6C es ácido 1-aminociclohexano carboxílico. También abarca procesos de síntesis de estos péptidos, composiciones que contienen estos péptidos y el uso de estos péptidos específicamente para la manufactura de un medicamento en el tratamiento y prevencion del cáncer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/629,642 US6596692B1 (en) | 2000-07-31 | 2000-07-31 | Substance P analogs for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029930A1 true AR029930A1 (es) | 2003-07-23 |
Family
ID=24523842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102429A AR029930A1 (es) | 2000-07-31 | 2001-05-22 | Peptidos analogos de la sustancia p, procesos de sintesis de los mismos, composiciones y el uso de dichos peptidos para la manufactura de un medicamento para el tratamiento de cancer |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6596692B1 (es) |
| AR (1) | AR029930A1 (es) |
| MY (1) | MY128151A (es) |
| TW (1) | TWI245772B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7173006B2 (en) * | 2002-12-23 | 2007-02-06 | Dabur Research Foundation | Drug comprising synthetic peptide analogs for the treatment of cancer |
| CA2580694A1 (en) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| US20070154448A1 (en) * | 2005-11-22 | 2007-07-05 | Ted Reid | Methods and compositions using Substance P to promote wound healing |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5410019A (en) | 1987-09-24 | 1995-04-25 | The Administrators Of The Tulane-Educational Fund | Therapeutic peptides |
| GB8806644D0 (en) | 1988-03-21 | 1988-04-20 | Imp Cancer Res Tech | Neuropeptide antagonists |
| US5434132A (en) | 1988-03-21 | 1995-07-18 | Imperial Cancer Research Technology, Ltd. | Neuropeptide antagonists |
| JPH09322218A (ja) | 1996-03-29 | 1997-12-12 | Casio Comput Co Ltd | 送受信システムもしくはそれに用いられる装置と方法 |
-
2000
- 2000-07-31 US US09/629,642 patent/US6596692B1/en not_active Expired - Fee Related
-
2001
- 2001-05-22 AR ARP010102429A patent/AR029930A1/es active IP Right Grant
- 2001-05-24 MY MYPI20012471A patent/MY128151A/en unknown
- 2001-07-31 TW TW090118680A patent/TWI245772B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MY128151A (en) | 2007-01-31 |
| US6596692B1 (en) | 2003-07-22 |
| TWI245772B (en) | 2005-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |