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UA87278C2 - Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт - Google Patents

Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт

Info

Publication number
UA87278C2
UA87278C2 UAA200602217A UAA200602217A UA87278C2 UA 87278 C2 UA87278 C2 UA 87278C2 UA A200602217 A UAA200602217 A UA A200602217A UA A200602217 A UAA200602217 A UA A200602217A UA 87278 C2 UA87278 C2 UA 87278C2
Authority
UA
Ukraine
Prior art keywords
pro
drug
functional food
biologically non
ace inhibitor
Prior art date
Application number
UAA200602217A
Other languages
English (en)
Ukrainian (uk)
Inventor
Наоюки Ямамото
Сейити Мизуно
Синго Нисимура (умер)
Таканобу Готоу
Кейити Мацуура
Original Assignee
Калпис Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Калпис Ко., Лтд. filed Critical Калпис Ко., Лтд.
Publication of UA87278C2 publication Critical patent/UA87278C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
UAA200602217A 2003-08-01 2004-07-30 Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт UA87278C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003285007 2003-08-01

Publications (1)

Publication Number Publication Date
UA87278C2 true UA87278C2 (ru) 2009-07-10

Family

ID=34113859

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200602131A UA89616C2 (ru) 2003-08-01 2004-07-30 Гидролизат казеина, способ его получения и применения
UAA200602217A UA87278C2 (ru) 2003-08-01 2004-07-30 Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA200602131A UA89616C2 (ru) 2003-08-01 2004-07-30 Гидролизат казеина, способ его получения и применения

Country Status (22)

Country Link
US (3) US20070122451A1 (ru)
EP (2) EP1669463B1 (ru)
JP (3) JP5341300B2 (ru)
KR (3) KR101115560B1 (ru)
CN (3) CN100398661C (ru)
AT (2) ATE442855T1 (ru)
AU (2) AU2004261855B2 (ru)
BR (2) BRPI0413238A (ru)
CA (2) CA2546497A1 (ru)
DE (2) DE602004023210D1 (ru)
DK (2) DK1661909T3 (ru)
EA (2) EA011570B1 (ru)
ES (2) ES2331312T3 (ru)
MX (2) MXPA06000878A (ru)
NO (2) NO20060995L (ru)
NZ (2) NZ545340A (ru)
PL (1) PL1669463T3 (ru)
PT (2) PT1669463E (ru)
TW (2) TWI349676B (ru)
UA (2) UA89616C2 (ru)
WO (2) WO2005012334A1 (ru)
ZA (2) ZA200601739B (ru)

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EP1992354B1 (en) * 2006-02-09 2014-04-09 Calpis Co., Ltd. Rheumatoid arthritis-preventive agent for oral intake
JP4956164B2 (ja) * 2006-12-06 2012-06-20 味の素株式会社 メラニン輸送及び／又は放出抑制剤
EP2130546B1 (en) * 2007-03-27 2013-02-27 Calpis Co., Ltd. Tripeptides for use in treating heart wall thickening
CN101095457B (zh) * 2007-06-23 2010-04-07 临夏州华安生物制品有限责任公司 酸水解酪蛋白的生产方法
CA2719857C (en) * 2008-03-26 2019-08-06 Glanbia Nutritionals (Ireland) Ltd. Leucine-rich peptide compositions and methods for isolation
CN101768209B (zh) * 2009-01-05 2011-08-31 北京林业大学 具有高体内活性的降血压肽及其制备和纯化方法
CN101570568B (zh) * 2009-06-15 2012-05-30 东北农业大学 一种发酵乳中的ace抑制肽及其制备方法
CN102187935B (zh) * 2010-03-19 2012-12-19 江南大学 一种制备酪蛋白磷酸肽与ace抑制肽的方法
CN102399261B (zh) * 2010-09-07 2014-06-25 任发政 具有血管紧张素转化酶c-端选择性抑制活性的三肽及其应用和组合物
US20120115786A1 (en) * 2010-11-09 2012-05-10 Calpis Co., Ltd. Agent for reducing risk in onset of disease ascribable to non-dipper circadian rhythm of blood pressure
US9523109B2 (en) 2011-06-24 2016-12-20 Calpis Co., Ltd. Method for enzymatically preparing peptides for use in improvement of brain function
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JP6251667B2 (ja) 2014-06-03 2017-12-20 アサヒカルピスウェルネス株式会社 錠剤型即放性製剤及びその製造方法
CN105693817B (zh) 2014-11-27 2020-06-05 西北大学 一类三肽化合物及其制备方法与应用
JP6005202B2 (ja) * 2015-03-19 2016-10-12 アサヒグループホールディングス株式会社 脳機能改善用ペプチドの酵素的製造方法
JP6625366B2 (ja) * 2015-08-05 2019-12-25 学校法人北里研究所 豚肉の熟成中に生成する生理活性ペプチドを含む血圧降下剤及び食品、並びにペプチドを指標とする豚肉の熟成評価法
CN106119325A (zh) * 2016-06-23 2016-11-16 哈尔滨商业大学 一种具有增加肌肉含量和力量作用的酪蛋白水解物的制备方法
CN107375897A (zh) * 2017-08-15 2017-11-24 普维食品发展（上海）有限公司 一种辅助降血压的组合物及其用途
CN107348511B (zh) * 2017-08-21 2018-04-06 东方红（通化）生物医药股份有限公司 一种具有辅助降血压作用的西洋参/人参提取物的发酵提取方法
CN108003231A (zh) * 2017-11-13 2018-05-08 江苏大学 一种降低小分子肽中游离氨基酸含量的方法
CN108588156A (zh) * 2018-04-24 2018-09-28 浙江大学 一种水牛乳酪蛋白抗氧化活性肽的制备方法
CN112041328B (zh) * 2018-04-26 2024-06-21 志瑞亚新药工业株式会社 二肽和含有该二肽的药物组合物
CN110467649A (zh) * 2019-09-12 2019-11-19 浙江省农业科学院 一种抑制血管紧张素转换酶活性的多肽qeip及其应用
JP2022135015A (ja) * 2021-03-04 2022-09-15 国立大学法人東京工業大学 オピオイド受容体作動剤
CN113321719B (zh) * 2021-05-20 2022-03-18 澳优乳业（中国）有限公司 一种寡肽及其制备方法与应用
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CN118085027B (zh) * 2024-03-15 2024-12-03 中国海洋大学 一种活性提升的ace抑制肽及其应用

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Also Published As

Publication number Publication date
AU2004261855B2 (en) 2010-09-16
NO20060994L (no) 2006-02-28
DE602004023210D1 (de) 2009-10-29
BRPI0413242A (pt) 2006-10-03
ATE442855T1 (de) 2009-10-15
PT1669463E (pt) 2009-01-23
JPWO2005012334A1 (ja) 2008-01-17
DK1669463T3 (da) 2009-01-26
NO20060995L (no) 2006-02-28
WO2005012334A1 (ja) 2005-02-10
AU2004261522B2 (en) 2010-09-16
KR101174299B1 (ko) 2012-08-16
JP2011102327A (ja) 2011-05-26
JPWO2005012542A1 (ja) 2007-09-27
MXPA06000878A (es) 2006-03-30
HK1094008A1 (zh) 2007-03-16
CN100398661C (zh) 2008-07-02
KR101115560B1 (ko) 2012-03-13
KR20060118395A (ko) 2006-11-23
EP1661909A1 (en) 2006-05-31
CA2532537A1 (en) 2005-02-10
CA2546497A1 (en) 2005-02-10
CN100439393C (zh) 2008-12-03
EA200600352A1 (ru) 2006-08-25
ZA200601739B (en) 2007-05-30
US20110082281A1 (en) 2011-04-07
PT1661909E (pt) 2009-12-17
DK1661909T3 (da) 2010-01-18
WO2005012542A1 (ja) 2005-02-10
HK1093991A1 (zh) 2007-03-16
EP1669463B1 (en) 2008-10-15
EP1669463A1 (en) 2006-06-14
KR20060120567A (ko) 2006-11-27
CN101381401A (zh) 2009-03-11
MXPA06000879A (es) 2006-03-30
CN1833031A (zh) 2006-09-13
EP1661909B1 (en) 2009-09-16
US20070299014A1 (en) 2007-12-27
UA89616C2 (ru) 2010-02-25
KR101115557B1 (ko) 2012-03-13
JP5341300B2 (ja) 2013-11-13
TWI349676B (en) 2011-10-01
ATE411035T1 (de) 2008-10-15
DE602004017202D1 (de) 2008-11-27
AU2004261855A1 (en) 2005-02-10
NZ545340A (en) 2010-04-30
ZA200601746B (en) 2007-05-30
BRPI0413238A (pt) 2006-10-03
CN1832958A (zh) 2006-09-13
ES2331312T3 (es) 2009-12-29
US20070122451A1 (en) 2007-05-31
AU2004261522A1 (en) 2005-02-10
KR20110039379A (ko) 2011-04-15
NZ545341A (en) 2009-06-26
EA010098B1 (ru) 2008-06-30
US8580557B2 (en) 2013-11-12
ES2313067T3 (es) 2009-03-01
PL1669463T3 (pl) 2009-02-27
TWI341866B (en) 2011-05-11
TW200505471A (en) 2005-02-16
EA011570B1 (ru) 2009-04-28
JP4669396B2 (ja) 2011-04-13
TW200507869A (en) 2005-03-01
EP1661909A4 (en) 2006-08-30
WO2005012334A8 (ja) 2005-06-30
EA200600349A1 (ru) 2006-08-25
EP1669463A4 (en) 2006-08-23

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